Inbred Strains
of Rats: AXC
Inbr.?.
Colour: Agouti with white belly and feet.
Genet. A hi.
Origin: A substrain of ACI. Curtiss and Dunning 1926 at the Columbia University
Institute for Cancer Research. To Albert Segaloff of the Alton Ochsner
Medical Foundation, New Orleans before 1956, to Southwestern Foundation
for Biomedical Research in 1976.
Characteristics
Median life-span 906 days in both sexes. There is a 25% incidence of
moderate to severe nephropathy at 30-41 months. Pituitary adenomas in
65% of females and 10% of males, mammary adenocarcinoma in 26% of females,
prostate adenocarcinomas in 23% of males older than 29 months (
Gleiser and Shain 1986). Shain et al (
1986) have used this strain to study age related decreases
in ventral prostate content of moderately abundant, androgen responsive
proteins.
Gleiser
C. A. and Shain S. A. (1986) The aging AXC/SSh rat: assessment of longevity
and prevalence of neoplastic and nonneoplastic diseases in necropsied
rats. J. Gerontol. 41, 590-598.
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Shain S.
A., Schultz J. J., and De L. C. (1986) Aging in the AXC/SSh rat: characterization
of moderately abundant ventral prostate proteins showing age-dependent
diminution and one protein exhibiting age-invariant content. Mech.
Ageing Dev. 37, 147-162.
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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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