of Mice: RLC
Inbr. F20+?. Albino. Genet. rlc/rlc.
Origin: A spontaneous autosomal
recessive mutation with rupture of the lens capsule and dislocation of
the lens nucleus, designated rlc
occurred in the CXSN/A strain.
This was crossed with BALB/c followed by more than 20 generations of sib
Opacity of the lens of both eyes develops spontaneously at 35-60 days
of age. Histologically there is irregular swelling, condensation, degeneration
and fragmentation of lens fibers in the deep cortex, leading to rupture
of the lens capsule at the posterior pole at 45-100 days of age. Following
rupture, the lens nucleus dislocates behind the lens or occasionally in
the anterior chamber (Iida et al, 1997
The gene maps to the middle section of chromosome 14 near D14Mit39 at
about position 30.0 (Matsushima et al,
Iida F., Matsushima
Y., Hiai H., Uga S., and Honda Y. (1997) Rupture of lens cateract: a novel
hereditary recessive cateract model in the mouse. Exp. Eye Res.
Y., Kamoto T., Iida F., Abujiang P., Honda Y., and Hiai H. (1996) Mapping
of rupture of lens cataract (rlc) on mouse chromosome 14. Genomics
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,