| Gene: 187 | Name: Ccr6 | Family: GPCR | Subfamily: Chemokine | Accession: NM_009835 | GI: 6753317 |
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Gene
187 Wild-type control mice and
homozygous mutant mice were evaluated by the following examinations or tests:
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Gene
187 RT-PCR Summary: Lower levels of RNA transcripts are detectable in lung, pancreas, thymus, bone marrow, skeletal muscle, stomach, small intestine, large intestine, cecum, testis, epididymis, seminal vesicle, coagulating gland and prostate gland. No RNA transcripts are detectable in brain, cortex, subcortical region, cerebellum, brainstem, olfactory bulb, spinal cord, eye, Harderian glands, heart, liver, kidney, skin, gallbladder, urinary bladder, pituitary gland, adrenal gland, salivary gland, tongue, ovaries, uterus and white fat. LacZ Summary: Expression: Lymph Nodes No Expression:
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Gene
187 The following mice were necropsied.
Body weight, body length, and organ weights were obtained, and gross
pathological findings were recorded. 49 Day Cohort Mouse ID numbers
are as follows: Necropsy Findings: There were no genotype-related or
biologically significant differences noted between mutant and wild-type
control mice for any of the parameters evaluated at necropsy. Incidental
lesions were present in some mice. For example, reduced testicular size, and aortic
and adrenal gland discoloration were reported in one 49 day homozygous mutant
male (175188). Additionally, in one 300 day homozygous mutant female (224099)
increased subcutaneous fat correlated with high fat % at
densitometry. These findings were considered to represent background
lesions occasionally seen in this strain of mice, lesions due to spontaneous
disease, age-related lesions, lesions due to procedural artifacts, and/or
lesions of a nonspecific etiology. They were not considered to be related
to genotype. Body and Organ Weight Findings: Differences in body length, body weight, organ weights, and/or organ weight to body weight ratios were present between individual mice. Reduced testicular and epididymis weight in one 49 day homozygous mutant male (175188) correlated to observed reduced testicular size at necropsy. The variability between mice usually fell within our historical reference ranges and was not correlated with genotype. |
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Gene
187 There were no significant
differences detected in the homozygous mutant animals when compared with age-
and gender-matched wild-type control mice. Tissues from the following mice
were evaluated histologically. 49 Day Cohort Mouse ID numbers
are as follows: Bone marrow was examined in
sections of sternum, vertebrae, and/or femur and tibia. Marrow cellularity,
myeloid:erythroid (M:E) ratio, myeloid and erythroid maturation sequences,
and numbers of megakaryocytes were evaluated. Certain histopathological lesions, including dissecting aortic aneurysm, diffuse unilateral adrenal necrosis, Harderian gland adenitis, and testicular degeneration, were present in a 49 day homozygous mutant male (175188) that could have occured spontaneously in mice of this age group. Therefore, we have not reported these findings as phenotypic changes, but we have presented them here for your consideration. Other incidental lesions were present in some tissues. For example, there was moderate hyperostosis of multiple bones in one 300 day homozygous male (264764). These findings were considered to represent background lesions occasionally seen in this strain of mice, lesions due to spontaneous disease, age-related lesions, lesions due to procedural artifacts, and/or lesions of a nonspecific etiology. They were not considered to be genotype related. |
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Gene187 There were no significant
differences in the homozygous mutant animals when compared with age- and
gender-matched wild-type control mice. Blood samples from the following
mice were evaluated by a complete blood count and differential cell count. |
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Gene
187 There were no significant
differences in the homozygous mutant animals when compared with age- and
gender-matched wild-type control mice. Serum samples from the following
mice were evaluated by a clinical chemistry panel. 49 Day Cohort Mouse ID numbers
are as follows: |
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Gene
187 The following mice were evaluated by dual-energy x-ray absorptiometry. 49 Day Cohort Mouse ID numbers
are as follows: Incidental densitometric differences were present between some mice. For example, 49 day (175178) and 300 day (224099) homozygous mutant female mice had increased fat %. These findings were considered to represent background differences occasionally seen in this strain of mice, differences due to spontaneous disease, age-related differences, differences due to procedural artifacts, and/or differences of a nonspecific etiology. They were not considered to be genotype related. |
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Gene
187 There were no significant
differences detected in the homozygous mutant animals when compared with age-
and gender-matched wild-type control mice. The following mice were evaluated
by physical examination. 49 Day Cohort Mouse ID numbers
are as follows: Individual homozygous mutant mice had only occasional minor differences in observed physical features compared to wild-type control mice. These findings were considered to represent individual variability, background features occasionally seen in this strain of mice, findings due to spontaneous disease, age-related findings, procedural artifacts, and/or findings of a nonspecific etiology. However, none of these differences was regarded as biologically significant or genotype related. |
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Gene
187 There were no significant
differences detected in the homozygous mutant mice when compared with age-
and gender-matched wild-type control mice. Body weights and body lengths
were measured for mice at 49, 90, 180, and 300 days of age. 49 Day Cohort Mouse ID numbers
are as follows: Differences in body length and body weight were present between individual mice. The variability between mice usually fell within our historical reference ranges and was not correlated with genotype. |
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Gene 187 Three homozygous mutant mice of each gender were set up in a fertility mating one on one with each other at seven to ten weeks of age. The number of pups born from three litters was recorded. Three weeks later, the live pups were counted and weaned. Mouse ID numbers are as follows: 3 homozygous mutant females (273405, 286839, 290971)
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