Inbred Strains
of Rats: WKHT
Inbr. F17 (1991).
Colour: Albino.
Genet. c.
Origin: From a cross between SHR and WKY, with selection for high blood
pressureand low spontaneous activity (Hendley
et al 1988, Knardahl and Hendley 1990, Hendley and Fan, 1992).
Characteristics
Have been used as a model for studying the effects of drugs on aortic
aneurysms. Propranolol significantly reduces the size of abdominal aortic
aneurysms independently of the dose and by a mechanism which may be unrelated
to blood pressure (
Slaiby et al, 1994)
Hendley
E. D., Cierpial M. A., and MacCarthy R. (1988) Sympathetic-adrenal medullary
response to stress in hyperactive and hypertensive rats. Physiol.
Behav. 44, 47-51.
\par
Hendley
E. D. and Fan X. M. (1992) Regional differences in brain norepinephrine
and dopamine uptake kinetics in inbred rat strains with hypertension and
or hyperactivity. Brain Res. 586, 44-52.
\par
Knardahl
S. and Hendley E. D. (1990) Association between cardiovascular reactivity
to stress and hypertension or behavior. Am. J. Physiol. (Heart Circ.
Physiol.) 28, H248-H257.
\par
Slaiby
J. M., Ricci M. A., Gadowski G. R., Hendley E. D., and Pilcher D. B. (1994)
Expansion of aortic-aneurysms is reduced by propranolol in a hypertensive
rat model. Journal of Vascular Surgery 20, 178-183.
\par
INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
Analysis Tools