IS

Inbr.F23+.

Colour: Abouti .

Genet: +.

Origin: from a cross between a wild male and a Wistar female, with sib mating since 1968.

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Characteristics

Malformations of the thoracicolumbar vertebrae leading to kyphoscoliosis with restricted spinal canals and compressed spinal cords. The malformations occur from the 12th. thoracic to the 6th. lumbar vertebrae. Up to 7 vertebrae are affected, and some degree of abnormality occurs in 90% of individuals (Ishibashi 1976). Yamada et al (1982) suggest that the condition is controlled by one or a few genetic factors, and they were able to develop a partially congenic strain which still showed the abnormalities at N3F3 when backcrossed to BN with selection for skeletal abnormalities.

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Ishibashi M. (1976) "Ishibashi rat"--A new strain of rats with congenital spinal malformations. Teratology 14, 242.

Yamada J., Nikaido H., Moritake S., and Maekawa R. (1982) Genetic analysis of the vertebral anomalies of the IS strain of rat and the development of a BN congenic line with the anomalies. Lab. Anim. 16, 40-47.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK