Inbred Strains
of Rats: LOU
Inbr. F35.
Colour: Albino.
Genet. c.
Origin: Bazin and Beckers from rats of presumed Wistar origin kept at
the Universite Catholique de Louvain. LOU/C was selected among 28 parallel
sublines for its high incidence of plasmacytomas, and LOU/M for its low
incidence. The two are histocomaptible (Bazin 1977,
Bazin and Beckers 1978).
Characteristics
Develop spontaneous plasmacytomas after about 8 months of age, with an
incidence of about 30% in males and 16% in females. These develop rapidly,
and may be detected by palpation. They usually develop in the ileocoecal
lymph nodes, and about 60% of them synthesise monoclonal immunoglobulins
(Bence-Jones proteins) of IgG1 (35%), IgE (36%) or IgA classes. Surgical
removal of ileocaecal lymph nodes decreases plasmacytoma incidence to
less than 2% (
Moriame et al 1977). Ultrastructure
of the tumours described by Burtonboy et al (
1978).
Tumours are transplantable in solid or ascites form, and retain their
secretory properties through successive passages (
Bazin
et al 1972, Bazin et al 1973,
Bazin 1974, Bazin et al 1974a,b, Beckers
and Bazin 1978). More than 800 transplantable immunocytomas are now available.
LOU/M
Inbr. F?+36.
Colour: Albino.
Genet. c.
Origin: see LOU/C. Histocompatible with LOU/C and maintained by selection
of LOU/M males on the basis of acceptance of skin grafts from LOU/C rats
(Bazin 1977, Beckers
and Bazin 1978).
Characteristics
Good antibody response to ovalbumin with
Bordetella pertussis
organsisms as adjuvent (
Bazin and Platteau
1976). Susceptible to the development of cerebral malaria when inoculated
with
Plasmodium berghei ANKA (
Neill 1991).
Bazin H.,
Deckers C., Beckers A., and Heremans J. F. (1972) Transplantable immunoglobulin-secreting
tumours in rats. I. General features of LOU/Wsl strain rat immunocytomas
and their monoclonal proteins. Int. J. Cancer 10, 568-580.
\par
Bazin H.,
Beckers A., Deckers C., and Moriame M. (1973) Transplantable immunoglobulin-secreting
tumors in rats. V. Monoclonal immunoglobulins secreted by 250 ileocecal
immunocytomas in LOU/Wsl rats. J. Natl. Cancer Inst. 51,
1359-1361.
\par
Bazin
H., Beckers A., and Querinjean P. (1974a) Three classes and four (sub)classes
of rat immunoglobulins: IgM. IgA, IgE and IgG1, IgG2a, IgG2b, IgG2c. Eur.
J. Immunol. 4, 44-48.
\par
Bazin H.
and Platteau B. (1976) Production of circulating reaginic (IgE) antibodies
by oral administration of ovalbumin to rats. Immunol. 30,
679-683.
\par
Bazin H. (1974) Tumeurs
secretant des immunoglobulines chez le rat LOU/Wsl. Etude portant sur
200 immunocytomes. Ann. Immunol. (Paris) 125C, 277-279.
\par
Bazin H. (1977) Inbred
strains. Rat News Lett. 1, 27.
\par
Beckers
A. and Bazin H. (1978) Incidence of spontaneous ileocecal immunocytomas
in hybrids of LOU/C rats and rat strains with low spontaneous tumor incidence:
Brief communication. J. Natl. Cancer Inst. 60, 1505-1508.
\par
Burtonboy
G., Beckers A., Rodhain J., Bazin H., and Lamy M. E. (1978) Rat ileocecal
immunocytoma. An ultrastructural study with special attention to the presence
of viral particles. J. Natl. Cancer Inst. 61, 477-484.
\par
Moriame
M., Beckers A., and Bazin H. (1977) Decrease in the incidence of malignant
ileo-caecal immunocytome in LOU/C rats after surgical removal of the ileo-caecal
lymph nodes. Cancer Lett. 3, 139-143.
\par
Neill L. A. (1991) LOU/M
rats dvelop cerebral malaria when inoculated with Plasmodium beraghei
ANKA. Rat News Lett. 24, 7-9.
\par
INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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