MGI MouseCyc MP annotations for PWY3DJ-11470

MGI MouseCyc experimental MP annotations for sphingosine and sphingosine-1-phosphate metabolism

Roles of genes might be detected in a summary/comparison table of high level MP categories.
Complete table of the annotations represented in this image is provided below.
Graph is also available as SVG (requires plug-in)

Gray arrows indicate "is_a";
Blue arrows indicate "part_of";

Compare annotations to MP categories for sphingosine and sphingosine-1-phosphate metabolism

Entry indicates that gene is in this pathway.
Colored entries indicate MP annotation.

ID	Term	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005385	cardiovascular system phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005384	cellular phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005382	craniofacial phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005381	digestive/alimentary phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005379	endocrine/exocrine gland phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005378	growth/size phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005397	hematopoietic system phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005376	homeostasis/metabolism phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005387	immune system phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005374	lethality-prenatal/perinatal	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005372	life span-post-weaning/aging	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005370	liver/biliary system phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005369	muscle phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0003631	nervous system phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0002873	normal phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005367	renal/urinary system phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005389	reproductive system phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005388	respiratory system phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
MP:0005390	skeleton phenotype	Acer1	Asah1	Asah2	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2

Full set of annotations for sphingosine and sphingosine-1-phosphate metabolism

ID	Term	Mouse gene	Alleles	Background	Color Key
MP:0000822	abnormal brain ventricle morphology	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0000076	abnormal calvaria morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0003091	abnormal cell migration	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0004787	abnormal dorsal aorta morphology	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0000107	abnormal frontal bone morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0000841	abnormal hindbrain morphology	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0002722	abnormal immune system organ morphology	Sgpl1	Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0005536	Leydig cell hypoplasia	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0002397	abnormal bone marrow morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0000130	abnormal cancellous bone morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0000266	abnormal heart morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0002123	abnormal hematopoiesis	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0002722	abnormal immune system organ morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S/SvEvBrd * 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0002135	abnormal kidney morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0002118	abnormal lipid homeostasis	Asah1	Asah1^tm1Esc/Asah1⁺	involves: 129S1/Sv * C57BL/6	color key
MP:0002145	abnormal T cell differentiation	Sphk1	Sphk1^tm1.1Cgh/Sphk1^tm2Cgh,Sphk2^tm1.1Cgh/Sphk2^tm1.1Cgh,Tg(Mx1-cre)1Cgn/?	involves: 129S4/SvJae * C57BL/6 * CBA	color key
MP:0000822	abnormal brain ventricle morphology	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0004787	abnormal dorsal aorta morphology	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0004261	abnormal embryonic neuroepithelium morphology	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0004261	abnormal embryonic neuroepithelium morphology	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0000841	abnormal hindbrain morphology	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0002723	abnormal immune serum protein physiology	Sphk1	Sphk1^tm1.1Cgh/Sphk1^tm2Cgh,Sphk2^tm1.1Cgh/Sphk2^tm1.1Cgh,Tg(Mx1-cre)1Cgn/?	involves: 129S4/SvJae * C57BL/6 * CBA	color key
MP:0002723	abnormal immune serum protein physiology	Sphk2	Sphk1^tm1.1Cgh/Sphk1^tm2Cgh,Sphk2^tm1.1Cgh/Sphk2^tm1.1Cgh,Tg(Mx1-cre)1Cgn/?	involves: 129S4/SvJae * C57BL/6 * CBA	color key
MP:0002136	abnormal kidney physiology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0001547	abnormal lipid level	Asah2	Asah2^tm1Rlp/Asah2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0000598	abnormal liver morphology	Asah1	Asah1^tm1Esc/Asah1⁺	involves: 129S1/Sv * C57BL/6	color key
MP:0002339	abnormal lymph node morphology	Sgpl1	Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0002339	abnormal lymph node morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0002401	abnormal lymphopoiesis	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0000897	abnormal midbrain morphology	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0000897	abnormal midbrain morphology	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0000278	abnormal myocardial fiber morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0004215	abnormal myocardial fiber physiology	Sphk1	Sphk1^tm1.1Cgh/Sphk1^tm1.1Cgh	involves: 129S4/SvJae * C57BL/6	color key
MP:0003720	abnormal neural tube closure	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0004982	abnormal osteoclast morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S/SvEvBrd * 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0004982	abnormal osteoclast morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0008871	abnormal ovarian follicle number	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0001126	abnormal ovary morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0003755	abnormal palate morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0002270	abnormal respiratory alveoli morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0002145	abnormal T cell differentiation	Sphk2	Sphk1^tm1.1Cgh/Sphk1^tm2Cgh,Sphk2^tm1.1Cgh/Sphk2^tm1.1Cgh,Tg(Mx1-cre)1Cgn/?	involves: 129S4/SvJae * C57BL/6 * CBA	color key
MP:0002459	abnormal B cell physiology	Sphk2	Sphk2^tm1Npa/Sphk2^tm1Npa	BALB/c-Sphk2	color key
MP:0003720	abnormal neural tube closure	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0004537	abnormal palatine shelf	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0004448	abnormal presphenoid bone morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0002124	abnormal red blood cell	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0005325	abnormal renal glomerulus morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0005508	abnormal skeleton morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0000496	abnormal small intestine morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0000767	abnormal smooth muscle morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0006380	abnormal spermatid morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0006379	abnormal spermatocyte morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0001156	abnormal spermatogenesis	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0002358	abnormal spleen periarteriolar lymphoid sheath morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0000157	abnormal sternum morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0006418	abnormal testis cord formation	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0001146	abnormal testis morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0002365	abnormal thymus cellularity	Sphk1	Sphk1^tm1.1Cgh/Sphk1^tm2Cgh,Sphk2^tm1.1Cgh/Sphk2^tm1.1Cgh,Tg(Mx1-cre)1Cgn/?	involves: 129S4/SvJae * C57BL/6 * CBA	color key
MP:0002365	abnormal thymus cellularity	Sphk2	Sphk1^tm1.1Cgh/Sphk1^tm2Cgh,Sphk2^tm1.1Cgh/Sphk2^tm1.1Cgh,Tg(Mx1-cre)1Cgn/?	involves: 129S4/SvJae * C57BL/6 * CBA	color key
MP:0002367	abnormal thymus lobule morphology	Sgpl1	Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0002367	abnormal thymus lobule morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S/SvEvBrd * 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0002375	abnormal thymus medulla morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S/SvEvBrd * 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0002375	abnormal thymus medulla morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0000540	abnormal urinary bladder epithelium morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S/SvEvBrd * 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0000516	abnormal urinary system morphology	Sgpl1	Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0000516	abnormal urinary system morphology	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0006055	abnormal vascular endothelial cell morphology	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0006055	abnormal vascular endothelial cell morphology	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0005592	abnormal vascular smooth muscle morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0005592	abnormal vascular smooth muscle morphology	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0005592	abnormal vascular smooth muscle morphology	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0001614	abnormal vasculature	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0001614	abnormal vasculature	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0001614	abnormal vasculature	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0000137	abnormal vertebrae morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0004599	abnormal vertebral arch morphology	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0001134	absent corpus luteum	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0001577	anemia	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0008869	anovulation	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0008146	asymmetric rib-sternum attachment	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0005017	decreased B cell number	Sgpl1	Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0005017	decreased B cell number	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0005018	decreased T cell number	Sphk1	Sphk1^tm1.1Cgh/Sphk1^tm2Cgh,Sphk2^tm1.1Cgh/Sphk2^tm1.1Cgh,Tg(Mx1-cre)1Cgn/?	involves: 129S4/SvJae * C57BL/6 * CBA	color key
MP:0005017	decreased B cell number	Sphk1	Sphk1^tm1.1Cgh/Sphk1^tm2Cgh,Sphk2^tm1.1Cgh/Sphk2^tm1.1Cgh,Tg(Mx1-cre)1Cgn/?	involves: 129S4/SvJae * C57BL/6 * CBA	color key
MP:0001262	decreased body weight	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0001262	decreased body weight	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0000333	decreased bone marrow cell number	Sphk1	Sphk1^tm1.1Cgh/Sphk1^tm2Cgh,Sphk2^tm1.1Cgh/Sphk2^tm1.1Cgh,Tg(Mx1-cre)1Cgn/?	involves: 129S4/SvJae * C57BL/6 * CBA	color key
MP:0005181	decreased circulating estradiol level	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0002780	decreased circulating testosterone level	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0005092	decreased double-positive T cell number	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0002875	decreased erythrocyte cell number	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0000208	decreased hematocrit	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0002874	decreased hemoglobin content	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0005016	decreased lymphocyte cell number	Sgpl1	Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0005016	decreased lymphocyte cell number	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0000222	decreased neutrophil cell number	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0008209	decreased pre-B cell number	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0008874	decreased sensitivity to xenobiotics	Sphk2	Sphk2^{Gt(NPX039)Byg}/Sphk2^{Gt(NPX039)Byg}	involves: 129P2/OlaHsd * C57BL/6	color key
MP:0005018	decreased T cell number	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0005018	decreased T cell number	Sphk2	Sphk1^tm1.1Cgh/Sphk1^tm2Cgh,Sphk2^tm1.1Cgh/Sphk2^tm1.1Cgh,Tg(Mx1-cre)1Cgn/?	involves: 129S4/SvJae * C57BL/6 * CBA	color key
MP:0005018	decreased T cell number	Sgpl1	Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0005017	decreased B cell number	Sphk2	Sphk1^tm1.1Cgh/Sphk1^tm2Cgh,Sphk2^tm1.1Cgh/Sphk2^tm1.1Cgh,Tg(Mx1-cre)1Cgn/?	involves: 129S4/SvJae * C57BL/6 * CBA	color key
MP:0005018	decreased T cell number	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S/SvEvBrd * 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0000333	decreased bone marrow cell number	Sphk2	Sphk1^tm1.1Cgh/Sphk1^tm2Cgh,Sphk2^tm1.1Cgh/Sphk2^tm1.1Cgh,Tg(Mx1-cre)1Cgn/?	involves: 129S4/SvJae * C57BL/6 * CBA	color key
MP:0008079	decreased CD8-positive T cell number	Sgpl1	Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0008075	decreased CD4-positive T cell number	Sgpl1	Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0006206	embryonic lethality before turning of embryo	Asah1	Asah1^tm1Esc/Asah1^tm1Esc	involves: 129S1/Sv * C57BL/6	color key
MP:0006207	embryonic lethality during organogenesis	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0006207	embryonic lethality during organogenesis	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0000914	exencephaly	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0000914	exencephaly	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0001926	female infertility	Sgpl1	Pdgfrb^tm1Sor/Pdgfrb⁺,Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)	color key
MP:0001926	female infertility	Sgpl1	Pdgfra^tm1Sor/Pdgfra⁺,Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0001926	female infertility	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0005244	hemopericardium	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0005244	hemopericardium	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0001914	hemorrhage	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0001914	hemorrhage	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0001914	hemorrhage	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0008078	increased CD8-positive T cell number	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0008074	increased CD4-positive T cell number	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0005014	increased B cell number	Sphk1	Sphk1^tm1Npa/Sphk1^tm1Npa	BALB/c-Sphk1	color key
MP:0005014	increased B cell number	Sphk2	Sphk2^tm1Npa/Sphk2^tm1Npa	BALB/c-Sphk2	color key
MP:0005565	increased blood urea nitrogen level	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0000322	increased granulocyte number	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0000220	increased monocyte cell number	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0004984	increased osteoclast cell number	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0008082	increased single-positive T cell number	Sgpl1	Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0001915	intracranial hemorrhage	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0001915	intracranial hemorrhage	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0001917	intraventricular hemorrhage	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0001917	intraventricular hemorrhage	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0001859	kidney inflammation	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0008101	lymph node hypoplasia	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0002223	lymphoid hypoplasia	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0001925	male infertility	Sgpl1	Pdgfrb^tm1Sor/Pdgfrb⁺,Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)	color key
MP:0001925	male infertility	Sgpl1	Pdgfra^tm1Sor/Pdgfra⁺,Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0001925	male infertility	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0002169	no abnormal phenotype detected	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0002169	no abnormal phenotype detected	Sphk2	Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: C57BL/6	color key
MP:0004969	pale kidney	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0000603	pale liver	Asah1	Asah1^tm1Esc/Asah1⁺	involves: 129S1/Sv * C57BL/6	color key
MP:0005097	polychromatophilia	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0001732	postnatal growth retardation	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0001732	postnatal growth retardation	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0002083	premature death	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0002083	premature death	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0002989	small kidney	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	involves: 129S4/SvJaeSor	color key
MP:0001127	small ovary	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0001147	small testis	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key
MP:0006054	spinal hemorrhage	Sphk1	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0006054	spinal hemorrhage	Sphk2	Sphk1^tm1Rlp/Sphk1^tm1Rlp,Sphk2^tm1Rlp/Sphk2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6	color key
MP:0000694	spleen hypoplasia	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0001179	thick alveolar septum	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0000711	thymic cortex hypoplasia	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{tm1(SGPL1)Lex}	involves: 129S/SvEvBrd * 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	color key
MP:0000711	thymic cortex hypoplasia	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0001823	thymus hypoplasia	Sgpl1	Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}	involves: 129S/SvEvBrd * C57BL/6J	color key
MP:0001121	uterus hypoplasia	Sgpl1	Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	color key