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DEXA for Project: NIH-1795
Test Description: Mice were anesthetized by intraperitoneal injection of Avertin (1.25% 2,2,2,-tribromoethanol, 20 ml/kg body weight ), measured body length and weight, and then placed in a prone position on the platform of the PIXImusTM Densitometer (Lunar Inc.) for a DEXA scan. Using a Lunar PIXImus software, the Bone mineral density (BMD) and fat composition (% fat) and total tissue mass (TTM) were determined in the regions of interest (ROI, i.e., whole body, vertebrae, and both femurs).


Results

  BMD = Bone Mineral Density (g/cm2);
  BMC = Bone Mineral Content (g);
  LBM = Lean Body Mass (g);
  BMC / LBM = BMC / LBM (mg/g); 		  FAT(%) = % of Body FAT;
  FAT(g) = TTM X FAT(%)/100;
  TTM = Total Tissue Mass (g);
  vBMD = Volumetric BMD (mg/cm3)

MALE DATA




FEMALE DATA



DEXA Combined Gender Score
Parameter Score
Body BMD  97.0%
Body vBMD  97.8%
Body BMC/LBM  99.3%
Femur BMD  92.8%
Vertebral BMD  97.8%
Total Tissue Mass  98.2%
Body LBM  96.3%
Body % Fat  105.0%
Body Fat Content  103.8%
The Combined Gender Score provides the average ration of Hom to WT values combining
males and females, with a correction factor for the number of mice in each group. No score
is generated if there are fewer than 4 HOM mice or fewer than 3 WT mice


DEXA Analysis: Male
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
M-185wt0.04890.486626.6518.9821.1123.0615.510.05550.07815000
M-153het0.05590.617535.2124.1126.123.6616.820.06690.08595000
M-154het0.05250.547238.6328.027.2720.0716.270.06530.08550000
M-158hom0.05490.580628.0318.9422.1426.2216.890.07110.08755000
M-159hom0.04880.52426.116.4221.2924.6114.880.05870.07145000
M-186hom0.04720.462224.2718.4919.3223.9215.090.05770.06830000
M-187hom0.04920.549927.8718.9922.0324.9614.720.05650.07310000

DEXA Analysis: Female
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
F-147wt0.0440.358621.0928.6814.6824.4215.410.05590.06780000
F-183wt0.0490.486121.1419.3716.5629.3615.560.05960.07105000
F-199wt0.04720.431219.8225.2514.3829.9815.610.06910.06694999
F-170het0.05030.459322.426.8415.9328.8416.650.05950.07650000
F-172het0.04750.435721.6628.615.0328.9915.690.05810.06880000
F-146hom0.03930.291219.329.8913.2421.9914.440.03840.05770000
F-148hom0.04260.32722.5232.9714.7722.1415.380.0410.06010000
F-169hom0.04440.380619.6627.5813.8627.4715.160.05650.06180000
F-171hom0.04780.479518.8518.5114.8832.2215.10.06410.06845000




  DEXA Analysis data        Export Data to Spreadsheet
Mouse
Label 		Genotype Age (days) Site BMD BMC Length Weight FAT TTM
M-153 het 113 T-Animal Total 0.0559 0.6175 10.5 37.18 24.11 35.21
M-153 het 113 R-V 0.0669 0.0347 10.5 37.18 11.74 1.03
M-153 het 113 R-FL 0.0883 0.0406 10.5 37.18 21.68 1.08
M-153 het 113 R-FR 0.0836 0.0406 10.5 37.18 17.29 0.87
M-154 het 113 T-Animal Total 0.0525 0.5472 10.8 40.31 28.0 38.63
M-154 het 113 R-V 0.0653 0.0314 10.8 40.31 12.29 1.01
M-154 het 113 R-FL 0.0906 0.0392 10.8 40.31 30.61 1.06
M-154 het 113 R-FR 0.0804 0.039 10.8 40.31 25.93 1.06
F-170 het 111 T-Animal Total 0.0503 0.4593 9.2 23.98 26.84 22.4
F-170 het 111 R-V 0.0595 0.0219 9.2 23.98 17.71 0.68
F-170 het 111 R-FR 0.0729 0.0316 9.2 23.98 26.08 0.71
F-170 het 111 R-FL 0.0801 0.0298 9.2 23.98 30.93 0.69
F-172 het 111 T-Animal Total 0.0475 0.4357 9.3 23.37 28.6 21.66
F-172 het 111 R-V 0.0581 0.0218 9.3 23.37 17.32 0.67
F-172 het 111 R-FR 0.0679 0.0286 9.3 23.37 27.3 0.69
F-172 het 111 R-FL 0.0697 0.0278 9.3 23.37 33.22 0.8
F-146 hom 113 T-Animal Total 0.0393 0.2912 8.8 20.12 29.89 19.3
F-146 hom 113 R-V 0.0384 0.0124 8.8 20.12 14.36 0.61
F-146 hom 113 R-FL 0.0574 0.0202 8.8 20.12 33.85 0.69
F-146 hom 113 R-FR 0.058 0.0203 8.8 20.12 30.48 0.64
F-148 hom 113 T-Animal Total 0.0426 0.327 8.9 23.44 32.97 22.52
F-148 hom 113 R-V 0.041 0.0128 8.9 23.44 12.85 0.62
F-148 hom 113 R-FR 0.0579 0.0207 8.9 23.44 36.68 0.68
F-148 hom 113 R-FL 0.0623 0.0203 8.9 23.44 36.05 0.67
M-158 hom 112 T-Animal Total 0.0549 0.5806 9.7 29.8 18.94 28.03
M-158 hom 112 R-V 0.0711 0.028 9.7 29.8 7.41 0.78
M-158 hom 112 R-FL 0.0895 0.0357 9.7 29.8 20.44 0.69
M-158 hom 112 R-FR 0.0856 0.038 9.7 29.8 12.86 0.75
M-159 hom 112 T-Animal Total 0.0488 0.524 9.6 28.12 16.42 26.1
M-159 hom 112 R-V 0.0587 0.0258 9.6 28.12 6.99 0.86
M-159 hom 112 R-FL 0.075 0.0321 9.6 28.12 20.78 0.79
M-159 hom 112 R-FR 0.0679 0.0321 9.6 28.12 10.87 0.79
F-169 hom 111 T-Animal Total 0.0444 0.3806 8.9 21.05 27.58 19.66
F-169 hom 111 R-V 0.0565 0.019 8.9 21.05 13.5 0.59
F-169 hom 111 R-FR 0.0588 0.023 8.9 21.05 29.5 0.68
F-169 hom 111 R-FL 0.0648 0.0237 8.9 21.05 32.31 0.67
F-171 hom 111 T-Animal Total 0.0478 0.4795 9.2 20.8 18.51 18.85
F-171 hom 111 R-V 0.0641 0.0237 9.2 20.8 8.97 0.58
F-171 hom 111 R-FR 0.0666 0.0291 9.2 20.8 18.34 0.72
F-171 hom 111 R-FL 0.0703 0.0302 9.2 20.8 22.22 0.72
M-186 hom 111 T-Animal Total 0.0472 0.4622 9.2 25.96 18.49 24.27
M-186 hom 111 R-V 0.0577 0.0215 9.2 25.96 8.62 0.72
M-186 hom 111 R-FL 0.07 0.0278 9.2 25.96 19.51 0.78
M-186 hom 111 R-FR 0.0666 0.0308 9.2 25.96 15.46 0.73
M-187 hom 111 T-Animal Total 0.0492 0.5499 10.0 29.88 18.99 27.87
M-187 hom 111 R-FR 0.072 0.0352 10.0 29.88 13.16 0.71
M-187 hom 111 R-V 0.0565 0.027 10.0 29.88 8.76 0.92
M-187 hom 111 R-FL 0.0742 0.0323 10.0 29.88 19.85 0.87
F-147 wt 113 T-Animal Total 0.044 0.3586 8.9 22.3 28.68 21.09
F-147 wt 113 R-V 0.0559 0.0203 8.9 22.3 19.07 0.6
F-147 wt 113 R-FL 0.0709 0.0263 8.9 22.3 32.47 0.7
F-147 wt 113 R-FR 0.0647 0.0259 8.9 22.3 26.13 0.66
F-183 wt 111 T-Animal Total 0.049 0.4861 9.3 23.21 19.37 21.14
F-183 wt 111 R-V 0.0596 0.0234 9.3 23.21 7.5 0.7
F-183 wt 111 R-FL 0.0719 0.0293 9.3 23.21 23.87 0.72
F-183 wt 111 R-FR 0.0702 0.0316 9.3 23.21 18.79 0.64
M-185 wt 111 T-Animal Total 0.0489 0.4866 9.5 28.13 18.98 26.65
M-185 wt 111 R-FR 0.0749 0.0316 9.5 28.13 12.76 0.75
M-185 wt 111 R-FL 0.0814 0.0332 9.5 28.13 23.9 0.79
M-185 wt 111 R-V 0.0555 0.0273 9.5 28.13 9.98 1.02
F-199 wt 110 T-Animal Total 0.0472 0.4312 9.2 21.51 25.25 19.82
F-199 wt 110 R-V 0.0691 0.026 9.2 21.51 15.28 0.6
F-199 wt 110 R-FL 0.0685 0.0267 9.2 21.51 29.23 0.66
F-199 wt 110 R-FR 0.0654 0.0256 9.2 21.51 23.38 0.62
 


Copyright 2005 by Lexicon Genetics Incorporated
Lexicon Phenotypic Analysis software version 05.05.00.05