Compare GO annotations for ORTHOMCL1010 PPOD cluster

Possible outliers might be spotted in a summary/comparison table of high level GO categories.
Complete table of the annotations represented in this image is provided below.

Annotations are indicated by colored nodes: human, mouse, rat, chicken, zfish, fly, worm, dicty, dicot, yeast, pombe, ecoli.
Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Red arrows indicate "regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Chicken from GOA; Zfish from Zfin; Fly from Flybase; Worm from Wormbase; Dicot from TAIR; Dicty from Dictybase; Yeast from SGD; Pombe from Sanger; Ecoli from EcoliHub.
Organisms with experimental annotations are indicated: EXP, IC, IDA, IEP, IGI, IMP, IPI. In addition, ISS (ISA, ISM, ISO) annotations are so indicated.
Does not include evidence codes: IEA, IGC, NAS, ND, NR, RCA, TAS.
Graph is also available as SVG (requires viewer plug-in from Adobe)
Evidence codes are listed at the bottom of the page.
Graph generated Mon Mar 30 18:25:07 2009.

Compare annotations to GO categories for ORTHOMCL1010.

Entry indicates that ortholog exists for this gene.
Colored entries indicate experimental annotation.
Parentheses indicate ISS annotation only.

Category	ID	Term	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	Ecoli
Molecular Function	GO:0005488	binding	Human	Mouse	Rat	Chicken	(Zfish)	Fly	Worm	(Dicty)	Dicot	Yeast	Pombe	X
Molecular Function	GO:0003824	catalytic activity	Human	Mouse	Rat	Chicken	(Zfish)	Fly	Worm	(Dicty)	Dicot	Yeast	Pombe	X
Cellular Component	GO:0005623	cell	Human	Mouse	Rat	Chicken	(Zfish)	Fly	Worm	(Dicty)	Dicot	Yeast	Pombe	X
Cellular Component	GO:0044464	cell part	Human	Mouse	Rat	Chicken	(Zfish)	Fly	Worm	(Dicty)	Dicot	Yeast	Pombe	X
Cellular Component	GO:0032991	macromolecular complex	Human	Mouse	Rat	Chicken	(Zfish)	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Cellular Component	GO:0031974	membrane-enclosed lumen	Human	Mouse	(Rat)	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Cellular Component	GO:0043226	organelle	Human	Mouse	Rat	Chicken	(Zfish)	Fly	Worm	(Dicty)	Dicot	Yeast	Pombe	X
Cellular Component	GO:0044422	organelle part	Human	Mouse	(Rat)	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0065007	biological regulation	Human	Mouse	(Rat)	Chicken	(Zfish)	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0009987	cellular process	Human	Mouse	Rat	Chicken	(Zfish)	Fly	Worm	(Dicty)	Dicot	Yeast	Pombe	X
Biological Process	GO:0032502	developmental process	Human	Mouse	(Rat)	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0051234	establishment of localization	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0051179	localization	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0040011	locomotion	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0008152	metabolic process	Human	Mouse	Rat	Chicken	(Zfish)	Fly	Worm	(Dicty)	Dicot	Yeast	Pombe	X
Biological Process	GO:0032501	multicellular organismal process	Human	Mouse	(Rat)	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0048519	negative regulation of biological process	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0048518	positive regulation of biological process	Human	Mouse	(Rat)	Chicken	(Zfish)	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0050789	regulation of biological process	Human	Mouse	(Rat)	Chicken	(Zfish)	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0000003	reproduction	Human	Mouse	(Rat)	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0022414	reproductive process	Human	Mouse	(Rat)	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0050896	response to stimulus	Human	Mouse	(Rat)	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0016032	viral reproduction	Human	Mouse	(Rat)	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X

Full set of experimental (and ISS) annotations for ORTHOMCL1010

Category	ID	Term	DB Object	Evidence	With_From	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Top2a	IDA		Rat	RGD:1580614\|PMID:11334111
Molecular Function	GO:0005524	ATP binding	top2	ISS	InterPro:IPR003594	Dicty	dictyBase_REF:10155
Molecular Function	GO:0005524	ATP binding	top2	IC	GO:0003918	Pombe	PMID:17072883
Molecular Function	GO:0016887	ATPase activity	top2	ISS	UniProt:P15348	Dicty	dictyBase_REF:10155
Molecular Function	GO:0003682	chromatin binding	Q02880	IDA		Human	PMID:9049244
Molecular Function	GO:0003682	chromatin binding	P11388	IDA		Human	PMID:9049244
Molecular Function	GO:0003682	chromatin binding	Top2a	IDA		Rat	RGD:1580614\|PMID:11334111
Molecular Function	GO:0003682	chromatin binding	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Molecular Function	GO:0003677	DNA binding	Top2	IDA		Fly	FB:FBrf0126830\|PMID:10751154
Molecular Function	GO:0003677	DNA binding	top2	ISS	UniProt:P15348	Dicty	dictyBase_REF:10155
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	P11388	IDA		Human	PMID:16611985
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	Top2a	IGI	SGD:S000005032	Mouse	MGI:MGI:51613\|PMID:1331984
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	Top2a	IDA		Mouse	MGI:MGI:51613\|PMID:1331984
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	Top2a	IDA		Mouse	MGI:MGI:86770\|PMID:9094096
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	Top2a	IGI	SGD:S000005032	Mouse	MGI:MGI:3641141\|PMID:7937150
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	Top2a	IDA		Mouse	MGI:MGI:70738\|PMID:7842491
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	Top2a	IDA		Rat	RGD:1580614\|PMID:11334111
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	Top2a	ISO	RGD:62340	Rat	RGD:1624291
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	top2a	ISS	UniProtKB:P11388	Zfish	ZFIN:ZDB-PUB-071010-1
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	top2b	ISS	UniProtKB:P11388	Zfish	ZFIN:ZDB-PUB-071010-1
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	Top2	IDA		Fly	FB:FBrf0050127\|PMID:2547764
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	Top2	IDA		Fly	FB:FBrf0126830\|PMID:10751154
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	top2	ISS	UniProt:P15348	Dicty	dictyBase_REF:10155
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	TOP2	IDA		Yeast	SGD_REF:S000055795\|PMID:6323017
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	TOP2	IDA		Yeast	SGD_REF:S000058487\|PMID:6088500
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	top2	IDA		Pombe	PMID:8395535
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	top2	IMP		Pombe	PMID:6090122
Molecular Function	GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	top2	IGI	SGD:S000005032	Pombe	PMID:3023070
Molecular Function	GO:0003916	DNA topoisomerase activity	Top2a	IDA		Rat	RGD:1580614\|PMID:11334111
Molecular Function	GO:0008094	DNA-dependent ATPase activity	P11388	IDA		Human	PMID:12079377
Molecular Function	GO:0008094	DNA-dependent ATPase activity	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Molecular Function	GO:0008094	DNA-dependent ATPase activity	top2b	ISS	UniProtKB:P11388	Zfish	ZFIN:ZDB-PUB-071010-1
Molecular Function	GO:0008094	DNA-dependent ATPase activity	top2a	ISS	UniProtKB:P11388	Zfish	ZFIN:ZDB-PUB-071010-1
Molecular Function	GO:0008144	drug binding	P11388	IDA		Human	PMID:16914642
Molecular Function	GO:0008144	drug binding	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Molecular Function	GO:0000400	four-way junction DNA binding	Top2	IDA		Fly	FB:FBrf0051671\|PMID:2176156
Molecular Function	GO:0000400	four-way junction DNA binding	Top2	IDA		Fly	FB:FBrf0127508\|PMID:10786800
Molecular Function	GO:0042826	histone deacetylase binding	P11388	IPI	UniProtKB:Q13547	Human	PMID:11062478
Molecular Function	GO:0042826	histone deacetylase binding	Q02880	IPI	UniProtKB:Q13547	Human	PMID:11062478
Molecular Function	GO:0042826	histone deacetylase binding	Q02880	IPI	UniProtKB:Q13547	Human	PMID:11136718
Molecular Function	GO:0042826	histone deacetylase binding	Q02880	IPI	UniProtKB:Q92769	Human	PMID:11062478
Molecular Function	GO:0042826	histone deacetylase binding	P11388	IPI	UniProtKB:Q92769	Human	PMID:11062478
Molecular Function	GO:0042826	histone deacetylase binding	P11388	IPI	UniProtKB:Q13547	Human	PMID:11136718
Molecular Function	GO:0042826	histone deacetylase binding	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Molecular Function	GO:0003729	mRNA binding	Top2	IDA		Fly	FB:FBrf0126830\|PMID:10751154
Molecular Function	GO:0005515	protein binding	Top2a	IPI	UniProtKB:P49792\|UniProtKB:Q9ERU9	Mouse	MGI:MGI:3799606\|PMID:18394993
Molecular Function	GO:0005515	protein binding	Top2a	ISO	RGD:62340	Rat	RGD:1624291
Molecular Function	GO:0008022	protein C-terminus binding	Q02880	IPI	UniProtKB:P04637	Human	PMID:10666337
Molecular Function	GO:0008022	protein C-terminus binding	P11388	IPI	UniProtKB:P38398	Human	PMID:15965487
Molecular Function	GO:0008022	protein C-terminus binding	P11388	IPI	UniProtKB:P04637	Human	PMID:10666337
Molecular Function	GO:0008022	protein C-terminus binding	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Molecular Function	GO:0046982	protein heterodimerization activity	P11388	IPI	UniProtKB:Q02880	Human	PMID:10473615
Molecular Function	GO:0046982	protein heterodimerization activity	Q02880	IPI	UniProtKB:P11388	Human	PMID:10473615
Molecular Function	GO:0046982	protein heterodimerization activity	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Molecular Function	GO:0042803	protein homodimerization activity	P11388	IPI	UniProtKB:P11388	Human	PMID:10473615
Molecular Function	GO:0042803	protein homodimerization activity	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Molecular Function	GO:0005080	protein kinase C binding	Q02880	IPI	UniProtKB:Q05655	Human	PMID:16611985
Molecular Function	GO:0005080	protein kinase C binding	P11388	IPI	UniProtKB:Q05655	Human	PMID:16611985
Molecular Function	GO:0005080	protein kinase C binding	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Molecular Function	GO:0000182	rDNA binding	Top2	IDA		Fly	FB:FBrf0194408\|PMID:16675949
Molecular Function	GO:0003696	satellite DNA binding	Top2	IDA		Fly	FB:FBrf0194408\|PMID:16675949
Molecular Function	GO:0043565	sequence-specific DNA binding	Top2a	IDA		Rat	RGD:1580614\|PMID:11334111
Molecular Function	GO:0043566	structure-specific DNA binding	Top2a	IDA		Rat	RGD:1580614\|PMID:11334111
Molecular Function	GO:0043130	ubiquitin binding	P11388	IMP		Human	PMID:15965487
Molecular Function	GO:0043130	ubiquitin binding	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Cellular Component	GO:0005814	centriole	P11388	IDA		Human	PMID:9049244
Cellular Component	GO:0005814	centriole	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Cellular Component	GO:0008623	chromatin accessibility complex	Top2	IDA		Fly	FB:FBrf0097684\|PMID:9252192
Cellular Component	GO:0005694	chromosome	P11388	IDA		Human	PMID:9049244
Cellular Component	GO:0005694	chromosome	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Cellular Component	GO:0005694	chromosome	Top2	IDA		Fly	FB:FBrf0128696\|PMID:10885744
Cellular Component	GO:0005694	chromosome	top2	ISS	UniProt:P15348	Dicty	dictyBase_REF:10155
Cellular Component	GO:0000793	condensed chromosome	Top2a	IDA		Mouse	MGI:MGI:2158857\|PMID:11835579
Cellular Component	GO:0000793	condensed chromosome	Top2a	ISO	RGD:62340	Rat	RGD:1624291
Cellular Component	GO:0005737	cytoplasm	Top2	IDA		Fly	FB:FBrf0132311\|PMID:11139335
Cellular Component	GO:0005829	cytosol	Q02880	IDA		Human	PMID:9049244
Cellular Component	GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)	P11388	IDA		Human	PMID:10473615
Cellular Component	GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Cellular Component	GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)	Top2a	IDA		Rat	RGD:1580614\|PMID:11334111
Cellular Component	GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)	top2b	ISS	UniProtKB:P11388	Zfish	ZFIN:ZDB-PUB-071010-1
Cellular Component	GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)	top2a	ISS	UniProtKB:P11388	Zfish	ZFIN:ZDB-PUB-071010-1
Cellular Component	GO:0000792	heterochromatin	Q02880	IDA		Human	PMID:9049244
Cellular Component	GO:0005626	insoluble fraction	Top2	IDA		Fly	FB:FBrf0126830\|PMID:10751154
Cellular Component	GO:0005739	mitochondrion	TOP2	IDA		Yeast	SGD_REF:S000117178\|PMID:16823961
Cellular Component	GO:0005730	nucleolus	Top2a	IDA		Mouse	MGI:MGI:2158857\|PMID:11835579
Cellular Component	GO:0005730	nucleolus	Top2a	ISO	RGD:62340	Rat	RGD:1624291
Cellular Component	GO:0005654	nucleoplasm	Q02880	IDA		Human	PMID:9049244
Cellular Component	GO:0005654	nucleoplasm	P11388	IDA		Human	PMID:9049244
Cellular Component	GO:0005654	nucleoplasm	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Cellular Component	GO:0005634	nucleus	Q02880	IDA		Human	PMID:9049244
Cellular Component	GO:0005634	nucleus	P11388	IDA		Human	PMID:16611985
Cellular Component	GO:0005634	nucleus	P11388	IDA		Human	PMID:10788521
Cellular Component	GO:0005634	nucleus	P11388	IDA		Human	PMID:10959840
Cellular Component	GO:0005634	nucleus	Top2a	IDA		Mouse	MGI:MGI:895157\|PMID:9224616
Cellular Component	GO:0005634	nucleus	Top2a	IDA		Mouse	MGI:MGI:86770\|PMID:9094096
Cellular Component	GO:0005634	nucleus	Top2b	IDA		Mouse	MGI:MGI:2158857\|PMID:11835579
Cellular Component	GO:0005634	nucleus	Top2b	IDA		Mouse	MGI:MGI:895157\|PMID:9224616
Cellular Component	GO:0005634	nucleus	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Cellular Component	GO:0005634	nucleus	Top2a	IDA		Rat	RGD:61772\|PMID:8390253
Cellular Component	GO:0005634	nucleus	Top2a	IDA		Rat	RGD:1580614\|PMID:11334111
Cellular Component	GO:0005634	nucleus	Top2a	ISO	RGD:62340	Rat	RGD:1624291
Cellular Component	GO:0005634	nucleus	top2a	ISS	UniProtKB:Q01320	Zfish	ZFIN:ZDB-PUB-071010-1
Cellular Component	GO:0005634	nucleus	top2b	ISS	UniProtKB:Q01320	Zfish	ZFIN:ZDB-PUB-071010-1
Cellular Component	GO:0005634	nucleus	Top2	IDA		Fly	FB:FBrf0050127\|PMID:2547764
Cellular Component	GO:0005634	nucleus	Top2	IDA		Fly	FB:FBrf0108679
Cellular Component	GO:0005634	nucleus	Top2	IDA		Fly	FB:FBrf0128696\|PMID:10885744
Cellular Component	GO:0005634	nucleus	Top2	IDA		Fly	FB:FBrf0132311\|PMID:11139335
Cellular Component	GO:0005634	nucleus	top2	ISS	UniProt:P15348	Dicty	dictyBase_REF:10155
Cellular Component	GO:0005634	nucleus	TOP2	IDA		Yeast	SGD_REF:S000058487\|PMID:6088500
Cellular Component	GO:0005634	nucleus	top2	IDA		Pombe	PMID:16823372
Cellular Component	GO:0005625	soluble fraction	Top2	IDA		Fly	FB:FBrf0126830\|PMID:10751154
Cellular Component	GO:0000795	synaptonemal complex	TOP2	IDA		Yeast	SGD_REF:S000053634\|PMID:1315786
Biological Process	GO:0030263	apoptotic chromosome condensation	P11388	IDA		Human	PMID:10959840
Biological Process	GO:0030263	apoptotic chromosome condensation	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Biological Process	GO:0007409	axonogenesis	Top2b	IMP	MGI:MGI:2179201	Mouse	MGI:MGI:2178151\|PMID:10615047
Biological Process	GO:0051301	cell division	cin-4	IMP	WB:WBRNAi00007532\|WB:WBPhenotype:0001143	Worm	WB:WBPaper00005599\|PMID:12445391
Biological Process	GO:0051301	cell division	top-2	IMP	WB:WBRNAi00007532\|WB:WBPhenotype:0001143	Worm	WB:WBPaper00005599\|PMID:12445391
Biological Process	GO:0006333	chromatin assembly or disassembly	TOP2	IMP		Yeast	SGD_REF:S000052145\|PMID:9199287
Biological Process	GO:0031055	chromatin remodeling at centromere	TOP2	IMP		Yeast	SGD_REF:S000127402\|PMID:18701701
Biological Process	GO:0006342	chromatin silencing	Top2	IDA		Fly	FB:FBrf0194408\|PMID:16675949
Biological Process	GO:0030261	chromosome condensation	Top2a	IMP		Mouse	MGI:MGI:2158879\|PMID:11835580
Biological Process	GO:0030261	chromosome condensation	Top2a	ISO	RGD:62340	Rat	RGD:1624291
Biological Process	GO:0030261	chromosome condensation	top2a	ISS	UniProtKB:Q01320	Zfish	ZFIN:ZDB-PUB-071010-1
Biological Process	GO:0030261	chromosome condensation	top2b	ISS	UniProtKB:Q01320	Zfish	ZFIN:ZDB-PUB-071010-1
Biological Process	GO:0007059	chromosome segregation	P11388	IMP		Human	PMID:15965487
Biological Process	GO:0007059	chromosome segregation	P11388	IMP		Human	PMID:11136718
Biological Process	GO:0007059	chromosome segregation	P11388	IMP		Human	PMID:15456904
Biological Process	GO:0007059	chromosome segregation	Top2a	IMP		Mouse	MGI:MGI:2158879\|PMID:11835580
Biological Process	GO:0007059	chromosome segregation	Top2a	IDA		Mouse	MGI:MGI:70738\|PMID:7842491
Biological Process	GO:0007059	chromosome segregation	Top2a	ISO	RGD:62340	Rat	RGD:1624291
Biological Process	GO:0007059	chromosome segregation	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Biological Process	GO:0007059	chromosome segregation	top2b	ISS	UniProtKB:Q01320	Zfish	ZFIN:ZDB-PUB-071010-1
Biological Process	GO:0007059	chromosome segregation	top2a	ISS	UniProtKB:Q01320	Zfish	ZFIN:ZDB-PUB-071010-1
Biological Process	GO:0000910	cytokinesis	cin-4	IMP	WB:WBRNAi00007532\|WB:WBPhenotype:0001143	Worm	WB:WBPaper00005599\|PMID:12445391
Biological Process	GO:0000910	cytokinesis	top-2	IMP	WB:WBRNAi00007532\|WB:WBPhenotype:0001143	Worm	WB:WBPaper00005599\|PMID:12445391
Biological Process	GO:0006266	DNA ligation	P11388	IDA		Human	PMID:15491148
Biological Process	GO:0006266	DNA ligation	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Biological Process	GO:0006271	DNA strand elongation during DNA replication	TOP2	IMP		Yeast	SGD_REF:S000051896\|PMID:2549254
Biological Process	GO:0006265	DNA topological change	Top2a	IDA		Mouse	MGI:MGI:895157\|PMID:9224616
Biological Process	GO:0006265	DNA topological change	Top2a	IDA		Mouse	MGI:MGI:51613\|PMID:1331984
Biological Process	GO:0006265	DNA topological change	Top2a	IDA		Rat	RGD:1580614\|PMID:11334111
Biological Process	GO:0006265	DNA topological change	Top2a	ISO	RGD:62340	Rat	RGD:1624291
Biological Process	GO:0006265	DNA topological change	top2b	ISS	UniProtKB:Q01320	Zfish	ZFIN:ZDB-PUB-071010-1
Biological Process	GO:0006265	DNA topological change	top2a	ISS	UniProtKB:Q01320	Zfish	ZFIN:ZDB-PUB-071010-1
Biological Process	GO:0006265	DNA topological change	Top2	IDA		Fly	FB:FBrf0050127\|PMID:2547764
Biological Process	GO:0006265	DNA topological change	Top2	IDA		Fly	FB:FBrf0127508\|PMID:10786800
Biological Process	GO:0006265	DNA topological change	top2	ISS	SGD:S000005032	Dicty	dictyBase_REF:10155
Biological Process	GO:0006265	DNA topological change	TOP2	IDA		Yeast	SGD_REF:S000058487\|PMID:6088500
Biological Process	GO:0006265	DNA topological change	top2	IDA		Pombe	PMID:8395535
Biological Process	GO:0006265	DNA topological change	top2	IMP		Pombe	PMID:6090122
Biological Process	GO:0006265	DNA topological change	top2	IGI	SGD:S000005032	Pombe	PMID:3023070
Biological Process	GO:0040016	embryonic cleavage	Top2a	IMP		Mouse	MGI:MGI:2158879\|PMID:11835580
Biological Process	GO:0040016	embryonic cleavage	Top2a	ISO	RGD:62340	Rat	RGD:1624291
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	cin-4	IMP	WB:WBRNAi00007532\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00005599\|PMID:12445391
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	top-2	IMP	WB:WBRNAi00007532\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00005599\|PMID:12445391
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	cin-4	IMP	WB:WBRNAi00025955\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	top-2	IMP	WB:WBRNAi00025955\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	cin-4	IMP	WB:WBRNAi00027031\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	top-2	IMP	WB:WBRNAi00027031\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	cin-4	IMP	WB:WBRNAi00027032\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	top-2	IMP	WB:WBRNAi00027032\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	top-2	IMP	WB:WBRNAi00050651\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00025054\|PMID:15791247
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	cin-4	IMP	WB:WBRNAi00059135\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00025054\|PMID:15791247
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	top-2	IMP	WB:WBRNAi00059135\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00025054\|PMID:15791247
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	cin-4	IMP	WB:mr127\|WB:WBPhenotype:0000050	Worm	WB:WBPerson7224
Biological Process	GO:0006325	establishment or maintenance of chromatin architecture	top2	IGI	GeneDB_Spombe:SPBC1703.14c	Pombe	PMID:6090122
Biological Process	GO:0030900	forebrain development	Top2b	IMP	MGI:MGI:3521923	Mouse	MGI:MGI:3521808\|PMID:12773624
Biological Process	GO:0051310	metaphase plate congression	Top2	IDA		Fly	FB:FBrf0167777\|PMID:14600258
Biological Process	GO:0007076	mitotic chromosome condensation	Top2	IMP		Fly	FB:FBrf0200397\|PMID:17412918
Biological Process	GO:0007076	mitotic chromosome condensation	top2	IMP		Pombe	PMID:15957215
Biological Process	GO:0007052	mitotic spindle organization	Top2	IMP		Fly	FB:FBrf0200397\|PMID:17412918
Biological Process	GO:0006406	mRNA export from nucleus	top2	IMP		Pombe	PMID:15161942
Biological Process	GO:0001764	neuron migration	Top2b	IMP	MGI:MGI:3521923	Mouse	MGI:MGI:3521808\|PMID:12773624
Biological Process	GO:0043065	positive regulation of apoptosis	P11388	IDA		Human	PMID:16611985
Biological Process	GO:0043065	positive regulation of apoptosis	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Biological Process	GO:0045870	positive regulation of retroviral genome replication	P11388	IMP		Human	PMID:16712776
Biological Process	GO:0045870	positive regulation of retroviral genome replication	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Top2a	IMP		Mouse	MGI:MGI:50301\|PMID:1683482
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Top2a	ISO	RGD:62340	Rat	RGD:1624291
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	top2b	ISS	UniProtKB:Q01320	Zfish	ZFIN:ZDB-PUB-071010-1
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	top2a	ISS	UniProtKB:Q01320	Zfish	ZFIN:ZDB-PUB-071010-1
Biological Process	GO:0007131	reciprocal meiotic recombination	TOP2	IMP		Yeast	SGD_REF:S000047736\|PMID:2156624
Biological Process	GO:0000019	regulation of mitotic recombination	TOP2	IMP		Yeast	SGD_REF:S000052967\|PMID:2902925
Biological Process	GO:0000003	reproduction	cin-4	IMP	WB:WBRNAi00038161\|WB:WBPhenotype:0000689	Worm	WB:WBPaper00024497\|PMID:15489339
Biological Process	GO:0000003	reproduction	top-2	IMP	WB:WBRNAi00038161\|WB:WBPhenotype:0000689	Worm	WB:WBPaper00024497\|PMID:15489339
Biological Process	GO:0000712	resolution of meiotic joint molecules as recombinants	top2	IMP		Pombe	PMID:9763441
Biological Process	GO:0006974	response to DNA damage stimulus	P11388	IDA		Human	PMID:16611985
Biological Process	GO:0006974	response to DNA damage stimulus	Top2a	ISO	RGD:1352729	Rat	RGD:1624291
Biological Process	GO:0000819	sister chromatid segregation	Top2	IDA		Fly	FB:FBrf0167777\|PMID:14600258
Biological Process	GO:0000819	sister chromatid segregation	Top2	IDA		Fly	FB:FBrf0167778\|PMID:14600262
Biological Process	GO:0042790	transcription of nuclear rRNA large RNA polymerase I transcript	top2	IGI	GeneDB_Spombe:SPBC1703.14c	Pombe	PMID:2839305

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IEP Inferred from expression pattern

IGC Inferred from genomic context

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

NAS Non-traceable Author Statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

NR Not recorded (appears in some legacy annotations)