GEPR/3

Inbr. F32 (Jbe 1989).

Colour: Albino.

Genet. c

Origin: Jobe, 1971 from outbred Sprague-Dawley stock. Selected for moderate susceptibility to audiogenic stimuli-induced seizures (Reigel et al 1986a).

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Characteristics

Good reproductive performance. In response to a standard sound stimulus animals exhibit a single wild running phase followed by clonic convulsions. They often show postictal rage including vocalization, jumping, biting movements and intermittent catatonia (Reigel et al 1986a). Not susceptible to audogenic seizures at birth (Jobe et al 1980). Susceptibility begins at approx. 15 days of age (Reigel et al 1986b, 1989). May prove a useful model for assessing anti-convulsant drugs (Reigel et al 1986a, Dailey et al 1989).

A different substrain, GEPR-9, is subject to seizures of greater severity. They become sensitive from about 21 days of age post-partum (Hjeresen et al 1987).

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Hjeresen D. L., Franck J. E., and Amend D. L. (1987) Ontogeny of seizure incidence, latency, and severity in genetically epilepsy prone rats. Devel. Psychobiol. 20, 355-363. \par

Jobe P. C., Brown R. D., Dailey J. W., Ray T. B., Woods T. W., Mims M. E., and Barnsfather S. (1980) Effects of multiple exposures to intense acoustic stimulation on audiogenic seizure (AGS) susceptibility (S) and intensity (I) in rats. A developmental study in progeny from a genetically susceptible colony. Neurosci. Abstr. 6, 278.8. \par

Reigel C. E. J., Dailey J. W., and Jobe P. C. (1986a) The genetically epilepsy-prone rat: an overview of seizure-prone characteristics and responsiveness to anticonvulsant drugs. Life Sci. 39, 763-774. \par

Reigel C. E., Jobe P. C., Dailey J. W., and Savage D. D. (1986b) Ontogeny of sound-induced seizure susceptibility and severity in the genetically epilepsy-prone rat (GEPR). Neurosci. Abstr. 12, 73. \par

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK