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Inbred Strains of Mice: APN

APN

Inbr. (1998) F26. Albino, c. Origin: Outbred Swiss Webster mice from Connaught Laboratories, Toronto, Canada, selected by Casley and Whitehouse, Banting Research Centre, Ottawa, Canada, for nonresponsive serum alanine aminotransferase (ALT) following administration of 150mg/kg acetaminophen per os, with brother x sister mating started in 1993 (see also APS).


Characteristics

Low caffeine 3-demethylation activity (8/8). Hepatic CYP1A2 mRNA, protein and enzyme activity (MROD, acetanilide 4-hydroxylation) was significantly lower than for strain C3H (Casley et al 1997a, b).


Casley W. L., Menzies J. A., Girard M., Larocque L., Mousseau N., Whitehouse L. W., and Moon T. W. (1997a) Differences in caffein 3-demethylation activity among inbred mouse strains: a comparison of hepatic Cyp1a2 gene expression between two inbred strains. Fundam. Appl. Toxicol. 40, 228-237. \par


INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory