SWXL-

Inbr. ?. Set of 7 recombinant inbred strains maintained at the Jackson Laboratory.

SWXL-4 mice exhibit tonic-clonic and generalised seizures similar to the commonest epilepsy in humans. Seizures are observed in routine handling from about 80 days of age, and are due to a dominant gene Szf1 on chromosome 7 which accounts for about 32% of the variation in susceptibility (Frankel et al, 1994).

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Frankel W. N., Taylor B. A., Noebels J. L., and Lutz C. M. (1994) Genetic epilepsy model derived from common inbred mouse strains. Genetics 138, 481-489. \par

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK