Inbred Strains
of Mice: AU
Inbr: F? + 35. Genet:
a, U, rd+. Origin:
R. A. Fisher, about 1937. 50% Gruneberg's CBA, 28.5% Fisher's colour stocks
and 21.5% Gruneberg's wavy stock, the latter two being unrelated stocks
of American origin. To Medawar 1947, to Silvers at F23 in 1957, to Jackson
Laboratory 1967.
Characteristics
: Females do not reject male isografts. Unusual induction of kidney beta-glucuronidase
by testosterone (
Staats, 1976). High plasma
cholinesterase activity (1/22) (
Angel et al.,
1967., 1967). Resistant to skin ulceration by DMBA (cf. 9/22) (
Thomas et al., 1973., 1973). High degree
of genetic distinctiveness (2/27) (
Taylor, 1972).
Carries no detectable endogenous ecotropic MuLV DNA sequences (
Jenkins et al 1982). F1 hybrid crosses with CBA have been
suggested as a good model for auditory research (
Henry
and McGinn 1992). Resistant to the induction of arthritis by type
II collagen (
Ortman et al, 1994).
Angel C.
R., Mahin D. T., Farris R. D., and Woodward K. T. (1967) Heritability
of plasma cholinesterase activity in inbred mouse strains. Science
156, 529-530.
Henry K.
R. and McGinn M. D. (1992) The mouse as a model for human audition. A
review of the literature. Audiology 31, 181-189.
Jenkins
N. A., Copeland N. G., Taylor B. A., and Lee B. K. (1982) Organization,
distribution, and stability of endogenous ecotropic murine leukemia virus
DNA sequences in chromosomes of Mus musculus. J. Virol. 43,
26-36.
Ortman
R. A., Holderbaum D., Qu X. M., Banerjee S., and Haqqi T. M. (1994) BUB/BnJ
(H-2(q)) is a TCR deletion mutant mouse strain (TCR Vbetaa, KJ16- ) that
is susceptible to type II collagen-induced arthritis. J. Immunol.
152, 4175-4182.
Staats J. (1976) Standardized
nomenclature for inbred strains of mice: Sixth listing. Cancer Res.
36, 4333-4377.
Taylor B. A. (1972)
Genetic relationship between inbred strains of mice. J. Hered.
63, 83-86.
Thomas
P. E., Hutton J. J., and Taylor B. A. (1973) Genetic relationship between
aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced
skin ulceration in mice. Genetics 74, 655-659.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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