MGI MouseCyc MP annotations for PWY3DJ-5

MGI MouseCyc experimental MP annotations for biosynthesis of serotonin and melatonin

Roles of genes might be detected in a summary/comparison table of high level MP categories.
Complete table of the annotations represented in this image is provided below.
Graph is also available as SVG (requires plug-in)

Gray arrows indicate "is_a";
Blue arrows indicate "part_of";

Compare annotations to MP categories for biosynthesis of serotonin and melatonin

Entry indicates that gene is in this pathway.
Colored entries indicate MP annotation.

ID	Term	Aanat	Asmt	Ddc	Tph1	Tph2
MP:0005375	adipose tissue phenotype	Aanat	Asmt	Ddc	Tph1	Tph2
MP:0005386	behavior/neurological phenotype	Aanat	Asmt	Ddc	Tph1	Tph2
MP:0005385	cardiovascular system phenotype	Aanat	Asmt	Ddc	Tph1	Tph2
MP:0005378	growth/size phenotype	Aanat	Asmt	Ddc	Tph1	Tph2
MP:0005376	homeostasis/metabolism phenotype	Aanat	Asmt	Ddc	Tph1	Tph2
MP:0005373	lethality-postnatal	Aanat	Asmt	Ddc	Tph1	Tph2
MP:0005369	muscle phenotype	Aanat	Asmt	Ddc	Tph1	Tph2
MP:0005388	respiratory system phenotype	Aanat	Asmt	Ddc	Tph1	Tph2
MP:0005393	skin/coat/nails phenotype	Aanat	Asmt	Ddc	Tph1	Tph2
MP:0005392	touch/vibrissae phenotype	Aanat	Asmt	Ddc	Tph1	Tph2

Full set of annotations for biosynthesis of serotonin and melatonin

ID	Term	Mouse gene	Alleles	Background	Color Key
MP:0000230	abnormal blood pressure	Tph1	Tph1^tm1Mlt/Tph1^tm1Mlt	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	color key
MP:0000304	abnormal cardiac stroke volume	Tph1	Tph1^tm1Mlt/Tph1^tm1Mlt	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	color key
MP:0002572	abnormal emotion/affect behavior	Tph1	Tph1^tm1Lex/Tph1^tm1Lex,Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0002572	abnormal emotion/affect behavior	Tph2	Tph1^tm1Lex/Tph1^tm1Lex,Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0002572	abnormal emotion/affect behavior	Tph2	Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0003461	abnormal response to novel object	Tph1	Tph1^tm1Lex/Tph1^tm1Lex,Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0003461	abnormal response to novel object	Tph2	Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0003461	abnormal response to novel object	Tph2	Tph1^tm1Lex/Tph1^tm1Lex,Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0005322	abnormal serotonin level	Tph1	Tph1^tm1Lex/Tph1^tm1Lex,Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0005322	abnormal serotonin level	Tph1	Tph1^tm1Lex/Tph1^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0005322	abnormal serotonin level	Tph1	Tph1^tm1Mlt/Tph1^tm1Mlt	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	color key
MP:0005322	abnormal serotonin level	Tph2	Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0005322	abnormal serotonin level	Tph2	Tph1^tm1Lex/Tph1^tm1Lex,Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0005322	abnormal serotonin level	Tph2	Tph2^Arg447/Tph2^Arg447	BALB/cJ	color key
MP:0005322	abnormal serotonin level	Tph2	Tph2^Arg447/Tph2^Arg447	DBA/2J	color key
MP:0005322	abnormal serotonin level	Tph2	Tph2^Pro447/Tph2^Pro447	C57BL/6J	color key
MP:0005322	abnormal serotonin level	Tph2	Tph2^Pro447/Tph2^Pro447	129X1/SvJ	color key
MP:0005322	abnormal serotonin level	Tph2	Tph2^tm1Mca/Tph2⁺	involves: 129S6/SvEvTac * C57BL/6J	color key
MP:0005322	abnormal serotonin level	Tph2	Tph2^tm1Mca/Tph2^tm1Mca	involves: 129S6/SvEvTac * C57BL/6J	color key
MP:0001360	abnormal social investigation	Tph2	Gsk3b^tm1Jrw/Gsk3b⁺,Tph2^tm1Mca/Tph2^tm1Mca	involves: 129 * 129S6/SvEvTac * C57BL/6J	color key
MP:0001258	decreased body length	Tph1	Tph1^tm1Lex/Tph1^tm1Lex,Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0001258	decreased body length	Tph2	Tph1^tm1Lex/Tph1^tm1Lex,Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0001258	decreased body length	Tph2	Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0001262	decreased body weight	Tph1	Tph1^tm1Lex/Tph1^tm1Lex,Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0001262	decreased body weight	Tph2	Tph1^tm1Lex/Tph1^tm1Lex,Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0001262	decreased body weight	Tph2	Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0005140	decreased cardiac muscle contractility	Tph1	Tph1^tm1Mlt/Tph1^tm1Mlt	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	color key
MP:0003393	decreased cardiac output	Tph1	Tph1^tm1Mlt/Tph1^tm1Mlt	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	color key
MP:0003064	decreased coping response	Tph2	Tph2^tm1Mca/Tph2^tm1Mca	involves: 129S6/SvEvTac * C57BL/6J	color key
MP:0003064	decreased coping response	Tph2	Tph2^tm1Mca/Tph2⁺	involves: 129S6/SvEvTac * C57BL/6J	color key
MP:0005459	decreased percent body fat	Tph1	Tph1^tm1Lex/Tph1^tm1Lex,Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0005459	decreased percent body fat	Tph2	Tph1^tm1Lex/Tph1^tm1Lex,Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0003998	decreased thermal nociceptive threshold	Tph1	Tph1^tm1Lex/Tph1^tm1Lex,Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0003998	decreased thermal nociceptive threshold	Tph2	Tph1^tm1Lex/Tph1^tm1Lex,Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0000274	enlarged heart	Tph1	Tph1^tm1Mlt/Tph1^tm1Mlt	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	color key
MP:0002899	fatigue	Tph1	Tph1^tm1Mlt/Tph1^tm1Mlt	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	color key
MP:0001354	increased aggression towards males	Tph2	Tph2^tm1Mca/Tph2^tm1Mca	involves: 129S6/SvEvTac * C57BL/6J	color key
MP:0001354	increased aggression towards males	Tph2	Tph2^tm1Mca/Tph2⁺	involves: 129S6/SvEvTac * C57BL/6J	color key
MP:0001363	increased anxiety-related response	Tph2	Tph2^tm1Mca/Tph2^tm1Mca	involves: 129S6/SvEvTac * C57BL/6J	color key
MP:0001363	increased anxiety-related response	Tph2	Tph2^tm1Mca/Tph2⁺	involves: 129S6/SvEvTac * C57BL/6J	color key
MP:0002626	increased heart rate	Tph1	Tph1^tm1Mlt/Tph1^tm1Mlt	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	color key
MP:0003717	pallor	Tph1	Tph1^tm1Mlt/Tph1^tm1Mlt	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	color key
MP:0002082	postnatal lethality	Ddc	Ddc^{Gt(OST129277)Lex}/Ddc^{Gt(OST129277)Lex}	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0001954	respiratory distress	Tph1	Tph1^tm1Mlt/Tph1^tm1Mlt	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	color key