Inbred Strains
of Rats: W
Inbr. F120. (Hok).
Colour: Albino.
Genet. A, B, c, h.
Origin: Wistar Institute to University of Tokyo, Japan in 1938. To Hokkaido
in 1944. Inbred by Makino. Congenital cleft palate 0.5% (Shoji
1977).
W/Nhg
Inbr. ?
Colour: Albino.
Genet. c.
Origin: Wistar rats from the Zentralinstitut fur Versuchstier, Hannover
in 1964, inbred since 1973 in Neuherberg, Germany.
Characteristics
High incidence (97% in feales, 36% in males) of spontaneous thymomas starting
from about one year of age. They sometimes caused dyspnea, and were occasionally
the cause of death, but were not assocaited with any myopathies or autoimmune
disease (
Murray et al 1985).
Murray
A. B., Schaffer E., Nussel M., and Luz A. (1985) Incidence, morphology,
and ultrastructure of spontaneous thymoma-the most common neoplasm in
W/Nhg rats. J. Natl. Cancer Inst. 75, 369-375.
\par
Shoji R. (1977) Spontaneous
occurrence of congenital malformations and mortality in prenatal inbred
rats. Proc. Jpn. Acad. 53, 54-67.
\par
INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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