Inbred Strains
of Mice: EL
Inbr (Yok) 84. Albino.
c. Origin K.Imaizumi,
El (epilepsy)
mutation in non-inbred albino mice in 1954.
Characteristics
Epilepsy-like behaviour which can be induced by Megamide (
Nakano et al, 1996). Phenobarbital suppresses the seizures
dose-dependently, but zonisamide is ineffective (
Nagatomo et al, 1996a). Seizure susceptibility may be due
to a reduced number of nitric oxide-producing cells in the hippocampal
area (
Nagatomo et al, 1996b) Maint.
by Yok.
Nagatomo
I., Akasaki Y., Kuchiiwa S., Nakagawa S., and Takigawa M. (1996a) Sparse
distribution of NADPH diaphorase neurons in the hippocampal-formation
of the inbred mutant strain EL mouse. Brain Res. 730,
223-226.
Nagatomo
I., Akasaki Y., Nagase F., Nomaguchi M., and Takigawa M. (1996b) Relationships
between convulsive seizures and serum and brain concentrations of phenobarbital
and zonisamide in mutant inbred strain EL mouse. Brain Res. 731,
190-198.
Nakano
H., Saito K., and Suzuki K. (1996) Clinico-ECoG correlate of megimide-induced
epileptic seizures in epilepsy-prone EL and its mother strain nonepileptic
ddY mice. Physiol. Behav. 60, 809-816.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK