MGI MouseCyc MP annotations for PWY3DJ-34120

MGI MouseCyc experimental MP annotations for leucine degradation

Roles of genes might be detected in a summary/comparison table of high level MP categories.
Complete table of the annotations represented in this image is provided below.
Graph is also available as SVG (requires plug-in)

Gray arrows indicate "is_a";
Blue arrows indicate "part_of";

Compare annotations to MP categories for leucine degradation

Entry indicates that gene is in this pathway.
Colored entries indicate MP annotation.

ID	Term	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005375	adipose tissue phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005386	behavior/neurological phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005385	cardiovascular system phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005380	embryogenesis phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005378	growth/size phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005376	homeostasis/metabolism phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005373	lethality-postnatal	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005374	lethality-prenatal/perinatal	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005372	life span-post-weaning/aging	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005370	liver/biliary system phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005369	muscle phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0003631	nervous system phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005367	renal/urinary system phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005389	reproductive system phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005388	respiratory system phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005393	skin/coat/nails phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2

Full set of annotations for leucine degradation

ID	Term	Mouse gene	Alleles	Background	Color Key
MP:0000003	abnormal adipose tissue morphology	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0005332	abnormal amino acid level	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0005332	abnormal amino acid level	Dbt	Dbt^tm1Geh/Dbt^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0003860	abnormal carbon dioxide level	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0005311	abnormal circulating amino acid level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0005311	abnormal circulating amino acid level	Bcat2	Bcat2^m1Ytc/Bcat2^m1Ytc	C57BL/6J	color key
MP:0005311	abnormal circulating amino acid level	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0005311	abnormal circulating amino acid level	Dbt	Dbt^tm1Geh/Dbt^tm1Geh,Tg(tetO-DBT)525AGeh/0,Tg(tTALap)5Bjd/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI	color key
MP:0005311	abnormal circulating amino acid level	Dbt	Dbt^tm1Geh/Dbt^tm1Geh,Tg(tetO-DBT)A1Geh/0,Tg(tTALap)5Bjd/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI	color key
MP:0005311	abnormal circulating amino acid level	Dbt	Dbt^tm1Geh/Dbt^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001510	abnormal coat appearance	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0005584	abnormal enzyme/coenzyme activity	Dbt	Dbt^tm1Geh/Dbt^tm1Geh,Tg(tetO-DBT)A1Geh/0,Tg(tTALap)5Bjd/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI	color key
MP:0005584	abnormal enzyme/coenzyme activity	Dbt	Dbt^tm1Geh/Dbt^tm1Geh,Tg(tetO-DBT)525AGeh/0,Tg(tTALap)5Bjd/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI	color key
MP:0001432	abnormal food preference	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0001406	abnormal gait	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0002078	abnormal glucose homeostasis	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0000266	abnormal heart morphology	Hmgcl	Hmgcl^tm1Gam/Hmgcl^tm1Gam	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	color key
MP:0000607	abnormal hepatocyte morphology	Hmgcl	Hmgcl^tm1Gam/Hmgcl^tm1Gam	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	color key
MP:0000607	abnormal hepatocyte morphology	Hmgcl	Hmgcl^tm1Gam/Hmgcl⁺	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	color key
MP:0001764	abnormal homeostasis	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0003953	abnormal hormone level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0002118	abnormal lipid homeostasis	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0001711	abnormal placenta morphology	Hmgcl	Hmgcl^tm1Gam/Hmgcl^tm1Gam	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	color key
MP:0001961	abnormal reflex	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0001757	abnormal urine chemistry	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0000414	alopecia	Bcat2	Bcat2^m1Ytc/Bcat2^m1Ytc	C57BL/6J	color key
MP:0003311	aminoaciduria	Dbt	Dbt^tm1Geh/Dbt^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005156	bradykinesia	Bcat2	Bcat2^m1Ytc/Bcat2^m1Ytc	C57BL/6J	color key
MP:0004893	decreased adiponectin level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0001265	decreased body size	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0001262	decreased body weight	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0001262	decreased body weight	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0002175	decreased brain weight	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0002702	decreased circulating free fatty acid level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0005560	decreased circulating glucose level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0002727	decreased circulating insulin level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0003458	decreased circulating ketone body level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0005668	decreased circulating leptin level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0009289	decreased epididymal fat pad weight	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0004232	decreased muscle weight	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0005459	decreased percent body fat	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0006207	embryonic lethality during organogenesis	Hmgcl	Hmgcl^tm1Gam/Hmgcl^tm1Gam	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	color key
MP:0003068	enlarged kidney	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0005292	improved glucose tolerance	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0005533	increased body temperature	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0003909	increased eating behavior	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0004889	increased energy expenditure	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0002891	increased insulin sensitivity	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0003917	increased kidney weight	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0003960	increased lean body mass	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0002981	increased liver weight	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0005659	increased resistance to diet-induced obesity	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0002893	ketoaciduria	Bcat2	Bcat2^m1Ytc/Bcat2^m1Ytc	C57BL/6J	color key
MP:0008569	lethality at weaning	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0005202	lethargy	Dbt	Dbt^tm1Geh/Dbt^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0003717	pallor	Dbt	Dbt^tm1Geh/Dbt^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001762	polyuria	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0001732	postnatal growth retardation	Bcat2	Bcat2^m1Ytc/Bcat2^m1Ytc	C57BL/6J	color key
MP:0001732	postnatal growth retardation	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0002082	postnatal lethality	Dbt	Dbt^tm1Geh/Dbt^tm1Geh,Tg(tetO-DBT)525AGeh/0,Tg(tTALap)5Bjd/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI	color key
MP:0002082	postnatal lethality	Dbt	Dbt^tm1Geh/Dbt^tm1Geh,Tg(tetO-DBT)A1Geh/0,Tg(tTALap)5Bjd/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI	color key
MP:0002082	postnatal lethality	Dbt	Dbt^tm1Geh/Dbt^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0002083	premature death	Bcat2	Bcat2^m1Ytc/Bcat2^m1Ytc	C57BL/6J	color key
MP:0002083	premature death	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0002083	premature death	Dbt	Dbt^tm1Geh/Dbt^tm1Geh,Tg(tetO-DBT)A1Geh/0,Tg(tTALap)5Bjd/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI	color key
MP:0002083	premature death	Dbt	Dbt^tm1Geh/Dbt^tm1Geh,Tg(tetO-DBT)525AGeh/0,Tg(tTALap)5Bjd/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI	color key
MP:0001698	reduced embryo size	Hmgcl	Hmgcl^tm1Gam/Hmgcl^tm1Gam	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	color key
MP:0001921	reduced fertility	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0001954	respiratory distress	Dbt	Dbt^tm1Geh/Dbt^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0002064	seizures	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0003997	tonic-clonic seizures	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0000746	weakness	Bcat2	Bcat2^m1Ytc/Bcat2^m1Ytc	C57BL/6J	color key