WN

Inbr. F105 (N).

Colour: Albino,

Genet. c.

Origin: Heston in 1942 from Wistar stock of Nettleship, to National Institutes of Health in 1950 at F15.

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Characteristics

Anterior pituitary tumours nearly 100% in females over 18 months of age, pheochromocytomas or preneoplastic nodules in adrenal medulla about 40% in males, granulocytic leukaemai 14% in animals over 18 months of age. Rarely show hyperplastic cortical nodules or adrenal cortical adenomas. High incidence of severe chronic nephritis. (Snell 1967). High 10-week body weight in males (19/23) (Tanase et al 1982). High relative heart weight in 10-week old males (19/23) (Tanase et al 1982).

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Snell K. C. (1967) Renal disease of the rat, in Pathology of Laboratory Rats and Mice (Cotchin E. and Roe F. J., eds), pp. 105-147. Blackwell Scientific, Oxford.

Tanase H., Yamori Y., Hansen C. T., and Lovenberg W. (1982) Heart size in inbred strains of rats. Part 1. Genetic determination of the development of cardiovascular enlargement in rats. Hypertension 4, 864-872.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK