TMD

Inbr. F20+.

Colour: Black.

Genet. a.

Origin: PL Broadhurst from stock selected by Tryon for poor maze learning performance. Although TMD and TS3 are derived from the same outbred stock, they were inbred independently and should be regarded as different inbred strains (Festing 1979b).

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Characteristics

Low voluntary alcohol acceptance concentration (1/4) (Russell and Stern 1973, see also Amit and Smith, 1992). Low shock avoidance (7/8) (Rick and Fulker 1972). High brain GABA (3/8) (Rick et al 1971).

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Amit Z. and Smith B. R. (1992) Differential ethanol intake in Tryon Maze-Bright and Tryon Maze-Dull rats - implications for the validity of the animal-model of selectively bred rats for high ethanol-consumption. Psychopharmacology 108, 136-140. \par

Festing M. F. W. (1979b) Inbred strains in biomedical research, 1st ed. Macmillan Press, London, Basingstoke. \par

Rick J. T., Tunnicliff G., Kerkut G. A., Fulker D. W., Wilcock J., and Broadhurst P. L. (1971) GAG production in brain cortex related to activity and avoidance behaviour in eight strains of rat. Brain Res. 32, 234-238. \par

Rick J. T. and Fulker D. W. (1972) Some biochemical correlates of inherited behavourial differences. Prog. Brain Res. 36, 105-112. \par

Russell K. E. and Stern M. H. (1973) Sex and strain as factors in voluntary alcohol intake. Physiol. Behav. 10, 641-642. \par

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK