MGI 5.12 Find Mutations in a Gene

How do I find mutations in a specific gene?

Overview

You can use the Phenotypes, Alleles and Disease Models Query Form to find alleles of a gene, alleles associated with a specific phenotype, or alleles created by a specific type of mutation.

Accessing the Phenotypes, Alleles and Disease Models Query Form

On most MGI pages, you can access the Phenotypes, Alleles and Disease Models Query Form from the Search menu as shown in the image at right.

For this tutorial, open the Phenotypes, Alleles and Disease Models Query Form in a new window. Scroll down this page for further instructions.

Example 1. Finding Kit alleles

Type kit in the Gene/Marker text box.
Change contains to = in the drop-down menu to the right of Gene/Marker.
Click Search.

Search results are ordered by state, with alleles present in live mice appearing first and alleles present in cell lines last. Alleles may be spontaneous mutations, chemically or radiation induced, targeted null alleles (knock-out), targeted knock-ins, conditional alleles (Targeted, Floxed/Frt), or gene trapped reporters.

If the allele has been used to model a human disease, a link to the OMIM entry will be included in the "Human Diseases" column. Click an allele symbol in the first column of the search results to view details.