BDIX.

Inbr. F?+50.

Colour: Agouti .

Genet: A, C, H, P.

Origin: see BDI.

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Characteristics

Strain widely used in carcinogenesis and teratogenesis studies. Highly susceptible to the transplacental induction of malignant tumours of the central nervous system by ethyl nitrosourea (Druckrey et al 1970). A transplantable monocytic-myeloid leukaemia L5222 induced by ethyl nitrosourea has been used as a model for chemotherapy (Ivankovic and Zeller 1974). Transplantable colon tumour PROb grows progressively and metastasizes, whereas REGb grows slowly and is then rejected (Blottiere et al 1992a,b). DHD/K12 colon adenocarcinoma cells also metastasize, but RC-160 acts as an inhibitor (Qin et al 1992). These models have been used to study methods of treating peritoneal carcinoma including shockwave cavitation (Prat et al 1993) and the somatostatiin analog Lanreotide and the GRP antagonist BIM-26226 (Gouyon et al 1995). A transplantable ovarian carcinoma O-342 has been used in studies of potential chemotherapeutic use of a methotrexate-albumin conjugate (Steinmann et al 1995). Transplantable Sp-5 colorectal adenocarcinoma has been used in the study of the chemotherapeutic effects of 2'-deoxy-5-fluorouridine for pulmonary metastises (Ng et al 1995).

Has a defect in the expression of RT1.B, apparently due to absence of structural or controling gene (Male et al 1987). The activity of C-jun, JunB, JunD, Krox-24 and C-fos in the brain shows individual patterns of expression in untreated animals (Herdegen et al 1995).

Haematiology described by Lovell et al (1981); high MCHC (7/7), neutrophils (7/7), low lymphocytes (1/7), high monocytes (7/7), high eosinophils (7/7). Shows delayed development of the secondary centre of ossification of the epiphyses of the long bones compared with seven other strains (Stark et al, 1995).

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Blottiere H. M., Menoret A., Burg C., Douillard J. Y., and Lependu J. (1992a) Identification and characterization of a rat protein (p-105) auto-antigenic in rats bearing a progressive syngeneic colon-carcinoma. Int. J. Cancer 50, 315-320.

Druckrey H., Landschutz C., and Ivankovic S. (1970) Transplacentare Erzeugnung maligner Tumoren des Nervensystems. II. Athyl-nitrosoharnstoff an 10 genetisch definierten Ratten-stammen. Z. Krebsforsch. 73, 371-386.

Gouyon B. A., Reyldesmars F., Leromancer M., Pigeon C., Lewin M. J. M., and Lehy T. (1995) In-vivo effect of somatostatin analog, lanreotide, and/or GRP antagonist, BIM-26226, on the growth of colon-cancer peritoneal carcinomatosis in the rat. International Journal of Oncology 7, 1167-1173.

Herdegen T., Kovary K., Buhl A., Bravo R., Zimmermann M., and Gass P. (1995) Basal expression of the inducible transcription factors C-jun, JunB, JunD, C-fos, FosB, and Krox-24 in the adult-rat brain. J. Comp. Neurol. 354, 39-56.

Ivankovic S. and Zeller W. J. (1974) Leukemia L5222 of the rat strain BDIX. Blut 28, 288-292.

Lovell D. P., Archer R. K., Riley J., and Morgan R. K. (1981) Variation in haematological parameters among inbred strains. Lab. Anim. 15, 243-249.

Male D. K., Pryce G., and Butcher G. W. (1987) Serological evidence for a defect in RT1.B (I-A) expression by the BDIX rat strain. J. Immunogenet. 14, 301-312.

Ng B., Lenert J. T., Weksler B., Port J. L., Ellis J. L., and Burt M. E. (1995) Isolated lung perfusion with FUDR is an effective treatment for colorectal adenocarcinoma lung metastases in rats. Annals of Thoracic Surgery 59, 205-208.

Prat F., Chapelon J. Y., Elfadil F. A., Theillere Y., Ponchon T., and Cathignol D. (1993) Invivo effects of cavitation alone or in combination with chemotherapy in a peritoneal carcinomatosis in the rat. Brit. J. Cancer 68, 13-17.

Qin Y. F., Vancauteren M., Osteaux M., Schally A. V., and Willems G. (1992) Inhibitory effect of somatostatin analog RC-160 on the growth of hepatic metastases of colon cancer in rats - a study with magnetic-resonance-imaging. Cancer Res. 52, 6025-6030.

Stark C., Kahrmann B., and Walzel E. (1995) Epi-and metaphyseal morphology in the long bones of BDIX/Han rats. Lab. Anim. 30, 35-41.

Steinmann A., Friedrich E., and Rath U. (1995) A novel methotrexate-albumin (MTX-RSA)-conjugate causes significant growth delay of O-342 ovarian-carcinoma in-vivo. Oncology Reports 2, 107-109.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK