MGI MouseCyc MP annotations for PWY-4081

MGI MouseCyc experimental MP annotations for glutathione redox reactions I

Roles of genes might be detected in a summary/comparison table of high level MP categories.
Complete table of the annotations represented in this image is provided below.
Graph is also available as SVG (requires plug-in)

Gray arrows indicate "is_a";
Blue arrows indicate "part_of";

Compare annotations to MP categories for glutathione redox reactions I

Entry indicates that gene is in this pathway.
Colored entries indicate MP annotation.

ID	Term	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0005386	behavior/neurological phenotype	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0005385	cardiovascular system phenotype	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0005384	cellular phenotype	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0005381	digestive/alimentary phenotype	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0005380	embryogenesis phenotype	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0005379	endocrine/exocrine gland phenotype	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0005378	growth/size phenotype	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0005377	hearing/vestibular/ear phenotype	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0005397	hematopoietic system phenotype	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0005376	homeostasis/metabolism phenotype	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0005387	immune system phenotype	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0005373	lethality-postnatal	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0005374	lethality-prenatal/perinatal	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0005372	life span-post-weaning/aging	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0003631	nervous system phenotype	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0002873	normal phenotype	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr
MP:0005391	vision/eye phenotype	Gpx1	Gpx2	Gpx3	Gpx4	Gpx5	Gpx6	Gpx7	Gpx8	Gsr

