W/Hok

Inbr. F120. (Hok).

Colour: Albino.

Genet. A, B, c, h.

Origin: Wistar Institute to University of Tokyo, Japan in 1938. To Hokkaido in 1944. Inbred by Makino. Congenital cleft palate 0.5% (Shoji 1977).

W/Nhg

Inbr. ?

Colour: Albino.

Genet. c.

Origin: Wistar rats from the Zentralinstitut fur Versuchstier, Hannover in 1964, inbred since 1973 in Neuherberg, Germany.

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Characteristics

High incidence (97% in feales, 36% in males) of spontaneous thymomas starting from about one year of age. They sometimes caused dyspnea, and were occasionally the cause of death, but were not assocaited with any myopathies or autoimmune disease (Murray et al 1985).

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Murray A. B., Schaffer E., Nussel M., and Luz A. (1985) Incidence, morphology, and ultrastructure of spontaneous thymoma-the most common neoplasm in W/Nhg rats. J. Natl. Cancer Inst. 75, 369-375.

Shoji R. (1977) Spontaneous occurrence of congenital malformations and mortality in prenatal inbred rats. Proc. Jpn. Acad. 53, 54-67.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK