WKAH

Inbr. F239 (Hok).

Colour: Albino.

Genet. A, B, c, h.

Origin: King 1909 from Wistar Institute stock to Aptekman in 1946 at F135, to Hokkaido University in 1953 at F148. Formerly called WKA, Probably gentically identical to PA.

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Characteristics

Congenital clubfoot and polydactyly 2% (Shoji 1977, see also WCF). Infection with HTLV-1 results in a chronic progressive myeloneuropathy by 19-23 months of age. Strains F344, ACI and LEW were resistant (Seto et al 1995). Susceptible to the induction of EAU by interphotoreceptor retinol-binding protein (cf LEW, W/M, LEJ and BUF, but in contrast with TO) (Sasamoto et al, 1994).

Liver gangliosides are of the b-type (cf cf SHRSP) (Kasai et al 1993)

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Kasai N., Kamimura A., Miyoshi I., and Ariga T. (1993) Ganglioside distribution in the liver of inbred strains of rats and the cancerous liver of LEC rats. Journal of Biochemistry 113, 251-257.

Sasamoto Y., Kotake S., Yoshikawa K., Wiggert B., Gery I., and Matsuda H. (1994) Interphotoreceptor retinoid-binding protein-derived peptide can induce experimental autoimmune uveoretinitis in various rat strains. Current Eye Research 13, 845-849.

Seto K., Abe M., Ohya O., Itakura O., Ishiguro N., Ikeda H., Wakisaka A., and Yoshiki T. (1995) A rat model of HTLV-1 infection - development of chronic progressive myeloneuropathy in seropositive WKAH rats and related apoptosis. Acta Neuropathol. 89, 483-490.

Shoji R. (1977) Spontaneous occurrence of congenital malformations and mortality in prenatal inbred rats. Proc. Jpn. Acad. 53, 54-67.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK