Inbred Strains
of Rats: BH
Inbr. F?+17 (Ztm 1988).
Colour: Black-hooded,
Genet.a,h.
Origin: D. Wilson, University of Pennsylvania from unknown stock. To Dml,
who transferred stock to University of Iowa in 1973. Dml to Won to Ztm
in 1973.
Characteristics
Good reproductive performance; average litter size 7.0_3.2 young (Gartner,
unpublished). Has been used with LEW and congenic strains to define RT6
and RT7 (
Wonigeit 1979, Lubaroff et al 1979, Ely et al
1983, Lubaroff et al 1985). Resistant
to the induction of experimeental allergic encephalomyelitis due to genes
unlinked to the MHC (
Gasser et al 1978, Wonigeit 1979,
Gasser et al 1983). Glomerular inflitration rate 2.44 ml/min and renal
plasma flow of 3.55 ml/min in BH compared in several strains (
Hackbarth et al 1981). Haematology also studied by Hackbarth
et al (
1983). RT1
lv3 (
Wonigeit et al 1979). Females are extremely
sensitive to pentobarbital, which is lethal at 40mg/Kg (
Vieregge et al 1987).
BI.
Origin: Formerly called B3, but now extinct. Slow elimination of Trichinella
spiralis worms (11/12) (Bell, 1992)
Bell R. G. (1992) Variation
in responsiveness to Trichinella-spiralis infection in inbred rat
strains. Parasitology 105, 125-130.
\par
Ely J. M., Greiner
D. L., Lubaroff D. M., and Fitch F. W. (1983) Characterization of monoclonal
antibodies that define rat T cell alloantigens. J. Immunol. 130,
2798-2803.
\par
Gasser
D. L., Balyannis S. J., and Gonatas N. K. (1978) Influence of MHC-linked
and non-MHC-linked genes on susceptibility of rats to experimental allergic
encephalomyelitis, in Genetic control of autoimmune disease (Rose
N. R., Bigazzi P. E., and Warner N. L., eds), pp. 355-364. Elsevier-North
Holland, New York.
\par
Gasser
D. L., Hickey W. F., and Gonatas N. K. (1983) The genes for nonsusceptibility
to EAE in the Le-R and BH strains are not linked to RT1. Immunogenet.
17, 441-444.
\par
Hackbarth
H., Baunack E., and Winn M. (1981) Strain differences in kidney function
of inbred rats: 1. Glomerular filtration rate and renal plasma flow. Lab.
Anim. 15, 125-128.
\par
Hackbarth
H., Burow K., and Schimansky G. (1983) Strain differences in inbred rats:
Influence of strain and diet on haematological traits. Lab. Anim.
17, 7-12.
\par
Lubaroff
D. M., Rasmussen G. T., and Hunt H. D. (1979) Comparative studies of T-lymphocyte
antigens in the rat: Are ART, Ly, Pta and Ag-F the same? Transplant.
Proc. 11, 1642-1645.
\par
Lubaroff
D. M., Hunt H. D., and Rasmussen G. T. (1985) Evidence from capping experiments
for independence of the RT7 alloantigen and the leucocyte common antigen
in the rat. J. Immunogenet. 12, 239-245.
\par
Vieregge
V. T., Hackbarth H., and Bercher P. (1987) Die Pentobarbitalschlafzeit
zur pharmakogenetischen Differenzierung von Ratteninzuchtstammen. Z.
Versuchstierk. 29, 209-217.
\par
Wonigeit
K., Hedrich H. J., and Günther E. (1979) Serologic and histogenetic
analysis of apparently identical RT1 haplotypes. Transplant. Proc.
11, 1584-1587.
\par
Wonigeit K. (1979)
Characterization of the RT-Ly-1 and RT-Ly-2 alloantigenic systems by congenic
rat strains. Transplant. Proc. 11, 1631-1635.
\par
INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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