How do I find mouse models for a human disease or condition?
Overview
You can use the Human Disease Vocabulary Browser to narrow your search to a specific region of the mouse genome. Within this interval, you can choose to retrieve genes or other marker types associated with a human disease, mouse phenotype, or function.
Accessing the Human Disease Vocabulary Browser
On most MGI pages, you can access the Human Disease Vocabulary Browser from the Search menu as shown in the image at right.

For this tutorial, open the Human Disease Vocabulary Browser in a new window. Scroll down this page for further instructions.

Search Menu HDV Browser Screen Shot

Example 1. Finding mouse models of Huntington Disease
  1. Type Huntington in the text box.

  2. Click Search.
HDV Browser Screen Shot
  1. Click the link to Huntington Disease; HD from the list of results to view details about the mouse models associated with this disease.
HDV Search Results
  1. The Human Disease and Mouse Model Detail page lists mouse and human genes, transgenes and other mutations, and mouse models associated with Huntington Disease. For a detailed interpretation of this page, click Documentation Link.

    Click on OMIM ID: 143100 to view the corresponding Huntington Disease entry in Online Mendelian Inheritance in Man (OMIM).

HD & MM Detail Page