MGI MouseCyc MP annotations for PWY66-3

MGI MouseCyc experimental MP annotations for cholesterol biosynthesis II (via 24,25-dihydrolanosterol)

Roles of genes might be detected in a summary/comparison table of high level MP categories.
Complete table of the annotations represented in this image is provided below.
Graph is also available as SVG (requires plug-in)

Gray arrows indicate "is_a";
Blue arrows indicate "part_of";

Compare annotations to MP categories for cholesterol biosynthesis II (via 24,25-dihydrolanosterol)

Entry indicates that gene is in this pathway.
Colored entries indicate MP annotation.

ID	Term	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005386	behavior/neurological phenotype	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005385	cardiovascular system phenotype	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005382	craniofacial phenotype	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005381	digestive/alimentary phenotype	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005380	embryogenesis phenotype	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005378	growth/size phenotype	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005376	homeostasis/metabolism phenotype	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005373	lethality-postnatal	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005374	lethality-prenatal/perinatal	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005372	life span-post-weaning/aging	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005371	limbs/digits/tail phenotype	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005369	muscle phenotype	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0003631	nervous system phenotype	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005367	renal/urinary system phenotype	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005389	reproductive system phenotype	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005388	respiratory system phenotype	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005390	skeleton phenotype	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle
MP:0005393	skin/coat/nails phenotype	Dhcr7	Ebp	Fdft1	Hsd17b7	Lss	Sc4mol	Sc5d	Sqle

Full set of annotations for cholesterol biosynthesis II (via 24,25-dihydrolanosterol)

ID	Term	Mouse gene	Alleles	Background	Color Key
MP:0000822	abnormal brain ventricle morphology	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm2Fdp	involves: 129S4/SvJae	color key
MP:0000822	abnormal brain ventricle morphology	Dhcr7	Dhcr7^tm2Fdp/Dhcr7^tm2Fdp	involves: 129S4/SvJae	color key
MP:0001951	abnormal breathing	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0000076	abnormal calvaria morphology	Sc5d	Sc5d^tm1Fdp/Sc5d^tm1Fdp	involves: 129	color key
MP:0005278	abnormal cholesterol homeostasis	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0005278	abnormal cholesterol homeostasis	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	involves: 129P2/OlaHsd	color key
MP:0003947	abnormal cholesterol level	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm2Fdp	involves: 129S4/SvJae	color key
MP:0003947	abnormal cholesterol level	Dhcr7	Dhcr7^tm2Fdp/Dhcr7^tm2Fdp	involves: 129S4/SvJae	color key
MP:0000180	abnormal circulating cholesterol level	Sc5d	Sc5d^tm1Fdp/Sc5d^tm1Fdp	involves: 129	color key
MP:0000780	abnormal corpus callosum morphology	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm2Fdp	involves: 129S4/SvJae	color key
MP:0005319	abnormal enzyme/ coenzyme level	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	involves: 129P2/OlaHsd	color key
MP:0005584	abnormal enzyme/coenzyme activity	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	involves: 129P2/OlaHsd	color key
MP:0002886	abnormal glutamate-mediated receptor currents	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0000266	abnormal heart morphology	Hsd17b7	Hsd17b7^tm1Gibo/Hsd17b7^tm1Gibo	involves: 129S1/Sv * C57BL/6	color key
MP:0006108	abnormal hindbrain development	Hsd17b7	Hsd17b7^tm1Gibo/Hsd17b7^tm1Gibo	involves: 129S1/Sv * C57BL/6	color key
MP:0001547	abnormal lipid level	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	involves: 129P2/OlaHsd	color key
MP:0001547	abnormal lipid level	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0001176	abnormal lung development	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	involves: 129P2/OlaHsd	color key
MP:0001176	abnormal lung development	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0006382	abnormal lung epithelium morphology	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0001175	abnormal lung morphology	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	involves: 129P2/OlaHsd	color key
MP:0001175	abnormal lung morphology	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0004007	abnormal lung vasculature	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0003864	abnormal midbrain development	Hsd17b7	Hsd17b7^tm1Gibo/Hsd17b7^tm1Gibo	involves: 129S1/Sv * C57BL/6	color key
MP:0004096	abnormal midbrain-hindbrain boundary development	Hsd17b7	Hsd17b7^tm1Gibo/Hsd17b7^tm1Gibo	involves: 129S1/Sv * C57BL/6	color key
MP:0002237	abnormal nasal cavity morphology	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0003720	abnormal neural tube closure	Fdft1	Fdft1^tm1Yma/Fdft1^tm1Yma	involves: 129S7/SvEvBrd	color key
MP:0005306	abnormal phalanx morphology	Sc5d	Sc5d^tm1Fdp/Sc5d^tm1Fdp	involves: 129	color key
MP:0002270	abnormal respiratory alveoli morphology	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0001436	abnormal suckling behavior	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst,Tg(APOE-DHCR7)2Hoyu/0	involves: 129P2/OlaHsd * C57BL * C57BL/6J * FVB/N	color key
MP:0001436	abnormal suckling behavior	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0002274	abnormal type I pneumocyte morphology	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0001622	abnormal vasculogenesis	Hsd17b7	Hsd17b7^tm1Gibo/Hsd17b7^tm1Gibo	involves: 129S1/Sv * C57BL/6	color key
MP:0001529	abnormal vocalization	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0000414	alopecia	Ebp	Ebp^Td/Ebp⁺	Not Specified	color key
MP:0001957	apnea	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0002296	aspiration	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0001393	ataxia	Fdft1	Cnp^tm1(cre)Kan/Cnp⁺,Fdft1^tm1Kan/Fdft1^tm1Kan	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	color key
MP:0001177	atelectasis	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0000111	cleft palate	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	involves: 129P2/OlaHsd	color key
MP:0000111	cleft palate	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0000111	cleft palate	Sc5d	Sc5d^tm1Fdp/Sc5d^tm1Fdp	involves: 129	color key
MP:0001575	cyanosis	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0001265	decreased body size	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0001265	decreased body size	Ebp	Ebp^Td/Ebp⁺	Not Specified	color key
MP:0001262	decreased body weight	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	involves: 129P2/OlaHsd	color key
MP:0001262	decreased body weight	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0001262	decreased body weight	Ebp	Ebp^Td/Ebp⁺	Not Specified	color key
MP:0000774	decreased brain size	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0000774	decreased brain size	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm2Fdp	involves: 129S4/SvJae	color key
MP:0005574	decreased breathing frequency	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0003983	decreased cholesterol level	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst,Tg(APOE-DHCR7)2Hoyu/0	involves: 129P2/OlaHsd * C57BL * C57BL/6J * FVB/N	color key
MP:0003983	decreased cholesterol level	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0003983	decreased cholesterol level	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	involves: 129P2/OlaHsd	color key
MP:0003983	decreased cholesterol level	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm2Fdp	involves: 129S4/SvJae	color key
MP:0003983	decreased cholesterol level	Dhcr7	Dhcr7^tm2Fdp/Dhcr7^tm2Fdp	involves: 129S4/SvJae	color key
MP:0003983	decreased cholesterol level	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0005179	decreased circulating cholesterol level	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst,Tg(APOE-DHCR7)2Hoyu/0	involves: 129P2/OlaHsd * C57BL * C57BL/6J * FVB/N	color key
MP:0005631	decreased lung weight	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0000921	demyelination	Fdft1	Cnp^tm1(cre)Kan/Cnp⁺,Fdft1^tm1Kan/Fdft1^tm1Kan	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	color key
MP:0000825	dilated lateral ventricles	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm2Fdp	involves: 129S4/SvJae	color key
MP:0000825	dilated lateral ventricles	Dhcr7	Dhcr7^tm2Fdp/Dhcr7^tm2Fdp	involves: 129S4/SvJae	color key
MP:0000827	dilated third ventricle	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm2Fdp	involves: 129S4/SvJae	color key
MP:0000827	dilated third ventricle	Dhcr7	Dhcr7^tm2Fdp/Dhcr7^tm2Fdp	involves: 129S4/SvJae	color key
MP:0000539	distended urinary bladder	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0000539	distended urinary bladder	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	involves: 129P2/OlaHsd	color key
MP:0003984	embryonic growth retardation	Fdft1	Fdft1^tm1Yma/Fdft1^tm1Yma	involves: 129S7/SvEvBrd	color key
MP:0006207	embryonic lethality during organogenesis	Fdft1	Fdft1^tm1Yma/Fdft1^tm1Yma	involves: 129S7/SvEvBrd	color key
MP:0006207	embryonic lethality during organogenesis	Hsd17b7	Hsd17b7^tm1Gibo/Hsd17b7^tm1Gibo	involves: 129S1/Sv * C57BL/6	color key
MP:0004201	fetal growth retardation	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0004201	fetal growth retardation	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0001195	flaky skin	Ebp	Ebp^Td/Ebp⁺	Not Specified	color key
MP:0001402	hypoactivity	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0001402	hypoactivity	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	involves: 129P2/OlaHsd	color key
MP:0004144	hypotonia	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst,Tg(APOE-DHCR7)2Hoyu/0	involves: 129P2/OlaHsd * C57BL * C57BL/6J * FVB/N	color key
MP:0005039	hypoxia	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0001405	impaired coordination	Fdft1	Cnp^tm1(cre)Kan/Cnp⁺,Fdft1^tm1Kan/Fdft1^tm1Kan	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	color key
MP:0001524	impaired limb coordination	Fdft1	Cnp^tm1(cre)Kan/Cnp⁺,Fdft1^tm1Kan/Fdft1^tm1Kan	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	color key
MP:0006027	impaired respiratory alveologenesis	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst,Tg(APOE-DHCR7)2Hoyu/0	involves: 129P2/OlaHsd * C57BL * C57BL/6J * FVB/N	color key
MP:0006027	impaired respiratory alveologenesis	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	involves: 129P2/OlaHsd	color key
MP:0001745	increased circulating corticosterone level	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0000585	kinked tail	Sc5d	Sc5d^tm1Fdp/Sc5d^tm1Fdp	involves: 129	color key
MP:0000460	mandible hypoplasia	Sc5d	Sc5d^tm1Fdp/Sc5d^tm1Fdp	involves: 129	color key
MP:0002639	micrognathia	Sc5d	Sc5d^tm1Fdp/Sc5d^tm1Fdp	involves: 129	color key
MP:0002058	neonatal lethality	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0002058	neonatal lethality	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	involves: 129P2/OlaHsd	color key
MP:0002058	neonatal lethality	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0001404	no spontaneous movement	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0001435	no suckling reflex	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	involves: 129P2/OlaHsd	color key
MP:0001437	no swallowing reflex	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key
MP:0001722	pale yolk sac	Hsd17b7	Hsd17b7^tm1Gibo/Hsd17b7^tm1Gibo	involves: 129S1/Sv * C57BL/6	color key
MP:0001787	pericardial edema	Hsd17b7	Hsd17b7^tm1Gibo/Hsd17b7^tm1Gibo	involves: 129S1/Sv * C57BL/6	color key
MP:0002081	perinatal lethality	Sc5d	Sc5d^tm1Fdp/Sc5d^tm1Fdp	involves: 129	color key
MP:0001732	postnatal growth retardation	Fdft1	Cnp^tm1(cre)Kan/Cnp⁺,Fdft1^tm1Kan/Fdft1^tm1Kan	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	color key
MP:0002082	postnatal lethality	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst,Tg(APOE-DHCR7)2Hoyu/0	involves: 129P2/OlaHsd * C57BL * C57BL/6J * FVB/N	color key
MP:0002082	postnatal lethality	Ebp	Ebp^Td/Ebp⁺	Not Specified	color key
MP:0002083	premature death	Fdft1	Cnp^tm1(cre)Kan/Cnp⁺,Fdft1^tm1Kan/Fdft1^tm1Kan	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	color key
MP:0002080	prenatal lethality	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm2Fdp	involves: 129S4/SvJae	color key
MP:0002080	prenatal lethality	Ebp	Ebp^Td/Y	Not Specified	color key
MP:0002080	prenatal lethality	Ebp	Ebp^Td/Ebp⁺	Not Specified	color key
MP:0001178	pulmonary hypoplasia	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0001698	reduced embryo size	Hsd17b7	Hsd17b7^tm1Gibo/Hsd17b7^tm1Gibo	involves: 129S1/Sv * C57BL/6	color key
MP:0001921	reduced fertility	Fdft1	Cnp^tm1(cre)Kan/Cnp⁺,Fdft1^tm1Kan/Fdft1^tm1Kan	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	color key
MP:0001953	respiratory failure	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	involves: 129P2/OlaHsd	color key
MP:0000547	short limbs	Sc5d	Sc5d^tm1Fdp/Sc5d^tm1Fdp	involves: 129	color key
MP:0001212	skin lesions	Ebp	Ebp^Td/Ebp⁺	Not Specified	color key
MP:0003641	small lung	Dhcr7	Dhcr7^tm1Gst/Dhcr7^tm1Gst	B6.129P2-Dhcr7	color key
MP:0000936	small telencephalic vesicles	Hsd17b7	Hsd17b7^tm1Gibo/Hsd17b7^tm1Gibo	involves: 129S1/Sv * C57BL/6	color key
MP:0000564	syndactyly	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm2Fdp	involves: 129S4/SvJae	color key
MP:0000745	tremors	Fdft1	Cnp^tm1(cre)Kan/Cnp⁺,Fdft1^tm1Kan/Fdft1^tm1Kan	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	color key
MP:0000746	weakness	Dhcr7	Dhcr7^tm1Fdp/Dhcr7^tm1Fdp	involves: 129S4/SvJae	color key