MGI MouseCyc MP annotations for PWY-841

MGI MouseCyc experimental MP annotations for purine nucleotides de novo biosynthesis II

Roles of genes might be detected in a summary/comparison table of high level MP categories.
Complete table of the annotations represented in this image is provided below.
Graph is also available as SVG (requires plug-in)

Gray arrows indicate "is_a";
Blue arrows indicate "part_of";

Compare annotations to MP categories for purine nucleotides de novo biosynthesis II

Entry indicates that gene is in this pathway.
Colored entries indicate MP annotation.

ID	Term	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0005378	growth/size phenotype	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0005397	hematopoietic system phenotype	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0005376	homeostasis/metabolism phenotype	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0005387	immune system phenotype	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0005374	lethality-prenatal/perinatal	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0005372	life span-post-weaning/aging	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0005390	skeleton phenotype	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0005393	skin/coat/nails phenotype	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0002006	tumorigenesis	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0005391	vision/eye phenotype	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat

Full set of annotations for purine nucleotides de novo biosynthesis II

ID	Term	Mouse gene	Alleles	Background	Color Key
MP:0000179	abnormal blood chemistry	Ifnar1	Dnase2a^tm1Osa/Dnase2a^tm1Osa,Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	color key
MP:0004392	abnormal CD8-positive T cell physiology	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas * 129S6/SvEvTac	color key
MP:0008713	abnormal cytokine level	Ifnar1	Dnase2a^tm1Osa/Dnase2a^tm1Osa,Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	color key
MP:0003009	abnormal cytokine secretion	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas	color key
MP:0005078	abnormal cytotoxic T cell physiology	Impdh2	Impdh1^tm1Bmi/Impdh1^tm1Bmi,Impdh2^tm1Bmi/Impdh2⁺	involves: 129/Sv * C57BL/6	color key
MP:0005078	abnormal cytotoxic T cell physiology	Impdh1	Impdh1^tm1Bmi/Impdh1^tm1Bmi,Impdh2^tm1Bmi/Impdh2⁺	involves: 129/Sv * C57BL/6	color key
MP:0005078	abnormal cytotoxic T cell physiology	Impdh2	Hprt1^b-m3/Y,Impdh2^tm1Bmi/Impdh2⁺	involves: 129P2/OlaHsd	color key
MP:0002376	abnormal dendritic cell physiology	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas	color key
MP:0002123	abnormal hematopoiesis	Ifnar1	Ifnar1^tm1Pjh/Ifnar1^tm1Pjh	involves: 129S2/SvPas * BALB/c	color key
MP:0000716	abnormal immune system cell morphology	Impdh1	Impdh1^tm1Bmi/Impdh1^tm1Bmi,Impdh2^tm1Bmi/Impdh2⁺	involves: 129/Sv * C57BL/6	color key
MP:0000716	abnormal immune system cell morphology	Impdh1	Impdh1^tm1Bmi/Impdh1^tm1Bmi	involves: 129/Sv * C57BL/6	color key
MP:0000716	abnormal immune system cell morphology	Impdh2	Impdh1^tm1Bmi/Impdh1^tm1Bmi,Impdh2^tm1Bmi/Impdh2⁺	involves: 129/Sv * C57BL/6	color key
MP:0001657	abnormal induced morbidity/mortality	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt,Tg(Hmgcr-MX1)LStae/Tg(Hmgcr-MX1)LStae	involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL	color key
MP:0001845	abnormal inflammatory response	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas	color key
MP:0008559	abnormal interferon-gamma secretion	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas * 129S6/SvEvTac	color key
MP:0000717	abnormal lymphocyte cell number	Impdh2	Impdh2^tm1Bmi/Impdh2⁺	involves: 129P2/OlaHsd * C57BL/6	color key
MP:0000717	abnormal lymphocyte cell number	Impdh2	Hprt1^b-m3/Y,Impdh2^tm1Bmi/Impdh2⁺	involves: 129P2/OlaHsd	color key
MP:0002401	abnormal lymphopoiesis	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt,Slamf1^tm1Oono/Slamf1^tm1Oono	B6.129-Slamf1 Ifnar1	color key
MP:0002401	abnormal lymphopoiesis	Impdh1	Hprt1^b-m3/Y,Impdh1^tm1Bmi/Impdh1^tm1Bmi	involves: 129/Sv * C57BL/6	color key
MP:0002401	abnormal lymphopoiesis	Impdh1	Impdh1^tm1Bmi/Impdh1^tm1Bmi,Impdh2^tm1Bmi/Impdh2⁺	involves: 129/Sv * C57BL/6	color key
MP:0002401	abnormal lymphopoiesis	Impdh2	Impdh1^tm1Bmi/Impdh1^tm1Bmi,Impdh2^tm1Bmi/Impdh2⁺	involves: 129/Sv * C57BL/6	color key
MP:0002446	abnormal macrophage morphology	Ifnar1	Dnase2a^tm1Osa/Dnase2a^tm1Osa,Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	color key
MP:0002451	abnormal macrophage physiology	Ifnar1	Ifnar1^m1Btlr/Ifnar1^m1Btlr	C57BL/6J-Ifnar1	color key
MP:0002451	abnormal macrophage physiology	Ifnar1	Ifnar1^tm1Pjh/Ifnar1^tm1Pjh	involves: 129S2/SvPas * BALB/c	color key
MP:0005069	abnormal NK cell physiology	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas	color key
MP:0004982	abnormal osteoclast morphology	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	B6.129S2-Ifnar1	color key
MP:0005025	abnormal response to infection	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	B6.129S2-Ifnar1	color key
MP:0001191	abnormal skin condition	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt,Irf2^tm1Mak/Irf2^tm1Mak	involves: 129S2/SvPas * C57BL/6	color key
MP:0001793	altered susceptibility to infection	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas * C57BL/6	color key
MP:0001577	anemia	Ifnar1	Dnase2a^tm1Osa/Dnase2a^tm1Osa,Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	color key
MP:0005542	corneal vascularization	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas	color key
MP:0001806	decreased IgM level	Ifnar1	Cd19^tm1(cre)Cgn/Cd19⁺,Ifnar1^tm1Uka/Ifnar1^tm1Uka	B6.129P2-Cd19 Ifnar1	color key
MP:0005095	decreased T cell proliferation	Impdh1	Impdh1^tm1Bmi/Impdh1^tm1Bmi,Impdh2^tm1Bmi/Impdh2⁺	involves: 129/Sv * C57BL/6	color key
MP:0000063	decreased bone density	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	B6.129S2-Ifnar1	color key
MP:0008045	decreased NK cell number	Ifnar1	Ifnar1^tm1Pjh/Ifnar1^tm1Pjh	B6.129S2-Ifnar1	color key
MP:0008498	decreased IgG3 level	Ifnar1	Cd19^tm1(cre)Cgn/Cd19⁺,Ifnar1^tm1Uka/Ifnar1^tm1Uka	B6.129P2-Cd19 Ifnar1	color key
MP:0005095	decreased T cell proliferation	Impdh1	Hprt1^b-m3/Y,Impdh1^tm1Bmi/Impdh1^tm1Bmi	involves: 129/Sv * C57BL/6	color key
MP:0008496	decreased IgG2a level	Ifnar1	Cd19^tm1(cre)Cgn/Cd19⁺,Ifnar1^tm1Uka/Ifnar1^tm1Uka	B6.129P2-Cd19 Ifnar1	color key
MP:0005095	decreased T cell proliferation	Impdh1	Impdh1^tm1Bmi/Impdh1^tm1Bmi	involves: 129/Sv * C57BL/6	color key
MP:0008495	decreased IgG1 level	Ifnar1	Cd19^tm1(cre)Cgn/Cd19⁺,Ifnar1^tm1Uka/Ifnar1^tm1Uka	B6.129P2-Cd19 Ifnar1	color key
MP:0005095	decreased T cell proliferation	Impdh2	Impdh1^tm1Bmi/Impdh1^tm1Bmi,Impdh2^tm1Bmi/Impdh2⁺	involves: 129/Sv * C57BL/6	color key
MP:0008563	decreased interferon-alpha secretion	Ifnar1	Ifnar1^m1Btlr/Ifnar1^m1Btlr	C57BL/6J-Ifnar1	color key
MP:0008563	decreased interferon-alpha secretion	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	B6.129S2-Ifnar1	color key
MP:0008565	decreased interferon-beta secretion	Ifnar1	Ifnar1^m1Btlr/Ifnar1^m1Btlr	C57BL/6J-Ifnar1	color key
MP:0008565	decreased interferon-beta secretion	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	B6.129S2-Ifnar1	color key
MP:0008700	decreased interleukin-4 secretion	Impdh1	Hprt1^b-m3/Y,Impdh1^tm1Bmi/Impdh1^tm1Bmi	involves: 129/Sv * C57BL/6	color key
MP:0002410	decreased susceptibility to viral infection	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt,Tg(Hmgcr-MX1)LStae/Tg(Hmgcr-MX1)LStae	involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL	color key
MP:0005079	defective cytotoxic T cell cytolysis	Impdh1	Hprt1^b-m3/Y,Impdh1^tm1Bmi/Impdh1^tm1Bmi	involves: 129/Sv * C57BL/6	color key
MP:0006204	embryonic lethality before implantation	Impdh2	Impdh2^tm1Bmi/Impdh2^tm1Bmi	involves: 129P2/OlaHsd * C57BL/6	color key
MP:0000691	enlarged spleen	Ifnar1	Dnase2a^tm1Osa/Dnase2a^tm1Osa,Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	color key
MP:0005070	impaired NK cell cytolysis	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	B6.129S2-Ifnar1	color key
MP:0005070	impaired NK cell cytolysis	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas	color key
MP:0005070	impaired NK cell cytolysis	Ifnar1	Ifnar1^tm1Pjh/Ifnar1^tm1Pjh	B6.129S2-Ifnar1	color key
MP:0004762	increased anti-double stranded DNA antibody level	Ifnar1	Dnase2a^tm1Osa/Dnase2a^tm1Osa,Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	color key
MP:0008617	increased circulating interleukin-12 level	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas * 129S6/SvEvTac	color key
MP:0008635	increased circulating interleukin-18 level	Ifnar1	Dnase2a^tm1Osa/Dnase2a^tm1Osa,Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	color key
MP:0008553	increased circulating tumor necrosis factor level	Ifnar1	Dnase2a^tm1Osa/Dnase2a^tm1Osa,Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	color key
MP:0004499	increased incidence of chemically-induced tumors	Ifnar1	Ifnar1^tm1Pjh/Ifnar1^tm1Pjh	B6.129S2-Ifnar1	color key
MP:0002021	increased incidence of induced tumors	Ifnar1	Ifnar1^tm1Pjh/Ifnar1^tm1Pjh	B6.129S2-Ifnar1	color key
MP:0008476	increased spleen red pulp amount	Ifnar1	Dnase2a^tm1Osa/Dnase2a^tm1Osa,Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	color key
MP:0002418	increased susceptibility to viral infection	Ifnar1	Ifnar1^m1Btlr/Ifnar1^m1Btlr	C57BL/6J-Ifnar1	color key
MP:0002418	increased susceptibility to viral infection	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt,Ifngr1^tm1Agt/Ifngr1^tm1Agt	involves: 129S2/SvPas * 129S7/SvEvBrd	color key
MP:0002418	increased susceptibility to viral infection	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL	color key
MP:0002418	increased susceptibility to viral infection	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas	color key
MP:0002418	increased susceptibility to viral infection	Ifnar1	Ifnar1^tm1Pjh/Ifnar1^tm1Pjh	involves: 129S2/SvPas * BALB/c	color key
MP:0002418	increased susceptibility to viral infection	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt,Slamf1^tm1Oono/Slamf1^tm1Oono	B6.129-Slamf1 Ifnar1	color key
MP:0002418	increased susceptibility to viral infection	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas * 129S6/SvEvTac	color key
MP:0003721	increased tumor growth/size	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	B6.129S2-Ifnar1	color key
MP:0002933	joint inflammation	Ifnar1	Dnase2a^tm1Osa/Dnase2a^tm1Osa,Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	color key
MP:0001732	postnatal growth retardation	Ifnar1	Dnase2a^tm1Osa/Dnase2a^tm1Osa,Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	color key
MP:0003561	rheumatoid arthritis	Ifnar1	Dnase2a^tm1Osa/Dnase2a^tm1Osa,Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	color key