# Copyright © 2009, The Jackson Laboratory and SRI International. All Rights Reserved.
#
# Authors:
#    Carol J. Bult, The Jackson Laboratory
#    Emily J. Patek, The Jackson Laboratory
#    Alexei V. Evsikov, The Jackson Laboratory
#    Mary E. Dolan, The Jackson Laboratory & The University of Maine
#
# Please see the license agreement regarding the use of and distribution of this file.
# The format of this file is defined at http://bioinformatics.ai.sri.com/ptools/flatfile-format.html .
#
# Species: Mus musculus
# Database: NIL
# Version: 1.55
# File Name: pathways.dat
# Date and time generated: November 5, 2010, 13:26:10
#
UNIQUE-ID - SER-GLYSYN-PWY
TYPES - Amino-Acid-Biosynthesis
TYPES - Super-Pathways
COMMON-NAME - superpathway of serine and glycine biosynthesis I
PREDECESSORS - (GLYOHMETRANS-RXN RXN0-5114)
PREDECESSORS - GLYSYN-PWY
PREDECESSORS - SERSYN-PWY
REACTION-LAYOUT - (GLYSYN-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (SERSYN-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - GLYSYN-PWY
REACTION-LIST - SERSYN-PWY
SUB-PATHWAYS - SERSYN-PWY
SUB-PATHWAYS - GLYSYN-PWY
//
UNIQUE-ID - ALANINE-SYN2-PWY
TYPES - ALANINE-SYN
COMMON-NAME - alanine biosynthesis II
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - O0-3
CREDITS - |ingraham|
CREDITS - SRI
CREDITS - |shearer|
PREDECESSORS - (ALANINE-AMINOTRANSFERASE-RXN)
PRIMARIES - (ALANINE-AMINOTRANSFERASE-RXN NIL (L-ALPHA-ALANINE))
REACTION-LAYOUT - (ALANINE-AMINOTRANSFERASE-RXN (:LEFT-PRIMARIES L-ALPHA-ALANINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES PYRUVATE))
REACTION-LIST - ALANINE-AMINOTRANSFERASE-RXN
//
UNIQUE-ID - ARGININE-SYN4-PWY
TYPES - ARGININE-SYN
COMMON-NAME - arginine biosynthesis IV
PREDECESSORS - (ARGSUCCINLYA-RXN ARGSUCCINSYN-RXN)
PREDECESSORS - (ARGSUCCINSYN-RXN ORNCARBAMTRANSFER-RXN)
PREDECESSORS - (ORNCARBAMTRANSFER-RXN ORNITHINE-GLU-AMINOTRANSFORASE-RXN)
PREDECESSORS - (ORNITHINE-GLU-AMINOTRANSFORASE-RXN PROLINE-MULTI)
PREDECESSORS - (PROLINE-MULTI GLUTAMATE-DEHYDROGENASE-NADP+-RXN)
PRIMARIES - (ARGSUCCINLYA-RXN (L-ARGININO-SUCCINATE) (ARG))
PRIMARIES - (GLUTAMATE-DEHYDROGENASE-NADP+-RXN (2-KETOGLUTARATE) (GLT))
REACTION-LAYOUT - (ARGSUCCINLYA-RXN (:LEFT-PRIMARIES L-ARGININO-SUCCINATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ARG))
REACTION-LAYOUT - (ARGSUCCINSYN-RXN (:LEFT-PRIMARIES L-CITRULLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-ARGININO-SUCCINATE))
REACTION-LAYOUT - (ORNCARBAMTRANSFER-RXN (:LEFT-PRIMARIES L-ORNITHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-CITRULLINE))
REACTION-LAYOUT - (ORNITHINE-GLU-AMINOTRANSFORASE-RXN (:LEFT-PRIMARIES 2-KETOGLUTARATE L-ORNITHINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES L-GLUTAMATE_GAMMA-SEMIALDEHYDE GLT))
REACTION-LAYOUT - (PROLINE-MULTI (:LEFT-PRIMARIES GLT) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-GLUTAMATE_GAMMA-SEMIALDEHYDE))
REACTION-LAYOUT - (GLUTAMATE-DEHYDROGENASE-NADP+-RXN (:LEFT-PRIMARIES GLT) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 2-KETOGLUTARATE))
REACTION-LIST - ARGSUCCINLYA-RXN
REACTION-LIST - ARGSUCCINSYN-RXN
REACTION-LIST - ORNCARBAMTRANSFER-RXN
REACTION-LIST - ORNITHINE-GLU-AMINOTRANSFORASE-RXN
REACTION-LIST - PROLINE-MULTI
REACTION-LIST - GLUTAMATE-DEHYDROGENASE-NADP+-RXN
SYNONYMS - arginine biosynthesis 4
//
UNIQUE-ID - PWY-4983
TYPES - ARGININE-SYN
TYPES - ARGININE-DEG
TYPES - Metabolic-Regulators
COMMON-NAME - citrulline-nitric oxide cycle
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - PWY-5004
PREDECESSORS - (NITRIC-OXIDE-SYNTHASE-RXN ARGSUCCINLYA-RXN)
PREDECESSORS - (ARGSUCCINLYA-RXN ARGSUCCINSYN-RXN)
PREDECESSORS - (ARGSUCCINSYN-RXN NITRIC-OXIDE-SYNTHASE-RXN)
REACTION-LAYOUT - (ARGSUCCINLYA-RXN (:LEFT-PRIMARIES L-ARGININO-SUCCINATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ARG))
REACTION-LAYOUT - (ARGSUCCINSYN-RXN (:LEFT-PRIMARIES L-CITRULLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-ARGININO-SUCCINATE))
REACTION-LAYOUT - (NITRIC-OXIDE-SYNTHASE-RXN (:LEFT-PRIMARIES ARG) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-CITRULLINE))
REACTION-LIST - ARGSUCCINLYA-RXN
REACTION-LIST - ARGSUCCINSYN-RXN
REACTION-LIST - NITRIC-OXIDE-SYNTHASE-RXN
SUPER-PATHWAYS - PWY-5004
SYNONYMS - citrulline-NO cycle
//
UNIQUE-ID - ASPARAGINE-BIOSYNTHESIS
TYPES - ASPARAGINE-SYN
COMMON-NAME - asparagine biosynthesis I
CITATIONS - :EV-COMP-AINF:3442068425:ave
CREDITS - SRI
CREDITS - |fulcher|
PREDECESSORS - (ASNSYNB-RXN)
REACTION-LAYOUT - (ASNSYNB-RXN (:LEFT-PRIMARIES L-ASPARTATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ASN))
REACTION-LIST - ASNSYNB-RXN
//
UNIQUE-ID - ASPBIO-PWY
TYPES - ASPARTATE-SYN
COMMON-NAME - aspartate biosynthesis
CITATIONS - :EV-COMP-AINF:3380892013:cjb
PREDECESSORS - (ASPAMINOTRANS-RXN PYRUVATE-CARBOXYLASE-RXN)
PREDECESSORS - (PYRUVATE-CARBOXYLASE-RXN)
REACTION-LAYOUT - (ASPAMINOTRANS-RXN (:LEFT-PRIMARIES L-ASPARTATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES OXALACETIC_ACID))
REACTION-LAYOUT - (PYRUVATE-CARBOXYLASE-RXN (:LEFT-PRIMARIES PYRUVATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OXALACETIC_ACID))
REACTION-LIST - ASPAMINOTRANS-RXN
REACTION-LIST - PYRUVATE-CARBOXYLASE-RXN
//
UNIQUE-ID - PWY-3981
TYPES - Beta-Alanine-Biosynthesis
COMMON-NAME - β-alanine biosynthesis I
CITATIONS - :EV-COMP-AINF:3419591312:ave
PATHWAY-LINKS - (SPERMINE ARGSPECAT-PWY)
PATHWAY-LINKS - (SPERMIDINE BSUBPOLYAMSYN-PWY)
PREDECESSORS - (RXN-6423 SPERMIDINE-DEHYDROGENASE-RXN)
PREDECESSORS - (RXN-6382 RXN-6381)
PREDECESSORS - (RXN-6381 SPERMIDINE-DEHYDROGENASE-RXN)
PREDECESSORS - (SPERMIDINE-DEHYDROGENASE-RXN)
PREDECESSORS - (RXN-6421)
PREDECESSORS - (RXN-6381 RXN-6421)
PREDECESSORS - (RXN-6425 RXN-6424)
PREDECESSORS - (RXN-6424 RXN-6421)
PRIMARIES - (RXN-6425 (CPD-6123) (CPD-6122))
PRIMARIES - (RXN-6424 (CPD-6121) (CPD-6123))
PRIMARIES - (RXN-6421 (SPERMINE) (CPD-6121 CPD-313))
PRIMARIES - (SPERMIDINE-DEHYDROGENASE-RXN (SPERMIDINE) (4-AMINO-BUTYRALDEHYDE CPD-313))
PRIMARIES - (RXN-6423 (4-AMINO-BUTYRALDEHYDE) (CPD-6124))
PRIMARIES - (RXN-6382 (CPD-6082) (B-ALANINE))
PRIMARIES - (RXN-6381 (CPD-313) (CPD-6082))
REACTION-LAYOUT - (RXN-6424 (:LEFT-PRIMARIES CPD-6121) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-6123))
REACTION-LAYOUT - (RXN-6425 (:LEFT-PRIMARIES CPD-6123) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-6122))
REACTION-LAYOUT - (RXN-6423 (:LEFT-PRIMARIES 4-AMINO-BUTYRALDEHYDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-6124))
REACTION-LAYOUT - (RXN-6421 (:LEFT-PRIMARIES SPERMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-313 CPD-6121))
REACTION-LAYOUT - (RXN-6382 (:LEFT-PRIMARIES CPD-6082) (:DIRECTION :L2R) (:RIGHT-PRIMARIES B-ALANINE))
REACTION-LAYOUT - (RXN-6381 (:LEFT-PRIMARIES CPD-313) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-6082))
REACTION-LAYOUT - (SPERMIDINE-DEHYDROGENASE-RXN (:LEFT-PRIMARIES SPERMIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-313 4-AMINO-BUTYRALDEHYDE))
REACTION-LIST - RXN-6424
REACTION-LIST - RXN-6425
REACTION-LIST - RXN-6423
REACTION-LIST - RXN-6421
REACTION-LIST - RXN-6382
REACTION-LIST - RXN-6381
REACTION-LIST - SPERMIDINE-DEHYDROGENASE-RXN
SYNONYMS - β-alanine biosynthesis from polyamines
//
UNIQUE-ID - PWY-3982
TYPES - Beta-Alanine-Biosynthesis
COMMON-NAME - β-alanine biosynthesis III
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |caspi|
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |tissier|
PREDECESSORS - (BETA-UREIDOPROPIONASE-RXN DIHYDROPYRIMIDINASE-RXN)
PREDECESSORS - (DIHYDROPYRIMIDINASE-RXN 1.3.1.2-RXN)
PREDECESSORS - (1.3.1.2-RXN)
PRIMARIES - (BETA-UREIDOPROPIONASE-RXN (3-UREIDO-PROPIONATE) (B-ALANINE))
PRIMARIES - (DIHYDROPYRIMIDINASE-RXN (DI-H-URACIL) (3-UREIDO-PROPIONATE))
PRIMARIES - (1.3.1.2-RXN (URACIL) (DI-H-URACIL))
REACTION-LAYOUT - (BETA-UREIDOPROPIONASE-RXN (:LEFT-PRIMARIES 3-UREIDO-PROPIONATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES B-ALANINE))
REACTION-LAYOUT - (DIHYDROPYRIMIDINASE-RXN (:LEFT-PRIMARIES DI-H-URACIL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-UREIDO-PROPIONATE))
REACTION-LAYOUT - (1.3.1.2-RXN (:LEFT-PRIMARIES DI-H-URACIL) (:DIRECTION :R2L) (:RIGHT-PRIMARIES URACIL))
REACTION-LIST - BETA-UREIDOPROPIONASE-RXN
REACTION-LIST - DIHYDROPYRIMIDINASE-RXN
REACTION-LIST - 1.3.1.2-RXN
SYNONYMS - β-alanine biosynthesis from uracil
//
UNIQUE-ID - CYSTEINE-SYN2-PWY
TYPES - CYSTEINE-SYN
COMMON-NAME - cysteine biosynthesis II
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |wagg|
PATHWAY-LINKS - (HOMO-CYS METHIONINE-DEG1-PWY)
PATHWAY-LINKS - (SER SERSYN-PWY)
PREDECESSORS - (CYSTAGLY-RXN CYSTATHIONINE-BETA-SYNTHASE-RXN)
PRIMARIES - (CYSTATHIONINE-BETA-SYNTHASE-RXN (HOMO-CYS SER) NIL)
PRIMARIES - (CYSTAGLY-RXN (L-CYSTATHIONINE) (CYS))
PRIMARIES - (CYSTATHIONASE-RXN (L-CYSTATHIONINE) (CYS))
REACTION-LAYOUT - (CYSTAGLY-RXN (:LEFT-PRIMARIES L-CYSTATHIONINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CYS))
REACTION-LAYOUT - (CYSTATHIONINE-BETA-SYNTHASE-RXN (:LEFT-PRIMARIES SER HOMO-CYS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-CYSTATHIONINE))
REACTION-LIST - CYSTAGLY-RXN
REACTION-LIST - CYSTATHIONINE-BETA-SYNTHASE-RXN
//
UNIQUE-ID - HOMOCYSDEGR-PWY
TYPES - CYSTEINE-SYN
TYPES - HOMOCYSTEINE-DEG
COMMON-NAME - cysteine biosynthesis/homocysteine degradation
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - |caspi|
CREDITS - |Iourovitski|
CREDITS - SRI
IN-PATHWAY - PWY-5328
IN-PATHWAY - PWY-6292
PATHWAY-LINKS - (HOMO-CYS METHIONINE-DEG1-PWY)
PATHWAY-LINKS - (2-OXOBUTANOATE PWY-5130)
PATHWAY-LINKS - (CYS CYSTEINE-DEG-PWY PWY-5329)
PREDECESSORS - (CYSTAGLY-RXN CYSTATHIONINE-BETA-SYNTHASE-RXN)
PREDECESSORS - (CYSTATHIONINE-BETA-SYNTHASE-RXN)
PRIMARIES - (CYSTAGLY-RXN (L-CYSTATHIONINE) (CYS))
PRIMARIES - (CYSTATHIONINE-BETA-SYNTHASE-RXN (SER HOMO-CYS) NIL)
REACTION-LAYOUT - (CYSTAGLY-RXN (:LEFT-PRIMARIES L-CYSTATHIONINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CYS 2-OXOBUTANOATE))
REACTION-LAYOUT - (CYSTATHIONINE-BETA-SYNTHASE-RXN (:LEFT-PRIMARIES SER HOMO-CYS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-CYSTATHIONINE))
REACTION-LIST - CYSTAGLY-RXN
REACTION-LIST - CYSTATHIONINE-BETA-SYNTHASE-RXN
SUPER-PATHWAYS - PWY-5328
SUPER-PATHWAYS - PWY-6292
SYNONYMS - cysteine biosynthesis II
SYNONYMS - homocysteine degradation
//
UNIQUE-ID - PWY-6292
TYPES - CYSTEINE-SYN
TYPES - Super-Pathways
COMMON-NAME - cysteine biosynthesis III (mammalia)
PATHWAY-LINKS - (MET ADENOSYLHOMOCYSCAT-PWY)
PATHWAY-LINKS - (SER SERSYN-PWY)
PREDECESSORS - (CYSTATHIONINE-BETA-SYNTHASE-RXN ADENOSYLHOMOCYSTEINASE-RXN)
PREDECESSORS - HOMOCYSDEGR-PWY
PREDECESSORS - METHIONINE-DEG1-PWY
PRIMARIES - (CYSTAGLY-RXN (L-CYSTATHIONINE) (CYS))
REACTION-LAYOUT - (HOMOCYSDEGR-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (METHIONINE-DEG1-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - HOMOCYSDEGR-PWY
REACTION-LIST - METHIONINE-DEG1-PWY
SUB-PATHWAYS - HOMOCYSDEGR-PWY
SUB-PATHWAYS - METHIONINE-DEG1-PWY
//
UNIQUE-ID - ARGASEDEG-PWY
TYPES - GLUTAMATE-SYN
TYPES - ARGININE-DEG
COMMON-NAME - arginine degradation I (arginase pathway)
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - |caspi|
CREDITS - SRI
CREDITS - |hying|
PREDECESSORS - (PYRROLINECARBDEHYDROG-RXN SPONTPRO-RXN)
PREDECESSORS - (ORNITHINE-GLU-AMINOTRANSFORASE-RXN ARGINASE-RXN)
PREDECESSORS - (SPONTPRO-RXN ORNITHINE-GLU-AMINOTRANSFORASE-RXN)
PRIMARIES - (ARGINASE-RXN (ARG) (L-ORNITHINE))
REACTION-LAYOUT - (ORNITHINE-GLU-AMINOTRANSFORASE-RXN (:LEFT-PRIMARIES L-ORNITHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-GLUTAMATE_GAMMA-SEMIALDEHYDE GLT))
REACTION-LAYOUT - (SPONTPRO-RXN (:LEFT-PRIMARIES L-GLUTAMATE_GAMMA-SEMIALDEHYDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-DELTA1-PYRROLINE_5-CARBOXYLATE))
REACTION-LAYOUT - (PYRROLINECARBDEHYDROG-RXN (:LEFT-PRIMARIES L-DELTA1-PYRROLINE_5-CARBOXYLATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLT))
REACTION-LAYOUT - (ARGINASE-RXN (:LEFT-PRIMARIES ARG) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-ORNITHINE))
REACTION-LIST - ORNITHINE-GLU-AMINOTRANSFORASE-RXN
REACTION-LIST - SPONTPRO-RXN
REACTION-LIST - PYRROLINECARBDEHYDROG-RXN
REACTION-LIST - ARGINASE-RXN
SYNONYMS - arginase degradative pathway
SYNONYMS - glutamate biosynthesis
//
UNIQUE-ID - GLUTAMATE-SYN2-PWY
TYPES - GLUTAMATE-SYN
COMMON-NAME - glutamate biosynthesis II
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - SRI
CREDITS - |fulcher|
PATHWAY-LINKS - (GLT PROLINE-SYN2-PWY ARGININE-SYN4-PWY)
PREDECESSORS - (GLUTAMATE-DEHYDROGENASE-NADP+-RXN)
PRIMARIES - (GLUTAMATE-DEHYDROGENASE-NADP+-RXN (2-KETOGLUTARATE) (GLT))
REACTION-LAYOUT - (GLUTAMATE-DEHYDROGENASE-NADP+-RXN (:LEFT-PRIMARIES GLT) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 2-KETOGLUTARATE))
REACTION-LIST - GLUTAMATE-DEHYDROGENASE-NADP+-RXN
//
UNIQUE-ID - GLNSYN-PWY
TYPES - GLUTAMINE-SYN
COMMON-NAME - glutamine biosynthesis I
CREDITS - |shearer|
CREDITS - SRI
CREDITS - |fulcher|
CREDITS - O-18
CREDITS - |riley|
PREDECESSORS - (GLUTAMINESYN-RXN)
PRIMARIES - (GLUTAMINESYN-RXN (GLT))
REACTION-LAYOUT - (GLUTAMINESYN-RXN (:LEFT-PRIMARIES GLT) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLN))
REACTION-LIST - GLUTAMINESYN-RXN
SYNONYMS - glutamine - glutamate pathway
//
UNIQUE-ID - GLUTAMINE-SYN2-PWY
TYPES - GLUTAMINE-SYN
COMMON-NAME - glutamine biosynthesis II
CITATIONS - :EV-COMP-AINF:3380892013:cjb
PREDECESSORS - (GLUTAMINESYN-RXN GLUTAMATE-DEHYDROGENASE-NADP+-RXN)
PRIMARIES - (GLUTAMINESYN-RXN (GLT) (GLN))
PRIMARIES - (GLUTAMATE-DEHYDROGENASE-NADP+-RXN (2-KETOGLUTARATE) (GLT))
REACTION-LAYOUT - (GLUTAMINESYN-RXN (:LEFT-PRIMARIES GLT) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLN))
REACTION-LAYOUT - (GLUTAMATE-DEHYDROGENASE-NADP+-RXN (:LEFT-PRIMARIES GLT) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 2-KETOGLUTARATE))
REACTION-LIST - GLUTAMINESYN-RXN
REACTION-LIST - GLUTAMATE-DEHYDROGENASE-NADP+-RXN
//
UNIQUE-ID - PWY-5921
TYPES - GLUTAMINE-SYN
TYPES - Aminoacyl-tRNAs-Charging
COMMON-NAME - L-glutamine biosynthesis II (tRNA-dependent)
CITATIONS - :EV-COMP-AINF:3442068425:ave
CREDITS - SRI
CREDITS - |fulcher|
PREDECESSORS - (6.3.5.7-RXN RXN-9386)
PREDECESSORS - (RXN-9386)
PRIMARIES - (RXN-9386 (GLT) (GLUTAMYL-TRNA-GLN))
REACTION-LAYOUT - (6.3.5.7-RXN (:LEFT-PRIMARIES GLUTAMYL-TRNA-GLN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLUTAMINYL-TRNA-GLN GLT))
REACTION-LAYOUT - (RXN-9386 (:LEFT-PRIMARIES GLT) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLUTAMYL-TRNA-GLN))
REACTION-LIST - 6.3.5.7-RXN
REACTION-LIST - RXN-9386
SYNONYMS - glutaminyl-tRNA<sup>gln</sup> biosynthesis via transamidation
//
UNIQUE-ID - GLYSYN-ALA-PWY
TYPES - GLYCINE-SYN
COMMON-NAME - glycine biosynthesis III
CITATIONS - :EV-COMP-AINF:3442068425:ave
CREDITS - |hong|
CREDITS - O-16
CREDITS - |krieger|
PREDECESSORS - (ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN)
PRIMARIES - (ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN (GLYOX) (GLY))
REACTION-LAYOUT - (ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN (:LEFT-PRIMARIES GLYOX) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLY))
REACTION-LIST - ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN
//
UNIQUE-ID - GLYSYN-PWY
TYPES - GLYCINE-SYN
COMMON-NAME - glycine biosynthesis I
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |caspi|
CREDITS - O-18
CREDITS - |riley|
IN-PATHWAY - SER-GLYSYN-PWY
PATHWAY-LINKS - (SER SERSYN-PWY)
PREDECESSORS - (GLYOHMETRANS-RXN)
PRIMARIES - (GLYOHMETRANS-RXN (SER) (GLY))
REACTION-LAYOUT - (GLYOHMETRANS-RXN (:LEFT-PRIMARIES SER) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLY))
REACTION-LIST - GLYOHMETRANS-RXN
SUPER-PATHWAYS - SER-GLYSYN-PWY
//
UNIQUE-ID - GLYSYN-THR-PWY
TYPES - GLYCINE-SYN
COMMON-NAME - glycine biosynthesis IV
CITATIONS - :EV-COMP-AINF:3442068425:ave
CREDITS - SRI
CREDITS - |caspi|
CREDITS - |hong|
CREDITS - O-16
CREDITS - |krieger|
PREDECESSORS - (THREONINE-ALDOLASE-RXN)
PRIMARIES - (THREONINE-ALDOLASE-RXN (THR) (GLY))
REACTION-LAYOUT - (THREONINE-ALDOLASE-RXN (:LEFT-PRIMARIES THR) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLY))
REACTION-LIST - THREONINE-ALDOLASE-RXN
//
UNIQUE-ID - ADENOSYLHOMOCYSCAT-PWY
TYPES - METHIONINE-SYN
COMMON-NAME - methionine salvage II (mammalia)
CITATIONS - :EV-COMP-AINF:3419591312:ave
IN-PATHWAY - PWY-5328
PATHWAY-LINKS - (HOMO-CYS METHIONINE-DEG1-PWY)
PREDECESSORS - (HOMOCYSMETB12-RXN)
PREDECESSORS - (2.1.1.5-RXN)
PRIMARIES - (HOMOCYSMETB12-RXN (HOMO-CYS) (MET))
PRIMARIES - (2.1.1.5-RXN (HOMO-CYS) (MET))
REACTION-LAYOUT - (2.1.1.5-RXN (:LEFT-PRIMARIES HOMO-CYS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MET))
REACTION-LAYOUT - (HOMOCYSMETB12-RXN (:LEFT-PRIMARIES HOMO-CYS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MET))
REACTION-LIST - 2.1.1.5-RXN
REACTION-LIST - HOMOCYSMETB12-RXN
SUPER-PATHWAYS - PWY-5328
SYNONYMS - S-adenosylhomocysteine catabolism
SYNONYMS - S-adenosylhomocysteine degradation
//
UNIQUE-ID - PWY-4361
TYPES - METHIONINE-SYN
COMMON-NAME - methionine salvage I
CREDITS - |caspi|
CREDITS - SRI
CREDITS - |krieger|
CREDITS - O-18
CREDITS - |pellegrini-toole|
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |tissier|
PATHWAY-LINKS - (MET SAM-PWY)
PATHWAY-LINKS - (5-METHYLTHIOADENOSINE ARGSPECAT-PWY BSUBPOLYAMSYN-PWY)
PREDECESSORS - (R15-RXN R147-RXN)
PREDECESSORS - (R147-RXN R83-RXN)
PREDECESSORS - (R145-RXN 5.3.1.23-RXN)
PREDECESSORS - (5.3.1.23-RXN 5-METHYLTHIORIBOSE-KINASE-RXN)
PREDECESSORS - (5-METHYLTHIORIBOSE-KINASE-RXN METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN)
PREDECESSORS - (R82-RXN R145-RXN)
PREDECESSORS - (R83-RXN R82-RXN)
PRIMARIES - (R15-RXN (CPD-479) (MET))
PRIMARIES - (R147-RXN (CPD-85) (CPD-479))
PRIMARIES - (R83-RXN (2-HYDROXY-3-KETO-5-METHYLTHIO-1-PHOSPHOP) (CPD-85))
PRIMARIES - (R82-RXN (CPD-8999) (2-HYDROXY-3-KETO-5-METHYLTHIO-1-PHOSPHOP))
PRIMARIES - (R145-RXN (CPD-1063) (CPD-8999))
PRIMARIES - (5.3.1.23-RXN (CPD-444) (CPD-1063))
PRIMARIES - (5-METHYLTHIORIBOSE-KINASE-RXN (CPD-560) (CPD-444))
PRIMARIES - (METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN (5-METHYLTHIOADENOSINE) (CPD-560))
REACTION-LAYOUT - (R15-RXN (:LEFT-PRIMARIES CPD-479) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MET))
REACTION-LAYOUT - (R147-RXN (:LEFT-PRIMARIES CPD-85) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-479))
REACTION-LAYOUT - (R83-RXN (:LEFT-PRIMARIES 2-HYDROXY-3-KETO-5-METHYLTHIO-1-PHOSPHOP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-85))
REACTION-LAYOUT - (R82-RXN (:LEFT-PRIMARIES CPD-8999) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-HYDROXY-3-KETO-5-METHYLTHIO-1-PHOSPHOP))
REACTION-LAYOUT - (5.3.1.23-RXN (:LEFT-PRIMARIES CPD-444) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-1063))
REACTION-LAYOUT - (R145-RXN (:LEFT-PRIMARIES CPD-1063) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8999))
REACTION-LAYOUT - (5-METHYLTHIORIBOSE-KINASE-RXN (:LEFT-PRIMARIES CPD-560) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-444))
REACTION-LAYOUT - (METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN (:LEFT-PRIMARIES 5-METHYLTHIOADENOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-560))
REACTION-LIST - R15-RXN
REACTION-LIST - R147-RXN
REACTION-LIST - R83-RXN
REACTION-LIST - R82-RXN
REACTION-LIST - 5.3.1.23-RXN
REACTION-LIST - R145-RXN
REACTION-LIST - 5-METHYLTHIORIBOSE-KINASE-RXN
REACTION-LIST - METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN
SYNONYMS - Yang cycle
SYNONYMS - methylthioadenosine recycling
SYNONYMS - methionine regeneration
SYNONYMS - methionine recycling
SYNONYMS - methylthioribose recycling
//
UNIQUE-ID - PWY-5041
TYPES - S-adenosyl-L-methionine-cycle
COMMON-NAME - <i>S</i>-adenosyl-L-methionine cycle II
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (S-ADENMETSYN-RXN HOMOCYSMET-RXN)
PREDECESSORS - (RXN-7605 S-ADENMETSYN-RXN)
PREDECESSORS - (ADENOSYLHOMOCYSTEINASE-RXN RXN-7605)
PREDECESSORS - (HOMOCYSMET-RXN ADENOSYLHOMOCYSTEINASE-RXN)
PRIMARIES - (HOMOCYSMET-RXN (HOMO-CYS) (MET))
PRIMARIES - (RXN-7605 (S-ADENOSYLMETHIONINE) (ADENOSYL-HOMO-CYS))
PRIMARIES - (ADENOSYLHOMOCYSTEINASE-RXN (ADENOSYL-HOMO-CYS) (HOMO-CYS))
PRIMARIES - (S-ADENMETSYN-RXN (MET) (S-ADENOSYLMETHIONINE))
REACTION-LAYOUT - (HOMOCYSMET-RXN (:LEFT-PRIMARIES HOMO-CYS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MET))
REACTION-LAYOUT - (RXN-7605 (:LEFT-PRIMARIES S-ADENOSYLMETHIONINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ADENOSYL-HOMO-CYS))
REACTION-LAYOUT - (ADENOSYLHOMOCYSTEINASE-RXN (:LEFT-PRIMARIES ADENOSYL-HOMO-CYS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES HOMO-CYS))
REACTION-LAYOUT - (S-ADENMETSYN-RXN (:LEFT-PRIMARIES MET) (:DIRECTION :L2R) (:RIGHT-PRIMARIES S-ADENOSYLMETHIONINE))
REACTION-LIST - HOMOCYSMET-RXN
REACTION-LIST - RXN-7605
REACTION-LIST - ADENOSYLHOMOCYSTEINASE-RXN
REACTION-LIST - S-ADENMETSYN-RXN
SYNONYMS - activated methyl cycle
SYNONYMS - SAM cycle
//
UNIQUE-ID - CITRULBIO-PWY
TYPES - Citrulline-Biosynthesis
COMMON-NAME - citrulline biosynthesis
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - PWY-5004
PATHWAY-LINKS - (ARG ARGININE-SYN4-PWY)
PATHWAY-LINKS - (PRO PROLINE-SYN2-PWY)
PREDECESSORS - (GLUTKIN-RXN GLUTAMIN-RXN)
PREDECESSORS - (GLUTSEMIALDEHYDROG-RXN GLUTKIN-RXN)
PREDECESSORS - (ORNITHINE-GLU-AMINOTRANSFORASE-RXN GLUTSEMIALDEHYDROG-RXN)
PREDECESSORS - (ORNCARBAMTRANSFER-RXN ARGINASE-RXN)
PREDECESSORS - (ORNCARBAMTRANSFER-RXN ORNITHINE-GLU-AMINOTRANSFORASE-RXN)
PREDECESSORS - (ORNITHINE-GLU-AMINOTRANSFORASE-RXN SPONTPRO-RXN)
PREDECESSORS - (SPONTPRO-RXN RXN-821)
REACTION-LAYOUT - (RXN-821 (:LEFT-PRIMARIES PRO) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-DELTA1-PYRROLINE_5-CARBOXYLATE))
REACTION-LAYOUT - (GLUTSEMIALDEHYDROG-RXN (:LEFT-PRIMARIES L-GLUTAMATE_GAMMA-SEMIALDEHYDE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES L-GLUTAMATE-5-P))
REACTION-LAYOUT - (GLUTKIN-RXN (:LEFT-PRIMARIES GLT) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-GLUTAMATE-5-P))
REACTION-LAYOUT - (ORNCARBAMTRANSFER-RXN (:LEFT-PRIMARIES L-ORNITHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-CITRULLINE))
REACTION-LAYOUT - (ORNITHINE-GLU-AMINOTRANSFORASE-RXN (:LEFT-PRIMARIES L-ORNITHINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES L-GLUTAMATE_GAMMA-SEMIALDEHYDE GLT))
REACTION-LAYOUT - (SPONTPRO-RXN (:LEFT-PRIMARIES L-GLUTAMATE_GAMMA-SEMIALDEHYDE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES L-DELTA1-PYRROLINE_5-CARBOXYLATE))
REACTION-LAYOUT - (ARGINASE-RXN (:LEFT-PRIMARIES ARG) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-ORNITHINE))
REACTION-LAYOUT - (GLUTAMIN-RXN (:LEFT-PRIMARIES GLN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLT))
REACTION-LIST - RXN-821
REACTION-LIST - GLUTSEMIALDEHYDROG-RXN
REACTION-LIST - GLUTKIN-RXN
REACTION-LIST - ORNCARBAMTRANSFER-RXN
REACTION-LIST - ORNITHINE-GLU-AMINOTRANSFORASE-RXN
REACTION-LIST - SPONTPRO-RXN
REACTION-LIST - ARGINASE-RXN
REACTION-LIST - GLUTAMIN-RXN
SUPER-PATHWAYS - PWY-5004
//
UNIQUE-ID - PWY-4921
TYPES - Citrulline-Biosynthesis
COMMON-NAME - protein citrullination
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (PROTEIN-ARGININE-DEIMINASE-RXN)
REACTION-LAYOUT - (PROTEIN-ARGININE-DEIMINASE-RXN (:LEFT-PRIMARIES |Protein-L-Arginines|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PROTEIN-L-CITRULLINE))
REACTION-LIST - PROTEIN-ARGININE-DEIMINASE-RXN
//
UNIQUE-ID - PWY-5004
TYPES - Citrulline-Biosynthesis
TYPES - Super-Pathways
COMMON-NAME - superpathway of citrulline metabolism
KEY-REACTIONS - NITRIC-OXIDE-SYNTHASE-RXN
KEY-REACTIONS - ARGSUCCINSYN-RXN
KEY-REACTIONS - ORNCARBAMTRANSFER-RXN
PREDECESSORS - CITRULBIO-PWY
PREDECESSORS - PWY-4984
PREDECESSORS - (ARGSUCCINSYN-RXN)
PREDECESSORS - (ARGSUCCINLYA-RXN ARGSUCCINSYN-RXN)
PREDECESSORS - (ARGSUCCINSYN-RXN NITRIC-OXIDE-SYNTHASE-RXN)
PREDECESSORS - (NITRIC-OXIDE-SYNTHASE-RXN ARGSUCCINLYA-RXN)
PREDECESSORS - PWY-4983
REACTION-LAYOUT - (PWY-4983 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (PWY-4984 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (CITRULBIO-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - PWY-4983
REACTION-LIST - PWY-4984
REACTION-LIST - CITRULBIO-PWY
SUB-PATHWAYS - CITRULBIO-PWY
SUB-PATHWAYS - PWY-4984
SUB-PATHWAYS - PWY-4983
//
UNIQUE-ID - ARG-PRO-PWY
TYPES - PROLINE-SYN
TYPES - ARGININE-DEG
COMMON-NAME - arginine degradation VI (arginase 2 pathway)
CREDITS - |caspi|
CREDITS - SRI
CREDITS - |hying|
PREDECESSORS - (ORNITHINE-GLU-AMINOTRANSFORASE-RXN ARGINASE-RXN)
PREDECESSORS - (SPONTPRO-RXN ORNITHINE-GLU-AMINOTRANSFORASE-RXN)
PREDECESSORS - (PYRROLINECARBREDUCT-RXN SPONTPRO-RXN)
REACTION-LAYOUT - (SPONTPRO-RXN (:LEFT-PRIMARIES L-GLUTAMATE_GAMMA-SEMIALDEHYDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-DELTA1-PYRROLINE_5-CARBOXYLATE))
REACTION-LAYOUT - (ARGINASE-RXN (:LEFT-PRIMARIES ARG) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-ORNITHINE))
REACTION-LAYOUT - (ORNITHINE-GLU-AMINOTRANSFORASE-RXN (:LEFT-PRIMARIES L-ORNITHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-GLUTAMATE_GAMMA-SEMIALDEHYDE))
REACTION-LAYOUT - (PYRROLINECARBREDUCT-RXN (:LEFT-PRIMARIES PRO) (:DIRECTION :R2L) (:RIGHT-PRIMARIES L-DELTA1-PYRROLINE_5-CARBOXYLATE))
REACTION-LIST - SPONTPRO-RXN
REACTION-LIST - ARGINASE-RXN
REACTION-LIST - ORNITHINE-GLU-AMINOTRANSFORASE-RXN
REACTION-LIST - PYRROLINECARBREDUCT-RXN
SYNONYMS - proline biosynthesis from arginine
//
UNIQUE-ID - PROLINE-SYN2-PWY
TYPES - PROLINE-SYN
COMMON-NAME - proline biosynthesis II
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |caspi|
CREDITS - O-18
CREDITS - |riley|
PREDECESSORS - (GLUTKIN-RXN GLUTAMATE-DEHYDROGENASE-NADP+-RXN)
PREDECESSORS - (PYRROLINECARBREDUCT-RXN SPONTPRO-RXN)
PREDECESSORS - (SPONTPRO-RXN GLUTSEMIALDEHYDROG-RXN)
PREDECESSORS - (GLUTSEMIALDEHYDROG-RXN GLUTKIN-RXN)
REACTION-LAYOUT - (GLUTAMATE-DEHYDROGENASE-NADP+-RXN (:LEFT-PRIMARIES GLT) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 2-KETOGLUTARATE))
REACTION-LAYOUT - (GLUTKIN-RXN (:LEFT-PRIMARIES GLT) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-GLUTAMATE-5-P))
REACTION-LAYOUT - (GLUTSEMIALDEHYDROG-RXN (:LEFT-PRIMARIES L-GLUTAMATE_GAMMA-SEMIALDEHYDE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES L-GLUTAMATE-5-P))
REACTION-LAYOUT - (PYRROLINECARBREDUCT-RXN (:LEFT-PRIMARIES PRO) (:DIRECTION :R2L) (:RIGHT-PRIMARIES L-DELTA1-PYRROLINE_5-CARBOXYLATE))
REACTION-LAYOUT - (SPONTPRO-RXN (:LEFT-PRIMARIES L-GLUTAMATE_GAMMA-SEMIALDEHYDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-DELTA1-PYRROLINE_5-CARBOXYLATE))
REACTION-LIST - GLUTAMATE-DEHYDROGENASE-NADP+-RXN
REACTION-LIST - GLUTKIN-RXN
REACTION-LIST - GLUTSEMIALDEHYDROG-RXN
REACTION-LIST - PYRROLINECARBREDUCT-RXN
REACTION-LIST - SPONTPRO-RXN
SYNONYMS - prosyn
//
UNIQUE-ID - PWY-4981
TYPES - PROLINE-SYN
COMMON-NAME - proline biosynthesis II (from arginine)
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (ORNITHINE-GLU-AMINOTRANSFORASE-RXN CITRULLINASE-RXN)
PREDECESSORS - (CITRULLINASE-RXN ARGININE-DEIMINASE-RXN)
PREDECESSORS - (ORNCARBAMTRANSFER-RXN ARGININE-DEIMINASE-RXN)
PREDECESSORS - (ORNITHINE-GLU-AMINOTRANSFORASE-RXN ORNCARBAMTRANSFER-RXN)
PREDECESSORS - (SPONTPRO-RXN ORNITHINE-GLU-AMINOTRANSFORASE-RXN)
PREDECESSORS - (PYRROLINECARBREDUCT-RXN SPONTPRO-RXN)
REACTION-LAYOUT - (CITRULLINASE-RXN (:LEFT-PRIMARIES L-CITRULLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-ORNITHINE))
REACTION-LAYOUT - (PYRROLINECARBREDUCT-RXN (:LEFT-PRIMARIES PRO) (:DIRECTION :R2L) (:RIGHT-PRIMARIES L-DELTA1-PYRROLINE_5-CARBOXYLATE))
REACTION-LAYOUT - (SPONTPRO-RXN (:LEFT-PRIMARIES L-GLUTAMATE_GAMMA-SEMIALDEHYDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-DELTA1-PYRROLINE_5-CARBOXYLATE))
REACTION-LAYOUT - (ORNITHINE-GLU-AMINOTRANSFORASE-RXN (:LEFT-PRIMARIES L-ORNITHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-GLUTAMATE_GAMMA-SEMIALDEHYDE))
REACTION-LAYOUT - (ORNCARBAMTRANSFER-RXN (:LEFT-PRIMARIES L-ORNITHINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES L-CITRULLINE))
REACTION-LAYOUT - (ARGININE-DEIMINASE-RXN (:LEFT-PRIMARIES ARG) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-CITRULLINE))
REACTION-LIST - CITRULLINASE-RXN
REACTION-LIST - PYRROLINECARBREDUCT-RXN
REACTION-LIST - SPONTPRO-RXN
REACTION-LIST - ORNITHINE-GLU-AMINOTRANSFORASE-RXN
REACTION-LIST - ORNCARBAMTRANSFER-RXN
REACTION-LIST - ARGININE-DEIMINASE-RXN
//
UNIQUE-ID - PWY-6281
TYPES - Selenocysteine-Biosynthesis
COMMON-NAME - selenocysteine biosynthesis II (archaea and eukaryotes)
CITATIONS - :EV-COMP-AINF:3482054332:ave
PATHWAY-LINKS - (SER SERSYN-PWY)
PREDECESSORS - (RXN-10039 2.7.9.3-RXN)
PREDECESSORS - (2.7.9.3-RXN)
PREDECESSORS - (RXN-10039 RXN-10038)
PREDECESSORS - (RXN-10038 RXN0-2161)
PREDECESSORS - (RXN0-2161)
PRIMARIES - (RXN0-2161 (SER) NIL)
PRIMARIES - (RXN-10039 (|O-phospho-L-seryl-tRNASecs| SEPO3) (|Charged-SEC-tRNAs|))
REACTION-LAYOUT - (2.7.9.3-RXN (:LEFT-PRIMARIES CPD-678) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SEPO3))
REACTION-LAYOUT - (RXN-10039 (:LEFT-PRIMARIES SEPO3 |O-phospho-L-seryl-tRNASecs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-SEC-tRNAs|))
REACTION-LAYOUT - (RXN-10038 (:LEFT-PRIMARIES |L-seryl-SEC-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |O-phospho-L-seryl-tRNASecs|))
REACTION-LAYOUT - (RXN0-2161 (:LEFT-PRIMARIES SER) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |L-seryl-SEC-tRNAs|))
REACTION-LIST - 2.7.9.3-RXN
REACTION-LIST - RXN-10039
REACTION-LIST - RXN-10038
REACTION-LIST - RXN0-2161
//
UNIQUE-ID - SERSYN-PWY
TYPES - SERINE-BIOSYNTHESIS
COMMON-NAME - serine biosynthesis
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - O-18
CREDITS - |riley|
IN-PATHWAY - SER-GLYSYN-PWY
PATHWAY-LINKS - (SER GLYSYN-PWY)
PATHWAY-LINKS - (G3P GLYCOLYSIS)
PREDECESSORS - (PGLYCDEHYDROG-RXN)
PREDECESSORS - (PSERTRANSAM-RXN PGLYCDEHYDROG-RXN)
PREDECESSORS - (RXN0-5114 PSERTRANSAM-RXN)
REACTION-LAYOUT - (RXN0-5114 (:LEFT-PRIMARIES 3-P-SERINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SER))
REACTION-LAYOUT - (PGLYCDEHYDROG-RXN (:LEFT-PRIMARIES G3P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-P-HYDROXYPYRUVATE))
REACTION-LAYOUT - (PSERTRANSAM-RXN (:LEFT-PRIMARIES 3-P-SERINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 3-P-HYDROXYPYRUVATE))
REACTION-LIST - RXN0-5114
REACTION-LIST - PGLYCDEHYDROG-RXN
REACTION-LIST - PSERTRANSAM-RXN
SUPER-PATHWAYS - SER-GLYSYN-PWY
//
UNIQUE-ID - HOMOSER-THRESYN-PWY
TYPES - THREONINE-BIOSYNTHESIS
COMMON-NAME - threonine biosynthesis from homoserine
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - SRI
CREDITS - |shearer|
PREDECESSORS - (THRESYN-RXN HOMOSERKIN-RXN)
REACTION-LAYOUT - (THRESYN-RXN (:LEFT-PRIMARIES O-PHOSPHO-L-HOMOSERINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES THR))
REACTION-LAYOUT - (HOMOSERKIN-RXN (:LEFT-PRIMARIES HOMO-SER) (:DIRECTION :L2R) (:RIGHT-PRIMARIES O-PHOSPHO-L-HOMOSERINE))
REACTION-LIST - THRESYN-RXN
REACTION-LIST - HOMOSERKIN-RXN
//
UNIQUE-ID - TYRSYN2
TYPES - TYROSINE-SYN
COMMON-NAME - tyrosine biosynthesis II
PRIMARIES - (PHENYLALANINE-4-MONOOXYGENASE-RXN (PHE) (TYR))
REACTION-LAYOUT - (PHENYLALANINE-4-MONOOXYGENASE-RXN (:LEFT-PRIMARIES PHE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TYR))
REACTION-LIST - PHENYLALANINE-4-MONOOXYGENASE-RXN
//
UNIQUE-ID - TRNA-CHARGING-PWY
TYPES - Aminoacyl-tRNAs-Charging
COMMON-NAME - tRNA charging pathway
CITATIONS - :EV-COMP-AINF:3380892013:cjb
REACTION-LAYOUT - (GLYCINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES GLY |GLY-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-GLY-tRNAs|))
REACTION-LAYOUT - (HISTIDINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES HIS |HIS-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-HIS-tRNAs|))
REACTION-LAYOUT - (LYSINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES LYS |LYS-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-LYS-tRNAs|))
REACTION-LAYOUT - (METHIONINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES MET |MET-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-MET-tRNAs|))
REACTION-LAYOUT - (PHENYLALANINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES PHE |PHE-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-PHE-tRNAs|))
REACTION-LAYOUT - (PROLINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES |PRO-tRNAs| PRO) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-PRO-tRNAs|))
REACTION-LAYOUT - (SERINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES SER |SER-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-SER-tRNAs|))
REACTION-LAYOUT - (THREONINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES THR |THR-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-THR-tRNAs|))
REACTION-LAYOUT - (TRYPTOPHAN--TRNA-LIGASE-RXN (:LEFT-PRIMARIES TRP |TRP-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-TRP-tRNAs|))
REACTION-LAYOUT - (TYROSINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES |TYR-tRNAs| TYR) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-TYR-tRNAs|))
REACTION-LAYOUT - (ASPARTATE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES L-ASPARTATE |ASP-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-ASP-tRNAs|))
REACTION-LAYOUT - (ASPARAGINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES ASN |ASN-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-ASN-tRNAs|))
REACTION-LAYOUT - (ALANINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES L-ALPHA-ALANINE |ALA-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-ALA-tRNAs|))
REACTION-LAYOUT - (VALINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES VAL |VAL-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-VAL-tRNAs|))
REACTION-LAYOUT - (LEUCINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES |LEU-tRNAs| LEU) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-LEU-tRNAs|))
REACTION-LAYOUT - (ISOLEUCINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES ILE |ILE-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-ILE-tRNAs|))
REACTION-LAYOUT - (GLURS-RXN (:LEFT-PRIMARIES GLT |GLT-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-GLT-tRNAs|))
REACTION-LAYOUT - (GLUTAMINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES GLN |GLN-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-GLN-tRNAs|))
REACTION-LAYOUT - (CYSTEINE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES CYS |CYS-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-CYS-tRNAs|))
REACTION-LAYOUT - (ARGININE--TRNA-LIGASE-RXN (:LEFT-PRIMARIES ARG |ARG-tRNAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Charged-ARG-tRNAs|))
REACTION-LIST - GLYCINE--TRNA-LIGASE-RXN
REACTION-LIST - HISTIDINE--TRNA-LIGASE-RXN
REACTION-LIST - LYSINE--TRNA-LIGASE-RXN
REACTION-LIST - METHIONINE--TRNA-LIGASE-RXN
REACTION-LIST - PHENYLALANINE--TRNA-LIGASE-RXN
REACTION-LIST - PROLINE--TRNA-LIGASE-RXN
REACTION-LIST - SERINE--TRNA-LIGASE-RXN
REACTION-LIST - THREONINE--TRNA-LIGASE-RXN
REACTION-LIST - TRYPTOPHAN--TRNA-LIGASE-RXN
REACTION-LIST - TYROSINE--TRNA-LIGASE-RXN
REACTION-LIST - ASPARTATE--TRNA-LIGASE-RXN
REACTION-LIST - ASPARAGINE--TRNA-LIGASE-RXN
REACTION-LIST - ALANINE--TRNA-LIGASE-RXN
REACTION-LIST - VALINE--TRNA-LIGASE-RXN
REACTION-LIST - LEUCINE--TRNA-LIGASE-RXN
REACTION-LIST - ISOLEUCINE--TRNA-LIGASE-RXN
REACTION-LIST - GLURS-RXN
REACTION-LIST - GLUTAMINE--TRNA-LIGASE-RXN
REACTION-LIST - CYSTEINE--TRNA-LIGASE-RXN
REACTION-LIST - ARGININE--TRNA-LIGASE-RXN
//
UNIQUE-ID - PWY-5750
TYPES - Carbohydrates-Biosynthesis
COMMON-NAME - itaconate biosynthesis
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (ACONITATE-DECARBOXYLASE-RXN ACONITATEDEHYDR-RXN)
PREDECESSORS - (ACONITATEDEHYDR-RXN CITSYN-RXN)
PREDECESSORS - (CITSYN-RXN PYRUVATE-CARBOXYLASE-RXN)
REACTION-LAYOUT - (ACONITATE-DECARBOXYLASE-RXN (:LEFT-PRIMARIES CIS-ACONITATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ITACONATE))
REACTION-LAYOUT - (ACONITATEDEHYDR-RXN (:LEFT-PRIMARIES CIT) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CIS-ACONITATE))
REACTION-LAYOUT - (CITSYN-RXN (:LEFT-PRIMARIES OXALACETIC_ACID) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CIT))
REACTION-LAYOUT - (PYRUVATE-CARBOXYLASE-RXN (:LEFT-PRIMARIES PYRUVATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OXALACETIC_ACID))
REACTION-LIST - ACONITATE-DECARBOXYLASE-RXN
REACTION-LIST - ACONITATEDEHYDR-RXN
REACTION-LIST - CITSYN-RXN
REACTION-LIST - PYRUVATE-CARBOXYLASE-RXN
//
UNIQUE-ID - GLYCOCAT-PWY
TYPES - CARBO-BIOSYNTHESIS
TYPES - Glycogen-Degradation
COMMON-NAME - glycogen degradation I
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - O-18
CREDITS - |riley|
PREDECESSORS - (GLUCOKIN-RXN AMYLOMALT-RXN)
PREDECESSORS - (AMYLOMALT-RXN RXN0-5183)
PREDECESSORS - (RXN0-5183 RXN0-5182)
PREDECESSORS - (RXN0-5146 GLYCOPHOSPHORYL-RXN)
PREDECESSORS - (RXN0-5182 RXN0-5146)
PREDECESSORS - (PHOSPHOGLUCMUT-RXN RXN0-5182)
PRIMARIES - (RXN0-5182 (MALTOTETRAOSE) (MALTOTRIOSE GLC-1-P))
PRIMARIES - (RXN0-5183 (MALTOTRIOSE) (MALTOSE ALPHA-GLUCOSE))
PRIMARIES - (RXN0-5146 (CPD0-971) (MALTOTETRAOSE CPD0-1027))
REACTION-LAYOUT - (GLUCOKIN-RXN (:LEFT-PRIMARIES GLC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC-6-P))
REACTION-LAYOUT - (RXN0-5183 (:LEFT-PRIMARIES MALTOTRIOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALPHA-GLUCOSE MALTOSE))
REACTION-LAYOUT - (RXN0-5182 (:LEFT-PRIMARIES MALTOTETRAOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC-1-P MALTOTRIOSE))
REACTION-LAYOUT - (RXN0-5146 (:LEFT-PRIMARIES CPD0-971) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD0-1027 MALTOTETRAOSE))
REACTION-LAYOUT - (PHOSPHOGLUCMUT-RXN (:LEFT-PRIMARIES GLC-1-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALPHA-GLC-6-P))
REACTION-LAYOUT - (GLYCOPHOSPHORYL-RXN (:LEFT-PRIMARIES |Glycogens|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC-1-P CPD0-971))
REACTION-LAYOUT - (AMYLOMALT-RXN (:LEFT-PRIMARIES MALTOSE MALTOTRIOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC MALTOTETRAOSE))
REACTION-LIST - GLUCOKIN-RXN
REACTION-LIST - RXN0-5183
REACTION-LIST - RXN0-5182
REACTION-LIST - RXN0-5146
REACTION-LIST - PHOSPHOGLUCMUT-RXN
REACTION-LIST - GLYCOPHOSPHORYL-RXN
REACTION-LIST - AMYLOMALT-RXN
SYNONYMS - glycogen catabolism
//
UNIQUE-ID - PWY-842
TYPES - CARBO-BIOSYNTHESIS
TYPES - POLYSACCHARIDES-DEG
COMMON-NAME - starch degradation
CITATIONS - :EV-COMP-AINF:3443363899:ave
PATHWAY-LINKS - (GLC-6-P PENTOSE-P-PWY GLYCOLYSIS)
PREDECESSORS - (RXN-1685 RXN-1828)
PREDECESSORS - (RXN-1824 RXN-1823)
PREDECESSORS - (RXN-1825 RXN-1824)
PREDECESSORS - (RXN-1826 RXN-1824)
PREDECESSORS - (RXN-1828 RXN-1825)
PREDECESSORS - (RXN-2141 RXN-1827)
PREDECESSORS - (RXN-1685 RXN-2141)
PREDECESSORS - (PHOSPHOGLUCMUT-RXN RXN-1826)
PREDECESSORS - (GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN RXN-1685)
PREDECESSORS - (GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN PHOSPHOGLUCMUT-RXN)
PRIMARIES - (RXN-2141 (ALPHA-MALTOSE) (ALPHA-GLUCOSE))
PRIMARIES - (RXN-1827 (|1-4-alpha-D-Glucan|) (ALPHA-MALTOSE))
PRIMARIES - (GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN (ALPHA-GLC-6-P) (GLC-6-P))
PRIMARIES - (PHOSPHOGLUCMUT-RXN (GLC-1-P) (ALPHA-GLC-6-P))
PRIMARIES - (RXN-1685 (ALPHA-GLUCOSE) (ALPHA-GLC-6-P))
REACTION-LAYOUT - (GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN (:LEFT-PRIMARIES ALPHA-GLC-6-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC-6-P))
REACTION-LAYOUT - (PHOSPHOGLUCMUT-RXN (:LEFT-PRIMARIES GLC-1-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALPHA-GLC-6-P))
REACTION-LAYOUT - (RXN-1685 (:LEFT-PRIMARIES ALPHA-GLUCOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALPHA-GLC-6-P))
REACTION-LAYOUT - (RXN-2141 (:LEFT-PRIMARIES ALPHA-MALTOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALPHA-GLUCOSE))
REACTION-LAYOUT - (RXN-1828 (:LEFT-PRIMARIES ALPHA-GLUCOSE |Long-linear-glucans|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES |Short-glucans| |Short-glucans|))
REACTION-LAYOUT - (RXN-1827 (:LEFT-PRIMARIES |1-4-alpha-D-Glucan|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALPHA-MALTOSE |1-4-alpha-D-Glucan|))
REACTION-LAYOUT - (RXN-1826 (:LEFT-PRIMARIES |Long-linear-glucans|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC-1-P))
REACTION-LAYOUT - (RXN-1825 (:LEFT-PRIMARIES |Long-linear-glucans|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Short-glucans|))
REACTION-LAYOUT - (RXN-1824 (:LEFT-PRIMARIES |Large-branched-glucans|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Long-linear-glucans|))
REACTION-LAYOUT - (RXN-1823 (:LEFT-PRIMARIES |Starch|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Large-branched-glucans|))
REACTION-LIST - GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN
REACTION-LIST - PHOSPHOGLUCMUT-RXN
REACTION-LIST - RXN-1685
REACTION-LIST - RXN-2141
REACTION-LIST - RXN-1828
REACTION-LIST - RXN-1827
REACTION-LIST - RXN-1826
REACTION-LIST - RXN-1825
REACTION-LIST - RXN-1824
REACTION-LIST - RXN-1823
SYNONYMS - starch mobilization
//
UNIQUE-ID - GLUCONEO-PWY
TYPES - Gluconeogenesis
COMMON-NAME - gluconeogenesis I
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - O-18
CREDITS - |riley|
PREDECESSORS - (PEPCARBOX-RXN MALATE-DEH-RXN)
PREDECESSORS - (2PGADEHYDRAT-RXN PEPCARBOX-RXN)
PREDECESSORS - (PGLUCISOM-RXN F16BDEPHOS-RXN)
PREDECESSORS - (F16BDEPHOS-RXN F16ALDOLASE-RXN)
PREDECESSORS - (F16ALDOLASE-RXN GAPOXNPHOSPHN-RXN)
PREDECESSORS - (GAPOXNPHOSPHN-RXN PHOSGLYPHOS-RXN)
PREDECESSORS - (PHOSGLYPHOS-RXN 3PGAREARR-RXN)
PREDECESSORS - (3PGAREARR-RXN 2PGADEHYDRAT-RXN)
PREDECESSORS - (2PGADEHYDRAT-RXN PEPCARBOXYKIN-RXN)
PREDECESSORS - (PEPCARBOXYKIN-RXN MALATE-DEH-RXN)
PREDECESSORS - (2PGADEHYDRAT-RXN PEPSYNTH-RXN)
PREDECESSORS - (PEPSYNTH-RXN MALIC-NAD-RXN)
PREDECESSORS - (PEPSYNTH-RXN MALIC-NADP-RXN)
PREDECESSORS - (MALIC-NAD-RXN)
PREDECESSORS - (MALIC-NADP-RXN)
PRIMARIES - (F16ALDOLASE-RXN (DIHYDROXY-ACETONE-PHOSPHATE GAP) NIL)
REACTION-LAYOUT - (PEPCARBOX-RXN (:LEFT-PRIMARIES OXALACETIC_ACID) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHO-ENOL-PYRUVATE))
REACTION-LAYOUT - (MALIC-NADP-RXN (:LEFT-PRIMARIES MAL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRUVATE))
REACTION-LAYOUT - (MALIC-NAD-RXN (:LEFT-PRIMARIES MAL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRUVATE))
REACTION-LAYOUT - (PEPSYNTH-RXN (:LEFT-PRIMARIES PYRUVATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHO-ENOL-PYRUVATE))
REACTION-LAYOUT - (MALATE-DEH-RXN (:LEFT-PRIMARIES MAL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OXALACETIC_ACID))
REACTION-LAYOUT - (PEPCARBOXYKIN-RXN (:LEFT-PRIMARIES OXALACETIC_ACID) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHO-ENOL-PYRUVATE))
REACTION-LAYOUT - (2PGADEHYDRAT-RXN (:LEFT-PRIMARIES 2-PG) (:DIRECTION :R2L) (:RIGHT-PRIMARIES PHOSPHO-ENOL-PYRUVATE))
REACTION-LAYOUT - (3PGAREARR-RXN (:LEFT-PRIMARIES G3P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 2-PG))
REACTION-LAYOUT - (PHOSGLYPHOS-RXN (:LEFT-PRIMARIES G3P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DPG))
REACTION-LAYOUT - (GAPOXNPHOSPHN-RXN (:LEFT-PRIMARIES GAP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES DPG))
REACTION-LAYOUT - (F16ALDOLASE-RXN (:LEFT-PRIMARIES FRUCTOSE-16-DIPHOSPHATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES GAP DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LAYOUT - (F16BDEPHOS-RXN (:LEFT-PRIMARIES FRUCTOSE-16-DIPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LAYOUT - (PGLUCISOM-RXN (:LEFT-PRIMARIES GLC-6-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LIST - PEPCARBOX-RXN
REACTION-LIST - MALIC-NADP-RXN
REACTION-LIST - MALIC-NAD-RXN
REACTION-LIST - PEPSYNTH-RXN
REACTION-LIST - MALATE-DEH-RXN
REACTION-LIST - PEPCARBOXYKIN-RXN
REACTION-LIST - 2PGADEHYDRAT-RXN
REACTION-LIST - 3PGAREARR-RXN
REACTION-LIST - PHOSGLYPHOS-RXN
REACTION-LIST - GAPOXNPHOSPHN-RXN
REACTION-LIST - F16ALDOLASE-RXN
REACTION-LIST - F16BDEPHOS-RXN
REACTION-LIST - PGLUCISOM-RXN
//
UNIQUE-ID - PWY-6142
TYPES - Gluconeogenesis
TYPES - Super-Pathways
COMMON-NAME - gluconeogenesis II (<i>Methanobacterium thermoautotrophicum</i>)
CITATIONS - :EV-COMP-AINF:3482054332:ave
PATHWAY-LINKS - (DIHYDROXY-ACETONE-PHOSPHATE PWY-6141)
PATHWAY-LINKS - (PYRUVATE ALANINE-SYN2-PWY)
PATHWAY-LINKS - (OXALACETIC_ACID P42-PWY ASPARTATESYN-PWY)
PREDECESSORS - (PYRUVATE-CARBOXYLASE-RXN RXN0-5224)
PREDECESSORS - (PYRUVATE-CARBOXYLASE-RXN PYRUFLAVREDUCT-RXN)
PREDECESSORS - (PEPCARBOX-RXN PEPDEPHOS-RXN)
PREDECESSORS - (PGLUCISOM-RXN R302-RXN)
PREDECESSORS - (R302-RXN F16ALDOLASE-RXN)
PREDECESSORS - (F16ALDOLASE-RXN TRIOSEPISOMERIZATION-RXN)
PREDECESSORS - (F16ALDOLASE-RXN 1.2.7.6-RXN)
PREDECESSORS - (TRIOSEPISOMERIZATION-RXN 1.2.7.6-RXN)
PREDECESSORS - (1.2.7.6-RXN 3PGAREARR-RXN)
PREDECESSORS - (3PGAREARR-RXN 2PGADEHYDRAT-RXN)
PREDECESSORS - (2PGADEHYDRAT-RXN PEPDEPHOS-RXN)
PREDECESSORS - (PEPDEPHOS-RXN PYRUFLAVREDUCT-RXN)
PREDECESSORS - (PYRUFLAVREDUCT-RXN ACETYLSYNCLTH-RXN)
PREDECESSORS - CODH-PWY
PRIMARIES - (3PGAREARR-RXN (2-PG) (G3P))
PRIMARIES - (PGLUCISOM-RXN (FRUCTOSE-6P) (GLC-6-P))
PRIMARIES - (F16ALDOLASE-RXN (GAP) (FRUCTOSE-16-DIPHOSPHATE))
PRIMARIES - (1.2.7.6-RXN (G3P) (GAP))
PRIMARIES - (2PGADEHYDRAT-RXN (PHOSPHO-ENOL-PYRUVATE) (2-PG))
PRIMARIES - (PEPDEPHOS-RXN (PYRUVATE) (PHOSPHO-ENOL-PYRUVATE))
REACTION-LAYOUT - (RXN0-5224 (:LEFT-PRIMARIES CARBON-DIOXIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES HCO3))
REACTION-LAYOUT - (PYRUVATE-CARBOXYLASE-RXN (:LEFT-PRIMARIES PYRUVATE HCO3) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OXALACETIC_ACID))
REACTION-LAYOUT - (PEPCARBOX-RXN (:LEFT-PRIMARIES OXALACETIC_ACID) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CARBON-DIOXIDE PHOSPHO-ENOL-PYRUVATE))
REACTION-LAYOUT - (PEPDEPHOS-RXN (:LEFT-PRIMARIES PYRUVATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHO-ENOL-PYRUVATE))
REACTION-LAYOUT - (2PGADEHYDRAT-RXN (:LEFT-PRIMARIES 2-PG) (:DIRECTION :R2L) (:RIGHT-PRIMARIES PHOSPHO-ENOL-PYRUVATE))
REACTION-LAYOUT - (3PGAREARR-RXN (:LEFT-PRIMARIES G3P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 2-PG))
REACTION-LAYOUT - (1.2.7.6-RXN (:LEFT-PRIMARIES GAP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES G3P))
REACTION-LAYOUT - (TRIOSEPISOMERIZATION-RXN (:LEFT-PRIMARIES GAP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LAYOUT - (F16ALDOLASE-RXN (:LEFT-PRIMARIES FRUCTOSE-16-DIPHOSPHATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES GAP DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LAYOUT - (R302-RXN (:LEFT-PRIMARIES FRUCTOSE-6P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FRUCTOSE-16-DIPHOSPHATE))
REACTION-LAYOUT - (PGLUCISOM-RXN (:LEFT-PRIMARIES GLC-6-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LAYOUT - (PYRUFLAVREDUCT-RXN (:LEFT-PRIMARIES PYRUVATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CARBON-DIOXIDE ACETYL-COA))
REACTION-LAYOUT - (CODH-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - RXN0-5224
REACTION-LIST - PYRUVATE-CARBOXYLASE-RXN
REACTION-LIST - PEPCARBOX-RXN
REACTION-LIST - PEPDEPHOS-RXN
REACTION-LIST - 2PGADEHYDRAT-RXN
REACTION-LIST - 3PGAREARR-RXN
REACTION-LIST - 1.2.7.6-RXN
REACTION-LIST - TRIOSEPISOMERIZATION-RXN
REACTION-LIST - F16ALDOLASE-RXN
REACTION-LIST - R302-RXN
REACTION-LIST - PGLUCISOM-RXN
REACTION-LIST - PYRUFLAVREDUCT-RXN
REACTION-LIST - CODH-PWY
SUB-PATHWAYS - CODH-PWY
SYNONYMS - carbohydrate biosynthesis (<i>Methanobacterium thermoautotrophicum</i>)
//
UNIQUE-ID - GALACTMETAB-PWY
TYPES - SUGAR-NUCLEOTIDES
TYPES - Sugars-And-Polysaccharides
COMMON-NAME - UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)
CITATIONS - :EV-COMP-AINF:3442068425:ave
PREDECESSORS - (GALACTURIDYLYLTRANS-RXN GALACTOKIN-RXN)
PREDECESSORS - (UDPGLUCEPIM-RXN GALACTURIDYLYLTRANS-RXN)
PREDECESSORS - (GALACTURIDYLYLTRANS-RXN GLUC1PURIDYLTRANS-RXN)
PREDECESSORS - (GALACTURIDYLYLTRANS-RXN UDPGLUCEPIM-RXN)
PRIMARIES - (GLUC1PURIDYLTRANS-RXN (GLC-1-P) NIL)
PRIMARIES - (GALACTURIDYLYLTRANS-RXN (UDP-GLUCOSE GALACTOSE-1P) (GLC-1-P))
REACTION-LAYOUT - (GLUC1PURIDYLTRANS-RXN (:LEFT-PRIMARIES GLC-1-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-GLUCOSE))
REACTION-LAYOUT - (UDPGLUCEPIM-RXN (:LEFT-PRIMARIES UDP-GLUCOSE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES UDP-GALACTOSE))
REACTION-LAYOUT - (GALACTURIDYLYLTRANS-RXN (:LEFT-PRIMARIES GALACTOSE-1P UDP-GLUCOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-GALACTOSE GLC-1-P))
REACTION-LAYOUT - (GALACTOKIN-RXN (:LEFT-PRIMARIES ALPHA-D-GALACTOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GALACTOSE-1P))
REACTION-LIST - GLUC1PURIDYLTRANS-RXN
REACTION-LIST - UDPGLUCEPIM-RXN
REACTION-LIST - GALACTURIDYLYLTRANS-RXN
REACTION-LIST - GALACTOKIN-RXN
SYNONYMS - Leloir pathway
//
UNIQUE-ID - P61-PWY
TYPES - SUGAR-NUCLEOTIDES
TYPES - Sugars-And-Polysaccharides
COMMON-NAME - UDP-glucose conversion
CITATIONS - :EV-COMP-AINF:3380892013:cjb
PREDECESSORS - (GLUC1PURIDYLTRANS-RXN PHOSPHOGLUCMUT-RXN)
PRIMARIES - (GLUC1PURIDYLTRANS-RXN NIL (UDP-GLUCOSE))
REACTION-LAYOUT - (PHOSPHOGLUCMUT-RXN (:LEFT-PRIMARIES GLC-1-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ALPHA-GLC-6-P))
REACTION-LAYOUT - (GLUC1PURIDYLTRANS-RXN (:LEFT-PRIMARIES GLC-1-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-GLUCOSE))
REACTION-LIST - PHOSPHOGLUCMUT-RXN
REACTION-LIST - GLUC1PURIDYLTRANS-RXN
//
UNIQUE-ID - PWY-3821
TYPES - GALACTOSE-DEGRADATION
TYPES - SUGAR-NUCLEOTIDES
COMMON-NAME - galactose degradation III
CITATIONS - :EV-COMP-AINF:3442068424:ave
PREDECESSORS - (UGD-RXN UDPGLUCEPIM-RXN)
PREDECESSORS - (UDPGLUCEPIM-RXN UTPHEXPURIDYLYLTRANS-RXN)
PREDECESSORS - (UTPHEXPURIDYLYLTRANS-RXN GALACTOKIN-RXN)
PREDECESSORS - (GLUC1PURIDYLTRANS-RXN UDPGLUCEPIM-RXN)
PREDECESSORS - (SUCROSE-SYNTHASE-RXN UDPGLUCEPIM-RXN)
PRIMARIES - (UGD-RXN (UDP-GLUCOSE) (UDP-GLUCURONATE))
PRIMARIES - (SUCROSE-SYNTHASE-RXN (UDP-GLUCOSE) (SUCROSE))
PRIMARIES - (GLUC1PURIDYLTRANS-RXN (UDP-GLUCOSE) (GLC-1-P))
PRIMARIES - (UDPGLUCEPIM-RXN (UDP-GALACTOSE) (UDP-GLUCOSE))
PRIMARIES - (UTPHEXPURIDYLYLTRANS-RXN (GALACTOSE-1P) (UDP-GALACTOSE))
REACTION-LAYOUT - (UGD-RXN (:LEFT-PRIMARIES UDP-GLUCOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-GLUCURONATE))
REACTION-LAYOUT - (GLUC1PURIDYLTRANS-RXN (:LEFT-PRIMARIES GLC-1-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES UDP-GLUCOSE))
REACTION-LAYOUT - (SUCROSE-SYNTHASE-RXN (:LEFT-PRIMARIES UDP-GLUCOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUCROSE))
REACTION-LAYOUT - (UDPGLUCEPIM-RXN (:LEFT-PRIMARIES UDP-GLUCOSE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES UDP-GALACTOSE))
REACTION-LAYOUT - (UTPHEXPURIDYLYLTRANS-RXN (:LEFT-PRIMARIES GALACTOSE-1P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-GALACTOSE))
REACTION-LAYOUT - (GALACTOKIN-RXN (:LEFT-PRIMARIES ALPHA-D-GALACTOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GALACTOSE-1P))
REACTION-LIST - UGD-RXN
REACTION-LIST - GLUC1PURIDYLTRANS-RXN
REACTION-LIST - SUCROSE-SYNTHASE-RXN
REACTION-LIST - UDPGLUCEPIM-RXN
REACTION-LIST - UTPHEXPURIDYLYLTRANS-RXN
REACTION-LIST - GALACTOKIN-RXN
SYNONYMS - UDP-D-galatose biosynthesis (from D-galactose)
//
UNIQUE-ID - PWY-4821
TYPES - SUGAR-NUCLEOTIDES
COMMON-NAME - UDP-D-xylose biosynthesis
CITATIONS - :EV-COMP-AINF:3380892013:cjb
PREDECESSORS - (UDP-GLUCURONATE-DECARBOXYLASE-RXN UGD-RXN)
PREDECESSORS - (UGD-RXN)
PRIMARIES - (UDP-GLUCURONATE-DECARBOXYLASE-RXN (UDP-GLUCURONATE) (UDP-D-XYLOSE))
PRIMARIES - (UGD-RXN (UDP-GLUCOSE) (UDP-GLUCURONATE))
REACTION-LAYOUT - (UDP-GLUCURONATE-DECARBOXYLASE-RXN (:LEFT-PRIMARIES UDP-GLUCURONATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-D-XYLOSE))
REACTION-LAYOUT - (UGD-RXN (:LEFT-PRIMARIES UDP-GLUCOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-GLUCURONATE))
REACTION-LIST - UDP-GLUCURONATE-DECARBOXYLASE-RXN
REACTION-LIST - UGD-RXN
SYNONYMS - UDP-xylose biosynthesis
SYNONYMS - UDPXyl biosynthesis
SYNONYMS - UDP-glucuronate biosynthesis (from UDP-glucose)
SYNONYMS - UDP-glucuronic acid biosynthesis (from UDP-glucose)
SYNONYMS - UDPGlcA biosynthesis
//
UNIQUE-ID - PWY-5661
TYPES - SUGAR-NUCLEOTIDES
COMMON-NAME - GDP-glucose biosynthesis
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (2.7.7.34-RXN PHOSPHOGLUCMUT-RXN)
PREDECESSORS - (PHOSPHOGLUCMUT-RXN GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN)
PREDECESSORS - (GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN GLUCOKIN-RXN)
REACTION-LAYOUT - (2.7.7.34-RXN (:LEFT-PRIMARIES GLC-1-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GDP-D-GLUCOSE))
REACTION-LAYOUT - (PHOSPHOGLUCMUT-RXN (:LEFT-PRIMARIES GLC-1-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ALPHA-GLC-6-P))
REACTION-LAYOUT - (GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN (:LEFT-PRIMARIES ALPHA-GLC-6-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES GLC-6-P))
REACTION-LAYOUT - (GLUCOKIN-RXN (:LEFT-PRIMARIES GLC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC-6-P))
REACTION-LIST - 2.7.7.34-RXN
REACTION-LIST - PHOSPHOGLUCMUT-RXN
REACTION-LIST - GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN
REACTION-LIST - GLUCOKIN-RXN
//
UNIQUE-ID - PWY-6
TYPES - SUGAR-NUCLEOTIDES
COMMON-NAME - GDP-L-fucose biosynthesis II (from L-fucose)
CITATIONS - :EV-COMP-AINF:3380892013:cjb
PREDECESSORS - (2.7.7.30-RXN FUCOKINASE-RXN)
PREDECESSORS - (FUCOKINASE-RXN)
PRIMARIES - (2.7.7.30-RXN (CPD-488) (GUANOSINE_DIPHOSPHATE_FUCOSE))
PRIMARIES - (FUCOKINASE-RXN (L-FUCOSE) (CPD-488))
REACTION-LAYOUT - (2.7.7.30-RXN (:LEFT-PRIMARIES CPD-488) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GUANOSINE_DIPHOSPHATE_FUCOSE))
REACTION-LAYOUT - (FUCOKINASE-RXN (:LEFT-PRIMARIES L-FUCOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-488))
REACTION-LIST - 2.7.7.30-RXN
REACTION-LIST - FUCOKINASE-RXN
SYNONYMS - GDP-L-fucose biosynthesis (salvage pathway)
//
UNIQUE-ID - PWY-6144
TYPES - SUGAR-NUCLEOTIDES
COMMON-NAME - CMP-<i>N</i>-glycoloylneuraminate biosynthesis
CITATIONS - :EV-COMP-AINF:3482054330:ave
PATHWAY-LINKS - (CMP-N-ACETYL-NEURAMINATE PWY-6138)
PREDECESSORS - (1.14.18.2-RXN)
PRIMARIES - (1.14.18.2-RXN (CMP-N-ACETYL-NEURAMINATE) (CPD-262))
REACTION-LAYOUT - (1.14.18.2-RXN (:LEFT-PRIMARIES CMP-N-ACETYL-NEURAMINATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-262))
REACTION-LIST - 1.14.18.2-RXN
//
UNIQUE-ID - PWY-66
TYPES - SUGAR-NUCLEOTIDES
COMMON-NAME - GDP-L-fucose biosynthesis I (from GDP-D-mannose)
CITATIONS - :EV-COMP-AINF:3380892013:cjb
IN-PATHWAY - COLANSYN-PWY
PREDECESSORS - (1.1.1.271-RXN GDPMANDEHYDRA-RXN)
PREDECESSORS - (GDPMANDEHYDRA-RXN)
PRIMARIES - (1.1.1.271-RXN (GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE) (GUANOSINE_DIPHOSPHATE_FUCOSE))
PRIMARIES - (GDPMANDEHYDRA-RXN (GDP-MANNOSE) (GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE))
REACTION-LAYOUT - (1.1.1.271-RXN (:LEFT-PRIMARIES GUANOSINE_DIPHOSPHATE_FUCOSE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE))
REACTION-LAYOUT - (GDPMANDEHYDRA-RXN (:LEFT-PRIMARIES GDP-MANNOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE))
REACTION-LIST - 1.1.1.271-RXN
REACTION-LIST - GDPMANDEHYDRA-RXN
SYNONYMS - GDP-L-fucose biosynthesis I (<i>de novo</i> synthesis)
//
UNIQUE-ID - PWY-5657
TYPES - GDP-Mannose-Biosynthesis
COMMON-NAME - GDP-mannose biosynthesis I
CITATIONS - :EV-COMP-AINF:3442068425:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (GDP-MANNOSE PWY-5738 GDPRHAMSYN-PWY PWY-66)
PREDECESSORS - (2.7.7.13-RXN PHOSMANMUT-RXN)
PREDECESSORS - (PHOSMANMUT-RXN MANNPISOM-RXN)
PREDECESSORS - (MANNPISOM-RXN PGLUCISOM-RXN)
REACTION-LAYOUT - (2.7.7.13-RXN (:LEFT-PRIMARIES MANNOSE-1P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GDP-MANNOSE))
REACTION-LAYOUT - (PHOSMANMUT-RXN (:LEFT-PRIMARIES MANNOSE-1P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES MANNOSE-6P))
REACTION-LAYOUT - (MANNPISOM-RXN (:LEFT-PRIMARIES MANNOSE-6P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LAYOUT - (PGLUCISOM-RXN (:LEFT-PRIMARIES GLC-6-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LIST - 2.7.7.13-RXN
REACTION-LIST - PHOSMANMUT-RXN
REACTION-LIST - MANNPISOM-RXN
REACTION-LIST - PGLUCISOM-RXN
//
UNIQUE-ID - PWY-5659
TYPES - GDP-Mannose-Biosynthesis
COMMON-NAME - GDP-mannose biosynthesis
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - COLANSYN-PWY
PREDECESSORS - (2.7.7.13-RXN PHOSMANMUT-RXN)
PREDECESSORS - (PHOSMANMUT-RXN MANNPISOM-RXN)
PREDECESSORS - (MANNPISOM-RXN PGLUCISOM-RXN)
REACTION-LAYOUT - (2.7.7.13-RXN (:LEFT-PRIMARIES MANNOSE-1P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GDP-MANNOSE))
REACTION-LAYOUT - (PHOSMANMUT-RXN (:LEFT-PRIMARIES MANNOSE-1P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES MANNOSE-6P))
REACTION-LAYOUT - (MANNPISOM-RXN (:LEFT-PRIMARIES MANNOSE-6P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LAYOUT - (PGLUCISOM-RXN (:LEFT-PRIMARIES GLC-6-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LIST - 2.7.7.13-RXN
REACTION-LIST - PHOSMANMUT-RXN
REACTION-LIST - MANNPISOM-RXN
REACTION-LIST - PGLUCISOM-RXN
//
UNIQUE-ID - MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS
TYPES - Oligosaccharides-Biosynthesis
COMMON-NAME - dolichyl-diphosphooligosaccharide biosynthesis
CITATIONS - :EV-COMP-AINF:3482054329:ave
PATHWAY-LINKS - (DOLICHOLP PWY-6129)
PREDECESSORS - (RXN-5471 RXN-5470)
PREDECESSORS - (RXN-5469 RXN-5468)
PREDECESSORS - (RXN-5467 RXN-5466)
PREDECESSORS - (RXN-5465 RXN-5464)
PREDECESSORS - (RXN-5463 RXN-5462)
PREDECESSORS - (RXN-5462 2.4.1.142-RXN)
PREDECESSORS - (2.4.1.141-RXN 2.7.8.15-RXN)
PREDECESSORS - (2.4.1.142-RXN 2.4.1.141-RXN)
PREDECESSORS - (RXN-5464 RXN-5463)
PREDECESSORS - (RXN-5466 RXN-5465)
PREDECESSORS - (RXN-5468 RXN-5467)
PREDECESSORS - (RXN-5470 RXN-5469)
PREDECESSORS - (RXN-5472 RXN-5471)
PRIMARIES - (2.4.1.117-RXN (DOLICHOLP) (CPD-166))
PRIMARIES - (2.4.1.83-RXN (DOLICHOLP) (CPD-171))
PRIMARIES - (RXN-5472 (CPD-5170) (OLIGOSACCHARIDE-DIPHOSPHODOLICHOL))
PRIMARIES - (RXN-5471 (CPD-5169) (CPD-5170))
PRIMARIES - (RXN-5470 (CPD-5168) (CPD-5169))
PRIMARIES - (RXN-5469 (CPD-5167) (CPD-5168))
PRIMARIES - (RXN-5468 (CPD-5166) (CPD-5167))
PRIMARIES - (RXN-5467 (CPD-5165) (CPD-5166))
PRIMARIES - (RXN-5466 (CPD-5164) (CPD-5165))
PRIMARIES - (RXN-5465 (CPD-5163) (CPD-5164))
PRIMARIES - (RXN-5464 (CPD-5162) (CPD-5163))
PRIMARIES - (RXN-5463 (CPD-5161) (CPD-5162))
PRIMARIES - (RXN-5462 (ALPHA-D-MANNOSYLCHITOBIO) (CPD-5161))
PRIMARIES - (2.4.1.142-RXN NIL (ALPHA-D-MANNOSYLCHITOBIO))
PRIMARIES - (2.7.8.15-RXN (DOLICHOLP))
REACTION-LAYOUT - (2.4.1.117-RXN (:LEFT-PRIMARIES DOLICHOLP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-166))
REACTION-LAYOUT - (2.4.1.83-RXN (:LEFT-PRIMARIES DOLICHOLP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-171))
REACTION-LAYOUT - (RXN-5472 (:LEFT-PRIMARIES CPD-166 CPD-5170) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DOLICHOLP OLIGOSACCHARIDE-DIPHOSPHODOLICHOL))
REACTION-LAYOUT - (RXN-5471 (:LEFT-PRIMARIES CPD-166 CPD-5169) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DOLICHOLP CPD-5170))
REACTION-LAYOUT - (RXN-5470 (:LEFT-PRIMARIES CPD-166 CPD-5168) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DOLICHOLP CPD-5169))
REACTION-LAYOUT - (RXN-5469 (:LEFT-PRIMARIES CPD-171 CPD-5167) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DOLICHOLP CPD-5168))
REACTION-LAYOUT - (RXN-5468 (:LEFT-PRIMARIES CPD-171 CPD-5166) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DOLICHOLP CPD-5167))
REACTION-LAYOUT - (RXN-5467 (:LEFT-PRIMARIES CPD-171 CPD-5165) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DOLICHOLP CPD-5166))
REACTION-LAYOUT - (RXN-5466 (:LEFT-PRIMARIES CPD-171 CPD-5164) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DOLICHOLP CPD-5165))
REACTION-LAYOUT - (RXN-5465 (:LEFT-PRIMARIES CPD-5163) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-5164))
REACTION-LAYOUT - (RXN-5464 (:LEFT-PRIMARIES CPD-5162) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-5163))
REACTION-LAYOUT - (RXN-5462 (:LEFT-PRIMARIES ALPHA-D-MANNOSYLCHITOBIO) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-5161))
REACTION-LAYOUT - (RXN-5463 (:LEFT-PRIMARIES CPD-5161) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-5162))
REACTION-LAYOUT - (2.4.1.142-RXN (:LEFT-PRIMARIES NN-DIACETYLCHITOBIOSYLDIPHOSPHODOLICHO) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALPHA-D-MANNOSYLCHITOBIO))
REACTION-LAYOUT - (2.4.1.141-RXN (:LEFT-PRIMARIES CPD-190) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NN-DIACETYLCHITOBIOSYLDIPHOSPHODOLICHO))
REACTION-LAYOUT - (2.7.8.15-RXN (:LEFT-PRIMARIES DOLICHOLP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-190))
REACTION-LIST - 2.4.1.117-RXN
REACTION-LIST - 2.4.1.83-RXN
REACTION-LIST - RXN-5472
REACTION-LIST - RXN-5471
REACTION-LIST - RXN-5470
REACTION-LIST - RXN-5469
REACTION-LIST - RXN-5468
REACTION-LIST - RXN-5467
REACTION-LIST - RXN-5466
REACTION-LIST - RXN-5465
REACTION-LIST - RXN-5464
REACTION-LIST - RXN-5462
REACTION-LIST - RXN-5463
REACTION-LIST - 2.4.1.142-RXN
REACTION-LIST - 2.4.1.141-RXN
REACTION-LIST - 2.7.8.15-RXN
SYNONYMS - mannosyl-chito-dolichol biosynthesis
//
UNIQUE-ID - GLYCOGENSYNTH-PWY
TYPES - GLYCOGEN-BIOSYN
COMMON-NAME - glycogen biosynthesis I (from ADP-D-Glucose)
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - SRI
CREDITS - |keseler|
CREDITS - O-18
CREDITS - |riley|
POLYMERIZATION-LINKS - (|1-4-alpha-D-Glucan| GLYCOGENSYN-RXN GLYCOGENSYN-RXN)
PREDECESSORS - (GLYCOGEN-BRANCH-RXN GLYCOGENSYN-RXN)
PREDECESSORS - (GLYCOGENSYN-RXN GLUC1PADENYLTRANS-RXN)
PREDECESSORS - (GLUC1PADENYLTRANS-RXN)
REACTION-LAYOUT - (GLUC1PADENYLTRANS-RXN (:LEFT-PRIMARIES ATP GLC-1-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ADP-D-GLUCOSE))
REACTION-LAYOUT - (GLYCOGEN-BRANCH-RXN (:LEFT-PRIMARIES |1-4-alpha-D-Glucan|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |6-alpha-D--1-4-alpha-D-Glucano--Glucan|))
REACTION-LAYOUT - (GLYCOGENSYN-RXN (:LEFT-PRIMARIES |1-4-alpha-D-Glucan| ADP-D-GLUCOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |1-4-alpha-D-Glucan|))
REACTION-LIST - GLUC1PADENYLTRANS-RXN
REACTION-LIST - GLYCOGEN-BRANCH-RXN
REACTION-LIST - GLYCOGENSYN-RXN
//
UNIQUE-ID - PWY-5067
TYPES - GLYCOGEN-BIOSYN
COMMON-NAME - glycogen biosynthesis II (from UDP-D-Glucose)
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CLASS-INSTANCE-LINKS - RXN-7668
CREDITS - SRI
CREDITS - |caspi|
POLYMERIZATION-LINKS - (POLY-GLUCOSYLATED-GLYCOGENINS RXN-7668 RXN-7668)
PREDECESSORS - (RXN-7668 RXN-7667)
PREDECESSORS - (RXN-7667 GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN)
PREDECESSORS - (GLUC1PURIDYLTRANS-RXN)
PREDECESSORS - (GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN GLUC1PURIDYLTRANS-RXN)
PREDECESSORS - (RXN-7669 RXN-7668)
PRIMARIES - (RXN-7667 (GLUCOSYL-GLYCOGENIN CPD-7010) (CPD-7010))
PRIMARIES - (GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN (UDP-GLUCOSE) (GLUCOSYL-GLYCOGENIN))
PRIMARIES - (GLUC1PURIDYLTRANS-RXN (GLC-1-P) (UDP-GLUCOSE))
REACTION-LAYOUT - (RXN-7669 (:LEFT-PRIMARIES POLY-GLUCOSYLATED-GLYCOGENINS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |6-alpha-D--1-4-alpha-D-Glucano--Glucan|))
REACTION-LAYOUT - (RXN-7668 (:LEFT-PRIMARIES UDP-GLUCOSE POLY-GLUCOSYLATED-GLYCOGENINS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES POLY-GLUCOSYLATED-GLYCOGENINS))
REACTION-LAYOUT - (RXN-7667 (:LEFT-PRIMARIES UDP-GLUCOSE GLUCOSYL-GLYCOGENIN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-7010))
REACTION-LAYOUT - (GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN (:LEFT-PRIMARIES UDP-GLUCOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLUCOSYL-GLYCOGENIN))
REACTION-LAYOUT - (GLUC1PURIDYLTRANS-RXN (:LEFT-PRIMARIES GLC-1-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-GLUCOSE))
REACTION-LIST - RXN-7669
REACTION-LIST - RXN-7668
REACTION-LIST - RXN-7667
REACTION-LIST - GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN
REACTION-LIST - GLUC1PURIDYLTRANS-RXN
//
UNIQUE-ID - PWY-622
TYPES - GLYCOGEN-BIOSYN
COMMON-NAME - starch biosynthesis
CITATIONS - :EV-COMP-AINF:3443363899:ave
PATHWAY-LINKS - (GLC-6-P PWY-621)
PATHWAY-LINKS - (GLC-1-P PWY-621)
PATHWAY-LINKS - (G3P CALVIN-PWY)
POLYMERIZATION-LINKS - (|1-4-alpha-D-Glucan| GLYCOGENSYN-RXN GLYCOGENSYN-RXN)
PREDECESSORS - (GLUC1PADENYLTRANS-RXN PHOSPHOGLUCMUT-RXN)
PREDECESSORS - (GLYCOGENSYN-RXN GLUC1PADENYLTRANS-RXN)
PREDECESSORS - (PHOSPHOGLUCMUT-RXN GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN)
PREDECESSORS - (GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN PGLUCISOM-RXN)
PREDECESSORS - (RXN-7710 GLYCOGENSYN-RXN)
PRIMARIES - (GLYCOGENSYN-RXN (|1-4-alpha-D-Glucan|) (|1-4-alpha-D-Glucan|))
REACTION-LAYOUT - (RXN-7710 (:LEFT-PRIMARIES |1-4-alpha-D-Glucan|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Starch|))
REACTION-LAYOUT - (GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN (:LEFT-PRIMARIES ALPHA-GLC-6-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES GLC-6-P))
REACTION-LAYOUT - (GLYCOGENSYN-RXN (:LEFT-PRIMARIES |1-4-alpha-D-Glucan| ADP-D-GLUCOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |1-4-alpha-D-Glucan|))
REACTION-LAYOUT - (GLUC1PADENYLTRANS-RXN (:LEFT-PRIMARIES GLC-1-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ADP-D-GLUCOSE))
REACTION-LAYOUT - (PHOSPHOGLUCMUT-RXN (:LEFT-PRIMARIES GLC-1-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ALPHA-GLC-6-P))
REACTION-LAYOUT - (PGLUCISOM-RXN (:LEFT-PRIMARIES GLC-6-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LIST - RXN-7710
REACTION-LIST - GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN
REACTION-LIST - GLYCOGENSYN-RXN
REACTION-LIST - GLUC1PADENYLTRANS-RXN
REACTION-LIST - PHOSPHOGLUCMUT-RXN
REACTION-LIST - PGLUCISOM-RXN
//
UNIQUE-ID - COLANSYN-PWY
TYPES - Cell-Structure-Biosynthesis
TYPES - Super-Pathways
COMMON-NAME - colanic acid building blocks biosynthesis
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - |keseler|
CREDITS - O-18
CREDITS - |pellegrini-toole|
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (GDPMANDEHYDRA-RXN 2.7.7.13-RXN)
PREDECESSORS - PWY-5659
PREDECESSORS - PWY-66
PREDECESSORS - (UGD-RXN GLUC1PURIDYLTRANS-RXN)
PREDECESSORS - (UDPGLUCEPIM-RXN GALACTURIDYLYLTRANS-RXN)
PREDECESSORS - (GALACTURIDYLYLTRANS-RXN GALACTOKIN-RXN)
PRIMARIES - (MANNPISOM-RXN (FRUCTOSE-6P) NIL)
REACTION-LAYOUT - (PWY-5659 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (PWY-66 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (UGD-RXN (:LEFT-PRIMARIES UDP-GLUCOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-GLUCURONATE))
REACTION-LAYOUT - (GLUC1PURIDYLTRANS-RXN (:LEFT-PRIMARIES UTP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-GLUCOSE))
REACTION-LAYOUT - (UDPGLUCEPIM-RXN (:LEFT-PRIMARIES UDP-GLUCOSE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES UDP-GALACTOSE))
REACTION-LAYOUT - (GALACTURIDYLYLTRANS-RXN (:LEFT-PRIMARIES GALACTOSE-1P UDP-GLUCOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-GALACTOSE))
REACTION-LAYOUT - (GALACTOKIN-RXN (:LEFT-PRIMARIES ALPHA-D-GALACTOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GALACTOSE-1P))
REACTION-LIST - PWY-5659
REACTION-LIST - PWY-66
REACTION-LIST - UGD-RXN
REACTION-LIST - GLUC1PURIDYLTRANS-RXN
REACTION-LIST - UDPGLUCEPIM-RXN
REACTION-LIST - GALACTURIDYLYLTRANS-RXN
REACTION-LIST - GALACTOKIN-RXN
//
UNIQUE-ID - MANGDPMET-PWY
TYPES - Cell-Structure-Biosynthesis
COMMON-NAME - GDP-mannose metabolism
CITATIONS - :EV-COMP-AINF:3442068425:ave
PREDECESSORS - (PHOSMANMUT-RXN MANNKIN-RXN)
PREDECESSORS - (MANNKIN-RXN GDPMANMANHYDRO-RXN)
PREDECESSORS - (GDPMANMANHYDRO-RXN 2.7.7.13-RXN)
PREDECESSORS - (2.7.7.13-RXN PHOSMANMUT-RXN)
PREDECESSORS - (PHOSMANMUT-RXN MANNPISOM-RXN)
REACTION-LAYOUT - (MANNPISOM-RXN (:LEFT-PRIMARIES MANNOSE-6P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LAYOUT - (PHOSMANMUT-RXN (:LEFT-PRIMARIES MANNOSE-1P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES MANNOSE-6P))
REACTION-LAYOUT - (2.7.7.13-RXN (:LEFT-PRIMARIES MANNOSE-1P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GDP-MANNOSE))
REACTION-LAYOUT - (MANNKIN-RXN (:LEFT-PRIMARIES MANNOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MANNOSE-6P))
REACTION-LAYOUT - (GDPMANMANHYDRO-RXN (:LEFT-PRIMARIES GDP-MANNOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MANNOSE))
REACTION-LIST - MANNPISOM-RXN
REACTION-LIST - PHOSMANMUT-RXN
REACTION-LIST - 2.7.7.13-RXN
REACTION-LIST - MANNKIN-RXN
REACTION-LIST - GDPMANMANHYDRO-RXN
//
UNIQUE-ID - PWY-5514
TYPES - Cell-Structure-Biosynthesis
TYPES - UDP-Nac-Galactosamine-Biosynthesis
COMMON-NAME - UDP-<i>N</i>-acetyl-D-galactosamine biosynthesis II
CREDITS - SRI
CREDITS - |fulcher|
PREDECESSORS - (UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN NAG1P-URIDYLTRANS-RXN)
PREDECESSORS - (NAG1P-URIDYLTRANS-RXN PHOSACETYLGLUCOSAMINEMUT-RXN)
PREDECESSORS - (PHOSACETYLGLUCOSAMINEMUT-RXN GLUCOSAMINEPNACETYLTRANS-RXN)
PREDECESSORS - (GLUCOSAMINEPNACETYLTRANS-RXN GLUCOSAMINE-6-P-DEAMIN-RXN)
PREDECESSORS - (GLUCOSAMINE-6-P-DEAMIN-RXN)
PRIMARIES - (GLUCOSAMINE-6-P-DEAMIN-RXN (FRUCTOSE-6P) (D-GLUCOSAMINE-6-P))
REACTION-LAYOUT - (UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN (:LEFT-PRIMARIES UDP-N-ACETYL-D-GLUCOSAMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-N-ACETYL-GALACTOSAMINE))
REACTION-LAYOUT - (NAG1P-URIDYLTRANS-RXN (:LEFT-PRIMARIES N-ACETYL-D-GLUCOSAMINE-1-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-N-ACETYL-D-GLUCOSAMINE))
REACTION-LAYOUT - (PHOSACETYLGLUCOSAMINEMUT-RXN (:LEFT-PRIMARIES N-ACETYL-D-GLUCOSAMINE-1-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES N-ACETYL-D-GLUCOSAMINE-6-P))
REACTION-LAYOUT - (GLUCOSAMINEPNACETYLTRANS-RXN (:LEFT-PRIMARIES D-GLUCOSAMINE-6-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES N-ACETYL-D-GLUCOSAMINE-6-P))
REACTION-LAYOUT - (GLUCOSAMINE-6-P-DEAMIN-RXN (:LEFT-PRIMARIES D-GLUCOSAMINE-6-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LIST - UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN
REACTION-LIST - NAG1P-URIDYLTRANS-RXN
REACTION-LIST - PHOSACETYLGLUCOSAMINEMUT-RXN
REACTION-LIST - GLUCOSAMINEPNACETYLTRANS-RXN
REACTION-LIST - GLUCOSAMINE-6-P-DEAMIN-RXN
//
UNIQUE-ID - PWY-5963
TYPES - Cofactor-Biosynthesis
COMMON-NAME - molybdenum cofactor (sulfide) biosynthesis
CITATIONS - :EV-COMP-AINF:3442068425:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (CPD-8123 PWY-5354)
PREDECESSORS - (RXN-8351)
PRIMARIES - (RXN-8351 (CPD-8123) (CPD-8124))
REACTION-LAYOUT - (RXN-8351 (:LEFT-PRIMARIES CPD-8123) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8124))
REACTION-LIST - RXN-8351
//
UNIQUE-ID - PWY-922
TYPES - ISOPRENOIDS
TYPES - Cofactor-Biosynthesis
TYPES - Lipid-Biosynthesis
COMMON-NAME - mevalonate pathway I
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - O-18
CREDITS - |pellegrini-toole|
IN-PATHWAY - PWY66-5
PATHWAY-LINKS - (CPD-4211 PWY-5123)
PATHWAY-LINKS - (FARNESYL-PP PWY66-341 PWY-2921 PWY-2541 ERGOSTEROL-SYN-PWY)
PREDECESSORS - (IPPISOM-RXN DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN)
PREDECESSORS - (DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN PHOSPHOMEVALONATE-KINASE-RXN)
PREDECESSORS - (PHOSPHOMEVALONATE-KINASE-RXN MEVALONATE-KINASE-RXN)
PREDECESSORS - (MEVALONATE-KINASE-RXN 1.1.1.34-RXN)
PREDECESSORS - (1.1.1.34-RXN HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN)
PREDECESSORS - (HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN ACETYL-COA-ACETYLTRANSFER-RXN)
PRIMARIES - (HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN (ACETOACETYL-COA) (3-HYDROXY-3-METHYL-GLUTARYL-COA))
REACTION-LAYOUT - (IPPISOM-RXN (:LEFT-PRIMARIES DELTA3-ISOPENTENYL-PP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4211))
REACTION-LAYOUT - (DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN (:LEFT-PRIMARIES CPD-641) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DELTA3-ISOPENTENYL-PP))
REACTION-LAYOUT - (PHOSPHOMEVALONATE-KINASE-RXN (:LEFT-PRIMARIES CPD-499) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-641))
REACTION-LAYOUT - (MEVALONATE-KINASE-RXN (:LEFT-PRIMARIES MEVALONATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-499))
REACTION-LAYOUT - (1.1.1.34-RXN (:LEFT-PRIMARIES MEVALONATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 3-HYDROXY-3-METHYL-GLUTARYL-COA))
REACTION-LAYOUT - (HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN (:LEFT-PRIMARIES ACETYL-COA ACETOACETYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HYDROXY-3-METHYL-GLUTARYL-COA))
REACTION-LAYOUT - (ACETYL-COA-ACETYLTRANSFER-RXN (:LEFT-PRIMARIES ACETYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETOACETYL-COA))
REACTION-LIST - IPPISOM-RXN
REACTION-LIST - DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN
REACTION-LIST - PHOSPHOMEVALONATE-KINASE-RXN
REACTION-LIST - MEVALONATE-KINASE-RXN
REACTION-LIST - 1.1.1.34-RXN
REACTION-LIST - HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
REACTION-LIST - ACETYL-COA-ACETYLTRANSFER-RXN
SUPER-PATHWAYS - PWY66-5
SYNONYMS - isoprenoid pathway
SYNONYMS - MVA pathway
SYNONYMS - isopentenyl diphosphate biosynthesis - mevalonate dependent
//
UNIQUE-ID - PWY3DJ-1
TYPES - Nucleotide-Biosynthesis
TYPES - Cofactor-Biosynthesis
COMMON-NAME - cyclic AMP biosynthesis
COMMENT - Cyclic adenosine monophosphate (cAMP, cyclic AMP or 3'-5'-cyclic adenosine monophosphate) is a secondary
/messenger that is important in many biological processes. cAMP is derived from adenosine triphosphate (ATP)
/and used for intracellular signal transduction in many different organisms.  cAMP is transferring the effects of
/hormones like glucagon and adrenaline, which cannot get through the cell membrane. Its purposes include the
/activation of protein kinases and regulating the effects of adrenaline and glucagon. It is also used to regulate the
/passage of Ca2+ through ion channels.
/cAMP is synthesised from ATP by adenylyl cyclase which is located at the cell membranes. Adenylyl cyclase is
/activated by a range of signaling molecules through the activation of adenylyl cyclase stimulatory G (Gs)-coupled
/receptors and inhibited by agonists of adenylyl cyclase inhibitory G (Gi)-protein coupled receptors. Liver adenylyl
/cyclase responds more strongly to glucagon, and muscle adenylyl cyclase responds more strongly to adrenaline.
/cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase.
CREDITS - O3DJ-6
CREDITS - AU3DJ-15
PREDECESSORS - (3.6.5.1-RXN)
PREDECESSORS - (RXN0-5038 ADENYLATECYC-RXN)
REACTION-LAYOUT - (3.6.5.1-RXN (:LEFT-PRIMARIES GTP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GDP))
REACTION-LAYOUT - (RXN0-5038 (:LEFT-PRIMARIES CAMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES AMP))
REACTION-LAYOUT - (ADENYLATECYC-RXN (:LEFT-PRIMARIES ATP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CAMP))
REACTION-LIST - 3.6.5.1-RXN
REACTION-LIST - RXN0-5038
REACTION-LIST - ADENYLATECYC-RXN
//
UNIQUE-ID - PWY3DJ-35549
TYPES - Cofactor-Biosynthesis
COMMON-NAME - Biopterin recycling
CREDITS - AU3DJ-7
PATHWAY-LINKS - (TETRA-H-BIOPTERIN PWY3DJ-5 PWY66-301)
PATHWAY-LINKS - (CPD-5881 PWY3DJ-5 PWY66-301)
PREDECESSORS - (RXN3DJ-82 RXN-7908)
REACTION-LAYOUT - (RXN3DJ-82 (:LEFT-PRIMARIES BIOPTERIN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TETRA-H-BIOPTERIN))
REACTION-LAYOUT - (RXN-7908 (:LEFT-PRIMARIES CPD-5881) (:DIRECTION :L2R) (:RIGHT-PRIMARIES BIOPTERIN))
REACTION-LIST - RXN3DJ-82
REACTION-LIST - RXN-7908
//
UNIQUE-ID - PWY3DJ-7
TYPES - Cofactor-Biosynthesis
TYPES - Nucleotide-Biosynthesis
COMMON-NAME - cyclic GMP biosynthesis
CITATIONS - 10977868
COMMENT - cGMP synthesis is catalyzed by guanylyl (guanylate) cyclases, a family of enzymes that catalyze the conversion of
/GTP to cGMP. The family comprises both membrane-bound and soluble isoforms that are expressed in nearly all cell
/types. They are regulated by diverse extracellular agonists that include peptide hormones, bacterial toxins, and free
/radicals, as well as intracellular molecule, such as calcium and adenine nucleotides. Stimulation of guanylyl cyclases
/and the resultant accumulation of cGMP regulates complex signaling cascades through immediate downstream
/effectors, including cGMP-dependent protein kinases, cGMP-regulated phosphodiesterases, and cyclic nucleotide-
/gated ion channels. Guanylyl cyclases and cGMP-mediated signaling cascades play a central role in the regulation of
/diverse physiological processes, including vascular smooth muscle motility, intestinal fluid and electrolyte homeostasis, 
/and retinal phototransduction |CITS: [10977868]|.
CREDITS - AU3DJ-15
PREDECESSORS - (35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN GUANYLCYC-RXN)
REACTION-LAYOUT - (35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN (:LEFT-PRIMARIES CGMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GMP))
REACTION-LAYOUT - (GUANYLCYC-RXN (:LEFT-PRIMARIES GTP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CGMP))
REACTION-LIST - 35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN
REACTION-LIST - GUANYLCYC-RXN
//
UNIQUE-ID - SAM-PWY
TYPES - Cofactor-Biosynthesis
COMMON-NAME - S-adenosylmethionine biosynthesis
CITATIONS - :EV-COMP-AINF:3442068425:ave
CREDITS - O-18
CREDITS - |riley|
PREDECESSORS - (S-ADENMETSYN-RXN)
PRIMARIES - (HOMOCYSMET-RXN (HOMO-CYS) NIL)
REACTION-LAYOUT - (S-ADENMETSYN-RXN (:LEFT-PRIMARIES MET ATP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES S-ADENOSYLMETHIONINE))
REACTION-LIST - S-ADENMETSYN-RXN
//
UNIQUE-ID - COA-PWY
TYPES - CoA-Biosynthesis
COMMON-NAME - coenzyme A biosynthesis
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - |keseler|
CREDITS - SRI
CREDITS - |arnaud|
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |hartmut|
PREDECESSORS - (P-PANTOCYSLIG-RXN PANTOTHENATE-KIN-RXN)
PREDECESSORS - (P-PANTOCYSDECARB-RXN P-PANTOCYSLIG-RXN)
PREDECESSORS - (PANTEPADENYLYLTRAN-RXN P-PANTOCYSDECARB-RXN)
PREDECESSORS - (DEPHOSPHOCOAKIN-RXN PANTEPADENYLYLTRAN-RXN)
REACTION-LAYOUT - (PANTOTHENATE-KIN-RXN (:LEFT-PRIMARIES PANTOTHENATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 4-P-PANTOTHENATE))
REACTION-LAYOUT - (P-PANTOCYSLIG-RXN (:LEFT-PRIMARIES 4-P-PANTOTHENATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES R-4-PHOSPHOPANTOTHENOYL-L-CYSTEINE))
REACTION-LAYOUT - (P-PANTOCYSDECARB-RXN (:LEFT-PRIMARIES R-4-PHOSPHOPANTOTHENOYL-L-CYSTEINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PANTETHEINE-P))
REACTION-LAYOUT - (DEPHOSPHOCOAKIN-RXN (:LEFT-PRIMARIES DEPHOSPHO-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CO-A))
REACTION-LAYOUT - (PANTEPADENYLYLTRAN-RXN (:LEFT-PRIMARIES PANTETHEINE-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DEPHOSPHO-COA))
REACTION-LIST - PANTOTHENATE-KIN-RXN
REACTION-LIST - P-PANTOCYSLIG-RXN
REACTION-LIST - P-PANTOCYSDECARB-RXN
REACTION-LIST - DEPHOSPHOCOAKIN-RXN
REACTION-LIST - PANTEPADENYLYLTRAN-RXN
SYNONYMS - CoA biosynthesis
//
UNIQUE-ID - PWY0-1275
TYPES - Lipoate-Biosynthesis
COMMON-NAME - lipoate biosynthesis and incorporation II
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (RXN0-949 RXN0-5098)
PRIMARIES - (RXN0-949 NIL (|Lipoylated-domains|))
PRIMARIES - (RXN0-5098 (CPD-195) (|Octanoylated-domains|))
REACTION-LAYOUT - (RXN0-949 (:LEFT-PRIMARIES |Octanoylated-domains|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Lipoylated-domains|))
REACTION-LAYOUT - (RXN0-5098 (:LEFT-PRIMARIES CPD-195) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Octanoylated-domains|))
REACTION-LIST - RXN0-949
REACTION-LIST - RXN0-5098
//
UNIQUE-ID - PWY0-501
TYPES - Lipoate-Biosynthesis
COMMON-NAME - lipoate biosynthesis and incorporation I
CITATIONS - :EV-COMP-AINF:3442068425:ave
CREDITS - |caspi|
CREDITS - SRI
CREDITS - |arnaud|
PREDECESSORS - (RXN0-947 RXN-5741)
PREDECESSORS - (RXN0-949 RXN0-947)
PRIMARIES - (RXN0-949 (|Octanoylated-domains|) (|Lipoylated-domains|))
PRIMARIES - (RXN-5741 (CPD-195) (OCTANOYL-ACP))
REACTION-LAYOUT - (RXN-5741 (:LEFT-PRIMARIES CPD-195) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Octanoyl-ACPs|))
REACTION-LAYOUT - (RXN0-947 (:LEFT-PRIMARIES |Octanoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Octanoylated-domains|))
REACTION-LAYOUT - (RXN0-949 (:LEFT-PRIMARIES |Octanoylated-domains|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Lipoylated-domains|))
REACTION-LIST - RXN-5741
REACTION-LIST - RXN0-947
REACTION-LIST - RXN0-949
//
UNIQUE-ID - NADPHOS-DEPHOS-PWY
TYPES - NAD-Metabolism
COMMON-NAME - NAD phosphorylation and dephosphorylation
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - O-18
CREDITS - |riley|
PREDECESSORS - (NADPPHOSPHAT-RXN 1.6.1.2-RXN)
PREDECESSORS - (1.6.1.2-RXN NADPPHOSPHAT-RXN)
PREDECESSORS - (NAD-KIN-RXN NADPPHOSPHAT-RXN)
PREDECESSORS - (NADPPHOSPHAT-RXN NAD-KIN-RXN)
PREDECESSORS - (NAD-KIN-RXN)
PRIMARIES - (1.6.1.2-RXN NIL NIL)
PRIMARIES - (NAD-KIN-RXN (NAD) (NADP))
REACTION-LAYOUT - (NADPPHOSPHAT-RXN (:LEFT-PRIMARIES NADP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NAD))
REACTION-LAYOUT - (NAD-KIN-RXN (:LEFT-PRIMARIES NAD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NADP))
REACTION-LAYOUT - (1.6.1.2-RXN (:LEFT-PRIMARIES NAD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NADP))
REACTION-LIST - NADPPHOSPHAT-RXN
REACTION-LIST - NAD-KIN-RXN
REACTION-LIST - 1.6.1.2-RXN
//
UNIQUE-ID - NAD-BIOSYNTHESIS-II
TYPES - NAD-SYN
TYPES - Super-Pathways
COMMON-NAME - NAD salvage pathway II
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - |caspi|
CREDITS - SRI
CREDITS - |hying|
PREDECESSORS - (2.7.7.1-RXN RIBOSYLNICOTINAMIDE-KINASE-RXN)
PREDECESSORS - (RIBOSYLNICOTINAMIDE-KINASE-RXN RXN-5841)
PREDECESSORS - (RXN-5841 NADPYROPHOSPHAT-RXN)
PREDECESSORS - (NADPYROPHOSPHAT-RXN RXN-5822)
PRIMARIES - (NADPYROPHOSPHAT-RXN (NAD) (NICOTINAMIDE_NUCLEOTIDE))
REACTION-LAYOUT - (PWY3O-4106 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (RXN-5841 (:LEFT-PRIMARIES NICOTINAMIDE_NUCLEOTIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NICOTINAMIDE_RIBOSE))
REACTION-LAYOUT - (RXN-5822 (:LEFT-PRIMARIES NADP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NAD))
REACTION-LAYOUT - (NADPYROPHOSPHAT-RXN (:LEFT-PRIMARIES NAD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NICOTINAMIDE_NUCLEOTIDE))
REACTION-LIST - PWY3O-4106
REACTION-LIST - RXN-5841
REACTION-LIST - RXN-5822
REACTION-LIST - NADPYROPHOSPHAT-RXN
SYNONYMS - nicotinamide adenine dinucleotide salvage
//
UNIQUE-ID - NAD-BIOSYNTHESIS-III
TYPES - NAD-SYN
COMMON-NAME - NAD biosynthesis III
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (2.7.7.1-RXN 2.4.2.12-RXN)
PRIMARIES - (2.4.2.12-RXN (NIACINAMIDE) (NICOTINAMIDE_NUCLEOTIDE))
REACTION-LAYOUT - (2.7.7.1-RXN (:LEFT-PRIMARIES NICOTINAMIDE_NUCLEOTIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NAD))
REACTION-LAYOUT - (2.4.2.12-RXN (:LEFT-PRIMARIES NICOTINAMIDE_NUCLEOTIDE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES NIACINAMIDE))
REACTION-LIST - 2.7.7.1-RXN
REACTION-LIST - 2.4.2.12-RXN
SYNONYMS - nicotinamide adenine dinucleotide biosynthesis
//
UNIQUE-ID - NADSYN-PWY
TYPES - NAD-SYN
TYPES - Super-Pathways
COMMON-NAME - NAD biosynthesis II (from tryptophan)
PREDECESSORS - (RXN-5721 1.13.11.6-RXN)
PREDECESSORS - PWY-5651
PREDECESSORS - PWY-5653
PREDECESSORS - (1.13.11.6-RXN)
PRIMARIES - (NICONUCADENYLYLTRAN-RXN (NICOTINATE_NUCLEOTIDE) (DEAMIDO-NAD))
REACTION-LAYOUT - (PWY-5651 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (PWY-5653 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - PWY-5651
REACTION-LIST - PWY-5653
SUB-PATHWAYS - PWY-5651
SUB-PATHWAYS - PWY-5653
SYNONYMS - nicotinamide adenine dinucleotide biosynthesis
//
UNIQUE-ID - PWY-5653
TYPES - NAD-SYN
COMMON-NAME - NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - NADSYN-PWY
PATHWAY-LINKS - (2-AMINO-3-3-OXOPROP-2-ENYL-BUT-2-ENEDI PWY-5651)
PREDECESSORS - (QUINOPRIBOTRANS-RXN RXN-5721)
PREDECESSORS - (NICONUCADENYLYLTRAN-RXN QUINOPRIBOTRANS-RXN)
PREDECESSORS - (NAD-SYNTH-GLN-RXN NICONUCADENYLYLTRAN-RXN)
PRIMARIES - (NICONUCADENYLYLTRAN-RXN (NICOTINATE_NUCLEOTIDE) (DEAMIDO-NAD))
REACTION-LAYOUT - (RXN-5721 (:LEFT-PRIMARIES 2-AMINO-3-3-OXOPROP-2-ENYL-BUT-2-ENEDI) (:DIRECTION :L2R) (:RIGHT-PRIMARIES QUINOLINATE))
REACTION-LAYOUT - (QUINOPRIBOTRANS-RXN (:LEFT-PRIMARIES QUINOLINATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NICOTINATE_NUCLEOTIDE))
REACTION-LAYOUT - (NAD-SYNTH-GLN-RXN (:LEFT-PRIMARIES DEAMIDO-NAD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NAD))
REACTION-LAYOUT - (NICONUCADENYLYLTRAN-RXN (:LEFT-PRIMARIES NICOTINATE_NUCLEOTIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DEAMIDO-NAD))
REACTION-LIST - RXN-5721
REACTION-LIST - QUINOPRIBOTRANS-RXN
REACTION-LIST - NAD-SYNTH-GLN-RXN
REACTION-LIST - NICONUCADENYLYLTRAN-RXN
SUPER-PATHWAYS - NADSYN-PWY
//
UNIQUE-ID - PWY3O-4106
TYPES - NAD-SYN
COMMON-NAME - NAD salvage pathway III
CREDITS - SRI
CREDITS - |caspi|
CREDITS - O-16
CREDITS - |krieger|
IN-PATHWAY - NAD-BIOSYNTHESIS-II
PREDECESSORS - (2.7.7.1-RXN RIBOSYLNICOTINAMIDE-KINASE-RXN)
PRIMARIES - (NADPYROPHOSPHAT-RXN (NAD) (NICOTINAMIDE_NUCLEOTIDE))
REACTION-LAYOUT - (RIBOSYLNICOTINAMIDE-KINASE-RXN (:LEFT-PRIMARIES NICOTINAMIDE_RIBOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NICOTINAMIDE_NUCLEOTIDE))
REACTION-LAYOUT - (2.7.7.1-RXN (:LEFT-PRIMARIES NICOTINAMIDE_NUCLEOTIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NAD))
REACTION-LIST - RIBOSYLNICOTINAMIDE-KINASE-RXN
REACTION-LIST - 2.7.7.1-RXN
SYNONYMS - nicotinamide riboside salvage pathway
SYNONYMS - nicotinamide adenine dinucleotide salvage
//
UNIQUE-ID - PYRNUCYC-PWY
TYPES - NAD-SYN
COMMON-NAME - pyridine nucleotide cycling
CITATIONS - :EV-COMP-AINF:3380892013:cjb
PREDECESSORS - (NADPYROPHOSPHAT-RXN)
PREDECESSORS - (NMNNUCLEOSID-RXN NADPYROPHOSPHAT-RXN)
PREDECESSORS - (NICOTINAMID-RXN NMNNUCLEOSID-RXN)
PREDECESSORS - (NICOTINAMID-RXN NADNUCLEOSID-RXN)
PREDECESSORS - (NICOTINATEPRIBOSYLTRANS-RXN NICOTINAMID-RXN)
PREDECESSORS - (NICONUCADENYLYLTRAN-RXN NICOTINATEPRIBOSYLTRANS-RXN)
PREDECESSORS - (NMNAMIDOHYDRO-RXN NADPYROPHOSPHAT-RXN)
PREDECESSORS - (NICONUCADENYLYLTRAN-RXN NMNAMIDOHYDRO-RXN)
PREDECESSORS - (NAD-SYNTH-NH3-RXN NICONUCADENYLYLTRAN-RXN)
PREDECESSORS - (NAD-SYNTH-GLN-RXN NICONUCADENYLYLTRAN-RXN)
REACTION-LAYOUT - (NMNNUCLEOSID-RXN (:LEFT-PRIMARIES NICOTINAMIDE_NUCLEOTIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NIACINAMIDE))
REACTION-LAYOUT - (NADNUCLEOSID-RXN (:LEFT-PRIMARIES NAD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NIACINAMIDE))
REACTION-LAYOUT - (NICOTINAMID-RXN (:LEFT-PRIMARIES NIACINAMIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NIACINE))
REACTION-LAYOUT - (NICOTINATEPRIBOSYLTRANS-RXN (:LEFT-PRIMARIES NICOTINATE_NUCLEOTIDE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES NIACINE))
REACTION-LAYOUT - (NADPYROPHOSPHAT-RXN (:LEFT-PRIMARIES NAD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NICOTINAMIDE_NUCLEOTIDE))
REACTION-LAYOUT - (NMNAMIDOHYDRO-RXN (:LEFT-PRIMARIES NICOTINAMIDE_NUCLEOTIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NICOTINATE_NUCLEOTIDE))
REACTION-LAYOUT - (NAD-SYNTH-NH3-RXN (:LEFT-PRIMARIES DEAMIDO-NAD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NAD))
REACTION-LAYOUT - (NAD-SYNTH-GLN-RXN (:LEFT-PRIMARIES DEAMIDO-NAD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NAD))
REACTION-LAYOUT - (NICONUCADENYLYLTRAN-RXN (:LEFT-PRIMARIES NICOTINATE_NUCLEOTIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DEAMIDO-NAD))
REACTION-LIST - NMNNUCLEOSID-RXN
REACTION-LIST - NADNUCLEOSID-RXN
REACTION-LIST - NICOTINAMID-RXN
REACTION-LIST - NICOTINATEPRIBOSYLTRANS-RXN
REACTION-LIST - NADPYROPHOSPHAT-RXN
REACTION-LIST - NMNAMIDOHYDRO-RXN
REACTION-LIST - NAD-SYNTH-NH3-RXN
REACTION-LIST - NAD-SYNTH-GLN-RXN
REACTION-LIST - NICONUCADENYLYLTRAN-RXN
//
UNIQUE-ID - PWY-5123
TYPES - Polyprenyl-Biosynthesis
COMMON-NAME - <i>trans,trans</i>-farnesyl diphosphate biosynthesis
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |tissier|
IN-PATHWAY - PWY66-5
PATHWAY-LINKS - (FARNESYL-PP PWY66-341 PWY-5670)
PATHWAY-LINKS - (DELTA3-ISOPENTENYL-PP PWY-922)
PREDECESSORS - (GPPSYN-RXN IPPISOM-RXN)
PREDECESSORS - (FPPSYN-RXN GPPSYN-RXN)
PRIMARIES - (GPPSYN-RXN (CPD-4211) (GERANYL-PP))
PRIMARIES - (FPPSYN-RXN (GERANYL-PP) (FARNESYL-PP))
REACTION-LAYOUT - (IPPISOM-RXN (:LEFT-PRIMARIES DELTA3-ISOPENTENYL-PP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4211))
REACTION-LAYOUT - (FPPSYN-RXN (:LEFT-PRIMARIES DELTA3-ISOPENTENYL-PP GERANYL-PP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FARNESYL-PP))
REACTION-LAYOUT - (GPPSYN-RXN (:LEFT-PRIMARIES DELTA3-ISOPENTENYL-PP CPD-4211) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GERANYL-PP))
REACTION-LIST - IPPISOM-RXN
REACTION-LIST - FPPSYN-RXN
REACTION-LIST - GPPSYN-RXN
SUPER-PATHWAYS - PWY66-5
SYNONYMS - FPP biosynthesis
SYNONYMS - <i>trans,trans</i>-farnesyl diphosphate biosynthesis
//
UNIQUE-ID - PWY-5805
TYPES - Polyprenyl-Biosynthesis
COMMON-NAME - nonaprenyl diphosphate biosynthesis
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (FARNESYL-PP PWY-5123)
PREDECESSORS - (TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN RXN-8992)
PREDECESSORS - (RXN-8992 TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN)
PREDECESSORS - (TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN TRANS-PENTAPRENYLTRANSFERASE-RXN)
PREDECESSORS - (FARNESYLTRANSTRANSFERASE-RXN)
PREDECESSORS - (TRANS-PENTAPRENYLTRANSFERASE-RXN RXN-8813)
PREDECESSORS - (RXN-8813 FARNESYLTRANSTRANSFERASE-RXN)
PRIMARIES - (FARNESYLTRANSTRANSFERASE-RXN (FARNESYL-PP) (GERANYLGERANYL-PP))
PRIMARIES - (FPPSYN-RXN (GERANYL-PP) (FARNESYL-PP))
PRIMARIES - (GPPSYN-RXN (CPD-4211) (GERANYL-PP))
PRIMARIES - (IPPISOM-RXN (DELTA3-ISOPENTENYL-PP) (CPD-2411))
REACTION-LAYOUT - (TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN (:LEFT-PRIMARIES OCTAPRENYL-DIPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SOLANESYL-PYROPHOSPHATE))
REACTION-LAYOUT - (RXN-8992 (:LEFT-PRIMARIES ALL-TRANS-HEPTAPRENYL-DIPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OCTAPRENYL-DIPHOSPHATE))
REACTION-LAYOUT - (TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN (:LEFT-PRIMARIES ALL-TRANS-HEXAPRENYL-DIPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALL-TRANS-HEPTAPRENYL-DIPHOSPHATE))
REACTION-LAYOUT - (TRANS-PENTAPRENYLTRANSFERASE-RXN (:LEFT-PRIMARIES ALL-TRANS-PENTAPRENYL-DIPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALL-TRANS-HEXAPRENYL-DIPHOSPHATE))
REACTION-LAYOUT - (RXN-8813 (:LEFT-PRIMARIES GERANYLGERANYL-PP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALL-TRANS-PENTAPRENYL-DIPHOSPHATE))
REACTION-LAYOUT - (FARNESYLTRANSTRANSFERASE-RXN (:LEFT-PRIMARIES FARNESYL-PP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GERANYLGERANYL-PP))
REACTION-LIST - TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN
REACTION-LIST - RXN-8992
REACTION-LIST - TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN
REACTION-LIST - TRANS-PENTAPRENYLTRANSFERASE-RXN
REACTION-LIST - RXN-8813
REACTION-LIST - FARNESYLTRANSTRANSFERASE-RXN
SYNONYMS - solanesyl diphosphate biosynthesis
SYNONYMS - solanesyl pyrophosphate biosynthesis
//
UNIQUE-ID - HEME-BIOSYNTHESIS-II
TYPES - HEME-SYN
COMMON-NAME - heme biosynthesis from uroporphyrinogen-III I
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - |caspi|
CREDITS - |fulcher|
CREDITS - SRI
CREDITS - |hying|
IN-PATHWAY - PWY-5920
PATHWAY-LINKS - (UROPORPHYRINOGEN-III PWY-5189)
PREDECESSORS - (PROTOPORGENOXI-RXN RXN0-1461)
PREDECESSORS - (RXN0-1461 UROGENDECARBOX-RXN)
PREDECESSORS - (PROTOHEMEFERROCHELAT-RXN PROTOPORGENOXI-RXN)
REACTION-LAYOUT - (RXN0-1461 (:LEFT-PRIMARIES COPROPORPHYRINOGEN_III) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PROTOPORPHYRINOGEN))
REACTION-LAYOUT - (PROTOHEMEFERROCHELAT-RXN (:LEFT-PRIMARIES PROTOPORPHYRIN_IX) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PROTOHEME))
REACTION-LAYOUT - (PROTOPORGENOXI-RXN (:LEFT-PRIMARIES PROTOPORPHYRINOGEN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PROTOPORPHYRIN_IX))
REACTION-LAYOUT - (UROGENDECARBOX-RXN (:LEFT-PRIMARIES UROPORPHYRINOGEN-III) (:DIRECTION :L2R) (:RIGHT-PRIMARIES COPROPORPHYRINOGEN_III))
REACTION-LIST - RXN0-1461
REACTION-LIST - PROTOHEMEFERROCHELAT-RXN
REACTION-LIST - PROTOPORGENOXI-RXN
REACTION-LIST - UROGENDECARBOX-RXN
SUPER-PATHWAYS - PWY-5920
//
UNIQUE-ID - PWY-5920
TYPES - HEME-SYN
TYPES - Super-Pathways
COMMON-NAME - heme biosynthesis II
PATHWAY-LINKS - (GLY (GLYCINE-SYN . :INCOMING))
PREDECESSORS - (UROGENDECARBOX-RXN UROGENIIISYN-RXN)
PREDECESSORS - HEME-BIOSYNTHESIS-II
PREDECESSORS - PWY-5189
REACTION-LAYOUT - (HEME-BIOSYNTHESIS-II (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (PWY-5189 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - HEME-BIOSYNTHESIS-II
REACTION-LIST - PWY-5189
SUB-PATHWAYS - HEME-BIOSYNTHESIS-II
SUB-PATHWAYS - PWY-5189
//
UNIQUE-ID - PWY-5870
TYPES - Ubiquinone-Biosynthesis
COMMON-NAME - ubiquinone-8 biosynthesis (eukaryotic)
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (RXN-9346 DHHB-METHYLTRANSFER-RXN)
PREDECESSORS - (2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN RXN-9283)
PREDECESSORS - (RXN-9283 RXN-9280)
PREDECESSORS - (RXN-9280 RXN-9277)
PREDECESSORS - (RXN-9277 4OHBENZOATE-OCTAPRENYLTRANSFER-RXN)
PREDECESSORS - (DHHB-METHYLTRANSFER-RXN OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN)
PREDECESSORS - (OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN 2-OCTAPRENYL-METHOXY-BENZOQ-METH-RXN)
PREDECESSORS - (2-OCTAPRENYL-METHOXY-BENZOQ-METH-RXN 2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN)
PREDECESSORS - (4OHBENZOATE-OCTAPRENYLTRANSFER-RXN CHORPYRLY-RXN)
PREDECESSORS - (CHORPYRLY-RXN)
REACTION-LAYOUT - (RXN-9346 (:LEFT-PRIMARIES CPD-9956) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UBIQUINONE-8))
REACTION-LAYOUT - (RXN-9280 (:LEFT-PRIMARIES CPD-9894) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-9899))
REACTION-LAYOUT - (RXN-9283 (:LEFT-PRIMARIES CPD-9899) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-OCTAPRENYL-6-METHOXYPHENOL))
REACTION-LAYOUT - (RXN-9277 (:LEFT-PRIMARIES 3-OCTAPRENYL-4-HYDROXYBENZOATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-9894))
REACTION-LAYOUT - (CHORPYRLY-RXN (:LEFT-PRIMARIES CHORISMATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |4-hydroxybenzoate|))
REACTION-LAYOUT - (4OHBENZOATE-OCTAPRENYLTRANSFER-RXN (:LEFT-PRIMARIES |4-hydroxybenzoate|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-OCTAPRENYL-4-HYDROXYBENZOATE))
REACTION-LAYOUT - (2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN (:LEFT-PRIMARIES 2-OCTAPRENYL-6-METHOXYPHENOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OCTAPRENYL-METHOXY-BENZOQUINONE))
REACTION-LAYOUT - (2-OCTAPRENYL-METHOXY-BENZOQ-METH-RXN (:LEFT-PRIMARIES OCTAPRENYL-METHOXY-BENZOQUINONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OCTAPRENYL-METHYL-METHOXY-BENZQ))
REACTION-LAYOUT - (DHHB-METHYLTRANSFER-RXN (:LEFT-PRIMARIES OCTAPRENYL-METHYL-OH-METHOXY-BENZQ) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-9956))
REACTION-LAYOUT - (OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN (:LEFT-PRIMARIES OCTAPRENYL-METHYL-METHOXY-BENZQ) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OCTAPRENYL-METHYL-OH-METHOXY-BENZQ))
REACTION-LIST - RXN-9346
REACTION-LIST - RXN-9280
REACTION-LIST - RXN-9283
REACTION-LIST - RXN-9277
REACTION-LIST - CHORPYRLY-RXN
REACTION-LIST - 4OHBENZOATE-OCTAPRENYLTRANSFER-RXN
REACTION-LIST - 2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN
REACTION-LIST - 2-OCTAPRENYL-METHOXY-BENZOQ-METH-RXN
REACTION-LIST - DHHB-METHYLTRANSFER-RXN
REACTION-LIST - OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN
//
UNIQUE-ID - PWY3O-19
TYPES - Ubiquinone-Biosynthesis
COMMON-NAME - ubiquinone-6 biosynthesis (eukaryotic)
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - SRI
CREDITS - |caspi|
CREDITS - O-16
CREDITS - |hong|
PREDECESSORS - (RXN3O-58 RXN-9003)
PREDECESSORS - (RXN3O-117 RXN3O-102)
PREDECESSORS - (RXN3O-102 RXN3O-75)
PREDECESSORS - (RXN3O-54 RXN3O-12)
PREDECESSORS - (RXN3O-73 2.1.1.114-RXN)
PREDECESSORS - (2.1.1.114-RXN RXN3O-58)
PREDECESSORS - (RXN3O-12 RXN3O-73)
PREDECESSORS - (RXN3O-75 RXN3O-54)
PRIMARIES - (RXN3O-102 (2-HEXAPRENYL-3-METHYL-5-HYDROXY-6-METHOX) (UBIQUINOL-30))
PRIMARIES - (RXN3O-54 (2-HEXAPRENYL-6-METHOXY-14-BENZOQUINOL) (2-HEXAPRENYL-3-METHYL-6-METHOXY-14-BENZ))
REACTION-LAYOUT - (RXN-9003 (:LEFT-PRIMARIES |4-hydroxybenzoate| ALL-TRANS-HEXAPRENYL-DIPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HEXAPRENYL-4-HYDROXYBENZOATE))
REACTION-LAYOUT - (RXN3O-117 (:LEFT-PRIMARIES UBIQUINOL-30) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UBIQUINONE-6))
REACTION-LAYOUT - (RXN3O-102 (:LEFT-PRIMARIES 2-HEXAPRENYL-3-METHYL-5-HYDROXY-6-METHOX) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UBIQUINOL-30))
REACTION-LAYOUT - (RXN3O-75 (:LEFT-PRIMARIES 2-HEXAPRENYL-3-METHYL-6-METHOXY-14-BENZ) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-HEXAPRENYL-3-METHYL-5-HYDROXY-6-METHOX))
REACTION-LAYOUT - (RXN3O-54 (:LEFT-PRIMARIES 2-HEXAPRENYL-6-METHOXY-14-BENZOQUINOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-HEXAPRENYL-3-METHYL-6-METHOXY-14-BENZ))
REACTION-LAYOUT - (RXN3O-12 (:LEFT-PRIMARIES 2-HEXAPRENYL-6-METHOXYPHENOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-HEXAPRENYL-6-METHOXY-14-BENZOQUINOL))
REACTION-LAYOUT - (RXN3O-73 (:LEFT-PRIMARIES 3-HEXAPRENYL-4-HYDROXY-5-METHOXYBENZOATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-HEXAPRENYL-6-METHOXYPHENOL))
REACTION-LAYOUT - (2.1.1.114-RXN (:LEFT-PRIMARIES 3-HEXAPRENYL-45-DIHYDROXYBENZOATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HEXAPRENYL-4-HYDROXY-5-METHOXYBENZOATE))
REACTION-LAYOUT - (RXN3O-58 (:LEFT-PRIMARIES 3-HEXAPRENYL-4-HYDROXYBENZOATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HEXAPRENYL-45-DIHYDROXYBENZOATE))
REACTION-LIST - RXN-9003
REACTION-LIST - RXN3O-117
REACTION-LIST - RXN3O-102
REACTION-LIST - RXN3O-75
REACTION-LIST - RXN3O-54
REACTION-LIST - RXN3O-12
REACTION-LIST - RXN3O-73
REACTION-LIST - 2.1.1.114-RXN
REACTION-LIST - RXN3O-58
SYNONYMS - Q-6 biosynthesis
//
UNIQUE-ID - GLUT-REDOX-PWY
TYPES - Reductants
COMMON-NAME - glutathione redox reactions II
CITATIONS - :EV-COMP-AINF:3422608266:ave
CREDITS - SRI
CREDITS - |caspi|
CREDITS - O-18
CREDITS - |riley|
PREDECESSORS - (GLUTATHIONE-REDUCT-NADPH-RXN PRODISULFREDUCT-A-RXN)
PREDECESSORS - (PRODISULFREDUCT-A-RXN GLUTATHIONE-REDUCT-NADPH-RXN)
PRIMARIES - (PRODISULFREDUCT-A-RXN (GLUTATHIONE) (OXIDIZED-GLUTATHIONE))
PRIMARIES - (GLUTATHIONE-REDUCT-NADPH-RXN (OXIDIZED-GLUTATHIONE) (GLUTATHIONE))
REACTION-LAYOUT - (GLUTATHIONE-REDUCT-NADPH-RXN (:LEFT-PRIMARIES GLUTATHIONE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES OXIDIZED-GLUTATHIONE))
REACTION-LAYOUT - (PRODISULFREDUCT-A-RXN (:LEFT-PRIMARIES GLUTATHIONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OXIDIZED-GLUTATHIONE))
REACTION-LIST - GLUTATHIONE-REDUCT-NADPH-RXN
REACTION-LIST - PRODISULFREDUCT-A-RXN
//
UNIQUE-ID - GLUTATHIONESYN-PWY
TYPES - Reductants
COMMON-NAME - glutathione biosynthesis
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |keseler|
CREDITS - O-18
CREDITS - |riley|
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |hartmut|
IN-PATHWAY - PWY-4041
PREDECESSORS - (GLUTCYSLIG-RXN)
PREDECESSORS - (GLUTATHIONE-SYN-RXN GLUTCYSLIG-RXN)
REACTION-LAYOUT - (GLUTATHIONE-SYN-RXN (:LEFT-PRIMARIES L-GAMMA-GLUTAMYLCYSTEINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLUTATHIONE))
REACTION-LAYOUT - (GLUTCYSLIG-RXN (:LEFT-PRIMARIES GLT CYS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-GAMMA-GLUTAMYLCYSTEINE))
REACTION-LIST - GLUTATHIONE-SYN-RXN
REACTION-LIST - GLUTCYSLIG-RXN
SUPER-PATHWAYS - PWY-4041
//
UNIQUE-ID - PWY-4041
TYPES - Reductants
TYPES - Super-Pathways
COMMON-NAME - &gamma;-glutamyl cycle
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (GLUTCYSLIG-RXN RXN-6622)
PREDECESSORS - (RXN-6622 RXN-6601)
PREDECESSORS - (GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN RXN-6601)
PREDECESSORS - (RXN-6601 GLUTATHIONE-SYN-RXN)
PREDECESSORS - GLUTATHIONESYN-PWY
PREDECESSORS - (5-OXOPROLINASE-ATP-HYDROLYSING-RXN GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN)
PREDECESSORS - (GLUTCYSLIG-RXN 5-OXOPROLINASE-ATP-HYDROLYSING-RXN)
PREDECESSORS - (GLUTATHIONE-SYN-RXN GLUTCYSLIG-RXN)
PRIMARIES - (RXN-6601 (GLUTATHIONE) (CYS-GLY 5-L-GLUTAMYL-L-AMINO-ACID))
PRIMARIES - (RXN-6622 (CYS-GLY) (CYS GLY))
REACTION-LAYOUT - (GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN (:LEFT-PRIMARIES 5-L-GLUTAMYL-L-AMINO-ACID) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-OXOPROLINE))
REACTION-LAYOUT - (5-OXOPROLINASE-ATP-HYDROLYSING-RXN (:LEFT-PRIMARIES 5-OXOPROLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLT))
REACTION-LAYOUT - (RXN-6601 (:LEFT-PRIMARIES CYS-GLY 5-L-GLUTAMYL-L-AMINO-ACID) (:DIRECTION :R2L) (:RIGHT-PRIMARIES GLUTATHIONE))
REACTION-LAYOUT - (RXN-6622 (:LEFT-PRIMARIES CYS-GLY) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLY CYS))
REACTION-LAYOUT - (GLUTATHIONESYN-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN
REACTION-LIST - 5-OXOPROLINASE-ATP-HYDROLYSING-RXN
REACTION-LIST - RXN-6601
REACTION-LIST - RXN-6622
REACTION-LIST - GLUTATHIONESYN-PWY
SUB-PATHWAYS - GLUTATHIONESYN-PWY
SYNONYMS - glutathione metabolism
//
UNIQUE-ID - PWY-4081
TYPES - Reductants
COMMON-NAME - glutathione redox reactions I
CITATIONS - :EV-COMP-AINF:3380892014:cjb
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (GLUTATHIONE-REDUCT-NADPH-RXN GLUTATHIONE-PEROXIDASE-RXN)
PREDECESSORS - (GLUTATHIONE-REDUCT-NADPH-RXN 1.11.1.12-RXN)
PREDECESSORS - (GLUTATHIONE-PEROXIDASE-RXN GLUTATHIONE-REDUCT-NADPH-RXN)
PREDECESSORS - (1.11.1.12-RXN GLUTATHIONE-REDUCT-NADPH-RXN)
PRIMARIES - (GLUTATHIONE-REDUCT-NADPH-RXN (OXIDIZED-GLUTATHIONE) (GLUTATHIONE))
PRIMARIES - (GLUTATHIONE-PEROXIDASE-RXN (GLUTATHIONE) (OXIDIZED-GLUTATHIONE))
PRIMARIES - (1.11.1.12-RXN (GLUTATHIONE) (OXIDIZED-GLUTATHIONE))
REACTION-LAYOUT - (GLUTATHIONE-REDUCT-NADPH-RXN (:LEFT-PRIMARIES GLUTATHIONE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES OXIDIZED-GLUTATHIONE))
REACTION-LAYOUT - (1.11.1.12-RXN (:LEFT-PRIMARIES GLUTATHIONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OXIDIZED-GLUTATHIONE))
REACTION-LAYOUT - (GLUTATHIONE-PEROXIDASE-RXN (:LEFT-PRIMARIES GLUTATHIONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OXIDIZED-GLUTATHIONE))
REACTION-LIST - GLUTATHIONE-REDUCT-NADPH-RXN
REACTION-LIST - 1.11.1.12-RXN
REACTION-LIST - GLUTATHIONE-PEROXIDASE-RXN
//
UNIQUE-ID - THIOREDOX-PWY
TYPES - Reductants
COMMON-NAME - thioredoxin pathway
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - O-18
CREDITS - |riley|
PREDECESSORS - (THIOREDOXIN-REDUCT-NADPH-RXN THIOREDOXIN-RXN)
PREDECESSORS - (THIOREDOXIN-RXN THIOREDOXIN-REDUCT-NADPH-RXN)
PRIMARIES - (THIOREDOXIN-REDUCT-NADPH-RXN (|Red-Thioredoxin|) (|Ox-Thioredoxin|))
REACTION-LAYOUT - (THIOREDOXIN-RXN (:LEFT-PRIMARIES |Ox-Thioredoxin|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Red-Thioredoxin|))
REACTION-LAYOUT - (THIOREDOXIN-REDUCT-NADPH-RXN (:LEFT-PRIMARIES |Red-Thioredoxin|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Ox-Thioredoxin|))
REACTION-LIST - THIOREDOXIN-RXN
REACTION-LIST - THIOREDOXIN-REDUCT-NADPH-RXN
//
UNIQUE-ID - PWY-5663
TYPES - Tetrahydrobiopterin-Biosynthesis
COMMON-NAME - tetrahydrobiopterin biosynthesis I
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (RXN-8853 4.2.3.12-RXN)
PREDECESSORS - (4.2.3.12-RXN GTP-CYCLOHYDRO-I-RXN)
PRIMARIES - (SEPIAPTERIN-REDUCTASE-RXN (CPD-374) (BIOPTERIN))
REACTION-LAYOUT - (RXN-8853 (:LEFT-PRIMARIES TETRA-H-BIOPTERIN) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 6-PYRUVOYL-5678-TETRAHYDROPTERIN))
REACTION-LAYOUT - (GTP-CYCLOHYDRO-I-RXN (:LEFT-PRIMARIES GTP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIHYDRONEOPTERIN-P3))
REACTION-LAYOUT - (4.2.3.12-RXN (:LEFT-PRIMARIES DIHYDRONEOPTERIN-P3) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 6-PYRUVOYL-5678-TETRAHYDROPTERIN))
REACTION-LIST - RXN-8853
REACTION-LIST - GTP-CYCLOHYDRO-I-RXN
REACTION-LIST - 4.2.3.12-RXN
//
UNIQUE-ID - PWY-5664
TYPES - Tetrahydrobiopterin-Biosynthesis
COMMON-NAME - tetrahydrobiopterin biosynthesis II
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (RXN-8854 1.1.1.220-RXN)
PREDECESSORS - (1.1.1.220-RXN 4.2.3.12-RXN)
PREDECESSORS - (4.2.3.12-RXN GTP-CYCLOHYDRO-I-RXN)
PRIMARIES - (SEPIAPTERIN-REDUCTASE-RXN (CPD-374) (BIOPTERIN))
REACTION-LAYOUT - (RXN-8854 (:LEFT-PRIMARIES 6-LACTOYL-5678-TETRAHYDROPTERIN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TETRA-H-BIOPTERIN))
REACTION-LAYOUT - (1.1.1.220-RXN (:LEFT-PRIMARIES 6-LACTOYL-5678-TETRAHYDROPTERIN) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 6-PYRUVOYL-5678-TETRAHYDROPTERIN))
REACTION-LAYOUT - (GTP-CYCLOHYDRO-I-RXN (:LEFT-PRIMARIES GTP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIHYDRONEOPTERIN-P3))
REACTION-LAYOUT - (4.2.3.12-RXN (:LEFT-PRIMARIES DIHYDRONEOPTERIN-P3) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 6-PYRUVOYL-5678-TETRAHYDROPTERIN))
REACTION-LIST - RXN-8854
REACTION-LIST - 1.1.1.220-RXN
REACTION-LIST - GTP-CYCLOHYDRO-I-RXN
REACTION-LIST - 4.2.3.12-RXN
//
UNIQUE-ID - PWY-5189
TYPES - Tetrapyrrole-Biosynthesis
COMMON-NAME - tetrapyrrole biosynthesis II
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - PWY-5920
PATHWAY-LINKS - (UROPORPHYRINOGEN-III HEME-BIOSYNTHESIS-II)
PREDECESSORS - (UROGENIIISYN-RXN OHMETHYLBILANESYN-RXN)
PREDECESSORS - (OHMETHYLBILANESYN-RXN PORPHOBILSYNTH-RXN)
PREDECESSORS - (PORPHOBILSYNTH-RXN 5-AMINOLEVULINIC-ACID-SYNTHASE-RXN)
REACTION-LAYOUT - (UROGENIIISYN-RXN (:LEFT-PRIMARIES HYDROXYMETHYLBILANE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UROPORPHYRINOGEN-III))
REACTION-LAYOUT - (OHMETHYLBILANESYN-RXN (:LEFT-PRIMARIES PORPHOBILINOGEN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES HYDROXYMETHYLBILANE))
REACTION-LAYOUT - (PORPHOBILSYNTH-RXN (:LEFT-PRIMARIES 5-AMINO-LEVULINATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PORPHOBILINOGEN))
REACTION-LAYOUT - (5-AMINOLEVULINIC-ACID-SYNTHASE-RXN (:LEFT-PRIMARIES GLY) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-AMINO-LEVULINATE))
REACTION-LIST - UROGENIIISYN-RXN
REACTION-LIST - OHMETHYLBILANESYN-RXN
REACTION-LIST - PORPHOBILSYNTH-RXN
REACTION-LIST - 5-AMINOLEVULINIC-ACID-SYNTHASE-RXN
SUPER-PATHWAYS - PWY-5920
//
UNIQUE-ID - PWY-6076
TYPES - Vitamin-Biosynthesis
TYPES - HORMONE-SYN
COMMON-NAME - 1,25-dihydroxyvitamin D<sub>3</sub> biosynthesis
CITATIONS - :EV-COMP-AINF:3453644158:ave
CREDITS - SRI
CREDITS - |fulcher|
KEY-REACTIONS - CALCIDIOL-1-MONOOXYGENASE-RXN
PATHWAY-LINKS - (CPD-4187 PWY66-341)
PREDECESSORS - (CALCIDIOL-1-MONOOXYGENASE-RXN RXN-9829)
PREDECESSORS - (RXN-9829 RXN-9828)
PREDECESSORS - (RXN-9828 RXN-9827)
PREDECESSORS - (RXN-9827)
PRIMARIES - (RXN-9827 (CPD-4187) (CPD-10570))
REACTION-LAYOUT - (CALCIDIOL-1-MONOOXYGENASE-RXN (:LEFT-PRIMARIES CALCIDIOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CALCITRIOL))
REACTION-LAYOUT - (RXN-9829 (:LEFT-PRIMARIES VITAMIN_D3) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CALCIDIOL))
REACTION-LAYOUT - (RXN-9828 (:LEFT-PRIMARIES CPD-10570) (:DIRECTION :L2R) (:RIGHT-PRIMARIES VITAMIN_D3))
REACTION-LAYOUT - (RXN-9827 (:LEFT-PRIMARIES CPD-4187) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-10570))
REACTION-LIST - CALCIDIOL-1-MONOOXYGENASE-RXN
REACTION-LIST - RXN-9829
REACTION-LIST - RXN-9828
REACTION-LIST - RXN-9827
SYNONYMS - vitamin D<sub>3</sub> biosynthesis
//
UNIQUE-ID - PWY3DJ-81
TYPES - Vitamin-Biosynthesis
COMMON-NAME - riboflavin, FMN and FAD transformations
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - O3DJ-6
CREDITS - AU3DJ-15
CREDITS - AU3DJ-34097
CREDITS - AU3DJ-7
PREDECESSORS - (RXN0-5187 FAD-PYROPHOSPHATASE-RXN)
PREDECESSORS - (RIBOFLAVINKIN-RXN RXN0-5187)
PREDECESSORS - (FADSYN-RXN FAD-PYROPHOSPHATASE-RXN)
PREDECESSORS - (FAD-PYROPHOSPHATASE-RXN FADSYN-RXN)
PREDECESSORS - (FADSYN-RXN RIBOFLAVINKIN-RXN)
PRIMARIES - (FAD-PYROPHOSPHATASE-RXN (FAD) (FMN))
REACTION-LAYOUT - (RXN0-5187 (:LEFT-PRIMARIES FMN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES RIBOFLAVIN))
REACTION-LAYOUT - (FAD-PYROPHOSPHATASE-RXN (:LEFT-PRIMARIES FAD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FMN))
REACTION-LAYOUT - (FADSYN-RXN (:LEFT-PRIMARIES FMN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FAD))
REACTION-LAYOUT - (RIBOFLAVINKIN-RXN (:LEFT-PRIMARIES RIBOFLAVIN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FMN))
REACTION-LIST - RXN0-5187
REACTION-LIST - FAD-PYROPHOSPHATASE-RXN
REACTION-LIST - FADSYN-RXN
REACTION-LIST - RIBOFLAVINKIN-RXN
//
UNIQUE-ID - PWY3DJ-35471
TYPES - Ascorbate-Biosynthesis
COMMON-NAME - L-ascorbate biosynthesis VI
CITATIONS - 17222174
CITATIONS - 17222174:EV-AS-TAS:3388244937:ave
COMMENT - Vitamin C, a reducing agent and antioxidant, is a cofactor in reactions catalyzed by copper-dependent
/monooxygenases and iron-dependent dioxygenases. It is synthesized, in vertebrates having this capacity, from
/d-glucuronate. The latter is formed through direct hydrolysis of uridine diphosphate (UDP)-glucuronate by enzyme(s)
/bound to the endoplasmic reticulum membrane, sharing many properties with, and most likely identical to,
/UDP-glucuronosyltransferases|CITS: [17222174]|.
CREDITS - SRI
CREDITS - |fulcher|
CREDITS - O3DJ-6
CREDITS - AU3DJ-15
PREDECESSORS - (RXN3DJ-64 UGD-RXN)
PREDECESSORS - (GLUCURONATE-REDUCTASE-RXN RXN3DJ-64)
PREDECESSORS - (UGD-RXN GLUC1PURIDYLTRANS-RXN)
PREDECESSORS - (RXN-8783 GLUCURONATE-REDUCTASE-RXN)
PREDECESSORS - (L-GULONOLACTONE-OXIDASE-RXN RXN-8783)
PREDECESSORS - (RXN3DJ-13 L-GULONOLACTONE-OXIDASE-RXN)
PRIMARIES - (UDPSUGARHYDRO-RXN (|UDP-sugar|) (|Sugar-1-Phosphate|))
PRIMARIES - (GLUC1PURIDYLTRANS-RXN (GLC-1-P) (UDP-GLUCOSE))
PRIMARIES - (UDP-GLUCURONOSYLTRANSFERASE-RXN (UDP-GLUCURONATE) (|Beta-D-Glucuronides|))
REACTION-LAYOUT - (RXN-8783 (:LEFT-PRIMARIES L-GULONO-1-4-LACTONE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES L-GULONATE))
REACTION-LAYOUT - (RXN3DJ-64 (:LEFT-PRIMARIES UDP-GLUCURONATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLUCURONATE))
REACTION-LAYOUT - (GLUC1PURIDYLTRANS-RXN (:LEFT-PRIMARIES GLC-1-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-GLUCOSE))
REACTION-LAYOUT - (UGD-RXN (:LEFT-PRIMARIES UDP-GLUCOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-GLUCURONATE))
REACTION-LAYOUT - (GLUCURONATE-REDUCTASE-RXN (:LEFT-PRIMARIES L-GULONATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES GLUCURONATE))
REACTION-LAYOUT - (RXN3DJ-13 (:LEFT-PRIMARIES CPD-329) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ASCORBATE))
REACTION-LAYOUT - (L-GULONOLACTONE-OXIDASE-RXN (:LEFT-PRIMARIES L-GULONO-1-4-LACTONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-329))
REACTION-LIST - RXN-8783
REACTION-LIST - RXN3DJ-64
REACTION-LIST - GLUC1PURIDYLTRANS-RXN
REACTION-LIST - UGD-RXN
REACTION-LIST - GLUCURONATE-REDUCTASE-RXN
REACTION-LIST - RXN3DJ-13
REACTION-LIST - L-GULONOLACTONE-OXIDASE-RXN
SYNONYMS - vitamin C biosynthesis
SYNONYMS - ascorbic acid biosynthesis
//
UNIQUE-ID - PWY-6268
TYPES - Adenosylcobalamin-Biosynthesis
COMMON-NAME - adenosylcobalamin salvage from cobalamin
CITATIONS - :EV-COMP-AINF:3482054331:ave
PREDECESSORS - (COBALADENOSYLTRANS-RXN)
PRIMARIES - (COBALADENOSYLTRANS-RXN (COB-I-ALAMIN) (ADENOSYLCOBALAMIN))
REACTION-LAYOUT - (COBALADENOSYLTRANS-RXN (:LEFT-PRIMARIES COB-I-ALAMIN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ADENOSYLCOBALAMIN))
REACTION-LIST - COBALADENOSYLTRANS-RXN
SYNONYMS - vitamin B<sub>12</sub> biosynthesis
//
UNIQUE-ID - RIBOSYN2-PWY
TYPES - Flavin-Biosynthesis
COMMON-NAME - flavin biosynthesis I (bacteria)
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - O-18
CREDITS - |riley|
CREDITS - SRI
CREDITS - |keseler|
PREDECESSORS - (GTP-CYCLOHYDRO-II-RXN)
PREDECESSORS - (RIBOFLAVINSYNDEAM-RXN GTP-CYCLOHYDRO-II-RXN)
PREDECESSORS - (RIBOFLAVINSYNREDUC-RXN RIBOFLAVINSYNDEAM-RXN)
PREDECESSORS - (RIBOPHOSPHAT-RXN RIBOFLAVINSYNREDUC-RXN)
PREDECESSORS - (DIOHBUTANONEPSYN-RXN)
PREDECESSORS - (LUMAZINESYN-RXN DIOHBUTANONEPSYN-RXN)
PREDECESSORS - (LUMAZINESYN-RXN RIBOPHOSPHAT-RXN)
PREDECESSORS - (RIBOFLAVIN-SYN-RXN LUMAZINESYN-RXN)
PREDECESSORS - (RIBOFLAVINKIN-RXN RIBOFLAVIN-SYN-RXN)
PREDECESSORS - (FADSYN-RXN RIBOFLAVINKIN-RXN)
REACTION-LAYOUT - (GTP-CYCLOHYDRO-II-RXN (:LEFT-PRIMARIES GTP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIAMINO-OH-PHOSPHORIBOSYLAMINO-PYR))
REACTION-LAYOUT - (RIBOFLAVINSYNDEAM-RXN (:LEFT-PRIMARIES DIAMINO-OH-PHOSPHORIBOSYLAMINO-PYR) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-602))
REACTION-LAYOUT - (RIBOFLAVINSYNREDUC-RXN (:LEFT-PRIMARIES CPD-1086) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CPD-602))
REACTION-LAYOUT - (DIOHBUTANONEPSYN-RXN (:LEFT-PRIMARIES RIBULOSE-5P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIHYDROXY-BUTANONE-P))
REACTION-LAYOUT - (RIBOPHOSPHAT-RXN (:LEFT-PRIMARIES CPD-1086) (:DIRECTION :L2R) (:RIGHT-PRIMARIES AMINO-RIBOSYLAMINO-1H-3H-PYR-DIONE))
REACTION-LAYOUT - (LUMAZINESYN-RXN (:LEFT-PRIMARIES DIHYDROXY-BUTANONE-P AMINO-RIBOSYLAMINO-1H-3H-PYR-DIONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIMETHYL-D-RIBITYL-LUMAZINE))
REACTION-LAYOUT - (RIBOFLAVIN-SYN-RXN (:LEFT-PRIMARIES DIMETHYL-D-RIBITYL-LUMAZINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES RIBOFLAVIN AMINO-RIBOSYLAMINO-1H-3H-PYR-DIONE))
REACTION-LAYOUT - (FADSYN-RXN (:LEFT-PRIMARIES FMN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FAD))
REACTION-LAYOUT - (RIBOFLAVINKIN-RXN (:LEFT-PRIMARIES RIBOFLAVIN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FMN))
REACTION-LIST - GTP-CYCLOHYDRO-II-RXN
REACTION-LIST - RIBOFLAVINSYNDEAM-RXN
REACTION-LIST - RIBOFLAVINSYNREDUC-RXN
REACTION-LIST - DIOHBUTANONEPSYN-RXN
REACTION-LIST - RIBOPHOSPHAT-RXN
REACTION-LIST - LUMAZINESYN-RXN
REACTION-LIST - RIBOFLAVIN-SYN-RXN
REACTION-LIST - FADSYN-RXN
REACTION-LIST - RIBOFLAVINKIN-RXN
SYNONYMS - riboflavin, FMN and FAD biosynthesis
SYNONYMS - vitamin B<sub>2</sub> biosynthesis
//
UNIQUE-ID - 1CMET2-PWY
TYPES - Folate-Biosynthesis
COMMON-NAME - formylTHF biosynthesis I
CITATIONS - :EV-COMP-AINF:3453644158:ave
CREDITS - O-18
CREDITS - |riley|
HYPOTHETICAL-REACTIONS - FORMATETHFLIG-RXN
PATHWAY-LINKS - (10-FORMYL-THF (PWY-2161 . :OUTGOING))
PATHWAY-LINKS - (THF FOLSYN-PWY)
POLYMERIZATION-LINKS - (FORMYL-THF-GLU-N FORMYLTHFGLUSYNTH-RXN FORMYLTHFGLUSYNTH-RXN)
PREDECESSORS - (DIHYDROFOLATEREDUCT-RXN DIHYDROFOLATESYNTH-RXN)
PREDECESSORS - (DIHYDROFOLATEREDUCT-RXN THYMIDYLATESYN-RXN)
PREDECESSORS - (GCVMULTI-RXN DIHYDROFOLATEREDUCT-RXN)
PREDECESSORS - (GCVMULTI-RXN HOMOCYSMETB12-RXN)
PREDECESSORS - (GLYOHMETRANS-RXN DIHYDROFOLATEREDUCT-RXN)
PREDECESSORS - (GLYOHMETRANS-RXN HOMOCYSMETB12-RXN)
PREDECESSORS - (THYMIDYLATESYN-RXN GLYOHMETRANS-RXN)
PREDECESSORS - (THYMIDYLATESYN-RXN GCVMULTI-RXN)
PREDECESSORS - (1.5.1.20-RXN GCVMULTI-RXN)
PREDECESSORS - (1.5.1.20-RXN GLYOHMETRANS-RXN)
PREDECESSORS - (HOMOCYSMETB12-RXN 1.5.1.20-RXN)
PREDECESSORS - (METHYLENETHFDEHYDROG-NADP-RXN GCVMULTI-RXN)
PREDECESSORS - (METHYLENETHFDEHYDROG-NADP-RXN GLYOHMETRANS-RXN)
PREDECESSORS - (METHENYLTHFCYCLOHYDRO-RXN METHYLENETHFDEHYDROG-NADP-RXN)
PREDECESSORS - (FORMYLTHFDEFORMYL-RXN METHENYLTHFCYCLOHYDRO-RXN)
PREDECESSORS - (FORMATETHFLIG-RXN FORMYLTHFDEFORMYL-RXN)
PREDECESSORS - (FORMYLTHFDEFORMYL-RXN FORMATETHFLIG-RXN)
PRIMARIES - (1.5.1.20-RXN (METHYLENE-THF) NIL)
PRIMARIES - (DIHYDROFOLATESYNTH-RXN (7-8-DIHYDROPTEROATE) NIL)
PRIMARIES - (FORMATETHFLIG-RXN (FORMATE THF) NIL)
REACTION-LAYOUT - (DIHYDROFOLATESYNTH-RXN (:LEFT-PRIMARIES 7-8-DIHYDROPTEROATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIHYDROFOLATE))
REACTION-LAYOUT - (THYMIDYLATESYN-RXN (:LEFT-PRIMARIES METHYLENE-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIHYDROFOLATE))
REACTION-LAYOUT - (HOMOCYSMETB12-RXN (:LEFT-PRIMARIES 5-METHYL-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES THF))
REACTION-LAYOUT - (1.5.1.20-RXN (:LEFT-PRIMARIES 5-METHYL-THF) (:DIRECTION :R2L) (:RIGHT-PRIMARIES METHYLENE-THF))
REACTION-LAYOUT - (GCVMULTI-RXN (:LEFT-PRIMARIES THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES METHYLENE-THF))
REACTION-LAYOUT - (METHYLENETHFDEHYDROG-NADP-RXN (:LEFT-PRIMARIES METHYLENE-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-10-METHENYL-THF))
REACTION-LAYOUT - (GLYOHMETRANS-RXN (:LEFT-PRIMARIES THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES METHYLENE-THF))
REACTION-LAYOUT - (DIHYDROFOLATEREDUCT-RXN (:LEFT-PRIMARIES THF) (:DIRECTION :R2L) (:RIGHT-PRIMARIES DIHYDROFOLATE))
REACTION-LAYOUT - (FORMYLTHFDEFORMYL-RXN (:LEFT-PRIMARIES 10-FORMYL-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FORMATE THF))
REACTION-LAYOUT - (METHENYLTHFCYCLOHYDRO-RXN (:LEFT-PRIMARIES 5-10-METHENYL-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 10-FORMYL-THF))
REACTION-LAYOUT - (FORMATETHFLIG-RXN (:LEFT-PRIMARIES THF FORMATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 10-FORMYL-THF))
REACTION-LIST - DIHYDROFOLATESYNTH-RXN
REACTION-LIST - THYMIDYLATESYN-RXN
REACTION-LIST - HOMOCYSMETB12-RXN
REACTION-LIST - 1.5.1.20-RXN
REACTION-LIST - GCVMULTI-RXN
REACTION-LIST - METHYLENETHFDEHYDROG-NADP-RXN
REACTION-LIST - GLYOHMETRANS-RXN
REACTION-LIST - DIHYDROFOLATEREDUCT-RXN
REACTION-LIST - FORMYLTHFDEFORMYL-RXN
REACTION-LIST - METHENYLTHFCYCLOHYDRO-RXN
REACTION-LIST - FORMATETHFLIG-RXN
//
UNIQUE-ID - PWY-2161
TYPES - Folate-Biosynthesis
COMMON-NAME - folate polyglutamylation I
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CLASS-INSTANCE-LINKS - RXN0-2921
CLASS-INSTANCE-LINKS - FOLYLPOLYGLUTAMATESYNTH-RXN
CREDITS - SRI
CREDITS - |caspi|
POLYMERIZATION-LINKS - (FORMYL-THF-GLU-N FORMYLTHFGLUSYNTH-RXN FORMYLTHFGLUSYNTH-RXN)
POLYMERIZATION-LINKS - (METHYLENE-THF-GLU-N RXN0-2921 RXN0-2921)
POLYMERIZATION-LINKS - (THF-GLU-N FOLYLPOLYGLUTAMATESYNTH-RXN FOLYLPOLYGLUTAMATESYNTH-RXN)
PREDECESSORS - (FOLYLPOLYGLUTAMATESYNTH-RXN)
PREDECESSORS - (RXN0-2921 GLYOHMETRANS-RXN)
PREDECESSORS - (FORMYLTHFGLUSYNTH-RXN FORMATETHFLIG-RXN)
PREDECESSORS - (FORMATETHFLIG-RXN GLYOHMETRANS-RXN)
PREDECESSORS - (GLYOHMETRANS-RXN)
PRIMARIES - (FORMATETHFLIG-RXN (THF) (10-FORMYL-THF))
PRIMARIES - (GLYOHMETRANS-RXN (THF) (METHYLENE-THF))
REACTION-LAYOUT - (FORMYLTHFGLUSYNTH-RXN (:LEFT-PRIMARIES FORMYL-THF-GLU-N) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FORMYL-THF-GLU-N))
REACTION-LAYOUT - (RXN0-2921 (:LEFT-PRIMARIES METHYLENE-THF-GLU-N) (:DIRECTION :L2R) (:RIGHT-PRIMARIES METHYLENE-THF-GLU-N))
REACTION-LAYOUT - (FOLYLPOLYGLUTAMATESYNTH-RXN (:LEFT-PRIMARIES THF-GLU-N) (:DIRECTION :L2R) (:RIGHT-PRIMARIES THF-GLU-N))
REACTION-LAYOUT - (GLYOHMETRANS-RXN (:LEFT-PRIMARIES THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES METHYLENE-THF))
REACTION-LAYOUT - (FORMATETHFLIG-RXN (:LEFT-PRIMARIES THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 10-FORMYL-THF))
REACTION-LIST - FORMYLTHFGLUSYNTH-RXN
REACTION-LIST - RXN0-2921
REACTION-LIST - FOLYLPOLYGLUTAMATESYNTH-RXN
REACTION-LIST - GLYOHMETRANS-RXN
REACTION-LIST - FORMATETHFLIG-RXN
//
UNIQUE-ID - PWY-2161B
TYPES - Folate-Biosynthesis
COMMON-NAME - folate polyglutamylation II
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (|Folatepolyglutamate-n| PWY-2201)
PATHWAY-LINKS - (10-FORMYL-THF PWY-2201)
PATHWAY-LINKS - (THF FOLSYN-PWY)
PREDECESSORS - (RXN-3742 RXN-3741)
PREDECESSORS - (RXN-3741 RXN-3742)
PRIMARIES - (RXN-3741 (|Folatepolyglutamate-n| |Folatepolyglutamate-n|) (|Folatepolyglutamate-n|))
PRIMARIES - (RXN-3742 (|Folatepolyglutamate-n|) (|Folatepolyglutamate-n| |Folatepolyglutamate-n|))
REACTION-LAYOUT - (RXN-3742 (:LEFT-PRIMARIES GLT |Folatepolyglutamate-n|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Folatepolyglutamate-n|))
REACTION-LAYOUT - (RXN-3741 (:LEFT-PRIMARIES |Folatepolyglutamate-n|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Folatepolyglutamate-n| GLT))
REACTION-LIST - RXN-3742
REACTION-LIST - RXN-3741
//
UNIQUE-ID - PWY-2201
TYPES - Folate-Biosynthesis
COMMON-NAME - folate transformations
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (THF FOLSYN-PWY)
PREDECESSORS - (HOMOCYSMETB12-RXN RXN-5061)
PREDECESSORS - (2.1.1.19-RXN RXN-5061)
PREDECESSORS - (RXN-5061 GLYOHMETRANS-RXN)
PREDECESSORS - (HOMOCYSMETB12-RXN 1.5.1.20-RXN)
PREDECESSORS - (1.5.1.20-RXN GCVMULTI-RXN)
PREDECESSORS - (GCVMULTI-RXN 2.1.1.19-RXN)
PREDECESSORS - (2.1.1.19-RXN 1.5.1.20-RXN)
PREDECESSORS - (1.5.1.20-RXN GLYOHMETRANS-RXN)
PREDECESSORS - (5-FORMYL-THF-CYCLO-LIGASE-RXN 1.5.1.15-RXN)
PREDECESSORS - (1.5.1.15-RXN GLYOHMETRANS-RXN)
PREDECESSORS - (5-FORMYL-THF-CYCLO-LIGASE-RXN METHYLENETHFDEHYDROG-NADP-RXN)
PREDECESSORS - (METHYLENETHFDEHYDROG-NADP-RXN GLYOHMETRANS-RXN)
PREDECESSORS - (GLYOHMETRANS-RXN 2.1.1.19-RXN)
PREDECESSORS - (5-FORMYL-THF-CYCLO-LIGASE-RXN METHENYLTHFCYCLOHYDRO-RXN)
PREDECESSORS - (METHENYLTHFCYCLOHYDRO-RXN FORMATETHFLIG-RXN)
PREDECESSORS - (FORMATETHFLIG-RXN 2.1.1.19-RXN)
PREDECESSORS - (FORMYLTHFDEFORMYL-RXN FORMATETHFLIG-RXN)
PREDECESSORS - (GLYOHMETRANS-RXN FORMYLTHFDEFORMYL-RXN)
PREDECESSORS - (FORMATETHFLIG-RXN HOMOCYSMETB12-RXN)
PRIMARIES - (RXN-5061 (METHYLENE-THF) (5-METHYL-THF))
PRIMARIES - (METHYLENETHFDEHYDROG-NADP-RXN (METHYLENE-THF) (5-10-METHENYL-THF))
PRIMARIES - (METHENYLTHFCYCLOHYDRO-RXN (10-FORMYL-THF) (5-10-METHENYL-THF))
PRIMARIES - (HOMOCYSMETB12-RXN (5-METHYL-THF) (THF))
PRIMARIES - (GLYOHMETRANS-RXN (THF) (METHYLENE-THF))
PRIMARIES - (FORMYLTHFDEFORMYL-RXN (10-FORMYL-THF) (THF))
PRIMARIES - (FORMATETHFLIG-RXN (THF) (10-FORMYL-THF))
PRIMARIES - (5-FORMYL-THF-CYCLO-LIGASE-RXN (5-10-METHENYL-THF) (5-FORMYL-THF))
PRIMARIES - (2.1.1.19-RXN (5-METHYL-THF) (THF))
PRIMARIES - (1.5.1.20-RXN (METHYLENE-THF) (5-METHYL-THF))
PRIMARIES - (1.5.1.15-RXN (METHYLENE-THF) (5-10-METHENYL-THF))
REACTION-LAYOUT - (RXN-5061 (:LEFT-PRIMARIES 5-METHYL-THF) (:DIRECTION :R2L) (:RIGHT-PRIMARIES METHYLENE-THF))
REACTION-LAYOUT - (5-FORMYL-THF-CYCLO-LIGASE-RXN (:LEFT-PRIMARIES 5-FORMYL-THF) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 5-10-METHENYL-THF))
REACTION-LAYOUT - (1.5.1.15-RXN (:LEFT-PRIMARIES METHYLENE-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-10-METHENYL-THF))
REACTION-LAYOUT - (1.5.1.20-RXN (:LEFT-PRIMARIES 5-METHYL-THF) (:DIRECTION :R2L) (:RIGHT-PRIMARIES METHYLENE-THF))
REACTION-LAYOUT - (2.1.1.19-RXN (:LEFT-PRIMARIES THF) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 5-METHYL-THF))
REACTION-LAYOUT - (HOMOCYSMETB12-RXN (:LEFT-PRIMARIES 5-METHYL-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES THF))
REACTION-LAYOUT - (GCVMULTI-RXN (:LEFT-PRIMARIES THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES METHYLENE-THF))
REACTION-LAYOUT - (METHYLENETHFDEHYDROG-NADP-RXN (:LEFT-PRIMARIES METHYLENE-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-10-METHENYL-THF))
REACTION-LAYOUT - (GLYOHMETRANS-RXN (:LEFT-PRIMARIES THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES METHYLENE-THF))
REACTION-LAYOUT - (FORMYLTHFDEFORMYL-RXN (:LEFT-PRIMARIES 10-FORMYL-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES THF))
REACTION-LAYOUT - (METHENYLTHFCYCLOHYDRO-RXN (:LEFT-PRIMARIES 5-10-METHENYL-THF) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 10-FORMYL-THF))
REACTION-LAYOUT - (FORMATETHFLIG-RXN (:LEFT-PRIMARIES THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 10-FORMYL-THF))
REACTION-LIST - RXN-5061
REACTION-LIST - 5-FORMYL-THF-CYCLO-LIGASE-RXN
REACTION-LIST - 1.5.1.15-RXN
REACTION-LIST - 1.5.1.20-RXN
REACTION-LIST - 2.1.1.19-RXN
REACTION-LIST - HOMOCYSMETB12-RXN
REACTION-LIST - GCVMULTI-RXN
REACTION-LIST - METHYLENETHFDEHYDROG-NADP-RXN
REACTION-LIST - GLYOHMETRANS-RXN
REACTION-LIST - FORMYLTHFDEFORMYL-RXN
REACTION-LIST - METHENYLTHFCYCLOHYDRO-RXN
REACTION-LIST - FORMATETHFLIG-RXN
//
UNIQUE-ID - PWY-3841
TYPES - Folate-Biosynthesis
COMMON-NAME - formylTHF biosynthesis II
CITATIONS - :EV-COMP-AINF:3453644158:ave
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |hartmut|
POLYMERIZATION-LINKS - (FORMYL-THF-GLU-N FORMYLTHFGLUSYNTH-RXN FORMYLTHFGLUSYNTH-RXN)
POLYMERIZATION-LINKS - (THF-GLU-N FOLYLPOLYGLUTAMATESYNTH-RXN FOLYLPOLYGLUTAMATESYNTH-RXN)
PREDECESSORS - (5-FORMYL-THF-CYCLO-LIGASE-RXN RXN-6321)
PREDECESSORS - (METHENYLTHFCYCLOHYDRO-RXN 5-FORMYL-THF-CYCLO-LIGASE-RXN)
PREDECESSORS - (METHENYLTHFCYCLOHYDRO-RXN METHYLENETHFDEHYDROG-NADP-RXN)
PREDECESSORS - (METHYLENETHFDEHYDROG-NADP-RXN GLYOHMETRANS-RXN)
PREDECESSORS - (METHYLENETHFDEHYDROG-NADP-RXN GCVMULTI-RXN)
PREDECESSORS - (GLYOHMETRANS-RXN DIHYDROFOLATEREDUCT-RXN)
PREDECESSORS - (GCVMULTI-RXN DIHYDROFOLATEREDUCT-RXN)
PREDECESSORS - (DIHYDROFOLATEREDUCT-RXN DIHYDROFOLATESYNTH-RXN)
PREDECESSORS - (1.5.1.20-RXN GCVMULTI-RXN)
PREDECESSORS - (1.5.1.20-RXN GLYOHMETRANS-RXN)
PREDECESSORS - (THYMIDYLATESYN-RXN GCVMULTI-RXN)
PREDECESSORS - (THYMIDYLATESYN-RXN GLYOHMETRANS-RXN)
PREDECESSORS - (DIHYDROFOLATEREDUCT-RXN THYMIDYLATESYN-RXN)
PREDECESSORS - (RXN-6321 METHYLENETHFDEHYDROG-NADP-RXN)
PREDECESSORS - (RXN-6321 5-FORMYL-THF-CYCLO-LIGASE-RXN)
PREDECESSORS - (HOMOCYSMETB12-RXN 1.5.1.20-RXN)
PREDECESSORS - (FORMATETHFLIG-RXN HOMOCYSMETB12-RXN)
PREDECESSORS - (GCVMULTI-RXN HOMOCYSMETB12-RXN)
PREDECESSORS - (GLYOHMETRANS-RXN HOMOCYSMETB12-RXN)
PRIMARIES - (HOMOCYSMETB12-RXN (5-METHYL-THF) (THF))
PRIMARIES - (RXN-6321 (5-10-METHENYL-THF) (5-FORMYL-THF))
PRIMARIES - (5-FORMYL-THF-CYCLO-LIGASE-RXN (5-FORMYL-THF) (5-10-METHENYL-THF))
PRIMARIES - (FORMATETHFLIG-RXN (THF) (THF))
PRIMARIES - (THYMIDYLATESYN-RXN (METHYLENE-THF) (DIHYDROFOLATE))
PRIMARIES - (1.5.1.20-RXN (METHYLENE-THF) (5-METHYL-THF))
PRIMARIES - (METHENYLTHFCYCLOHYDRO-RXN (5-10-METHENYL-THF) (10-FORMYL-THF))
PRIMARIES - (METHYLENETHFDEHYDROG-NADP-RXN (METHYLENE-THF) (5-10-METHENYL-THF))
PRIMARIES - (GLYOHMETRANS-RXN (THF) (METHYLENE-THF))
PRIMARIES - (GCVMULTI-RXN (THF) (METHYLENE-THF))
PRIMARIES - (DIHYDROFOLATESYNTH-RXN (7-8-DIHYDROPTEROATE) (DIHYDROFOLATE))
PRIMARIES - (DIHYDROFOLATEREDUCT-RXN (DIHYDROFOLATE) (THF))
REACTION-LAYOUT - (HOMOCYSMETB12-RXN (:LEFT-PRIMARIES 5-METHYL-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES THF))
REACTION-LAYOUT - (RXN-6321 (:LEFT-PRIMARIES 5-10-METHENYL-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-FORMYL-THF))
REACTION-LAYOUT - (5-FORMYL-THF-CYCLO-LIGASE-RXN (:LEFT-PRIMARIES 5-FORMYL-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-10-METHENYL-THF))
REACTION-LAYOUT - (THYMIDYLATESYN-RXN (:LEFT-PRIMARIES METHYLENE-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIHYDROFOLATE))
REACTION-LAYOUT - (1.5.1.20-RXN (:LEFT-PRIMARIES 5-METHYL-THF) (:DIRECTION :R2L) (:RIGHT-PRIMARIES METHYLENE-THF))
REACTION-LAYOUT - (FORMATETHFLIG-RXN (:LEFT-PRIMARIES THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 10-FORMYL-THF))
REACTION-LAYOUT - (METHENYLTHFCYCLOHYDRO-RXN (:LEFT-PRIMARIES 5-10-METHENYL-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 10-FORMYL-THF))
REACTION-LAYOUT - (METHYLENETHFDEHYDROG-NADP-RXN (:LEFT-PRIMARIES METHYLENE-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-10-METHENYL-THF))
REACTION-LAYOUT - (GCVMULTI-RXN (:LEFT-PRIMARIES THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES METHYLENE-THF))
REACTION-LAYOUT - (GLYOHMETRANS-RXN (:LEFT-PRIMARIES THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES METHYLENE-THF))
REACTION-LAYOUT - (DIHYDROFOLATEREDUCT-RXN (:LEFT-PRIMARIES THF) (:DIRECTION :R2L) (:RIGHT-PRIMARIES DIHYDROFOLATE))
REACTION-LAYOUT - (DIHYDROFOLATESYNTH-RXN (:LEFT-PRIMARIES 7-8-DIHYDROPTEROATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIHYDROFOLATE))
REACTION-LIST - HOMOCYSMETB12-RXN
REACTION-LIST - RXN-6321
REACTION-LIST - 5-FORMYL-THF-CYCLO-LIGASE-RXN
REACTION-LIST - THYMIDYLATESYN-RXN
REACTION-LIST - 1.5.1.20-RXN
REACTION-LIST - FORMATETHFLIG-RXN
REACTION-LIST - METHENYLTHFCYCLOHYDRO-RXN
REACTION-LIST - METHYLENETHFDEHYDROG-NADP-RXN
REACTION-LIST - GCVMULTI-RXN
REACTION-LIST - GLYOHMETRANS-RXN
REACTION-LIST - DIHYDROFOLATEREDUCT-RXN
REACTION-LIST - DIHYDROFOLATESYNTH-RXN
//
UNIQUE-ID - PLPSAL-PWY
TYPES - Vitamin-B6-Biosynthesis
COMMON-NAME - pyridoxal 5'-phosphate salvage pathway
CITATIONS - :EV-COMP-AINF:3380892013:cjb
PREDECESSORS - (PYRIDOXKIN-RXN)
PREDECESSORS - (PMPOXI-RXN PYRAMKIN-RXN)
PREDECESSORS - (PNPOXI-RXN PNKIN-RXN)
REACTION-LAYOUT - (PYRIDOXKIN-RXN (:LEFT-PRIMARIES PYRIDOXAL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRIDOXAL_PHOSPHATE))
REACTION-LAYOUT - (PMPOXI-RXN (:LEFT-PRIMARIES PYRIDOXAMINE-5P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRIDOXAL_PHOSPHATE))
REACTION-LAYOUT - (PNPOXI-RXN (:LEFT-PRIMARIES PYRIDOXINE-5P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRIDOXAL_PHOSPHATE))
REACTION-LAYOUT - (PYRAMKIN-RXN (:LEFT-PRIMARIES PYRIDOXAMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRIDOXAMINE-5P))
REACTION-LAYOUT - (PNKIN-RXN (:LEFT-PRIMARIES PYRIDOXINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRIDOXINE-5P))
REACTION-LIST - PYRIDOXKIN-RXN
REACTION-LIST - PMPOXI-RXN
REACTION-LIST - PNPOXI-RXN
REACTION-LIST - PYRAMKIN-RXN
REACTION-LIST - PNKIN-RXN
SYNONYMS - vitamin B<sub>6</sub> salvage
//
UNIQUE-ID - PWY-6030
TYPES - HORMONE-SYN
COMMON-NAME - serotonin and melatonin biosynthesis
CITATIONS - :EV-COMP-AINF:3453644158:ave
CREDITS - O3DJ-6
CREDITS - AU3DJ-15
PREDECESSORS - (ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN RXN3DJ-35528)
PREDECESSORS - (RXN3DJ-35528 RXN3DJ-170)
PREDECESSORS - (RXN3DJ-170 TRYPTOPHAN-5-MONOOXYGENASE-RXN)
REACTION-LAYOUT - (TRYPTOPHAN-5-MONOOXYGENASE-RXN (:LEFT-PRIMARIES TRP TETRA-H-BIOPTERIN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-HYDROXY-TRYPTOPHAN))
REACTION-LAYOUT - (RXN3DJ-170 (:LEFT-PRIMARIES 5-HYDROXY-TRYPTOPHAN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SEROTONIN))
REACTION-LAYOUT - (RXN3DJ-35528 (:LEFT-PRIMARIES SEROTONIN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES N-ACETYL-SEROTONIN))
REACTION-LAYOUT - (ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN (:LEFT-PRIMARIES N-ACETYL-SEROTONIN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES N-ACETYL-5-METHOXY-TRYPTAMINE))
REACTION-LIST - TRYPTOPHAN-5-MONOOXYGENASE-RXN
REACTION-LIST - RXN3DJ-170
REACTION-LIST - RXN3DJ-35528
REACTION-LIST - ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN
//
UNIQUE-ID - PWY3DJ-2
TYPES - HORMONE-SYN
COMMON-NAME - biosynthesis of estrogens
CREDITS - AU3DJ-7
ENZYMES-NOT-USED - |MGI:88584-MONOMER|
PATHWAY-LINKS - (CHOLESTEROL PWY66-341)
PREDECESSORS - (ESTRONE-SULFOTRANSFERASE-RXN RXN3DJ-34329)
PREDECESSORS - (ESTRADIOL-17-BETA-DEHYDROGENASE-RXN RXN3DJ-34329)
PREDECESSORS - (RXN3DJ-34329 RXN3DJ-34318)
PREDECESSORS - (RXN3DJ-34318 RXN3DJ-26)
PREDECESSORS - (RXN3DJ-26 4.1.2.30-RXN)
PREDECESSORS - (4.1.2.30-RXN RXN3DJ-32)
PREDECESSORS - (RXN3DJ-32 RXN3DJ-22)
PREDECESSORS - (RXN3DJ-22 1.14.15.6-RXN)
PRIMARIES - (ESTRONE-SULFOTRANSFERASE-RXN (ESTRONE) (ESTRONE-SULFATE))
PRIMARIES - (4.1.2.30-RXN (17-ALPHA-HYDROXYPROGESTERONE) (ANDROST4ENE))
PRIMARIES - (1.14.15.6-RXN (CHOLESTEROL) (PREGNENOLONE))
REACTION-LAYOUT - (4.1.2.30-RXN (:LEFT-PRIMARIES 17-ALPHA-HYDROXYPROGESTERONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ANDROST4ENE))
REACTION-LAYOUT - (ESTRONE-SULFOTRANSFERASE-RXN (:LEFT-PRIMARIES ESTRONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ESTRONE-SULFATE))
REACTION-LAYOUT - (ESTRADIOL-17-BETA-DEHYDROGENASE-RXN (:LEFT-PRIMARIES CPD-352) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ESTRONE))
REACTION-LAYOUT - (RXN3DJ-34329 (:LEFT-PRIMARIES CPD3DJ-34313) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ESTRONE))
REACTION-LAYOUT - (RXN3DJ-34318 (:LEFT-PRIMARIES CPD3DJ-5) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD3DJ-34313))
REACTION-LAYOUT - (RXN3DJ-26 (:LEFT-PRIMARIES ANDROST4ENE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD3DJ-5))
REACTION-LAYOUT - (RXN3DJ-32 (:LEFT-PRIMARIES 17-ALPHA20-ALPHA-DIHYDROXYPREGN-4-EN-3-) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 17-ALPHA-HYDROXYPROGESTERONE))
REACTION-LAYOUT - (RXN3DJ-22 (:LEFT-PRIMARIES PREGNENOLONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 17-ALPHA20-ALPHA-DIHYDROXYPREGN-4-EN-3-))
REACTION-LAYOUT - (1.14.15.6-RXN (:LEFT-PRIMARIES CHOLESTEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PREGNENOLONE))
REACTION-LIST - 4.1.2.30-RXN
REACTION-LIST - ESTRONE-SULFOTRANSFERASE-RXN
REACTION-LIST - ESTRADIOL-17-BETA-DEHYDROGENASE-RXN
REACTION-LIST - RXN3DJ-34329
REACTION-LIST - RXN3DJ-34318
REACTION-LIST - RXN3DJ-26
REACTION-LIST - RXN3DJ-32
REACTION-LIST - RXN3DJ-22
REACTION-LIST - 1.14.15.6-RXN
//
UNIQUE-ID - PWY3DJ-35583
TYPES - HORMONE-SYN
COMMON-NAME - biosynthesis of prostaglandins
CITATIONS - 11729303
CITATIONS - 7754369
CITATIONS - 9618293
CITATIONS - 10484490
CITATIONS - 11729303:EV-EXP:3431340116:ave
COMMENT - Prostaglandins are potent lipid mediators derived from arachidonic acid that are involved in numerous homeostatic
/biological functions and inflammation.  Prostaglandins are formed by most cells in our bodies and act as autocrine
/and paracrine lipid mediators.  They are not stored but are synthesized <I>de novo</I> from membrane-released arachidonic
/acid when cells are activated by mechanical trauma or by specific cytokine, growth factor, and other stimuli |CITS: [11729303]|.
/
/At physiologic pH, prostaglandins traverse biologic membranes poorly. Accordingly, PG transport is carrier-mediated
/in many tissues.  The prostaglandin transporter, <A href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=full_report&list_uids=24546"><I>Slco2a1</I></A>, was first cloned in rats |CITS: [7754369]|.  Subsequently, the human |CITS: [9618293]|
/and mouse |CITS: [10484490]| prostaglandin transporters were cloned.
CREDITS - O3DJ-6
CREDITS - AU3DJ-15
CREDITS - AU3DJ-34097
PREDECESSORS - (RXN3DJ-35846 RXN3DJ-35600)
PREDECESSORS - (PROSTAGLANDIN-E-SYNTHASE-RXN RXN3DJ-35600)
PREDECESSORS - (PROSTAGLANDIN-D-SYNTHASE-RXN RXN3DJ-35600)
PREDECESSORS - (THROMBOXANE-A-SYNTHASE-RXN RXN3DJ-35600)
PREDECESSORS - (PROSTAGLANDIN-I-SYNTHASE-RXN RXN3DJ-35600)
PREDECESSORS - (RXN3DJ-35600 PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN)
REACTION-LAYOUT - (RXN3DJ-35846 (:LEFT-PRIMARIES PROSTAGLANDIN-H2) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5Z13E-15S-9-ALPHA11-ALPHA15-TRIHY))
REACTION-LAYOUT - (PROSTAGLANDIN-E-SYNTHASE-RXN (:LEFT-PRIMARIES PROSTAGLANDIN-H2) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5Z13E-15S-11-ALPHA15-DIHYDROXY-9-O))
REACTION-LAYOUT - (PROSTAGLANDIN-D-SYNTHASE-RXN (:LEFT-PRIMARIES PROSTAGLANDIN-H2) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O))
REACTION-LAYOUT - (THROMBOXANE-A-SYNTHASE-RXN (:LEFT-PRIMARIES PROSTAGLANDIN-H2) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALPHA11-ALPHA-EPOXY-15-HYDROXYTHROMBA))
REACTION-LAYOUT - (PROSTAGLANDIN-I-SYNTHASE-RXN (:LEFT-PRIMARIES PROSTAGLANDIN-H2) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA))
REACTION-LAYOUT - (RXN3DJ-35600 (:LEFT-PRIMARIES CPD3DJ-35588) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PROSTAGLANDIN-H2))
REACTION-LAYOUT - (PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN (:LEFT-PRIMARIES ARACHIDONIC_ACID) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PROSTAGLANDIN-H2))
REACTION-LIST - RXN3DJ-35846
REACTION-LIST - PROSTAGLANDIN-E-SYNTHASE-RXN
REACTION-LIST - PROSTAGLANDIN-D-SYNTHASE-RXN
REACTION-LIST - THROMBOXANE-A-SYNTHASE-RXN
REACTION-LIST - PROSTAGLANDIN-I-SYNTHASE-RXN
REACTION-LIST - RXN3DJ-35600
REACTION-LIST - PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN
//
UNIQUE-ID - PWY3DJ-4
TYPES - HORMONE-SYN
COMMON-NAME - biosynthesis of corticosteroids
ENZYMES-NOT-USED - |MGI:88584-MONOMER|
PATHWAY-LINKS - (CHOLESTEROL PWY66-341)
PREDECESSORS - (RXN3DJ-3848 RXN3DJ-74)
PREDECESSORS - (RXN3DJ-34330 CORTICOSTERONE-18-MONOOXYGENASE-RXN)
PREDECESSORS - (CORTICOSTERONE-18-MONOOXYGENASE-RXN RXN3DJ-15615)
PREDECESSORS - (RXN3DJ-15615 RXN3DJ-3848)
PREDECESSORS - (RXN3DJ-3848 RXN3DJ-3803)
PREDECESSORS - (RXN3DJ-3803 1.14.15.6-RXN)
PRIMARIES - (RXN3DJ-3848 (PROGESTERONE NADPH) (11-DEOXYCORTICOSTERONE))
PRIMARIES - (RXN3DJ-34330 (18-HYDROXYCORTICOSTERONE) (ALDOSTERONE))
PRIMARIES - (CORTICOSTERONE-18-MONOOXYGENASE-RXN (CORTICOSTERONE) (18-HYDROXYCORTICOSTERONE))
PRIMARIES - (RXN3DJ-15615 (11-DEOXYCORTICOSTERONE) (CORTICOSTERONE))
REACTION-LAYOUT - (RXN3DJ-74 (:LEFT-PRIMARIES GLC-6-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NADPH))
REACTION-LAYOUT - (CORTICOSTERONE-18-MONOOXYGENASE-RXN (:LEFT-PRIMARIES CORTICOSTERONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 18-HYDROXYCORTICOSTERONE))
REACTION-LAYOUT - (RXN3DJ-34330 (:LEFT-PRIMARIES 18-HYDROXYCORTICOSTERONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALDOSTERONE))
REACTION-LAYOUT - (RXN3DJ-15615 (:LEFT-PRIMARIES 11-DEOXYCORTICOSTERONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CORTICOSTERONE))
REACTION-LAYOUT - (RXN3DJ-3848 (:LEFT-PRIMARIES NADPH PROGESTERONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 11-DEOXYCORTICOSTERONE))
REACTION-LAYOUT - (RXN3DJ-3803 (:LEFT-PRIMARIES PREGNENOLONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PROGESTERONE))
REACTION-LAYOUT - (1.14.15.6-RXN (:LEFT-PRIMARIES CHOLESTEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PREGNENOLONE))
REACTION-LIST - RXN3DJ-74
REACTION-LIST - CORTICOSTERONE-18-MONOOXYGENASE-RXN
REACTION-LIST - RXN3DJ-34330
REACTION-LIST - RXN3DJ-15615
REACTION-LIST - RXN3DJ-3848
REACTION-LIST - RXN3DJ-3803
REACTION-LIST - 1.14.15.6-RXN
//
UNIQUE-ID - PWY3DJ-5
TYPES - HORMONE-SYN
COMMON-NAME - biosynthesis of serotonin and melatonin
CITATIONS - 16615082
CITATIONS - 15247473
CITATIONS - 16601191
CITATIONS - 17182745
CITATIONS - 9674691
CITATIONS - 3941912
CITATIONS - 16615082:EV-EXP-TAS:3435070827:ave
CITATIONS - 3941912:EV-EXP-IMP:3435070864:ave
COMMENT - Serotonin is a neurotransmitter that regulates sleep, anxiety, alcoholism, drug abuse, food intake, and sexual behavior 
/|CITS: [16615082]|.  In the central nervous system tryptophan hydroxylase 2  is a rate-limiting enzyme for
/serotonin biosynthesis |CITS: [15247473]|.  On the other hand, tryptophan hydroxylase 1 is a rate-limiting
/enzyme in the synthesis of "peripheral" serotonin, which is believed to act as a mitogen |CITS: [16601191]|.
/Circulating maternal serotonin is important for normal embryonic development in mice |CITS: [17182745]|.
/
/Melatonin is a "circadian rhythm" hormone regulating a number of different functions |CITS: [9674691]|.  It is
/synthesized in pineal gland in the same pathway as serotonin, by sequential action of serotonin N-acetyltransferase
/and acetylserotonin methyltransferase enzymes.  A number of inbred strains of mice, including C57BL/6J, lack
/one or both of these enzymes due to mutations in corresponding genes and are unable to synthesize melatonin |CITS: [3941912]|.
CREDITS - O3DJ-6
CREDITS - AU3DJ-15
CREDITS - AU3DJ-34097
PREDECESSORS - (ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN RXN3DJ-35528)
PREDECESSORS - (RXN3DJ-35528 RXN3DJ-170)
PREDECESSORS - (RXN3DJ-170 TRYPTOPHAN-5-MONOOXYGENASE-RXN)
PRIMARIES - (TRYPTOPHAN-5-MONOOXYGENASE-RXN (TRP) (5-HYDROXY-TRYPTOPHAN))
REACTION-LAYOUT - (ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN (:LEFT-PRIMARIES N-ACETYL-SEROTONIN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES N-ACETYL-5-METHOXY-TRYPTAMINE))
REACTION-LAYOUT - (RXN3DJ-35528 (:LEFT-PRIMARIES SEROTONIN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES N-ACETYL-SEROTONIN))
REACTION-LAYOUT - (RXN3DJ-170 (:LEFT-PRIMARIES 5-HYDROXY-TRYPTOPHAN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SEROTONIN))
REACTION-LAYOUT - (TRYPTOPHAN-5-MONOOXYGENASE-RXN (:LEFT-PRIMARIES TRP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-HYDROXY-TRYPTOPHAN))
REACTION-LIST - ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN
REACTION-LIST - RXN3DJ-35528
REACTION-LIST - RXN3DJ-170
REACTION-LIST - TRYPTOPHAN-5-MONOOXYGENASE-RXN
//
UNIQUE-ID - PWY3DJ-8
TYPES - HORMONE-SYN
COMMON-NAME - biosynthesis of androgens
CREDITS - AU3DJ-7
ENZYMES-NOT-USED - |MGI:88584-MONOMER|
PATHWAY-LINKS - (CHOLESTEROL PWY66-341)
PREDECESSORS - (1.1.1.64-RXN 4.1.2.30-RXN)
PREDECESSORS - (4.1.2.30-RXN RXN3DJ-34)
PREDECESSORS - (RXN3DJ-34 RXN3DJ-23)
PREDECESSORS - (RXN3DJ-23 1.14.15.6-RXN)
PRIMARIES - (ESTRONE-SULFOTRANSFERASE-RXN (ESTRONE) (ESTRONE-SULFATE))
PRIMARIES - (4.1.2.30-RXN (17-ALPHA-HYDROXYPROGESTERONE) (ANDROST4ENE))
PRIMARIES - (1.14.15.6-RXN (CHOLESTEROL) (PREGNENOLONE))
REACTION-LAYOUT - (4.1.2.30-RXN (:LEFT-PRIMARIES 17-ALPHA-HYDROXYPROGESTERONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ANDROST4ENE))
REACTION-LAYOUT - (1.1.1.64-RXN (:LEFT-PRIMARIES TESTOSTERONE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ANDROST4ENE))
REACTION-LAYOUT - (RXN3DJ-34 (:LEFT-PRIMARIES CPD3DJ-19) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 17-ALPHA-HYDROXYPROGESTERONE))
REACTION-LAYOUT - (RXN3DJ-23 (:LEFT-PRIMARIES PREGNENOLONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD3DJ-19))
REACTION-LAYOUT - (1.14.15.6-RXN (:LEFT-PRIMARIES CHOLESTEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PREGNENOLONE))
REACTION-LIST - 4.1.2.30-RXN
REACTION-LIST - 1.1.1.64-RXN
REACTION-LIST - RXN3DJ-34
REACTION-LIST - RXN3DJ-23
REACTION-LIST - 1.14.15.6-RXN
//
UNIQUE-ID - PWY66-301
TYPES - HORMONE-SYN
COMMON-NAME - catecholamine biosynthesis
CITATIONS - 6143403
CITATIONS - 7715703
CITATIONS - :EV-COMP-AINF:3380892013:cjb
COMMENT - Catecholamines, or "stress hormones", regulate multiple physiological processes both as neurotransmitters and blood-circulating hormones [1].  Mice homozygous for the tyrosine hydroxylase (Th),  which regulates the first (and rate-limiting) step in this pathway, die during mid-gestation (between  day11.5 and 15.5) [2].
CREDITS - |steininger|
CREDITS - SRI
PREDECESSORS - (RXN66-241 DOPAMINE-BETA-MONOOXYGENASE-RXN)
PREDECESSORS - (DOPAMINE-BETA-MONOOXYGENASE-RXN RXN66-221)
PREDECESSORS - (RXN66-221 TYROSINE-3-MONOOXYGENASE-RXN)
REACTION-LAYOUT - (RXN66-241 (:LEFT-PRIMARIES NOREPINEPHRINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-EPINEPHRINE))
REACTION-LAYOUT - (DOPAMINE-BETA-MONOOXYGENASE-RXN (:LEFT-PRIMARIES DOPAMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NOREPINEPHRINE))
REACTION-LAYOUT - (TYROSINE-3-MONOOXYGENASE-RXN (:LEFT-PRIMARIES TYR TETRA-H-BIOPTERIN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-DIHYDROXY-PHENYLALANINE))
REACTION-LAYOUT - (RXN66-221 (:LEFT-PRIMARIES L-DIHYDROXY-PHENYLALANINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DOPAMINE))
REACTION-LIST - RXN66-241
REACTION-LIST - DOPAMINE-BETA-MONOOXYGENASE-RXN
REACTION-LIST - TYROSINE-3-MONOOXYGENASE-RXN
REACTION-LIST - RXN66-221
SYNONYMS - dopamine biosynthesis
SYNONYMS - noradrenaline biosynthesis
SYNONYMS - adrenaline biosynthesis
//
UNIQUE-ID - PWY-5142
TYPES - Lipid-Biosynthesis
COMMON-NAME - acyl-ACP thioesterase pathway
CITATIONS - :EV-COMP-AINF:3422805052:ave
PATHWAY-LINKS - (|Fatty-Acids| PWY-5143)
PREDECESSORS - (RXN-7902)
PRIMARIES - (RXN-7902 (ACYL-ACP) (|Fatty-Acids|))
REACTION-LAYOUT - (RXN-7902 (:LEFT-PRIMARIES ACYL-ACP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Fatty-Acids|))
REACTION-LIST - RXN-7902
//
UNIQUE-ID - PWY-5143
TYPES - Lipid-Biosynthesis
COMMON-NAME - fatty acid activation
CITATIONS - :EV-COMP-AINF:3442068425:ave
CREDITS - SRI
CREDITS - |caspi|
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |zhang|
PATHWAY-LINKS - (|Fatty-Acyl-CoA| PWY-5080 PWY-282 PWY-5129 TRIGLSYN-PWY)
PATHWAY-LINKS - (|Fatty-Acids| LIPAS-PWY PWY-5142)
PREDECESSORS - (RXN-7904)
PRIMARIES - (RXN-7904 (|Fatty-Acids|) (|Fatty-Acyl-CoA|))
REACTION-LAYOUT - (RXN-7904 (:LEFT-PRIMARIES |Fatty-Acids|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Fatty-Acyl-CoA|))
REACTION-LIST - RXN-7904
SYNONYMS - acyl-CoA synthetase pathway
//
UNIQUE-ID - PWY-5148
TYPES - Lipid-Biosynthesis
COMMON-NAME - acyl-CoA hydrolysis
PREDECESSORS - (THIOESTER-RXN)
PRIMARIES - (THIOESTER-RXN (|Saturated-Fatty-Acyl-CoA|) (|Fatty-Acids|))
REACTION-LAYOUT - (THIOESTER-RXN (:LEFT-PRIMARIES |Saturated-Fatty-Acyl-CoA|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Fatty-Acids|))
REACTION-LIST - THIOESTER-RXN
SYNONYMS - acyl-CoA thioesterase pathway
//
UNIQUE-ID - PWY-5884
TYPES - Lipid-Biosynthesis
COMMON-NAME - wax esters biosynthesis I
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - O-27
CREDITS - |pujar|
PREDECESSORS - (2.3.1.75-RXN RXN-9344)
PREDECESSORS - (RXN-9344 RXN-1026)
PRIMARIES - (RXN-9344 (VERY-LONG-CHAIN-FATTY-ACYL-COA) (ACYL-COA |a-long-chain-alcohol|))
PRIMARIES - (2.3.1.75-RXN (|a-long-chain-alcohol|) (|a-long-chain-ester|))
PRIMARIES - (RXN-1026 (|Fatty-Acyl-CoA|) (VERY-LONG-CHAIN-FATTY-ACYL-COA))
REACTION-LAYOUT - (RXN-9344 (:LEFT-PRIMARIES VERY-LONG-CHAIN-FATTY-ACYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |a-long-chain-alcohol|))
REACTION-LAYOUT - (2.3.1.75-RXN (:LEFT-PRIMARIES |a-long-chain-alcohol|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |a-long-chain-ester|))
REACTION-LAYOUT - (RXN-1026 (:LEFT-PRIMARIES |Fatty-Acyl-CoA|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES VERY-LONG-CHAIN-FATTY-ACYL-COA))
REACTION-LIST - RXN-9344
REACTION-LIST - 2.3.1.75-RXN
REACTION-LIST - RXN-1026
SYNONYMS - jojoba wax biosynthesis
SYNONYMS - liquid seed wax biosynthesis
//
UNIQUE-ID - PWY-5885
TYPES - Lipid-Biosynthesis
COMMON-NAME - wax esters biosynthesis II
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - O-27
CREDITS - |pujar|
PATHWAY-LINKS - (|Triacylglycerols| TRIGLSYN-PWY)
PREDECESSORS - (RXN-9356 DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN)
PRIMARIES - (RXN-9356 (CPD-9965) (CPD-9966))
PRIMARIES - (DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN (DIACYLGLYCEROL) (|Triacylglycerols|))
PRIMARIES - (2.3.1.75-RXN (ACYL-COA) (CO-A))
REACTION-LAYOUT - (RXN-9356 (:LEFT-PRIMARIES CPD-9965) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CO-A |Medium-Chain-Esters|))
REACTION-LAYOUT - (DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN (:LEFT-PRIMARIES DIACYLGLYCEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CO-A |Triacylglycerols|))
REACTION-LIST - RXN-9356
REACTION-LIST - DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN
SYNONYMS - WS/DGAT biosynthesis
SYNONYMS - petunia wax biosynthesis
//
UNIQUE-ID - PWY0-1264
TYPES - Lipid-Biosynthesis
COMMON-NAME - biotin-carboxyl carrier protein assembly
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (RXN0-5055 BIOTIN-CARBOXYL-RXN)
PREDECESSORS - (BIOTIN-CARBOXYL-RXN RXN-7101)
PREDECESSORS - (RXN-7101 BIOTINLIG-RXN)
PREDECESSORS - (BIOTIN-CARBOXYL-RXN RXN0-5055)
PRIMARIES - (RXN0-5055 NIL (|BCCP-dimers|))
PRIMARIES - (BIOTINLIG-RXN (|BCCP-monomers|) NIL)
REACTION-LAYOUT - (RXN0-5055 (:LEFT-PRIMARIES |Carboxybiotin-BCCP|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |BCCP-dimers|))
REACTION-LAYOUT - (BIOTIN-CARBOXYL-RXN (:LEFT-PRIMARIES |BCCP-dimers|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Carboxybiotin-BCCP|))
REACTION-LAYOUT - (RXN-7101 (:LEFT-PRIMARIES |BCCP-biotin-monomers|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |BCCP-dimers|))
REACTION-LAYOUT - (BIOTINLIG-RXN (:LEFT-PRIMARIES |BCCP-monomers|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |BCCP-biotin-monomers|))
REACTION-LIST - RXN0-5055
REACTION-LIST - BIOTIN-CARBOXYL-RXN
REACTION-LIST - RXN-7101
REACTION-LIST - BIOTINLIG-RXN
SYNONYMS - BCCP assembly
//
UNIQUE-ID - PWY3DJ-11281
TYPES - Lipid-Biosynthesis
COMMON-NAME - sphingomyelin metabolism
CITATIONS - 2187537
CITATIONS - 8086039
CITATIONS - :EV-AS:3430061352:ave
COMMENT - Sphingomyelin is found in all tissues and lipoproteins; for example, it accounts for ~5% of the lipid phosphate in
/liver and 25% in pancreas|CITS: [2187537]|.
/Sphingomyelin has a function in signal transduction|CITS: [8086039]|.  The plasma membrane of cells is highly
/enriched in sphingomyelin and is considered largely to be found in the exoplasmic leaflet of the cell membrane.
/However, there is some evidence that there may also be a sphingomyelin pool in the inner leaflet of the membrane|CITS: [2187537]|.  
/Moreover, neutral sphingomyelinase-2 - an enzyme that breaks down sphingomyelin into ceramide has been found
/to localise exclusively to the inner leaflet further suggesting that there may be sphingomyelin present there.
/Sphingomyelin can accumulate in a rare hereditary disease called <A href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=257200">Niemann-Pick Disease</A>.  It is
/caused by a deficiency in the enzyme sphingomyelinase, which causes the accumulation of sphingomyelin in
/spleen, liver, lungs, bone marrow, and the brain, causing irreversible neurological damage.
CREDITS - O3DJ-6
CREDITS - AU3DJ-15
PATHWAY-LINKS - (|Ceramides| PWY3DJ-11470)
PATHWAY-LINKS - (|Ceramides| PWY3DJ-12)
PREDECESSORS - (2.7.8.27-RXN SPHINGOMYELIN-PHOSPHODIESTERASE-RXN)
PREDECESSORS - (SPHINGOMYELIN-PHOSPHODIESTERASE-RXN 2.7.8.27-RXN)
PRIMARIES - (2.7.8.27-RXN (|Ceramides|) NIL)
PRIMARIES - (SPHINGOMYELIN-PHOSPHODIESTERASE-RXN NIL (|Ceramides|))
PRIMARIES - (CERAMIDE-CHOLINEPHOSPHOTRANSFERASE-RXN (|Ceramides|) NIL)
REACTION-LAYOUT - (2.7.8.27-RXN (:LEFT-PRIMARIES |Ceramides|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Sphingomyelins|))
REACTION-LAYOUT - (SPHINGOMYELIN-PHOSPHODIESTERASE-RXN (:LEFT-PRIMARIES |Sphingomyelins|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Ceramides|))
REACTION-LIST - 2.7.8.27-RXN
REACTION-LIST - SPHINGOMYELIN-PHOSPHODIESTERASE-RXN
//
UNIQUE-ID - PWY3DJ-11470
TYPES - Lipid-Biosynthesis
COMMON-NAME - sphingosine and sphingosine-1-phosphate metabolism
CITATIONS - 15258913
CITATIONS - 12531549
CITATIONS - :EV-AS:3430061378:ave
COMMENT - In this pathway, ceramide, the breakdown product of sphingomyelin, is metabolized by ceramidase to generate
/sphingosine, which has been shown to be produced during the early stages of apoptosis; sphingosine itself is capable
/of inducing apoptosis when added exogenously to many cell types |CITS: [12531549]|. Sphingosine phosphorylation
/produces sphingosine 1-phosphate (S1P), a sphingolipid that regulates cell migration, survival, differentiation,
/angiogenesis, and development. S1P has been shown to activate an extracellular signaling pathway mediated
/through a family of specific G protein-coupled receptors. However, evidence indicates that S1P also mediates effects
/through a receptor-independent mechanism by functioning as a second messenger within cells. Intracellular S1P
/levels are regulated primarily by three highly conserved enzymes: sphingosine kinase (SPHK), which catalyzes the
/phosphorylation of sphingosine-producing S1P, S1P phosphatase (S1PP), which reverses the former reaction,
/and S1P lyase (SPL), a PLP-dependent enzyme that catalyzes the essentially irreversible cleavage of S1P at the
/C2-3 carboncarbon bond, yielding ethanolamine phosphate and a long-chain aldehyde |CITS: [15258913]|.
CREDITS - O3DJ-6
CREDITS - AU3DJ-15
PATHWAY-LINKS - (|Ceramides| (PWY3DJ-11281 . :INCOMING))
PREDECESSORS - (RXN3DJ-11417 CERAMIDASE-RXN)
PREDECESSORS - (2-HEXADECENAL-REDUCTASE-RXN RXN3DJ-11230)
PREDECESSORS - (RXN3DJ-25 RXN3DJ-11417)
PREDECESSORS - (RXN3DJ-11417 RXN3DJ-25)
PREDECESSORS - (RXN3DJ-11230 RXN3DJ-25)
PREDECESSORS - (RXN3DJ-11230 RXN3DJ-11417)
PRIMARIES - (RXN3DJ-25 (CPD3DJ-11366) (SPHINGOSINE))
PRIMARIES - (RXN3DJ-11230 (CPD3DJ-11366) (CPD-292))
REACTION-LAYOUT - (CERAMIDASE-RXN (:LEFT-PRIMARIES |Ceramides|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SPHINGOSINE))
REACTION-LAYOUT - (2-HEXADECENAL-REDUCTASE-RXN (:LEFT-PRIMARIES PALMITALDEHYDE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CPD-292))
REACTION-LAYOUT - (RXN3DJ-25 (:LEFT-PRIMARIES CPD3DJ-11366) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SPHINGOSINE))
REACTION-LAYOUT - (RXN3DJ-11230 (:LEFT-PRIMARIES CPD3DJ-11366) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-292))
REACTION-LAYOUT - (RXN3DJ-11417 (:LEFT-PRIMARIES SPHINGOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD3DJ-11366))
REACTION-LIST - CERAMIDASE-RXN
REACTION-LIST - 2-HEXADECENAL-REDUCTASE-RXN
REACTION-LIST - RXN3DJ-25
REACTION-LIST - RXN3DJ-11230
REACTION-LIST - RXN3DJ-11417
//
UNIQUE-ID - PWY3DJ-12
TYPES - Fatty-Acid-and-Lipid-Degradation
TYPES - Lipid-Biosynthesis
COMMON-NAME - ceramide biosynthesis
CITATIONS - 10652518
CITATIONS - 12531549
CITATIONS - :EV-AS:3430061304:ave
COMMENT - Ceramide receives a lot of attention as a potential endogenous mediator of apoptosis in response to cytokines,
/antigens, anticancer drugs, or environmental stress inducers |CITS: [10652518]|. These diverse stimuli can induce
/sphingomyelin hydrolysis accompanied by the accumulation of ceramide, which occurs before morphological changes.
/In addition, administration of exogenous ceramide analogs can mimic apoptotic cell death. These observations led to
/the proposal that ceramide has a key role in apoptosis signaling |CITS: [12531549]|.
CREDITS - O3DJ-6
CREDITS - AU3DJ-15
PATHWAY-LINKS - (|Ceramides| PWY3DJ-11281)
PREDECESSORS - (RXN3DJ-11100 RXN3DJ-118)
PREDECESSORS - (RXN3DJ-118 3-DEHYDROSPHINGANINE-REDUCTASE-RXN)
PREDECESSORS - (3-DEHYDROSPHINGANINE-REDUCTASE-RXN SERINE-C-PALMITOYLTRANSFERASE-RXN)
PRIMARIES - (CERAMIDASE-RXN (|Ceramides|) (SPHINGOSINE))
PRIMARIES - (RXN3DJ-118 (DIHYDRO-SPHINGOSINE) (CPD3DJ-82))
PRIMARIES - (SERINE-C-PALMITOYLTRANSFERASE-RXN (PALMITYL-COA) (DEHYDROSPHINGANINE))
PRIMARIES - (CERAMIDASE-YEAST-RXN NIL (PHYTOSPINGOSINE))
PRIMARIES - (RXN3O-328 (PHYTOSPINGOSINE) NIL)
PRIMARIES - (DHS-PHOSPHATASE-RXN (CPD-649) (DIHYDRO-SPHINGOSINE))
PRIMARIES - (RXN3O-1380 (DIHYDRO-SPHINGOSINE) (PHYTOSPINGOSINE))
REACTION-LAYOUT - (RXN3DJ-11100 (:LEFT-PRIMARIES CPD3DJ-82) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Ceramides|))
REACTION-LAYOUT - (RXN3DJ-118 (:LEFT-PRIMARIES DIHYDRO-SPHINGOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD3DJ-82))
REACTION-LAYOUT - (3-DEHYDROSPHINGANINE-REDUCTASE-RXN (:LEFT-PRIMARIES DIHYDRO-SPHINGOSINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES DEHYDROSPHINGANINE))
REACTION-LAYOUT - (SERINE-C-PALMITOYLTRANSFERASE-RXN (:LEFT-PRIMARIES PALMITYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DEHYDROSPHINGANINE))
REACTION-LIST - RXN3DJ-11100
REACTION-LIST - RXN3DJ-118
REACTION-LIST - 3-DEHYDROSPHINGANINE-REDUCTASE-RXN
REACTION-LIST - SERINE-C-PALMITOYLTRANSFERASE-RXN
//
UNIQUE-ID - PWY3FA-941
TYPES - Energy-Metabolism
TYPES - Lipid-Biosynthesis
COMMON-NAME - ketogenesis
CITATIONS - :EV-EXP:3453804007:ave
CREDITS - O3FA-6
CREDITS - AU3FA-5
PREDECESSORS - (ACETOACETATE-DECARBOXYLASE-RXN HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN)
PREDECESSORS - (3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN)
PREDECESSORS - (HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN)
PREDECESSORS - (HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN ACETYL-COA-ACETYLTRANSFER-RXN)
PREDECESSORS - (ACETYL-COA-ACETYLTRANSFER-RXN)
PRIMARIES - (3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN (3-KETOBUTYRATE) (CPD-335))
PRIMARIES - (HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN (3-HYDROXY-3-METHYL-GLUTARYL-COA) (3-KETOBUTYRATE))
PRIMARIES - (HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN (ACETOACETYL-COA) (3-HYDROXY-3-METHYL-GLUTARYL-COA))
PRIMARIES - (ACETYL-COA-ACETYLTRANSFER-RXN (ACETYL-COA) (ACETOACETYL-COA))
REACTION-LAYOUT - (ACETOACETATE-DECARBOXYLASE-RXN (:LEFT-PRIMARIES 3-KETOBUTYRATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETONE))
REACTION-LAYOUT - (3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN (:LEFT-PRIMARIES CPD-335) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 3-KETOBUTYRATE))
REACTION-LAYOUT - (HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN (:LEFT-PRIMARIES 3-HYDROXY-3-METHYL-GLUTARYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETYL-COA 3-KETOBUTYRATE))
REACTION-LAYOUT - (HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN (:LEFT-PRIMARIES ACETYL-COA ACETOACETYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HYDROXY-3-METHYL-GLUTARYL-COA))
REACTION-LAYOUT - (ACETYL-COA-ACETYLTRANSFER-RXN (:LEFT-PRIMARIES ACETYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETOACETYL-COA))
REACTION-LIST - ACETOACETATE-DECARBOXYLASE-RXN
REACTION-LIST - 3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN
REACTION-LIST - HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN
REACTION-LIST - HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
REACTION-LIST - ACETYL-COA-ACETYLTRANSFER-RXN
//
UNIQUE-ID - SPHINGOLIPID-SYN-PWY
TYPES - Fatty-Acid-and-Lipid-Degradation
TYPES - Lipid-Biosynthesis
COMMON-NAME - sphingolipid metabolism
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - O-16
CREDITS - |hong|
PREDECESSORS - (RXN3O-663 RXN3O-581)
PREDECESSORS - (RXN3O-581 RXN3O-4042)
PREDECESSORS - (RXN3O-4042 RXN3O-328)
PREDECESSORS - (RXN3O-504 RXN3O-458)
PREDECESSORS - (RXN3O-458 RXN3O-1380)
PREDECESSORS - (SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN SPHINGANINE-KINASE-RXN)
PREDECESSORS - (3-DEHYDROSPHINGANINE-REDUCTASE-RXN SERINE-C-PALMITOYLTRANSFERASE-RXN)
PREDECESSORS - (SPHINGANINE-KINASE-RXN 3-DEHYDROSPHINGANINE-REDUCTASE-RXN)
PREDECESSORS - (RXN3O-1380 3-DEHYDROSPHINGANINE-REDUCTASE-RXN)
PREDECESSORS - (DHS-PHOSPHATASE-RXN SPHINGANINE-KINASE-RXN)
PREDECESSORS - (RXN3O-1380 DHS-PHOSPHATASE-RXN)
PREDECESSORS - (RXN3O-328 RXN3O-1380)
PREDECESSORS - (RXN3O-328 RXN3O-504)
PREDECESSORS - (CERAMIDASE-YEAST-RXN RXN3O-328)
PREDECESSORS - (RXN3O-458 CERAMIDASE-YEAST-RXN)
PREDECESSORS - (RXN3O-680 RXN3O-663)
PRIMARIES - (CERAMIDASE-YEAST-RXN (|Phytoceramides|) (PHYTOSPINGOSINE))
PRIMARIES - (RXN3O-328 (PHYTOSPINGOSINE) (|Phytoceramides|))
PRIMARIES - (DHS-PHOSPHATASE-RXN (CPD-649) (DIHYDRO-SPHINGOSINE))
PRIMARIES - (RXN3O-1380 (DIHYDRO-SPHINGOSINE) (PHYTOSPINGOSINE))
REACTION-LAYOUT - (RXN3O-4042 (:LEFT-PRIMARIES |Phytoceramides|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Alpha-hydroxyphytoceramides|))
REACTION-LAYOUT - (RXN3O-680 (:LEFT-PRIMARIES MIPC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MIP2C))
REACTION-LAYOUT - (RXN3O-663 (:LEFT-PRIMARIES IPC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MIPC))
REACTION-LAYOUT - (RXN3O-581 (:LEFT-PRIMARIES |Alpha-hydroxyphytoceramides|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES IPC))
REACTION-LAYOUT - (RXN3O-504 (:LEFT-PRIMARIES PHYTOSPINGOSINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES PHTYOSPHINGOSINE-1-P))
REACTION-LAYOUT - (RXN3O-458 (:LEFT-PRIMARIES PHYTOSPINGOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHTYOSPHINGOSINE-1-P))
REACTION-LAYOUT - (DHS-PHOSPHATASE-RXN (:LEFT-PRIMARIES CPD-649) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIHYDRO-SPHINGOSINE))
REACTION-LAYOUT - (CERAMIDASE-YEAST-RXN (:LEFT-PRIMARIES |Phytoceramides|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHYTOSPINGOSINE))
REACTION-LAYOUT - (RXN3O-328 (:LEFT-PRIMARIES PHYTOSPINGOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Phytoceramides|))
REACTION-LAYOUT - (SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN (:LEFT-PRIMARIES CPD-649) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHORYL-ETHANOLAMINE PALMITALDEHYDE))
REACTION-LAYOUT - (RXN3O-1380 (:LEFT-PRIMARIES DIHYDRO-SPHINGOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHYTOSPINGOSINE))
REACTION-LAYOUT - (SPHINGANINE-KINASE-RXN (:LEFT-PRIMARIES DIHYDRO-SPHINGOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-649))
REACTION-LAYOUT - (3-DEHYDROSPHINGANINE-REDUCTASE-RXN (:LEFT-PRIMARIES DIHYDRO-SPHINGOSINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES DEHYDROSPHINGANINE))
REACTION-LAYOUT - (SERINE-C-PALMITOYLTRANSFERASE-RXN (:LEFT-PRIMARIES SER) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DEHYDROSPHINGANINE))
REACTION-LIST - RXN3O-4042
REACTION-LIST - RXN3O-680
REACTION-LIST - RXN3O-663
REACTION-LIST - RXN3O-581
REACTION-LIST - RXN3O-504
REACTION-LIST - RXN3O-458
REACTION-LIST - DHS-PHOSPHATASE-RXN
REACTION-LIST - CERAMIDASE-YEAST-RXN
REACTION-LIST - RXN3O-328
REACTION-LIST - SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN
REACTION-LIST - RXN3O-1380
REACTION-LIST - SPHINGANINE-KINASE-RXN
REACTION-LIST - 3-DEHYDROSPHINGANINE-REDUCTASE-RXN
REACTION-LIST - SERINE-C-PALMITOYLTRANSFERASE-RXN
//
UNIQUE-ID - TRIGLSYN-PWY
TYPES - Lipid-Biosynthesis
COMMON-NAME - triacylglycerol biosynthesis
CITATIONS - :EV-AS:3430735124:ave
COMMENT - Triacylglycerol (TAG) is the major lipid reserve in animals. The assembly of TAG occurs in the endoplasmic reticulum.
/Four consecutive reactions are catalyzed by ER membrane bound enzymes. The two intermediates, phosphatidate
/and 1,2-diacylglycerol, are also substrates for the synthesis of membrane lipids glycosylglycerides and
/phosphoglycerides. Thus, the last step in the pathway, catalyzed by diacylglycerol acyltransferase, is the only
/dedicated step in triacylglycerol synthesis.
PREDECESSORS - (RXN-1623 RXN-1381)
PREDECESSORS - (PHOSPHATIDATE-PHOSPHATASE-RXN RXN-1623)
PREDECESSORS - (DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN PHOSPHOLIPASE-C-RXN)
PREDECESSORS - (PHOSPHOLIPASE-C-RXN)
PREDECESSORS - (DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN PHOSPHATIDATE-PHOSPHATASE-RXN)
PREDECESSORS - (RXN-1641 PHOSPHATIDATE-PHOSPHATASE-RXN)
PRIMARIES - (RXN-1641 (DIACYLGLYCEROL) (|Triacylglycerols|))
PRIMARIES - (RXN-1381 (GLYCEROL-3P) (ACYL-SN-GLYCEROL-3P))
PRIMARIES - (DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN (DIACYLGLYCEROL) (|Triacylglycerols|))
PRIMARIES - (RXN-10462 NIL (ACYL-SN-GLYCEROL-3P))
REACTION-LAYOUT - (RXN-1641 (:LEFT-PRIMARIES DIACYLGLYCEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Triacylglycerols|))
REACTION-LAYOUT - (RXN-1623 (:LEFT-PRIMARIES ACYL-SN-GLYCEROL-3P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-PHOSPHATIDATE))
REACTION-LAYOUT - (RXN-1381 (:LEFT-PRIMARIES GLYCEROL-3P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACYL-SN-GLYCEROL-3P))
REACTION-LAYOUT - (DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN (:LEFT-PRIMARIES DIACYLGLYCEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Triacylglycerols|))
REACTION-LAYOUT - (PHOSPHATIDATE-PHOSPHATASE-RXN (:LEFT-PRIMARIES L-PHOSPHATIDATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIACYLGLYCEROL))
REACTION-LIST - RXN-1641
REACTION-LIST - RXN-1623
REACTION-LIST - RXN-1381
REACTION-LIST - DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN
REACTION-LIST - PHOSPHATIDATE-PHOSPHATASE-RXN
SYNONYMS - triglyceride biosynthesis
SYNONYMS - Kennedy pathway
SYNONYMS - TAG biosynthesis
//
UNIQUE-ID - PWY-3561
TYPES - Choline-Biosynthesis
COMMON-NAME - choline biosynthesis III
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |hartmut|
PREDECESSORS - (PHOSCHOL-RXN RXN-5781)
PREDECESSORS - (RXN-5781 2.7.7.15-RXN)
PREDECESSORS - (2.7.7.15-RXN)
PRIMARIES - (RXN-5781 (CDP-CHOLINE) (PHOSPHATIDYLCHOLINE))
PRIMARIES - (PHOSCHOL-RXN (PHOSPHATIDYLCHOLINE) (CHOLINE))
PRIMARIES - (2.7.8.2-RXN (CDP-CHOLINE) (PHOSPHATIDYLCHOLINE))
PRIMARIES - (2.7.7.15-RXN (PHOSPHORYL-CHOLINE) (CDP-CHOLINE))
REACTION-LAYOUT - (RXN-5781 (:LEFT-PRIMARIES CDP-CHOLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHATIDYLCHOLINE))
REACTION-LAYOUT - (PHOSCHOL-RXN (:LEFT-PRIMARIES PHOSPHATIDYLCHOLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CHOLINE))
REACTION-LAYOUT - (2.7.7.15-RXN (:LEFT-PRIMARIES PHOSPHORYL-CHOLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CDP-CHOLINE))
REACTION-LIST - RXN-5781
REACTION-LIST - PHOSCHOL-RXN
REACTION-LIST - 2.7.7.15-RXN
//
UNIQUE-ID - PWY-5080
TYPES - Fatty-acid-biosynthesis
COMMON-NAME - very long chain fatty acid biosynthesis
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |caspi|
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |zhang|
POLYMERIZATION-LINKS - (|Fatty-Acyl-CoA| RXN-7711 RXN-7697)
PREDECESSORS - (RXN-7699 RXN-7698)
PREDECESSORS - (RXN-7698 RXN-7697)
PREDECESSORS - (RXN-7711 RXN-7699)
PRIMARIES - (RXN-7711 (TRANS-D2-ENOYL-COA) (|Fatty-Acyl-CoA|))
PRIMARIES - (RXN-7701 (TRANS-D2-ENOYL-COA) (|Fatty-Acyl-CoA|))
PRIMARIES - (RXN-7697 (|Fatty-Acyl-CoA|) (3-KETOACYL-COA))
REACTION-LAYOUT - (RXN-7711 (:LEFT-PRIMARIES TRANS-D2-ENOYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Fatty-Acyl-CoA|))
REACTION-LAYOUT - (RXN-7699 (:LEFT-PRIMARIES D-3-HYDROXYACYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TRANS-D2-ENOYL-COA))
REACTION-LAYOUT - (RXN-7698 (:LEFT-PRIMARIES D-3-HYDROXYACYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 3-KETOACYL-COA))
REACTION-LAYOUT - (RXN-7697 (:LEFT-PRIMARIES |Fatty-Acyl-CoA|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-KETOACYL-COA))
REACTION-LIST - RXN-7711
REACTION-LIST - RXN-7699
REACTION-LIST - RXN-7698
REACTION-LIST - RXN-7697
SYNONYMS - VLCFAs biosynthesis
//
UNIQUE-ID - PWY-5965
TYPES - Fatty-acid-biosynthesis
COMMON-NAME - fatty acid biosynthesis initiation III
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (3-OXOACYL-ACP-SYNTH-BASE-RXN MALONYL-ACPDECARBOX-RXN)
PRIMARIES - (HOLO-ACP-SYNTH-RXN NIL (EG50003-MONOMER))
PRIMARIES - (ACETYL-COA-CARBOXYLTRANSFER-A-RXN (ACETYL-COA))
PRIMARIES - (ACP-S-ACETYLTRANSFER-RXN (ACETYL-COA))
PRIMARIES - (3-OXOACYL-ACP-SYNTH-BASE-RXN NIL (|Acetoacetyl-ACPs|))
PRIMARIES - (MALONYL-COA-ACP-TRANSACYL-RXN NIL (MALONYL-ACP))
REACTION-LAYOUT - (MALONYL-ACPDECARBOX-RXN (:LEFT-PRIMARIES MALONYL-ACP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETYL-ACP))
REACTION-LAYOUT - (3-OXOACYL-ACP-SYNTH-BASE-RXN (:LEFT-PRIMARIES ACETYL-ACP MALONYL-ACP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Acetoacetyl-ACPs|))
REACTION-LIST - MALONYL-ACPDECARBOX-RXN
REACTION-LIST - 3-OXOACYL-ACP-SYNTH-BASE-RXN
//
UNIQUE-ID - PWY-5966
TYPES - Fatty-acid-biosynthesis
COMMON-NAME - fatty acid biosynthesis initiation II
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (ACP-S-ACETYLTRANSFER-RXN)
PREDECESSORS - (3-OXOACYL-ACP-SYNTH-BASE-RXN ACP-S-ACETYLTRANSFER-RXN)
PRIMARIES - (HOLO-ACP-SYNTH-RXN NIL (EG50003-MONOMER))
PRIMARIES - (ACETYL-COA-CARBOXYLTRANSFER-A-RXN (ACETYL-COA))
PRIMARIES - (ACP-S-ACETYLTRANSFER-RXN (ACETYL-COA))
PRIMARIES - (3-OXOACYL-ACP-SYNTH-BASE-RXN NIL (|Acetoacetyl-ACPs|))
PRIMARIES - (MALONYL-COA-ACP-TRANSACYL-RXN NIL (MALONYL-ACP))
REACTION-LAYOUT - (ACP-S-ACETYLTRANSFER-RXN (:LEFT-PRIMARIES ACETYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETYL-ACP))
REACTION-LAYOUT - (3-OXOACYL-ACP-SYNTH-BASE-RXN (:LEFT-PRIMARIES ACETYL-ACP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Acetoacetyl-ACPs|))
REACTION-LIST - ACP-S-ACETYLTRANSFER-RXN
REACTION-LIST - 3-OXOACYL-ACP-SYNTH-BASE-RXN
//
UNIQUE-ID - PWY0-862
TYPES - Fatty-acid-biosynthesis
COMMON-NAME - <i>cis</i>-dodecenoyl biosynthesis
CITATIONS - :EV-COMP-AINF:3443363899:ave
PATHWAY-LINKS - (|Beta-hydroxydecanoyl-ACPs| PWY-5971)
PATHWAY-LINKS - (BETA-HYDROXYDECANOYL-ACP FASYN-ELONG-PWY)
PREDECESSORS - (5.3.3.14-RXN FABAUNSATDEHYDR-RXN)
PREDECESSORS - (RXN0-2141 5.3.3.14-RXN)
PREDECESSORS - (RXN0-2142 RXN0-2141)
PREDECESSORS - (RXN0-2144 RXN0-2142)
PREDECESSORS - (RXN0-2145 RXN0-2144)
REACTION-LAYOUT - (5.3.3.14-RXN (:LEFT-PRIMARIES |Trans-D2-decenoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Cis-delta-3-decenoyl-ACPs|))
REACTION-LAYOUT - (FABAUNSATDEHYDR-RXN (:LEFT-PRIMARIES |Beta-hydroxydecanoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Trans-D2-decenoyl-ACPs|))
REACTION-LAYOUT - (RXN0-2141 (:LEFT-PRIMARIES |Cis-delta-3-decenoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |b-Keto-cis-D5-dodecenoyl-ACPs|))
REACTION-LAYOUT - (RXN0-2142 (:LEFT-PRIMARIES |b-Keto-cis-D5-dodecenoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |b-Hydroxy-cis-D5-dodecenoyl-ACPs|))
REACTION-LAYOUT - (RXN0-2144 (:LEFT-PRIMARIES |b-Hydroxy-cis-D5-dodecenoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Trans-D3-cis-D5-dodecenoyl-ACPs|))
REACTION-LAYOUT - (RXN0-2145 (:LEFT-PRIMARIES |Trans-D3-cis-D5-dodecenoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Cis-Delta5-dodecenoyl-ACPs|))
REACTION-LIST - 5.3.3.14-RXN
REACTION-LIST - FABAUNSATDEHYDR-RXN
REACTION-LIST - RXN0-2141
REACTION-LIST - RXN0-2142
REACTION-LIST - RXN0-2144
REACTION-LIST - RXN0-2145
SYNONYMS - fatty acid elongation -- unsaturated
//
UNIQUE-ID - PWY-6000
TYPES - Gamma-linolenate-Biosynthesis
COMMON-NAME - &gamma;-linolenate biosynthesis II (animals)
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (LINOLEIC_ACID ("acquisition from diet" . :INCOMING))
PREDECESSORS - (1.14.19.3-RXN RXN-9673)
PRIMARIES - (RXN-9673 (LINOLEIC_ACID) NIL)
REACTION-LAYOUT - (RXN-9673 (:LEFT-PRIMARIES LINOLEIC_ACID) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-18))
REACTION-LAYOUT - (1.14.19.3-RXN (:LEFT-PRIMARIES CPD-18) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GAMMA-LINOLENOYL-COA))
REACTION-LIST - RXN-9673
REACTION-LIST - 1.14.19.3-RXN
//
UNIQUE-ID - PWY-5996
TYPES - Oleate-Biosynthesis
COMMON-NAME - oleate biosynthesis II (animals)
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (STEAROYL-COA PWY-5972)
PREDECESSORS - (RXN-9666 1.14.19.1-RXN)
PREDECESSORS - (1.14.19.1-RXN)
PRIMARIES - (RXN-9666 NIL (OLEATE-CPD))
PRIMARIES - (1.14.19.1-RXN (STEAROYL-COA) (OLEOYL-COA))
PRIMARIES - (LINOLEOYL-RXN NIL (LINOLEIC_ACID))
REACTION-LAYOUT - (RXN-9666 (:LEFT-PRIMARIES OLEOYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OLEATE-CPD))
REACTION-LAYOUT - (1.14.19.1-RXN (:LEFT-PRIMARIES STEAROYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OLEOYL-COA))
REACTION-LIST - RXN-9666
REACTION-LIST - 1.14.19.1-RXN
//
UNIQUE-ID - PWY-5994
TYPES - Palmitate-Biosynthesis
COMMON-NAME - palmitate biosynthesis I (animals)
CITATIONS - :EV-COMP-AINF:3442068425:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (|Trans-D2-decenoyl-ACPs| (PWY0-862 . :OUTGOING))
PATHWAY-LINKS - (|Palmitoyl-ACPs| PWY-5972)
PATHWAY-LINKS - (|Octanoyl-ACPs| (PWY0-501 . :OUTGOING))
PREDECESSORS - (RXN-9540 RXN-9654)
PREDECESSORS - (RXN-9654 RXN-9538)
PREDECESSORS - (RXN-9536 RXN-9653)
PREDECESSORS - (RXN-9653 RXN-9534)
PREDECESSORS - (RXN-9532 RXN-9652)
PREDECESSORS - (RXN-9652 RXN-9530)
PREDECESSORS - (RXN-9528 RXN-9651)
PREDECESSORS - (RXN-9651 RXN-9526)
PREDECESSORS - (RXN-9518 RXN-9648)
PREDECESSORS - (RXN-9648 RXN-9515)
PREDECESSORS - (RXN-9524 RXN-9650)
PREDECESSORS - (RXN-9650 RXN-9521)
PREDECESSORS - (3.1.2.21-RXN RXN-9534)
PREDECESSORS - (RXN-9549 RXN-9542)
PREDECESSORS - (RXN-9542 4.2.1.61-RXN)
PREDECESSORS - (4.2.1.61-RXN RXN-9540)
PREDECESSORS - (RXN-9538 RXN-9537)
PREDECESSORS - (RXN-9537 RXN-9536)
PREDECESSORS - (RXN-9534 RXN-9533)
PREDECESSORS - (RXN-9533 RXN-9532)
PREDECESSORS - (RXN-9530 RXN-9655)
PREDECESSORS - (RXN-9655 RXN-9528)
PREDECESSORS - (RXN-9526 4.2.1.59-RXN)
PREDECESSORS - (4.2.1.59-RXN RXN-9524)
PREDECESSORS - (RXN-9521 RXN-9520)
PREDECESSORS - (RXN-9520 RXN-9518)
PREDECESSORS - (RXN-9515 4.2.1.58-RXN)
PREDECESSORS - (4.2.1.58-RXN RXN-9514)
PRIMARIES - (3.1.2.21-RXN NIL (DODECANOATE))
PRIMARIES - (RXN-9549 NIL (PALMITATE))
REACTION-LAYOUT - (RXN-9654 (:LEFT-PRIMARIES |Myristoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |3-oxo-palmitoyl-ACPs|))
REACTION-LAYOUT - (RXN-9653 (:LEFT-PRIMARIES |Dodecanoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |3-oxo-myristoyl-ACPs|))
REACTION-LAYOUT - (RXN-9652 (:LEFT-PRIMARIES |Decanoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |3-oxo-dodecanoyl-ACPs|))
REACTION-LAYOUT - (RXN-9651 (:LEFT-PRIMARIES |Octanoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |3-oxo-decanoyl-ACPs|))
REACTION-LAYOUT - (RXN-9650 (:LEFT-PRIMARIES |Hexanoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |3-Oxo-octanoyl-ACPs|))
REACTION-LAYOUT - (RXN-9648 (:LEFT-PRIMARIES |Butanoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |3-oxo-hexanoyl-ACPs|))
REACTION-LAYOUT - (3.1.2.21-RXN (:LEFT-PRIMARIES |Dodecanoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DODECANOATE))
REACTION-LAYOUT - (RXN-9549 (:LEFT-PRIMARIES |Palmitoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PALMITATE))
REACTION-LAYOUT - (RXN-9542 (:LEFT-PRIMARIES |Palmitoyl-ACPs|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES |2-Hexadecenoyl-ACPs|))
REACTION-LAYOUT - (4.2.1.61-RXN (:LEFT-PRIMARIES |R-3-Hydroxypalmitoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |2-Hexadecenoyl-ACPs|))
REACTION-LAYOUT - (RXN-9540 (:LEFT-PRIMARIES |R-3-Hydroxypalmitoyl-ACPs|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES |3-oxo-palmitoyl-ACPs|))
REACTION-LAYOUT - (RXN-9538 (:LEFT-PRIMARIES |Myristoyl-ACPs|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES |Tetradec-2-enoyl-ACPs|))
REACTION-LAYOUT - (RXN-9537 (:LEFT-PRIMARIES |R-3-hydroxymyristoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Tetradec-2-enoyl-ACPs|))
REACTION-LAYOUT - (RXN-9536 (:LEFT-PRIMARIES |R-3-hydroxymyristoyl-ACPs|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES |3-oxo-myristoyl-ACPs|))
REACTION-LAYOUT - (RXN-9534 (:LEFT-PRIMARIES |Dodecanoyl-ACPs|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES |Dodec-2-enoyl-ACPs|))
REACTION-LAYOUT - (RXN-9533 (:LEFT-PRIMARIES |R-3-hydroxydodecanoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Dodec-2-enoyl-ACPs|))
REACTION-LAYOUT - (RXN-9532 (:LEFT-PRIMARIES |R-3-hydroxydodecanoyl-ACPs|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES |3-oxo-dodecanoyl-ACPs|))
REACTION-LAYOUT - (RXN-9655 (:LEFT-PRIMARIES |Beta-hydroxydecanoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Trans-D2-decenoyl-ACPs|))
REACTION-LAYOUT - (RXN-9530 (:LEFT-PRIMARIES |Decanoyl-ACPs|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES |Trans-D2-decenoyl-ACPs|))
REACTION-LAYOUT - (RXN-9528 (:LEFT-PRIMARIES |Beta-hydroxydecanoyl-ACPs|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES |3-oxo-decanoyl-ACPs|))
REACTION-LAYOUT - (4.2.1.59-RXN (:LEFT-PRIMARIES |3-Hydroxy-octanoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |2-Octenoyl-ACPs|))
REACTION-LAYOUT - (RXN-9526 (:LEFT-PRIMARIES |Octanoyl-ACPs|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES |2-Octenoyl-ACPs|))
REACTION-LAYOUT - (RXN-9524 (:LEFT-PRIMARIES |3-Hydroxy-octanoyl-ACPs|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES |3-Oxo-octanoyl-ACPs|))
REACTION-LAYOUT - (4.2.1.58-RXN (:LEFT-PRIMARIES |Beta-3-hydroxybutyryl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Crotonyl-ACPs|))
REACTION-LAYOUT - (RXN-9514 (:LEFT-PRIMARIES |Acetoacetyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Beta-3-hydroxybutyryl-ACPs|))
REACTION-LAYOUT - (RXN-9518 (:LEFT-PRIMARIES |R-3-hydroxyhexanoyl-ACPs|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES |3-oxo-hexanoyl-ACPs|))
REACTION-LAYOUT - (RXN-9520 (:LEFT-PRIMARIES |R-3-hydroxyhexanoyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Hex-2-enoyl-ACPs|))
REACTION-LAYOUT - (RXN-9521 (:LEFT-PRIMARIES |Hexanoyl-ACPs|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES |Hex-2-enoyl-ACPs|))
REACTION-LAYOUT - (RXN-9515 (:LEFT-PRIMARIES |Crotonyl-ACPs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Butanoyl-ACPs|))
REACTION-LIST - RXN-9654
REACTION-LIST - RXN-9653
REACTION-LIST - RXN-9652
REACTION-LIST - RXN-9651
REACTION-LIST - RXN-9650
REACTION-LIST - RXN-9648
REACTION-LIST - 3.1.2.21-RXN
REACTION-LIST - RXN-9549
REACTION-LIST - RXN-9542
REACTION-LIST - 4.2.1.61-RXN
REACTION-LIST - RXN-9540
REACTION-LIST - RXN-9538
REACTION-LIST - RXN-9537
REACTION-LIST - RXN-9536
REACTION-LIST - RXN-9534
REACTION-LIST - RXN-9533
REACTION-LIST - RXN-9532
REACTION-LIST - RXN-9655
REACTION-LIST - RXN-9530
REACTION-LIST - RXN-9528
REACTION-LIST - 4.2.1.59-RXN
REACTION-LIST - RXN-9526
REACTION-LIST - RXN-9524
REACTION-LIST - 4.2.1.58-RXN
REACTION-LIST - RXN-9514
REACTION-LIST - RXN-9518
REACTION-LIST - RXN-9520
REACTION-LIST - RXN-9521
REACTION-LIST - RXN-9515
SYNONYMS - palmitic acid biosynthesis
SYNONYMS - de novo lipogenesis
//
UNIQUE-ID - PHOSLIPSYN-PWY
TYPES - Phospholipid-Biosynthesis
TYPES - Super-Pathways
COMMON-NAME - phospholipid biosynthesis I
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - O-18
CREDITS - |riley|
PATHWAY-LINKS - (DIHYDROXY-ACETONE-PHOSPHATE GLYCOLYSIS)
PREDECESSORS - PWY0-1319
PREDECESSORS - (PHOSPHAGLYPSYN-RXN CDPDIGLYSYN-RXN)
PREDECESSORS - (PHOSPHASERSYN-RXN CDPDIGLYSYN-RXN)
PREDECESSORS - PWY-5669
PREDECESSORS - PWY-5668
PREDECESSORS - PWY-5667
PRIMARIES - (PHOSPHASERSYN-RXN (CDPDIACYLGLYCEROL) (L-1-PHOSPHATIDYL-SERINE))
REACTION-LAYOUT - (PWY-5669 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (PWY-5668 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (PWY-5667 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - PWY-5669
REACTION-LIST - PWY-5668
REACTION-LIST - PWY-5667
SYNONYMS - phospholipid biosynthesis
//
UNIQUE-ID - PWY-6352
TYPES - Phospholipid-Biosynthesis
COMMON-NAME - 3-phosphoinositide biosynthesis
CITATIONS - :EV-COMP-AINF:3482054332:ave
PATHWAY-LINKS - (1-PHOSPHATIDYL-1D-MYO-INOSITOL-35-BISPH PWY-6367)
PATHWAY-LINKS - (MYO-INOSITOL PWY-2301)
PREDECESSORS - (2.7.1.150-RXN RXN-10938)
PREDECESSORS - (RXN-10938 2.7.1.150-RXN)
PREDECESSORS - (2.7.1.150-RXN 1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN)
PREDECESSORS - (1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN 2.7.8.11-RXN)
PREDECESSORS - (2.7.1.153-RXN 2.7.1.68-RXN)
PREDECESSORS - (2.7.1.68-RXN 1-PHOSPHATIDYLINOSITOL-KINASE-RXN)
PREDECESSORS - (2.7.1.154-RXN 1-PHOSPHATIDYLINOSITOL-KINASE-RXN)
PREDECESSORS - (1-PHOSPHATIDYLINOSITOL-KINASE-RXN 2.7.8.11-RXN)
PRIMARIES - (1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN (|L-1-phosphatidyl-inositols|) (CPD-177))
PRIMARIES - (2.7.8.11-RXN (MYO-INOSITOL) NIL)
PRIMARIES - (1-PHOSPHATIDYLINOSITOL-KINASE-RXN (|L-1-phosphatidyl-inositols|) (CPD-1108))
REACTION-LAYOUT - (RXN-10938 (:LEFT-PRIMARIES 1-PHOSPHATIDYL-1D-MYO-INOSITOL-35-BISPH) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-177))
REACTION-LAYOUT - (2.7.1.150-RXN (:LEFT-PRIMARIES CPD-177) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 1-PHOSPHATIDYL-1D-MYO-INOSITOL-35-BISPH))
REACTION-LAYOUT - (1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN (:LEFT-PRIMARIES |L-1-phosphatidyl-inositols|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-177))
REACTION-LAYOUT - (2.7.1.153-RXN (:LEFT-PRIMARIES PHOSPHATIDYL-MYO-INOSITOL-45-BISPHOSPHA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHATIDYLINOSITOL-345-TRIPHOSPHATE))
REACTION-LAYOUT - (2.7.1.68-RXN (:LEFT-PRIMARIES CPD-1108) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHATIDYL-MYO-INOSITOL-45-BISPHOSPHA))
REACTION-LAYOUT - (2.7.1.154-RXN (:LEFT-PRIMARIES CPD-1108) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 1-PHOSPHATIDYL-1D-MYO-INOSITOL-34-BISPH))
REACTION-LAYOUT - (2.7.8.11-RXN (:LEFT-PRIMARIES MYO-INOSITOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |L-1-phosphatidyl-inositols|))
REACTION-LAYOUT - (1-PHOSPHATIDYLINOSITOL-KINASE-RXN (:LEFT-PRIMARIES |L-1-phosphatidyl-inositols|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-1108))
REACTION-LIST - RXN-10938
REACTION-LIST - 2.7.1.150-RXN
REACTION-LIST - 1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN
REACTION-LIST - 2.7.1.153-RXN
REACTION-LIST - 2.7.1.68-RXN
REACTION-LIST - 2.7.1.154-RXN
REACTION-LIST - 2.7.8.11-RXN
REACTION-LIST - 1-PHOSPHATIDYLINOSITOL-KINASE-RXN
SYNONYMS - phosphatidylinositol-3,4-bisphosphate biosynthesis
SYNONYMS - phosphatidylinositol 3-phosphate biosynthesis
SYNONYMS - phosphatidylinositol-3,4,5-triphosphate biosynthesis
//
UNIQUE-ID - PWY-6367
TYPES - Cyclitols-Biosynthesis
TYPES - Phospholipid-Biosynthesis
COMMON-NAME - D-<i>myo</i>-inositol-5-phosphate metabolism
CITATIONS - :EV-COMP-AINF:3482054332:ave
PATHWAY-LINKS - (1-PHOSPHATIDYL-1D-MYO-INOSITOL-35-BISPH PWY-6352)
PATHWAY-LINKS - (INOSITOL-1-4-5-TRISPHOSPHATE PWY-6362 PWY-6364 PWY-6363)
PREDECESSORS - (2.7.1.149-RXN RXN-9779)
PREDECESSORS - (RXN-9779 2.7.1.149-RXN)
PREDECESSORS - (2.7.1.149-RXN RXN-10958)
PREDECESSORS - (3.1.4.11-RXN 2.7.1.149-RXN)
PRIMARIES - (2.7.1.149-RXN (1-PHOSPHATIDYL-1D-MYO-INOSITOL-5-PHOSPHA) (PHOSPHATIDYL-MYO-INOSITOL-45-BISPHOSPHA))
PRIMARIES - (3.1.4.11-RXN NIL (INOSITOL-1-4-5-TRISPHOSPHATE))
REACTION-LAYOUT - (RXN-9779 (:LEFT-PRIMARIES PHOSPHATIDYL-MYO-INOSITOL-45-BISPHOSPHA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 1-PHOSPHATIDYL-1D-MYO-INOSITOL-5-PHOSPHA))
REACTION-LAYOUT - (RXN-10958 (:LEFT-PRIMARIES 1-PHOSPHATIDYL-1D-MYO-INOSITOL-35-BISPH) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 1-PHOSPHATIDYL-1D-MYO-INOSITOL-5-PHOSPHA))
REACTION-LAYOUT - (2.7.1.149-RXN (:LEFT-PRIMARIES 1-PHOSPHATIDYL-1D-MYO-INOSITOL-5-PHOSPHA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHATIDYL-MYO-INOSITOL-45-BISPHOSPHA))
REACTION-LAYOUT - (3.1.4.11-RXN (:LEFT-PRIMARIES PHOSPHATIDYL-MYO-INOSITOL-45-BISPHOSPHA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES INOSITOL-1-4-5-TRISPHOSPHATE))
REACTION-LIST - RXN-9779
REACTION-LIST - RXN-10958
REACTION-LIST - 2.7.1.149-RXN
REACTION-LIST - 3.1.4.11-RXN
//
UNIQUE-ID - PWY-5269
TYPES - Cardiolipin-Biosynthesis
COMMON-NAME - cardiolipin biosynthesis II
CITATIONS - :EV-COMP-AINF:3482054332:ave
PATHWAY-LINKS - (CDPDIACYLGLYCEROL PWY-5667)
PREDECESSORS - (RXN-8141 PGPPHOSPHA-RXN)
PREDECESSORS - (PGPPHOSPHA-RXN PHOSPHAGLYPSYN-RXN)
PRIMARIES - (PGPPHOSPHA-RXN (L-1-PHOSPHATIDYL-GLYCEROL-P) (L-1-PHOSPHATIDYL-GLYCEROL))
PRIMARIES - (PHOSPHAGLYPSYN-RXN (CDPDIACYLGLYCEROL) (L-1-PHOSPHATIDYL-GLYCEROL-P))
PRIMARIES - (RXN-8141 (L-1-PHOSPHATIDYL-GLYCEROL) (CARDIOLIPIN))
REACTION-LAYOUT - (RXN-8141 (:LEFT-PRIMARIES L-1-PHOSPHATIDYL-GLYCEROL CDPDIACYLGLYCEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CARDIOLIPIN))
REACTION-LAYOUT - (PGPPHOSPHA-RXN (:LEFT-PRIMARIES L-1-PHOSPHATIDYL-GLYCEROL-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-1-PHOSPHATIDYL-GLYCEROL))
REACTION-LAYOUT - (PHOSPHAGLYPSYN-RXN (:LEFT-PRIMARIES CDPDIACYLGLYCEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-1-PHOSPHATIDYL-GLYCEROL-P))
REACTION-LIST - RXN-8141
REACTION-LIST - PGPPHOSPHA-RXN
REACTION-LIST - PHOSPHAGLYPSYN-RXN
//
UNIQUE-ID - PWY-5668
TYPES - Cardiolipin-Biosynthesis
COMMON-NAME - cardiolipin biosynthesis I
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - PHOSLIPSYN-PWY
PATHWAY-LINKS - (CDPDIACYLGLYCEROL PWY-5667)
PATHWAY-LINKS - (DIHYDROXY-ACETONE-PHOSPHATE GLYCOLYSIS)
PREDECESSORS - (PHOSPHAGLYPSYN-RXN)
PREDECESSORS - (PGPPHOSPHA-RXN PHOSPHAGLYPSYN-RXN)
PREDECESSORS - (CARDIOLIPSYN-RXN PGPPHOSPHA-RXN)
PRIMARIES - (CARDIOLIPSYN-RXN NIL (CARDIOLIPIN))
PRIMARIES - (RXN-10462 (GLYCEROL-3P) (ACYL-SN-GLYCEROL-3P))
PRIMARIES - (PHOSPHASERSYN-RXN (CDPDIACYLGLYCEROL) (L-1-PHOSPHATIDYL-SERINE))
REACTION-LAYOUT - (PHOSPHAGLYPSYN-RXN (:LEFT-PRIMARIES CDPDIACYLGLYCEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-1-PHOSPHATIDYL-GLYCEROL-P))
REACTION-LAYOUT - (CARDIOLIPSYN-RXN (:LEFT-PRIMARIES L-1-PHOSPHATIDYL-GLYCEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CARDIOLIPIN))
REACTION-LAYOUT - (PGPPHOSPHA-RXN (:LEFT-PRIMARIES L-1-PHOSPHATIDYL-GLYCEROL-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-1-PHOSPHATIDYL-GLYCEROL))
REACTION-LIST - PHOSPHAGLYPSYN-RXN
REACTION-LIST - CARDIOLIPSYN-RXN
REACTION-LIST - PGPPHOSPHA-RXN
//
UNIQUE-ID - PWY-5667
TYPES - CDP-diacylglycerol-Biosynthesis
COMMON-NAME - CDP-diacylglycerol biosynthesis I
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - PWY4FS-8
IN-PATHWAY - PHOSLIPSYN-PWY
PATHWAY-LINKS - (CDPDIACYLGLYCEROL PWY-5669 PWY-5668)
PATHWAY-LINKS - (DIHYDROXY-ACETONE-PHOSPHATE GLYCOLYSIS)
PREDECESSORS - (CDPDIGLYSYN-RXN RXN-1623)
PREDECESSORS - (RXN-1623 RXN-1381)
PREDECESSORS - (RXN-1381 GLYC3PDEHYDROGBIOSYN-RXN)
PREDECESSORS - (CDPDIGLYSYN-RXN)
PRIMARIES - (PHOSPHASERSYN-RXN (CDPDIACYLGLYCEROL) (L-1-PHOSPHATIDYL-SERINE))
REACTION-LAYOUT - (GLYC3PDEHYDROGBIOSYN-RXN (:LEFT-PRIMARIES GLYCEROL-3P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LAYOUT - (RXN-1381 (:LEFT-PRIMARIES GLYCEROL-3P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACYL-SN-GLYCEROL-3P))
REACTION-LAYOUT - (RXN-1623 (:LEFT-PRIMARIES ACYL-SN-GLYCEROL-3P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-PHOSPHATIDATE))
REACTION-LAYOUT - (CDPDIGLYSYN-RXN (:LEFT-PRIMARIES L-PHOSPHATIDATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CDPDIACYLGLYCEROL))
REACTION-LIST - GLYC3PDEHYDROGBIOSYN-RXN
REACTION-LIST - RXN-1381
REACTION-LIST - RXN-1623
REACTION-LIST - CDPDIGLYSYN-RXN
SUPER-PATHWAYS - PWY4FS-8
SYNONYMS - CDP-diacylglycerol biosynthesis
//
UNIQUE-ID - PWY0-1319
TYPES - CDP-diacylglycerol-Biosynthesis
COMMON-NAME - CDP-diacylglycerol biosynthesis II
CITATIONS - :EV-COMP-AINF:3482054331:ave
PATHWAY-LINKS - (ACYL-ACP (PWY0-881 . :INCOMING) (PWY-6284 . :INCOMING))
PATHWAY-LINKS - (CDPDIACYLGLYCEROL PWY-5668 PWY-5669)
PATHWAY-LINKS - (DIHYDROXY-ACETONE-PHOSPHATE GLYCOLYSIS)
PREDECESSORS - (RXN-10462 GLYC3PDEHYDROGBIOSYN-RXN)
PREDECESSORS - (1-ACYLGLYCEROL-3-P-ACYLTRANSFER-RXN RXN-10462)
PREDECESSORS - (CDPDIGLYSYN-RXN 1-ACYLGLYCEROL-3-P-ACYLTRANSFER-RXN)
REACTION-LAYOUT - (RXN-10462 (:LEFT-PRIMARIES GLYCEROL-3P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACYL-SN-GLYCEROL-3P))
REACTION-LAYOUT - (1-ACYLGLYCEROL-3-P-ACYLTRANSFER-RXN (:LEFT-PRIMARIES ACYL-SN-GLYCEROL-3P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-PHOSPHATIDATE))
REACTION-LAYOUT - (GLYC3PDEHYDROGBIOSYN-RXN (:LEFT-PRIMARIES GLYCEROL-3P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LAYOUT - (CDPDIGLYSYN-RXN (:LEFT-PRIMARIES L-PHOSPHATIDATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CDPDIACYLGLYCEROL))
REACTION-LIST - RXN-10462
REACTION-LIST - 1-ACYLGLYCEROL-3-P-ACYLTRANSFER-RXN
REACTION-LIST - GLYC3PDEHYDROGBIOSYN-RXN
REACTION-LIST - CDPDIGLYSYN-RXN
//
UNIQUE-ID - PWY3O-450
TYPES - PhosphatidylcholineBiosynthesis
COMMON-NAME - phosphatidylcholine biosynthesis I
CREDITS - O-16
CREDITS - |hong|
PREDECESSORS - (RXN-5781 2.7.7.15-RXN)
PREDECESSORS - (2.7.7.15-RXN CHOLINE-KINASE-RXN)
PRIMARIES - (RXN-5781 NIL (PHOSPHATIDYLCHOLINE))
REACTION-LAYOUT - (RXN-5781 (:LEFT-PRIMARIES CDP-CHOLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHATIDYLCHOLINE))
REACTION-LAYOUT - (2.7.7.15-RXN (:LEFT-PRIMARIES PHOSPHORYL-CHOLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CDP-CHOLINE))
REACTION-LAYOUT - (CHOLINE-KINASE-RXN (:LEFT-PRIMARIES CHOLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHORYL-CHOLINE))
REACTION-LIST - RXN-5781
REACTION-LIST - 2.7.7.15-RXN
REACTION-LIST - CHOLINE-KINASE-RXN
//
UNIQUE-ID - PWY-5669
TYPES - PhosphatidylethanolamineBiosynthesis
COMMON-NAME - phosphatidylethanolamine biosynthesis I
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - PHOSLIPSYN-PWY
PATHWAY-LINKS - (CDPDIACYLGLYCEROL PWY-5667)
PATHWAY-LINKS - (DIHYDROXY-ACETONE-PHOSPHATE GLYCOLYSIS)
PREDECESSORS - (PHOSPHASERSYN-RXN)
PREDECESSORS - (PHOSPHASERDECARB-RXN PHOSPHASERSYN-RXN)
PRIMARIES - (RXN-10462 (GLYCEROL-3P) (ACYL-SN-GLYCEROL-3P))
PRIMARIES - (PHOSPHASERSYN-RXN (CDPDIACYLGLYCEROL) (L-1-PHOSPHATIDYL-SERINE))
REACTION-LAYOUT - (PHOSPHASERDECARB-RXN (:LEFT-PRIMARIES L-1-PHOSPHATIDYL-SERINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-1-PHOSPHATIDYL-ETHANOLAMINE))
REACTION-LAYOUT - (PHOSPHASERSYN-RXN (:LEFT-PRIMARIES CDPDIACYLGLYCEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-1-PHOSPHATIDYL-SERINE))
REACTION-LIST - PHOSPHASERDECARB-RXN
REACTION-LIST - PHOSPHASERSYN-RXN
//
UNIQUE-ID - PWY4FS-6
TYPES - PhosphatidylethanolamineBiosynthesis
COMMON-NAME - phosphatidylethanolamine biosynthesis II
CITATIONS - :EV-COMP-AINF:3453644158:ave
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |zhang|
PREDECESSORS - (ETHANOLAMINEPHOSPHOTRANSFERASE-RXN 2.7.7.14-RXN)
PREDECESSORS - (2.7.7.14-RXN ETHANOLAMINE-KINASE-RXN)
PRIMARIES - (ETHANOLAMINEPHOSPHOTRANSFERASE-RXN (CDP-ETHANOLAMINE) (L-1-PHOSPHATIDYL-ETHANOLAMINE))
PRIMARIES - (2.7.7.14-RXN (PHOSPHORYL-ETHANOLAMINE) (CDP-ETHANOLAMINE))
PRIMARIES - (ETHANOLAMINE-KINASE-RXN (ETHANOL-AMINE) (PHOSPHORYL-ETHANOLAMINE))
REACTION-LAYOUT - (ETHANOLAMINEPHOSPHOTRANSFERASE-RXN (:LEFT-PRIMARIES CDP-ETHANOLAMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-1-PHOSPHATIDYL-ETHANOLAMINE))
REACTION-LAYOUT - (2.7.7.14-RXN (:LEFT-PRIMARIES PHOSPHORYL-ETHANOLAMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CDP-ETHANOLAMINE))
REACTION-LAYOUT - (ETHANOLAMINE-KINASE-RXN (:LEFT-PRIMARIES ETHANOL-AMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHORYL-ETHANOLAMINE))
REACTION-LIST - ETHANOLAMINEPHOSPHOTRANSFERASE-RXN
REACTION-LIST - 2.7.7.14-RXN
REACTION-LIST - ETHANOLAMINE-KINASE-RXN
//
UNIQUE-ID - PWY4FS-7
TYPES - PhosphatidylglycerolBiosynthesis
TYPES - Super-Pathways
COMMON-NAME - phosphatidylglycerol biosynthesis I (plastid)
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |zhang|
PREDECESSORS - (PGPPHOSPHA-RXN PHOSPHAGLYPSYN-RXN)
PREDECESSORS - (PHOSPHAGLYPSYN-RXN CDPDIGLYSYN-RXN)
PREDECESSORS - PWY0-1319
PRIMARIES - (PHOSPHAGLYPSYN-RXN (CDPDIACYLGLYCEROL) (L-1-PHOSPHATIDYL-GLYCEROL-P))
PRIMARIES - (PGPPHOSPHA-RXN (L-1-PHOSPHATIDYL-GLYCEROL-P) (L-1-PHOSPHATIDYL-GLYCEROL))
REACTION-LAYOUT - (PGPPHOSPHA-RXN (:LEFT-PRIMARIES L-1-PHOSPHATIDYL-GLYCEROL-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-1-PHOSPHATIDYL-GLYCEROL))
REACTION-LAYOUT - (PHOSPHAGLYPSYN-RXN (:LEFT-PRIMARIES CDPDIACYLGLYCEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-1-PHOSPHATIDYL-GLYCEROL-P))
REACTION-LIST - PGPPHOSPHA-RXN
REACTION-LIST - PHOSPHAGLYPSYN-RXN
//
UNIQUE-ID - PWY4FS-8
TYPES - PhosphatidylglycerolBiosynthesis
TYPES - Super-Pathways
COMMON-NAME - phosphatidylglycerol biosynthesis II
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |zhang|
PREDECESSORS - (PGPPHOSPHA-RXN PHOSPHAGLYPSYN-RXN)
PREDECESSORS - (PHOSPHAGLYPSYN-RXN CDPDIGLYSYN-RXN)
PREDECESSORS - PWY-5667
PRIMARIES - (PHOSPHAGLYPSYN-RXN (CDPDIACYLGLYCEROL) (L-1-PHOSPHATIDYL-GLYCEROL-P))
PRIMARIES - (PGPPHOSPHA-RXN (L-1-PHOSPHATIDYL-GLYCEROL-P) (L-1-PHOSPHATIDYL-GLYCEROL))
REACTION-LAYOUT - (PGPPHOSPHA-RXN (:LEFT-PRIMARIES L-1-PHOSPHATIDYL-GLYCEROL-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-1-PHOSPHATIDYL-GLYCEROL))
REACTION-LAYOUT - (PHOSPHAGLYPSYN-RXN (:LEFT-PRIMARIES GLYCEROL-3P CDPDIACYLGLYCEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-1-PHOSPHATIDYL-GLYCEROL-P))
REACTION-LAYOUT - (PWY-5667 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - PGPPHOSPHA-RXN
REACTION-LIST - PHOSPHAGLYPSYN-RXN
REACTION-LIST - PWY-5667
SUB-PATHWAYS - PWY-5667
//
UNIQUE-ID - PWY-6061
TYPES - Sterol-Biosynthesis
COMMON-NAME - bile acid biosynthesis, neutral pathway
CITATIONS - :EV-COMP-AINF:3453644158:ave
CREDITS - SRI
CREDITS - |fulcher|
KEY-REACTIONS - CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN
PATHWAY-LINKS - (CHOLESTEROL PWY66-5 PWY66-4 PWY66-3 PWY66-341)
PREDECESSORS - (RXN-9852 RXN-9850)
PREDECESSORS - (RXN-9851 RXN-9850)
PREDECESSORS - (RXN-9800 RXN-9950)
PREDECESSORS - (GLYCINE-N-CHOLOYLTRANSFERASE-RXN RXN-9950)
PREDECESSORS - (RXN-9950 RXN-9799)
PREDECESSORS - (RXN-9850 RXN-9848)
PREDECESSORS - (RXN-9848 RXN-9847)
PREDECESSORS - (RXN-9847 RXN-9846)
PREDECESSORS - (RXN-9846 RXN-9845)
PREDECESSORS - (RXN-9845 6.2.1.28-RXN)
PREDECESSORS - (6.2.1.28-RXN RXN-9844)
PREDECESSORS - (RXN-9844 RXN-9843)
PREDECESSORS - (RXN-9843 RXN-9842)
PREDECESSORS - (RXN-9842 RXN-9841)
PREDECESSORS - (RXN-9841 RXN-9840)
PREDECESSORS - (RXN-9840 1.1.1.181-RXN)
PREDECESSORS - (RXN-9799 4.2.1.107-RXN)
PREDECESSORS - (4.2.1.107-RXN RXN-9798)
PREDECESSORS - (RXN-9798 RXN-9797)
PREDECESSORS - (RXN-9797 6.2.1.29-RXN)
PREDECESSORS - (6.2.1.29-RXN 1.2.1.40-RXN)
PREDECESSORS - (1.2.1.40-RXN CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN)
PREDECESSORS - (CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN CHOLESTANETRIOL-26-MONOOXYGENASE-RXN)
PREDECESSORS - (CHOLESTANETRIOL-26-MONOOXYGENASE-RXN RXN-9796)
PREDECESSORS - (RXN-9796 RXN-9794)
PREDECESSORS - (RXN-9794 1.14.13.95-RXN)
PREDECESSORS - (1.14.13.95-RXN 1.1.1.181-RXN)
PREDECESSORS - (1.1.1.181-RXN CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN)
PREDECESSORS - (CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN)
PRIMARIES - (RXN-9850 (CPD-10591) (CPD-10556))
PRIMARIES - (RXN-9950 (CPD-7257) (CPD-202))
PRIMARIES - (RXN-9852 (CPD-10556) (CPD-7283))
PRIMARIES - (RXN-9851 (CPD-10556) (GLYCOCHENODEOXYCHOLIC_ACID))
PRIMARIES - (RXN-9800 (CPD-202) (CPD-3743))
PRIMARIES - (GLYCINE-N-CHOLOYLTRANSFERASE-RXN (CPD-202) (GLYCOCHOLIC_ACID))
PRIMARIES - (2.3.1.176-RXN (CPD-7257) (CPD-202))
PRIMARIES - (4.2.1.107-RXN (CPD-7243) (CPD-7275))
REACTION-LAYOUT - (RXN-9950 (:LEFT-PRIMARIES CPD-7257) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-202))
REACTION-LAYOUT - (RXN-9852 (:LEFT-PRIMARIES CPD-10556) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-7283))
REACTION-LAYOUT - (RXN-9851 (:LEFT-PRIMARIES CPD-10556) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLYCOCHENODEOXYCHOLIC_ACID))
REACTION-LAYOUT - (RXN-9850 (:LEFT-PRIMARIES CPD-10591) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-10556))
REACTION-LAYOUT - (RXN-9848 (:LEFT-PRIMARIES CPD-10590) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-10591))
REACTION-LAYOUT - (RXN-9847 (:LEFT-PRIMARIES CPD-10589) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-10590))
REACTION-LAYOUT - (RXN-9846 (:LEFT-PRIMARIES CPD-10588) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-10589))
REACTION-LAYOUT - (RXN-9845 (:LEFT-PRIMARIES CPD-72) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-10588))
REACTION-LAYOUT - (6.2.1.28-RXN (:LEFT-PRIMARIES CPD-1834) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-72))
REACTION-LAYOUT - (RXN-9844 (:LEFT-PRIMARIES CPD-10587) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-1834))
REACTION-LAYOUT - (RXN-9843 (:LEFT-PRIMARIES CPD-10586) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-10587))
REACTION-LAYOUT - (RXN-9842 (:LEFT-PRIMARIES CPD-7238) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-10586))
REACTION-LAYOUT - (RXN-9841 (:LEFT-PRIMARIES CPD-10548) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-7238))
REACTION-LAYOUT - (RXN-9840 (:LEFT-PRIMARIES CPD-1087) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-10548))
REACTION-LAYOUT - (RXN-9800 (:LEFT-PRIMARIES CPD-202) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3743))
REACTION-LAYOUT - (GLYCINE-N-CHOLOYLTRANSFERASE-RXN (:LEFT-PRIMARIES CPD-202) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLYCOCHOLIC_ACID))
REACTION-LAYOUT - (RXN-9799 (:LEFT-PRIMARIES CPD-7275) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-7257))
REACTION-LAYOUT - (4.2.1.107-RXN (:LEFT-PRIMARIES CPD-7275) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CPD-7243))
REACTION-LAYOUT - (RXN-9798 (:LEFT-PRIMARIES CPD-10505) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-7243))
REACTION-LAYOUT - (RXN-9797 (:LEFT-PRIMARIES CPD-71) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-10505))
REACTION-LAYOUT - (6.2.1.29-RXN (:LEFT-PRIMARIES CPD-1836) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-71))
REACTION-LAYOUT - (1.2.1.40-RXN (:LEFT-PRIMARIES 3-ALPHA7-ALPHA12-ALPHA-TRIHYDROX) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-1836))
REACTION-LAYOUT - (CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN (:LEFT-PRIMARIES 5-BETA-CHOLESTANE-3-ALPHA7-TETRAOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-ALPHA7-ALPHA12-ALPHA-TRIHYDROX))
REACTION-LAYOUT - (CHOLESTANETRIOL-26-MONOOXYGENASE-RXN (:LEFT-PRIMARIES 5-BETA-CHOLESTANE-3-ALPHA7-ALPHA12-ALP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-BETA-CHOLESTANE-3-ALPHA7-TETRAOL))
REACTION-LAYOUT - (RXN-9796 (:LEFT-PRIMARIES CPD-10503) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-BETA-CHOLESTANE-3-ALPHA7-ALPHA12-ALP))
REACTION-LAYOUT - (RXN-9794 (:LEFT-PRIMARIES CPD-7237) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-10503))
REACTION-LAYOUT - (1.14.13.95-RXN (:LEFT-PRIMARIES CPD-1087) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-7237))
REACTION-LAYOUT - (1.1.1.181-RXN (:LEFT-PRIMARIES CPD-266) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-1087))
REACTION-LAYOUT - (CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN (:LEFT-PRIMARIES CHOLESTEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-266))
REACTION-LIST - RXN-9950
REACTION-LIST - RXN-9852
REACTION-LIST - RXN-9851
REACTION-LIST - RXN-9850
REACTION-LIST - RXN-9848
REACTION-LIST - RXN-9847
REACTION-LIST - RXN-9846
REACTION-LIST - RXN-9845
REACTION-LIST - 6.2.1.28-RXN
REACTION-LIST - RXN-9844
REACTION-LIST - RXN-9843
REACTION-LIST - RXN-9842
REACTION-LIST - RXN-9841
REACTION-LIST - RXN-9840
REACTION-LIST - RXN-9800
REACTION-LIST - GLYCINE-N-CHOLOYLTRANSFERASE-RXN
REACTION-LIST - RXN-9799
REACTION-LIST - 4.2.1.107-RXN
REACTION-LIST - RXN-9798
REACTION-LIST - RXN-9797
REACTION-LIST - 6.2.1.29-RXN
REACTION-LIST - 1.2.1.40-RXN
REACTION-LIST - CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN
REACTION-LIST - CHOLESTANETRIOL-26-MONOOXYGENASE-RXN
REACTION-LIST - RXN-9796
REACTION-LIST - RXN-9794
REACTION-LIST - 1.14.13.95-RXN
REACTION-LIST - 1.1.1.181-RXN
REACTION-LIST - CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN
SYNONYMS - bile acid biosynthesis (classic pathway)
//
UNIQUE-ID - PWY-6132
TYPES - Sterol-Biosynthesis
COMMON-NAME - lanosterol biosynthesis
IN-PATHWAY - PWY66-4
IN-PATHWAY - PWY66-3
IN-PATHWAY - PWY66-341
PATHWAY-LINKS - (EPOXYSQUALENE PWY-5670)
PATHWAY-LINKS - (LANOSTEROL PWY-6074)
PREDECESSORS - (LANOSTEROL-SYNTHASE-RXN)
REACTION-LAYOUT - (LANOSTEROL-SYNTHASE-RXN (:LEFT-PRIMARIES EPOXYSQUALENE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES LANOSTEROL))
REACTION-LIST - LANOSTEROL-SYNTHASE-RXN
SUPER-PATHWAYS - PWY66-4
SUPER-PATHWAYS - PWY66-3
SUPER-PATHWAYS - PWY66-341
//
UNIQUE-ID - PWY66-3
TYPES - Sterol-Biosynthesis
TYPES - Super-Pathways
COMMON-NAME - cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
PATHWAY-LINKS - (CPD-4187 PWY-6076)
PATHWAY-LINKS - (LANOSTEROL (PWY66-4 . :OUTGOING) (PWY66-341 . :OUTGOING))
PATHWAY-LINKS - (FARNESYL-PP PWY-5123)
PREDECESSORS - (RXN66-10 LANOSTEROL-SYNTHASE-RXN)
PREDECESSORS - (LANOSTEROL-SYNTHASE-RXN SQUALENE-MONOOXYGENASE-RXN)
PREDECESSORS - PWY-6132
PREDECESSORS - PWY-5670
PREDECESSORS - (RXN66-11 RXN66-10)
PREDECESSORS - (RXN66-12 RXN66-11)
PREDECESSORS - (RXN66-13 RXN66-12)
PREDECESSORS - (RXN66-14 RXN66-13)
PREDECESSORS - (RXN66-15 RXN66-14)
PREDECESSORS - (RXN66-16 RXN66-15)
PREDECESSORS - (RXN66-17 RXN66-16)
PREDECESSORS - (RXN66-18 RXN66-17)
PREDECESSORS - (RXN66-19 RXN66-18)
PREDECESSORS - (RXN66-20 RXN66-19)
PREDECESSORS - (RXN66-21 RXN66-20)
PREDECESSORS - (RXN66-22 RXN66-21)
PREDECESSORS - (RXN66-23 RXN66-22)
PREDECESSORS - (RXN66-24 RXN66-23)
PREDECESSORS - (RXN66-25 RXN66-24)
PREDECESSORS - (1.14.21.6-RXN RXN66-25)
PREDECESSORS - (RXN66-323 1.14.21.6-RXN)
PRIMARIES - (RXN66-13 (CPD-8608) (CPD-8609))
REACTION-LAYOUT - (PWY-6132 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (1.14.21.6-RXN (:LEFT-PRIMARIES CPD-4186) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4187))
REACTION-LAYOUT - (PWY-5670 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (RXN66-323 (:LEFT-PRIMARIES CHOLESTEROL) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CPD-4187))
REACTION-LAYOUT - (RXN66-25 (:LEFT-PRIMARIES CPD-4186) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CPD-8621))
REACTION-LAYOUT - (RXN66-24 (:LEFT-PRIMARIES CPD-8620) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8621))
REACTION-LAYOUT - (RXN66-23 (:LEFT-PRIMARIES CPD-8619) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8620))
REACTION-LAYOUT - (RXN66-22 (:LEFT-PRIMARIES CPD-8618) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8619))
REACTION-LAYOUT - (RXN66-21 (:LEFT-PRIMARIES CPD-8617) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8618))
REACTION-LAYOUT - (RXN66-20 (:LEFT-PRIMARIES CPD-4184) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8617))
REACTION-LAYOUT - (RXN66-19 (:LEFT-PRIMARIES CPD-8614) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4184))
REACTION-LAYOUT - (RXN66-18 (:LEFT-PRIMARIES CPD-8613) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8614))
REACTION-LAYOUT - (RXN66-17 (:LEFT-PRIMARIES CPD-8612) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8613))
REACTION-LAYOUT - (RXN66-16 (:LEFT-PRIMARIES CPD-8611) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8612))
REACTION-LAYOUT - (RXN66-15 (:LEFT-PRIMARIES CPD-8610) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8611))
REACTION-LAYOUT - (RXN66-14 (:LEFT-PRIMARIES CPD-8609) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8610))
REACTION-LAYOUT - (RXN66-13 (:LEFT-PRIMARIES CPD-8608) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8609))
REACTION-LAYOUT - (RXN66-12 (:LEFT-PRIMARIES CPD-8607) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8608))
REACTION-LAYOUT - (RXN66-11 (:LEFT-PRIMARIES CPD-8606) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8607))
REACTION-LAYOUT - (RXN66-10 (:LEFT-PRIMARIES LANOSTEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8606))
REACTION-LIST - PWY-6132
REACTION-LIST - 1.14.21.6-RXN
REACTION-LIST - PWY-5670
REACTION-LIST - RXN66-323
REACTION-LIST - RXN66-25
REACTION-LIST - RXN66-24
REACTION-LIST - RXN66-23
REACTION-LIST - RXN66-22
REACTION-LIST - RXN66-21
REACTION-LIST - RXN66-20
REACTION-LIST - RXN66-19
REACTION-LIST - RXN66-18
REACTION-LIST - RXN66-17
REACTION-LIST - RXN66-16
REACTION-LIST - RXN66-15
REACTION-LIST - RXN66-14
REACTION-LIST - RXN66-13
REACTION-LIST - RXN66-12
REACTION-LIST - RXN66-11
REACTION-LIST - RXN66-10
SUB-PATHWAYS - PWY-6132
SUB-PATHWAYS - PWY-5670
//
UNIQUE-ID - PWY66-341
TYPES - Sterol-Biosynthesis
TYPES - Super-Pathways
COMMON-NAME - cholesterol biosynthesis I
PATHWAY-LINKS - (CPD-4187 PWY-6076)
PATHWAY-LINKS - (5-ALPHA-CHOLESTA-724-DIEN-3-BETA-OL (PWY66-4 . :OUTGOING))
PATHWAY-LINKS - (LANOSTEROL (PWY66-3 . :OUTGOING))
PATHWAY-LINKS - (FARNESYL-PP PWY-5123)
PREDECESSORS - (RXN66-303 LANOSTEROL-SYNTHASE-RXN)
PREDECESSORS - (LANOSTEROL-SYNTHASE-RXN SQUALENE-MONOOXYGENASE-RXN)
PREDECESSORS - PWY-6132
PREDECESSORS - (RXN66-316 RXN66-311)
PREDECESSORS - PWY-5670
PREDECESSORS - (RXN66-321 RXN66-320)
PREDECESSORS - (RXN66-319 RXN66-318)
PREDECESSORS - (RXN66-317 RXN66-316)
PREDECESSORS - (RXN66-315 RXN66-314)
PREDECESSORS - (RXN66-313 RXN66-312)
PREDECESSORS - (RXN66-311 RXN66-310)
PREDECESSORS - (RXN66-306 RXN66-305)
PREDECESSORS - (RXN66-304 RXN66-303)
PREDECESSORS - (RXN66-305 RXN66-304)
PREDECESSORS - (RXN66-310 RXN66-306)
PREDECESSORS - (RXN66-312 RXN66-311)
PREDECESSORS - (RXN66-314 RXN66-313)
PREDECESSORS - (RXN66-316 RXN66-315)
PREDECESSORS - (RXN66-318 RXN66-317)
PREDECESSORS - (RXN66-320 RXN66-319)
PREDECESSORS - (1.14.21.6-RXN RXN66-321)
PREDECESSORS - (RXN66-323 1.14.21.6-RXN)
PRIMARIES - (RXN66-311 (CPD-4575) (CPD-4576))
PRIMARIES - (RXN66-316 (CPD-4579) (CPD-4580))
PRIMARIES - (RXN66-305 (CPD-4573) (44-DIMETHYL-CHOLESTA-812-24-TRIENOL))
REACTION-LAYOUT - (PWY-6132 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (RXN66-313 (:LEFT-PRIMARIES CPD-4577) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4578))
REACTION-LAYOUT - (1.14.21.6-RXN (:LEFT-PRIMARIES CPD-4186) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4187))
REACTION-LAYOUT - (RXN66-306 (:LEFT-PRIMARIES 44-DIMETHYL-CHOLESTA-812-24-TRIENOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 44-DIMETHYL-824-CHOLESTADIENOL))
REACTION-LAYOUT - (PWY-5670 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (RXN66-323 (:LEFT-PRIMARIES CHOLESTEROL) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CPD-4187))
REACTION-LAYOUT - (RXN66-321 (:LEFT-PRIMARIES 5-ALPHA-CHOLESTA-724-DIEN-3-BETA-OL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4186))
REACTION-LAYOUT - (RXN66-320 (:LEFT-PRIMARIES ZYMOSTEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-ALPHA-CHOLESTA-724-DIEN-3-BETA-OL))
REACTION-LAYOUT - (RXN66-319 (:LEFT-PRIMARIES CPD-4581) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ZYMOSTEROL))
REACTION-LAYOUT - (RXN66-318 (:LEFT-PRIMARIES CPD-4702) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4581))
REACTION-LAYOUT - (RXN66-317 (:LEFT-PRIMARIES CPD-4580) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4702))
REACTION-LAYOUT - (RXN66-316 (:LEFT-PRIMARIES CPD-4579) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4580))
REACTION-LAYOUT - (RXN66-315 (:LEFT-PRIMARIES 4-METHYL-824-CHOLESTADIENOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4579))
REACTION-LAYOUT - (RXN66-314 (:LEFT-PRIMARIES CPD-4578) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 4-METHYL-824-CHOLESTADIENOL))
REACTION-LAYOUT - (RXN66-312 (:LEFT-PRIMARIES CPD-4576) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4577))
REACTION-LAYOUT - (RXN66-311 (:LEFT-PRIMARIES CPD-4575) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4576))
REACTION-LAYOUT - (RXN66-310 (:LEFT-PRIMARIES 44-DIMETHYL-824-CHOLESTADIENOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4575))
REACTION-LAYOUT - (RXN66-305 (:LEFT-PRIMARIES CPD-4573) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 44-DIMETHYL-CHOLESTA-812-24-TRIENOL))
REACTION-LAYOUT - (RXN66-304 (:LEFT-PRIMARIES CPD-4568) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4573))
REACTION-LAYOUT - (RXN66-303 (:LEFT-PRIMARIES LANOSTEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4568))
REACTION-LIST - PWY-6132
REACTION-LIST - RXN66-313
REACTION-LIST - 1.14.21.6-RXN
REACTION-LIST - RXN66-306
REACTION-LIST - PWY-5670
REACTION-LIST - RXN66-323
REACTION-LIST - RXN66-321
REACTION-LIST - RXN66-320
REACTION-LIST - RXN66-319
REACTION-LIST - RXN66-318
REACTION-LIST - RXN66-317
REACTION-LIST - RXN66-316
REACTION-LIST - RXN66-315