Full set of annotations for glutathione redox reactions I

ID	Term	Mouse gene	Alleles	Background	Color Key
MP:0001648	abnormal apoptosis	Gpx4	Gpx4^tm1Yana/Gpx4^tm1Yana	involves: C57BL/6 * CBA	color key
MP:0000358	abnormal cell content/ morphology	Gpx1	Gpx1^tm1Kola/Gpx1^tm1Kola	involves: 129S2/SvPas * CF1	color key
MP:0003077	abnormal cell cycle	Gpx1	Gpx1^tm1Kola/Gpx1^tm1Kola	involves: 129S2/SvPas * CF1	color key
MP:0001663	abnormal digestive system physiology	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001663	abnormal digestive system physiology	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005319	abnormal enzyme/ coenzyme level	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005319	abnormal enzyme/ coenzyme level	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005584	abnormal enzyme/coenzyme activity	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh	involves: 129S1/Sv * 129X1/SvJ	color key
MP:0005584	abnormal enzyme/coenzyme activity	Gpx1	Gpx1^tm1Ysh/Gpx1⁺	involves: 129S1/Sv * 129X1/SvJ	color key
MP:0005584	abnormal enzyme/coenzyme activity	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005584	abnormal enzyme/coenzyme activity	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0008267	abnormal hippocampus CA3 region morphology	Gpx4	Gpx4^tm2Marc/Gpx4^tm2Marc,Tg(Camk2a-cre)2Gsc/0	involves: 129S2/SvPas * FVB/N	color key
MP:0001547	abnormal lipid level	Gpx1	Gpx1^tm1Mgr/Gpx1^tm1Mgr	involves: 129 * C57BL/6J	color key
MP:0006036	abnormal mitochondrial physiology	Gpx1	Gpx1^tm1Mgr/Gpx1^tm1Mgr	involves: 129 * C57BL/6J	color key
MP:0006036	abnormal mitochondrial physiology	Gpx4	Gpx4^tm1Ssd/Gpx4⁺	B6.129-Gpx4	color key
MP:0005464	abnormal platelet physiology	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0002792	abnormal retinal vasculature	Gsr	Gsr^{Gt(OST124402)Lex}/Gsr^{Gt(OST124402)Lex}	involves: 129S5/SvEvBrd * C57BL/6J	color key
MP:0004841	abnormal small intestine crypts of Lieberkuhn morphology	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh	B6.129-Gpx1	color key
MP:0002557	abnormal social/conspecific interaction	Gpx4	Gpx4^tm2Marc/Gpx4^tm2Marc,Tg(Camk2a-cre)2Gsc/0	involves: 129S2/SvPas * FVB/N	color key
MP:0006080	CNS ischemia	Gpx1	Gpx1^tm1Kola/Gpx1^tm1Kola	involves: 129S2/SvPas * BALB/c * CF1	color key
MP:0005164	abnormal response to injury	Gpx1	Gpx1^tm1Kola/Gpx1^tm1Kola	involves: 129S2/SvPas * BALB/c * CF1	color key
MP:0004841	abnormal small intestine crypts of Lieberkuhn morphology	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0000859	abnormal somatosensory cortex morphology	Gpx4	Gpx4^tm2Marc/Gpx4^tm2Marc,Tg(Camk2a-cre)2Gsc/0	involves: 129S2/SvPas * FVB/N	color key
MP:0001674	abnormal triploblastic development	Gpx4	Gpx4^tm1Prol/Gpx4^tm1Prol	involves: 129/Sv * C57BL/6J	color key
MP:0003354	astrocytosis	Gpx4	Gpx4^tm2Marc/Gpx4^tm2Marc,Tg(Camk2a-cre)2Gsc/0	involves: 129S2/SvPas * FVB/N	color key
MP:0001393	ataxia	Gpx4	Gpx4^tm2Marc/Gpx4^tm2Marc,Tg(Camk2a-cre)2Gsc/0	involves: 129S2/SvPas * FVB/N	color key
MP:0005150	cachexia	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005150	cachexia	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0000316	cellular necrosis	Gpx1	Gpx1^tm1Kola/Gpx1^tm1Kola	involves: 129S2/SvPas * CF1	color key
MP:0002857	cochlear ganglion degeneration	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0004398	cochlear inner hair cell degeneration	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0004404	cochlear outer hair cell degeneration	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0002816	colitis	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0002816	colitis	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0000947	convulsive seizures	Gpx4	Gpx4^tm2Marc/Gpx4^tm2Marc,Tg(Camk2a-cre)2Gsc/0	involves: 129S2/SvPas * FVB/N	color key
MP:0000491	crypts of Lieberkuhn abscesses	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0000491	crypts of Lieberkuhn abscesses	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005534	decreased body temperature	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005534	decreased body temperature	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001262	decreased body weight	Gpx1	Gpx1^tm1Mgr/Gpx1^tm1Mgr	involves: 129 * C57BL/6J	color key
MP:0001262	decreased body weight	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001262	decreased body weight	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0004765	decreased brainstem auditory evoked potential	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0000352	decreased cell proliferation	Gpx1	Gpx1^tm1Kola/Gpx1^tm1Kola	involves: 129S2/SvPas * CF1	color key
MP:0003207	decreased cellular sensitivity to gamma-irradiation	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh	B6.129-Gpx1	color key
MP:0003207	decreased cellular sensitivity to gamma-irradiation	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005036	diarrhea	Gpx1	Gpx1^tm1Ysh/Gpx1⁺,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005036	diarrhea	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005036	diarrhea	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005036	diarrhea	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005036	diarrhea	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005036	diarrhea	Gpx2	Gpx1^tm1Ysh/Gpx1⁺,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0008762	embryonic lethality	Gpx4	Gpx4^tm1Ssd/Gpx4^tm1Ssd	B6.129-Gpx4	color key
MP:0006205	embryonic lethality before somite formation	Gpx4	Gpx4^tm1Prol/Gpx4^tm1Prol	involves: 129/Sv * C57BL/6J	color key
MP:0006205	embryonic lethality before somite formation	Gpx4	Gpx4^tm2.1Marc/Gpx4^tm2.1Marc	involves: 129S2/SvPas * BALB/c * C57BL/6	color key
MP:0006206	embryonic lethality before turning of embryo	Gpx4	Gpx4^tm1Yana/Gpx4^tm1Yana	involves: C57BL/6 * CBA	color key
MP:0001696	failure to gastrulate	Gpx4	Gpx4^tm1Prol/Gpx4^tm1Prol	involves: 129/Sv * C57BL/6J	color key
MP:0001696	failure to gastrulate	Gpx4	Gpx4^tm1Yana/Gpx4^tm1Yana	involves: C57BL/6 * CBA	color key
MP:0008406	increased cellular sensitivity to hydrogen peroxide	Gpx1	Gpx1^tm1Kola/Gpx1^tm1Kola	involves: 129S2/SvPas * CF1	color key
MP:0008412	increased cellular sensitivity to oxidative stress	Gpx1	Gpx1^tm1Kola/Gpx1^tm1Kola	involves: 129S2/SvPas * CF1	color key
MP:0006060	increased cerebral infarction size	Gpx1	Gpx1^tm1Kola/Gpx1^tm1Kola	involves: 129S2/SvPas * BALB/c * CF1	color key
MP:0001846	increased inflammatory response	Gpx1	Gpx1^tm1Kola/Gpx1^tm1Kola	involves: 129S2/SvPas * BALB/c * CF1	color key
MP:0001658	increased mortality induced by gamma-irradiation	Gpx4	Gpx4^tm1Prol/Gpx4⁺	involves: 129/Sv * C57BL/6J	color key
MP:0003203	increased neuron apoptosis	Gpx1	Gpx1^tm1Kola/Gpx1^tm1Kola	involves: 129S2/SvPas * BALB/c * CF1	color key
MP:0003203	increased neuron apoptosis	Gpx4	Gpx4^tm2Marc/Gpx4^tm2Marc,Tg(Camk2a-cre)2Gsc/0	involves: 129S2/SvPas * FVB/N	color key
MP:0003076	increased susceptibility to ischemic brain injury	Gpx1	Gpx1^tm1Kola/Gpx1^tm1Kola	involves: 129S2/SvPas * BALB/c * CF1	color key
MP:0004597	increased susceptibility to noise-induced hearing loss	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0003288	intestinal edema	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0003288	intestinal edema	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001858	intestinal inflammation	Gpx1	Gpx1^tm1Ysh/Gpx1⁺,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001858	intestinal inflammation	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001858	intestinal inflammation	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001858	intestinal inflammation	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001858	intestinal inflammation	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001858	intestinal inflammation	Gpx2	Gpx1^tm1Ysh/Gpx1⁺,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0002169	no abnormal phenotype detected	Gpx4	Gpx4^tm1Prol/Gpx4⁺	involves: 129/Sv	color key
MP:0002169	no abnormal phenotype detected	Gsr	Gsr^a1Neu/Gsr^a1Neu	Not Specified	color key
MP:0003674	oxidative stress	Gpx1	Gpx1^tm1Kola/Gpx1^tm1Kola	involves: 129S2/SvPas * BALB/c * CF1	color key
MP:0003674	oxidative stress	Gpx4	Gpx4^tm1Ssd/Gpx4⁺	B6.129-Gpx4	color key
MP:0005035	perianal ulceration	Gpx1	Gpx1^tm1Ysh/Gpx1⁺,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005035	perianal ulceration	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005035	perianal ulceration	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005035	perianal ulceration	Gpx2	Gpx1^tm1Ysh/Gpx1⁺,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001732	postnatal growth retardation	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001732	postnatal growth retardation	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0002082	postnatal lethality	Gpx4	Gpx4^tm2Marc/Gpx4^tm2Marc,Tg(Camk2a-cre)2Gsc/0	involves: 129S2/SvPas * FVB/N	color key
MP:0002083	premature death	Gpx1	Gpx1^tm1Ysh/Gpx1⁺,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0002083	premature death	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0002083	premature death	Gpx2	Gpx1^tm1Ysh/Gpx1⁺,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0002083	premature death	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001698	reduced embryo size	Gpx4	Gpx4^tm1Yana/Gpx4^tm1Yana	involves: C57BL/6 * CBA	color key
MP:0003306	small intestinal inflammation	Gpx1	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0003306	small intestinal inflammation	Gpx2	Gpx1^tm1Ysh/Gpx1^tm1Ysh,Gpx2^tm2Coh/Gpx2^tm2Coh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001263	weight loss	Gpx4	Gpx4^tm2Marc/Gpx4^tm2Marc,Tg(Camk2a-cre)2Gsc/0	involves: 129S2/SvPas * FVB/N	color key