REACTION-LIST - RXN66-314
REACTION-LIST - RXN66-312
REACTION-LIST - RXN66-311
REACTION-LIST - RXN66-310
REACTION-LIST - RXN66-305
REACTION-LIST - RXN66-304
REACTION-LIST - RXN66-303
SUB-PATHWAYS - PWY-6132
SUB-PATHWAYS - PWY-5670
//
UNIQUE-ID - PWY66-4
TYPES - Sterol-Biosynthesis
TYPES - Super-Pathways
COMMON-NAME - cholesterol biosynthesis III (via desmosterol)
PATHWAY-LINKS - (CPD-8646 PWY-6076)
PATHWAY-LINKS - (5-ALPHA-CHOLESTA-724-DIEN-3-BETA-OL (PWY66-341 . :OUTGOING))
PATHWAY-LINKS - (LANOSTEROL (PWY66-3 . :OUTGOING))
PATHWAY-LINKS - (FARNESYL-PP PWY-5123)
PREDECESSORS - (RXN66-303 LANOSTEROL-SYNTHASE-RXN)
PREDECESSORS - (LANOSTEROL-SYNTHASE-RXN SQUALENE-MONOOXYGENASE-RXN)
PREDECESSORS - PWY-6132
PREDECESSORS - (RXN66-316 RXN66-311)
PREDECESSORS - PWY-5670
PREDECESSORS - (RXN66-28 RXN66-27)
PREDECESSORS - (RXN66-27 RXN66-26)
PREDECESSORS - (RXN66-26 RXN66-320)
PREDECESSORS - (RXN66-320 RXN66-319)
PREDECESSORS - (RXN66-318 RXN66-317)
PREDECESSORS - (RXN66-316 RXN66-315)
PREDECESSORS - (RXN66-314 RXN66-313)
PREDECESSORS - (RXN66-312 RXN66-311)
PREDECESSORS - (RXN66-310 RXN66-306)
PREDECESSORS - (RXN66-305 RXN66-304)
PREDECESSORS - (RXN66-304 RXN66-303)
PREDECESSORS - (RXN66-306 RXN66-305)
PREDECESSORS - (RXN66-311 RXN66-310)
PREDECESSORS - (RXN66-313 RXN66-312)
PREDECESSORS - (RXN66-315 RXN66-314)
PREDECESSORS - (RXN66-317 RXN66-316)
PREDECESSORS - (RXN66-319 RXN66-318)
PRIMARIES - (RXN66-311 (CPD-4575) (CPD-4576))
PRIMARIES - (RXN66-316 (CPD-4579) (CPD-4580))
PRIMARIES - (RXN66-305 (CPD-4573) (44-DIMETHYL-CHOLESTA-812-24-TRIENOL))
REACTION-LAYOUT - (PWY-6132 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (RXN66-313 (:LEFT-PRIMARIES CPD-4577) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4578))
REACTION-LAYOUT - (RXN66-306 (:LEFT-PRIMARIES 44-DIMETHYL-CHOLESTA-812-24-TRIENOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 44-DIMETHYL-824-CHOLESTADIENOL))
REACTION-LAYOUT - (PWY-5670 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (RXN66-28 (:LEFT-PRIMARIES DESMOSTEROL-CPD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CHOLESTEROL))
REACTION-LAYOUT - (RXN66-27 (:LEFT-PRIMARIES DESMOSTEROL-CPD) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CPD-8646))
REACTION-LAYOUT - (RXN66-26 (:LEFT-PRIMARIES 5-ALPHA-CHOLESTA-724-DIEN-3-BETA-OL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8646))
REACTION-LAYOUT - (RXN66-320 (:LEFT-PRIMARIES ZYMOSTEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-ALPHA-CHOLESTA-724-DIEN-3-BETA-OL))
REACTION-LAYOUT - (RXN66-319 (:LEFT-PRIMARIES CPD-4581) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ZYMOSTEROL))
REACTION-LAYOUT - (RXN66-318 (:LEFT-PRIMARIES CPD-4702) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4581))
REACTION-LAYOUT - (RXN66-317 (:LEFT-PRIMARIES CPD-4580) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4702))
REACTION-LAYOUT - (RXN66-316 (:LEFT-PRIMARIES CPD-4579) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4580))
REACTION-LAYOUT - (RXN66-315 (:LEFT-PRIMARIES 4-METHYL-824-CHOLESTADIENOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4579))
REACTION-LAYOUT - (RXN66-314 (:LEFT-PRIMARIES CPD-4578) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 4-METHYL-824-CHOLESTADIENOL))
REACTION-LAYOUT - (RXN66-312 (:LEFT-PRIMARIES CPD-4576) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4577))
REACTION-LAYOUT - (RXN66-311 (:LEFT-PRIMARIES CPD-4575) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4576))
REACTION-LAYOUT - (RXN66-310 (:LEFT-PRIMARIES 44-DIMETHYL-824-CHOLESTADIENOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4575))
REACTION-LAYOUT - (RXN66-305 (:LEFT-PRIMARIES CPD-4573) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 44-DIMETHYL-CHOLESTA-812-24-TRIENOL))
REACTION-LAYOUT - (RXN66-304 (:LEFT-PRIMARIES CPD-4568) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4573))
REACTION-LAYOUT - (RXN66-303 (:LEFT-PRIMARIES LANOSTEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-4568))
REACTION-LIST - PWY-6132
REACTION-LIST - RXN66-313
REACTION-LIST - RXN66-306
REACTION-LIST - PWY-5670
REACTION-LIST - RXN66-28
REACTION-LIST - RXN66-27
REACTION-LIST - RXN66-26
REACTION-LIST - RXN66-320
REACTION-LIST - RXN66-319
REACTION-LIST - RXN66-318
REACTION-LIST - RXN66-317
REACTION-LIST - RXN66-316
REACTION-LIST - RXN66-315
REACTION-LIST - RXN66-314
REACTION-LIST - RXN66-312
REACTION-LIST - RXN66-311
REACTION-LIST - RXN66-310
REACTION-LIST - RXN66-305
REACTION-LIST - RXN66-304
REACTION-LIST - RXN66-303
SUB-PATHWAYS - PWY-6132
SUB-PATHWAYS - PWY-5670
//
UNIQUE-ID - PWY66-5
TYPES - Sterol-Biosynthesis
TYPES - Super-Pathways
COMMON-NAME - superpathway of cholesterol biosynthesis
PATHWAY-LINKS - (CPD-4187 PWY-6076)
PREDECESSORS - (GPPSYN-RXN IPPISOM-RXN)
PREDECESSORS - PWY-922
PREDECESSORS - (2.5.1.21-RXN FPPSYN-RXN)
PREDECESSORS - PWY-5123
PREDECESSORS - PWY66-4
PREDECESSORS - PWY66-3
PREDECESSORS - PWY66-341
REACTION-LAYOUT - (PWY-922 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (PWY-5123 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - PWY-922
REACTION-LIST - PWY-5123
SUB-PATHWAYS - PWY-922
SUB-PATHWAYS - PWY-5123
//
UNIQUE-ID - PWY-6100
TYPES - Metabolic-Regulators
COMMON-NAME - L-carnitine biosynthesis
CITATIONS - :EV-COMP-AINF:3453644158:ave
CREDITS - SRI
CREDITS - |fulcher|
KEY-REACTIONS - TRIMETHYLLYSINE-DIOXYGENASE-RXN
PREDECESSORS - (1.14.11.1-RXN 1.2.1.47-RXN)
PREDECESSORS - (1.2.1.47-RXN RXN-9896)
PREDECESSORS - (RXN-9896 TRIMETHYLLYSINE-DIOXYGENASE-RXN)
PREDECESSORS - (TRIMETHYLLYSINE-DIOXYGENASE-RXN)
PRIMARIES - (1.14.11.1-RXN (GAMMA-BUTYROBETAINE) (CARNITINE))
PRIMARIES - (RXN-9896 (3-HYDROXY-N6N6N6-TRIMETHYL-L-LYSINE) (4-TRIMETHYLAMMONIOBUTANAL))
PRIMARIES - (TRIMETHYLLYSINE-DIOXYGENASE-RXN (N6N6N6-TRIMETHYL-L-LYSINE) (3-HYDROXY-N6N6N6-TRIMETHYL-L-LYSINE))
REACTION-LAYOUT - (1.14.11.1-RXN (:LEFT-PRIMARIES GAMMA-BUTYROBETAINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CARNITINE))
REACTION-LAYOUT - (1.2.1.47-RXN (:LEFT-PRIMARIES 4-TRIMETHYLAMMONIOBUTANAL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GAMMA-BUTYROBETAINE))
REACTION-LAYOUT - (RXN-9896 (:LEFT-PRIMARIES 3-HYDROXY-N6N6N6-TRIMETHYL-L-LYSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 4-TRIMETHYLAMMONIOBUTANAL))
REACTION-LAYOUT - (TRIMETHYLLYSINE-DIOXYGENASE-RXN (:LEFT-PRIMARIES N6N6N6-TRIMETHYL-L-LYSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HYDROXY-N6N6N6-TRIMETHYL-L-LYSINE))
REACTION-LIST - 1.14.11.1-RXN
REACTION-LIST - 1.2.1.47-RXN
REACTION-LIST - RXN-9896
REACTION-LIST - TRIMETHYLLYSINE-DIOXYGENASE-RXN
SYNONYMS - (<i>R</i>)-carnitine biosynthesis
//
UNIQUE-ID - PWY-6405
TYPES - Metabolic-Regulators
COMMON-NAME - Rapoport-Luebering glycolytic shunt
CITATIONS - :EV-COMP-AINF:3482054332:ave
PATHWAY-LINKS - (2-PG GLYCOLYSIS)
PATHWAY-LINKS - (G3P GLYCOLYSIS)
PATHWAY-LINKS - (DPG GLYCOLYSIS)
PREDECESSORS - (RXN-11102 BISPHOSPHOGLYCERATE-MUTASE-RXN)
PREDECESSORS - (BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN BISPHOSPHOGLYCERATE-MUTASE-RXN)
REACTION-LAYOUT - (BISPHOSPHOGLYCERATE-MUTASE-RXN (:LEFT-PRIMARIES DPG) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 23-DIPHOSPHOGLYCERATE))
REACTION-LAYOUT - (BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN (:LEFT-PRIMARIES 23-DIPHOSPHOGLYCERATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES G3P))
REACTION-LAYOUT - (RXN-11102 (:LEFT-PRIMARIES 23-DIPHOSPHOGLYCERATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-PG))
REACTION-LIST - BISPHOSPHOGLYCERATE-MUTASE-RXN
REACTION-LIST - BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN
REACTION-LIST - RXN-11102
//
UNIQUE-ID - PWY-6121
TYPES - AIR-Biosynthesis
COMMON-NAME - 5-aminoimidazole ribonucleotide biosynthesis I
IN-PATHWAY - PWY-6277
PATHWAY-LINKS - (PRPP PWY0-662 PWY0-661)
PATHWAY-LINKS - (5-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE DENOVOPURINE2-PWY PWY-841 THISYN-PWY)
PREDECESSORS - (GLYRIBONUCSYN-RXN PRPPAMIDOTRANS-RXN)
PREDECESSORS - (GART-RXN GLYRIBONUCSYN-RXN)
PREDECESSORS - (FGAMSYN-RXN GART-RXN)
PREDECESSORS - (AIRS-RXN FGAMSYN-RXN)
REACTION-LAYOUT - (AIRS-RXN (:LEFT-PRIMARIES 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE))
REACTION-LAYOUT - (FGAMSYN-RXN (:LEFT-PRIMARIES 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE))
REACTION-LAYOUT - (GART-RXN (:LEFT-PRIMARIES 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE))
REACTION-LAYOUT - (GLYRIBONUCSYN-RXN (:LEFT-PRIMARIES 5-P-BETA-D-RIBOSYL-AMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE))
REACTION-LAYOUT - (PRPPAMIDOTRANS-RXN (:LEFT-PRIMARIES 5-P-BETA-D-RIBOSYL-AMINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES PRPP))
REACTION-LIST - AIRS-RXN
REACTION-LIST - FGAMSYN-RXN
REACTION-LIST - GART-RXN
REACTION-LIST - GLYRIBONUCSYN-RXN
REACTION-LIST - PRPPAMIDOTRANS-RXN
SUPER-PATHWAYS - PWY-6277
//
UNIQUE-ID - PWY-6122
TYPES - AIR-Biosynthesis
COMMON-NAME - 5-aminoimidazole ribonucleotide biosynthesis II
CITATIONS - :EV-COMP-AINF:3482054331:ave
PATHWAY-LINKS - (PRPP PWY0-662 PWY0-661)
PATHWAY-LINKS - (5-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE DENOVOPURINE2-PWY PWY-841 THISYN-PWY)
PREDECESSORS - (FGAMSYN-RXN GARTRANSFORMYL2-RXN)
PREDECESSORS - (GARTRANSFORMYL2-RXN GLYRIBONUCSYN-RXN)
PREDECESSORS - (GLYRIBONUCSYN-RXN PRPPAMIDOTRANS-RXN)
PREDECESSORS - (AIRS-RXN FGAMSYN-RXN)
REACTION-LAYOUT - (GARTRANSFORMYL2-RXN (:LEFT-PRIMARIES 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE))
REACTION-LAYOUT - (AIRS-RXN (:LEFT-PRIMARIES 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE))
REACTION-LAYOUT - (FGAMSYN-RXN (:LEFT-PRIMARIES 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE))
REACTION-LAYOUT - (GLYRIBONUCSYN-RXN (:LEFT-PRIMARIES 5-P-BETA-D-RIBOSYL-AMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE))
REACTION-LAYOUT - (PRPPAMIDOTRANS-RXN (:LEFT-PRIMARIES 5-P-BETA-D-RIBOSYL-AMINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES PRPP))
REACTION-LIST - GARTRANSFORMYL2-RXN
REACTION-LIST - AIRS-RXN
REACTION-LIST - FGAMSYN-RXN
REACTION-LIST - GLYRIBONUCSYN-RXN
REACTION-LIST - PRPPAMIDOTRANS-RXN
//
UNIQUE-ID - PWY-6277
TYPES - AIR-Biosynthesis
TYPES - Super-Pathways
COMMON-NAME - superpathway of 5-aminoimidazole ribonucleotide biosynthesis
CITATIONS - :EV-COMP-AINF:3482054331:ave
PATHWAY-LINKS - (PRPP PWY0-662 PWY0-661)
PATHWAY-LINKS - (5-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE DENOVOPURINE2-PWY PWY-841 THISYN-PWY)
PREDECESSORS - PWY-6122
PREDECESSORS - PWY-6121
PREDECESSORS - (FGAMSYN-RXN GARTRANSFORMYL2-RXN)
PREDECESSORS - (GARTRANSFORMYL2-RXN GLYRIBONUCSYN-RXN)
PREDECESSORS - (GLYRIBONUCSYN-RXN PRPPAMIDOTRANS-RXN)
PREDECESSORS - (AIRS-RXN FGAMSYN-RXN)
REACTION-LAYOUT - (PWY-6121 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (GARTRANSFORMYL2-RXN (:LEFT-PRIMARIES 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE))
REACTION-LAYOUT - (AIRS-RXN (:LEFT-PRIMARIES 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE))
REACTION-LAYOUT - (FGAMSYN-RXN (:LEFT-PRIMARIES 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE))
REACTION-LAYOUT - (GLYRIBONUCSYN-RXN (:LEFT-PRIMARIES 5-P-BETA-D-RIBOSYL-AMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE))
REACTION-LAYOUT - (PRPPAMIDOTRANS-RXN (:LEFT-PRIMARIES 5-P-BETA-D-RIBOSYL-AMINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES PRPP))
REACTION-LIST - PWY-6121
REACTION-LIST - GARTRANSFORMYL2-RXN
REACTION-LIST - AIRS-RXN
REACTION-LIST - FGAMSYN-RXN
REACTION-LIST - GLYRIBONUCSYN-RXN
REACTION-LIST - PRPPAMIDOTRANS-RXN
SUB-PATHWAYS - PWY-6121
//
UNIQUE-ID - PWY-6124
TYPES - IMP-Biosynthesis
COMMON-NAME - inosine-5'-phosphate biosynthesis II
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (IMP PWY-6125 PWY-6126)
PATHWAY-LINKS - (5-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE (|AIR-Biosynthesis| . :INCOMING))
PREDECESSORS - (SAICARSYN-RXN AIRCARBOXY-RXN)
PREDECESSORS - (AICARSYN-RXN SAICARSYN-RXN)
PREDECESSORS - (AICARTRANSFORM-RXN AICARSYN-RXN)
PREDECESSORS - (IMPCYCLOHYDROLASE-RXN AICARTRANSFORM-RXN)
PRIMARIES - (AMPSYN-RXN (ADENYLOSUCC) (AMP))
REACTION-LAYOUT - (IMPCYCLOHYDROLASE-RXN (:LEFT-PRIMARIES IMP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES PHOSPHORIBOSYL-FORMAMIDO-CARBOXAMIDE))
REACTION-LAYOUT - (AICARTRANSFORM-RXN (:LEFT-PRIMARIES AICAR) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHORIBOSYL-FORMAMIDO-CARBOXAMIDE))
REACTION-LAYOUT - (AICARSYN-RXN (:LEFT-PRIMARIES P-RIBOSYL-4-SUCCCARB-AMINOIMIDAZOLE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES AICAR))
REACTION-LAYOUT - (SAICARSYN-RXN (:LEFT-PRIMARIES PHOSPHORIBOSYL-CARBOXY-AMINOIMIDAZOLE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES P-RIBOSYL-4-SUCCCARB-AMINOIMIDAZOLE))
REACTION-LAYOUT - (AIRCARBOXY-RXN (:LEFT-PRIMARIES PHOSPHORIBOSYL-CARBOXY-AMINOIMIDAZOLE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE))
REACTION-LIST - IMPCYCLOHYDROLASE-RXN
REACTION-LIST - AICARTRANSFORM-RXN
REACTION-LIST - AICARSYN-RXN
REACTION-LIST - SAICARSYN-RXN
REACTION-LIST - AIRCARBOXY-RXN
SYNONYMS - IMP biosynthesis II
//
UNIQUE-ID - P1-PWY
TYPES - Purine-Nucleotides-Salvage
TYPES - PYR-NUC-SYN
COMMON-NAME - salvage pathways of purine and pyrimidine nucleotides
CITATIONS - :EV-COMP-AINF:3453644158:ave
CREDITS - O-18
CREDITS - |pellegrini-toole|
PREDECESSORS - (GUANPRIBOSYLTRAN-RXN RXN0-5199)
PREDECESSORS - (CMPKI-RXN CYTIKIN-RXN)
PREDECESSORS - (CYTIKIN-RXN CYTIDEAM2-RXN)
PREDECESSORS - (UMPKI-RXN URACIL-PRIBOSYLTRANS-RXN)
PREDECESSORS - (THYMIDYLATESYN-RXN THYKI-RXN)
PREDECESSORS - (DTMPKI-RXN THYKI-RXN)
PREDECESSORS - (THYKI-RXN THYM-PHOSPH-RXN)
PREDECESSORS - (ADENYL-KIN-RXN ADENPRIBOSYLTRAN-RXN)
PREDECESSORS - (ADENPRIBOSYLTRAN-RXN ADENPHOSPHOR-RXN)
PREDECESSORS - (GUANYL-KIN-RXN GUANPRIBOSYLTRAN-RXN)
PREDECESSORS - (URIDINEKIN-RXN URACIL-PRIBOSYLTRANS-RXN)
PREDECESSORS - (CYTIDEAM2-RXN URIDINEKIN-RXN)
REACTION-LAYOUT - (RXN0-5199 (:LEFT-PRIMARIES GUANOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GUANINE))
REACTION-LAYOUT - (CYTIKIN-RXN (:LEFT-PRIMARIES CYTIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ADP CMP))
REACTION-LAYOUT - (URIDINEKIN-RXN (:LEFT-PRIMARIES URIDINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ADP UMP))
REACTION-LAYOUT - (PRPPSYN-RXN (:LEFT-PRIMARIES RIBOSE-5P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES AMP PRPP))
REACTION-LAYOUT - (GUANYL-KIN-RXN (:LEFT-PRIMARIES GMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ADP GDP))
REACTION-LAYOUT - (GUANPRIBOSYLTRAN-RXN (:LEFT-PRIMARIES GUANINE PRPP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GMP))
REACTION-LAYOUT - (CMPKI-RXN (:LEFT-PRIMARIES CMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CDP ADP))
REACTION-LAYOUT - (CYTIDEAM2-RXN (:LEFT-PRIMARIES CYTIDINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES URIDINE))
REACTION-LAYOUT - (UMPKI-RXN (:LEFT-PRIMARIES UMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP ADP))
REACTION-LAYOUT - (URACIL-PRIBOSYLTRANS-RXN (:LEFT-PRIMARIES UMP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES URACIL PRPP))
REACTION-LAYOUT - (ADENPHOSPHOR-RXN (:LEFT-PRIMARIES ADENOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ADENINE))
REACTION-LAYOUT - (THYMIDYLATESYN-RXN (:LEFT-PRIMARIES DUMP METHYLENE-THF) (:DIRECTION :R2L) (:RIGHT-PRIMARIES TMP))
REACTION-LAYOUT - (DTMPKI-RXN (:LEFT-PRIMARIES TMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TDP ADP))
REACTION-LAYOUT - (THYKI-RXN (:LEFT-PRIMARIES THYMIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ADP TMP))
REACTION-LAYOUT - (THYM-PHOSPH-RXN (:LEFT-PRIMARIES THYMIDINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES THYMINE DEOXY-RIBOSE-1P))
REACTION-LAYOUT - (ADENYL-KIN-RXN (:LEFT-PRIMARIES AMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ADP))
REACTION-LAYOUT - (ADENPRIBOSYLTRAN-RXN (:LEFT-PRIMARIES AMP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ADENINE PRPP))
REACTION-LIST - RXN0-5199
REACTION-LIST - CYTIKIN-RXN
REACTION-LIST - URIDINEKIN-RXN
REACTION-LIST - PRPPSYN-RXN
REACTION-LIST - GUANYL-KIN-RXN
REACTION-LIST - GUANPRIBOSYLTRAN-RXN
REACTION-LIST - CMPKI-RXN
REACTION-LIST - CYTIDEAM2-RXN
REACTION-LIST - UMPKI-RXN
REACTION-LIST - URACIL-PRIBOSYLTRANS-RXN
REACTION-LIST - ADENPHOSPHOR-RXN
REACTION-LIST - THYMIDYLATESYN-RXN
REACTION-LIST - DTMPKI-RXN
REACTION-LIST - THYKI-RXN
REACTION-LIST - THYM-PHOSPH-RXN
REACTION-LIST - ADENYL-KIN-RXN
REACTION-LIST - ADENPRIBOSYLTRAN-RXN
SYNONYMS - purine and pyrimidine metabolism
//
UNIQUE-ID - P121-PWY
TYPES - Purine-Nucleotides-Salvage
COMMON-NAME - salvage pathways of purine nucleosides I
CITATIONS - :EV-COMP-AINF:3453644158:ave
CREDITS - O-18
CREDITS - |pellegrini-toole|
PREDECESSORS - (IMP-DEHYDROG-RXN INOSINEKIN-RXN)
PREDECESSORS - (ADENYLOSUCCINATE-SYNTHASE-RXN INOSINEKIN-RXN)
PREDECESSORS - (INOSINEKIN-RXN ADENODEAMIN-RXN)
PREDECESSORS - (GUANINE-DEAMINASE-RXN RXN0-5199)
PREDECESSORS - (GUANPRIBOSYLTRAN-RXN RXN0-5199)
PREDECESSORS - (IMP-DEHYDROG-RXN HYPOXANPRIBOSYLTRAN-RXN)
PREDECESSORS - (ADENPHOSPHOR-RXN ADENPRIBOSYLTRAN-RXN)
PREDECESSORS - (INOPHOSPHOR-RXN ADENODEAMIN-RXN)
PREDECESSORS - (ADENODEAMIN-RXN ADENPHOSPHOR-RXN)
PREDECESSORS - (HYPOXANPRIBOSYLTRAN-RXN INOPHOSPHOR-RXN)
PREDECESSORS - (ADENYLOSUCCINATE-SYNTHASE-RXN HYPOXANPRIBOSYLTRAN-RXN)
PREDECESSORS - (AMPSYN-RXN ADENYLOSUCCINATE-SYNTHASE-RXN)
PREDECESSORS - (ADENPRIBOSYLTRAN-RXN AMPSYN-RXN)
REACTION-LAYOUT - (GUANOSINEKIN-RXN (:LEFT-PRIMARIES GUANOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GMP))
REACTION-LAYOUT - (GUANINE-DEAMINASE-RXN (:LEFT-PRIMARIES GUANINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHINE))
REACTION-LAYOUT - (GUANPRIBOSYLTRAN-RXN (:LEFT-PRIMARIES GUANINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GMP))
REACTION-LAYOUT - (RXN0-5199 (:LEFT-PRIMARIES GUANOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GUANINE))
REACTION-LAYOUT - (IMP-DEHYDROG-RXN (:LEFT-PRIMARIES IMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHOSINE-5-PHOSPHATE))
REACTION-LAYOUT - (ADENPRIBOSYLTRAN-RXN (:LEFT-PRIMARIES AMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ADENINE))
REACTION-LAYOUT - (AMPSYN-RXN (:LEFT-PRIMARIES ADENYLOSUCC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES AMP))
REACTION-LAYOUT - (ADENYLOSUCCINATE-SYNTHASE-RXN (:LEFT-PRIMARIES IMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ADENYLOSUCC))
REACTION-LAYOUT - (INOSINEKIN-RXN (:LEFT-PRIMARIES INOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES IMP))
REACTION-LAYOUT - (HYPOXANPRIBOSYLTRAN-RXN (:LEFT-PRIMARIES IMP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES HYPOXANTHINE))
REACTION-LAYOUT - (INOPHOSPHOR-RXN (:LEFT-PRIMARIES INOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES HYPOXANTHINE))
REACTION-LAYOUT - (ADENPHOSPHOR-RXN (:LEFT-PRIMARIES ADENOSINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ADENINE))
REACTION-LAYOUT - (ADENODEAMIN-RXN (:LEFT-PRIMARIES ADENOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES INOSINE))
REACTION-LIST - GUANOSINEKIN-RXN
REACTION-LIST - GUANINE-DEAMINASE-RXN
REACTION-LIST - GUANPRIBOSYLTRAN-RXN
REACTION-LIST - RXN0-5199
REACTION-LIST - IMP-DEHYDROG-RXN
REACTION-LIST - ADENPRIBOSYLTRAN-RXN
REACTION-LIST - AMPSYN-RXN
REACTION-LIST - ADENYLOSUCCINATE-SYNTHASE-RXN
REACTION-LIST - INOSINEKIN-RXN
REACTION-LIST - HYPOXANPRIBOSYLTRAN-RXN
REACTION-LIST - INOPHOSPHOR-RXN
REACTION-LIST - ADENPHOSPHOR-RXN
REACTION-LIST - ADENODEAMIN-RXN
SYNONYMS - purine salvage
//
UNIQUE-ID - SALVADEHYPOX-PWY
TYPES - Purine-Nucleotides-Salvage
COMMON-NAME - salvage pathways of adenine, hypoxanthine, and their nucleosides
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - SRI
CREDITS - |arnaud|
PATHWAY-LINKS - (IMP DENOVOPURINE2-PWY)
PREDECESSORS - (RXN0-901 RXN0-902)
PREDECESSORS - (RXN0-902 INOPHOSPHOR-RXN)
PREDECESSORS - (AMP-NUCLEOSID-RXN ADENPRIBOSYLTRAN-RXN)
PREDECESSORS - (INOPHOSPHOR-RXN ADENODEAMIN-RXN)
PREDECESSORS - (INOPHOSPHOR-RXN DEOXYINOPHOSPHOR-RXN)
PREDECESSORS - (ADENODEAMIN-RXN ADENPHOSPHOR-RXN)
PREDECESSORS - (ADENPHOSPHOR-RXN AMP-NUCLEOSID-RXN)
PREDECESSORS - (ADENPRIBOSYLTRAN-RXN AMP-NUCLEOSID-RXN)
PREDECESSORS - (HYPOXANPRIBOSYLTRAN-RXN INOPHOSPHOR-RXN)
PREDECESSORS - (ADENPRIBOSYLTRAN-RXN DEOXYADENPHOSPHOR-RXN)
PREDECESSORS - (DEOXYADENPHOSPHOR-RXN ADDALT-RXN)
PREDECESSORS - (ADDALT-RXN DEOXYINOPHOSPHOR-RXN)
PREDECESSORS - (DEOXYINOPHOSPHOR-RXN INOPHOSPHOR-RXN)
PREDECESSORS - (INOSINEKIN-RXN ADENODEAMIN-RXN)
PRIMARIES - (GUANPHOSPHOR-RXN NIL (GUANINE))
PRIMARIES - (INOPHOSPHOR-RXN (INOSINE) NIL)
REACTION-LAYOUT - (RXN0-901 (:LEFT-PRIMARIES XANTHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES URATE))
REACTION-LAYOUT - (HYPOXANPRIBOSYLTRAN-RXN (:LEFT-PRIMARIES IMP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES HYPOXANTHINE))
REACTION-LAYOUT - (RXN0-902 (:LEFT-PRIMARIES HYPOXANTHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHINE))
REACTION-LAYOUT - (INOSINEKIN-RXN (:LEFT-PRIMARIES INOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES IMP))
REACTION-LAYOUT - (ADENODEAMIN-RXN (:LEFT-PRIMARIES ADENOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES INOSINE))
REACTION-LAYOUT - (ADDALT-RXN (:LEFT-PRIMARIES DEOXYADENOSINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES DEOXYINOSINE))
REACTION-LAYOUT - (ADENPHOSPHOR-RXN (:LEFT-PRIMARIES ADENOSINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ADENINE))
REACTION-LAYOUT - (DEOXYADENPHOSPHOR-RXN (:LEFT-PRIMARIES ADENINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES DEOXYADENOSINE))
REACTION-LAYOUT - (DEOXYINOPHOSPHOR-RXN (:LEFT-PRIMARIES DEOXYINOSINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES HYPOXANTHINE))
REACTION-LAYOUT - (INOPHOSPHOR-RXN (:LEFT-PRIMARIES INOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES HYPOXANTHINE))
REACTION-LAYOUT - (ADENPRIBOSYLTRAN-RXN (:LEFT-PRIMARIES AMP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ADENINE))
REACTION-LAYOUT - (AMP-NUCLEOSID-RXN (:LEFT-PRIMARIES AMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ADENINE))
REACTION-LIST - RXN0-901
REACTION-LIST - HYPOXANPRIBOSYLTRAN-RXN
REACTION-LIST - RXN0-902
REACTION-LIST - INOSINEKIN-RXN
REACTION-LIST - ADENODEAMIN-RXN
REACTION-LIST - ADDALT-RXN
REACTION-LIST - ADENPHOSPHOR-RXN
REACTION-LIST - DEOXYADENPHOSPHOR-RXN
REACTION-LIST - DEOXYINOPHOSPHOR-RXN
REACTION-LIST - INOPHOSPHOR-RXN
REACTION-LIST - ADENPRIBOSYLTRAN-RXN
REACTION-LIST - AMP-NUCLEOSID-RXN
SYNONYMS - purine ribonucleotide/ribonucleoside metabolism
//
UNIQUE-ID - SALVPURINE2-PWY
TYPES - Purine-Nucleotides-Salvage
COMMON-NAME - salvage pathways of guanine, xanthine, and their nucleosides
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |arnaud|
PATHWAY-LINKS - (RIBOSE-1P (PWY0-661 . :OUTGOING))
PATHWAY-LINKS - (GMP DENOVOPURINE2-PWY)
PATHWAY-LINKS - (XANTHOSINE-5-PHOSPHATE DENOVOPURINE2-PWY)
PATHWAY-LINKS - (IMP DENOVOPURINE2-PWY)
PREDECESSORS - (DEOXYGUANPHOSPHOR-RXN GUANPRIBOSYLTRAN-RXN)
PREDECESSORS - (DEOXYGUANPHOSPHOR-RXN RXN0-5199)
PREDECESSORS - (DEOXYGUANPHOSPHOR-RXN GUANINE-DEAMINASE-RXN)
PREDECESSORS - (GUANPRIBOSYLTRAN-RXN RXN0-5199)
PREDECESSORS - (GUANPRIBOSYLTRAN-RXN GUANINE-DEAMINASE-RXN)
PREDECESSORS - (GUANOSINEKIN-RXN RXN0-5199)
PREDECESSORS - (RXN0-5199 GUANINE-DEAMINASE-RXN)
PREDECESSORS - (XANPRIBOSYLTRAN-RXN XANTHOSINEPHOSPHORY-RXN)
PREDECESSORS - (XANPRIBOSYLTRAN-RXN GUANINE-DEAMINASE-RXN)
PRIMARIES - (RXN0-5199 (GUANINE) (GUANOSINE))
PRIMARIES - (GUANOSINEKIN-RXN (GUANOSINE) (GMP))
PRIMARIES - (GUANINE-DEAMINASE-RXN (GUANINE) (XANTHINE))
PRIMARIES - (XANPRIBOSYLTRAN-RXN (XANTHINE) (XANTHOSINE-5-PHOSPHATE))
PRIMARIES - (GUANPHOSPHOR-RXN (GUANINE) (GUANOSINE))
PRIMARIES - (DEOXYGUANPHOSPHOR-RXN (GUANINE) (DEOXYGUANOSINE))
PRIMARIES - (GUANPRIBOSYLTRAN-RXN (GUANINE) (GMP))
PRIMARIES - (INOPHOSPHOR-RXN (INOSINE) NIL)
REACTION-LAYOUT - (RXN0-5199 (:LEFT-PRIMARIES GUANOSINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES GUANINE))
REACTION-LAYOUT - (GUANPRIBOSYLTRAN-RXN (:LEFT-PRIMARIES GUANINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GMP))
REACTION-LAYOUT - (DEOXYGUANPHOSPHOR-RXN (:LEFT-PRIMARIES DEOXYGUANOSINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES GUANINE))
REACTION-LAYOUT - (GUANOSINEKIN-RXN (:LEFT-PRIMARIES GUANOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GMP))
REACTION-LAYOUT - (GUANINE-DEAMINASE-RXN (:LEFT-PRIMARIES GUANINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHINE))
REACTION-LAYOUT - (XANTHOSINEPHOSPHORY-RXN (:LEFT-PRIMARIES XANTHOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHINE))
REACTION-LAYOUT - (XANPRIBOSYLTRAN-RXN (:LEFT-PRIMARIES XANTHOSINE-5-PHOSPHATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES XANTHINE))
REACTION-LIST - RXN0-5199
REACTION-LIST - GUANPRIBOSYLTRAN-RXN
REACTION-LIST - DEOXYGUANPHOSPHOR-RXN
REACTION-LIST - GUANOSINEKIN-RXN
REACTION-LIST - GUANINE-DEAMINASE-RXN
REACTION-LIST - XANTHOSINEPHOSPHORY-RXN
REACTION-LIST - XANPRIBOSYLTRAN-RXN
SYNONYMS - purine ribonucleotide/ribonucleoside metabolism
//
UNIQUE-ID - PWY-5686
TYPES - PYR-NUC-SYN
COMMON-NAME - uridine-5'-phosphate biosynthesis
CITATIONS - :EV-COMP-AINF:3453644158:ave
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |hartmut|
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - PWY0-162
PATHWAY-LINKS - (UMP PWY-5687)
PATHWAY-LINKS - (CARBAMOYL-P ARGININE-SYN)
PREDECESSORS - (OROTPDECARB-RXN OROPRIBTRANS-RXN)
PREDECESSORS - (OROPRIBTRANS-RXN DIHYDROOROTATE-DEHYDROGENASE-RXN)
PREDECESSORS - (DIHYDROOROTATE-DEHYDROGENASE-RXN DIHYDROOROT-RXN)
PREDECESSORS - (DIHYDROOROT-RXN ASPCARBTRANS-RXN)
PREDECESSORS - (ASPCARBTRANS-RXN CARBPSYN-RXN)
PREDECESSORS - (CARBPSYN-RXN)
PRIMARIES - (OROPRIBTRANS-RXN (OROTATE) (OROTIDINE-5-PHOSPHATE))
REACTION-LAYOUT - (OROTPDECARB-RXN (:LEFT-PRIMARIES OROTIDINE-5-PHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UMP))
REACTION-LAYOUT - (OROPRIBTRANS-RXN (:LEFT-PRIMARIES OROTIDINE-5-PHOSPHATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES OROTATE))
REACTION-LAYOUT - (DIHYDROOROTATE-DEHYDROGENASE-RXN (:LEFT-PRIMARIES DI-H-OROTATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OROTATE))
REACTION-LAYOUT - (DIHYDROOROT-RXN (:LEFT-PRIMARIES DI-H-OROTATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CARBAMYUL-L-ASPARTATE))
REACTION-LAYOUT - (ASPCARBTRANS-RXN (:LEFT-PRIMARIES CARBAMOYL-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CARBAMYUL-L-ASPARTATE))
REACTION-LAYOUT - (CARBPSYN-RXN (:LEFT-PRIMARIES HCO3) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CARBAMOYL-P))
REACTION-LIST - OROTPDECARB-RXN
REACTION-LIST - OROPRIBTRANS-RXN
REACTION-LIST - DIHYDROOROTATE-DEHYDROGENASE-RXN
REACTION-LIST - DIHYDROOROT-RXN
REACTION-LIST - ASPCARBTRANS-RXN
REACTION-LIST - CARBPSYN-RXN
SUPER-PATHWAYS - PWY0-162
SYNONYMS - pyrimidine biosynthesis
SYNONYMS - <i>de novo</i> biosynthesis of uridine-5'-phosphate
SYNONYMS - <i>de novo</i> biosynthesis of uridine-5'-monophosphate
//
UNIQUE-ID - PWY-5687
TYPES - PYR-NUC-SYN
COMMON-NAME - pyrimidine ribonucleotides interconversion
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |hartmut|
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - PWY0-162
PATHWAY-LINKS - (UMP PWY-5686)
PREDECESSORS - (CTPSYN-RXN UDPKIN-RXN)
PREDECESSORS - (UDPKIN-RXN UMPKI-RXN)
PREDECESSORS - (CDPKIN-RXN CTPSYN-RXN)
PRIMARIES - (OROPRIBTRANS-RXN (PRPP OROTATE) NIL)
REACTION-LAYOUT - (CDPKIN-RXN (:LEFT-PRIMARIES CDP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CTP))
REACTION-LAYOUT - (CTPSYN-RXN (:LEFT-PRIMARIES UTP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CTP))
REACTION-LAYOUT - (UDPKIN-RXN (:LEFT-PRIMARIES UDP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UTP))
REACTION-LAYOUT - (UMPKI-RXN (:LEFT-PRIMARIES UMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP))
REACTION-LIST - CDPKIN-RXN
REACTION-LIST - CTPSYN-RXN
REACTION-LIST - UDPKIN-RXN
REACTION-LIST - UMPKI-RXN
SUPER-PATHWAYS - PWY0-162
SYNONYMS - pyrimidine biosynthesis
//
UNIQUE-ID - PWY0-162
TYPES - PYR-NUC-SYN
TYPES - Super-Pathways
COMMON-NAME - pyrimidine ribonucleotides <i>de novo</i> biosynthesis
PATHWAY-LINKS - (PRPP (|PRPP-Biosynthesis| . :INCOMING))
PATHWAY-LINKS - (CARBAMOYL-P ARGININE-SYN)
PREDECESSORS - (UMPKI-RXN OROTPDECARB-RXN)
PREDECESSORS - PWY-5687
PREDECESSORS - PWY-5686
REACTION-LAYOUT - (PWY-5687 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (PWY-5686 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - PWY-5687
REACTION-LIST - PWY-5686
SUB-PATHWAYS - PWY-5687
SUB-PATHWAYS - PWY-5686
SYNONYMS - pyrimidine biosynthesis
//
UNIQUE-ID - PWY0-163
TYPES - PYR-NUC-SYN
COMMON-NAME - salvage pathways of pyrimidine ribonucleotides
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - |ingraham|
CREDITS - O0-3
CREDITS - SRI
CREDITS - |arnaud|
PATHWAY-LINKS - (UMP PWY0-162)
PREDECESSORS - (URKI-RXN CYTIDEAM2-RXN)
PREDECESSORS - (URPHOS-RXN CYTIDEAM2-RXN)
PREDECESSORS - (CYTIDINEKIN-RXN)
PREDECESSORS - (CMPKI-RXN CYTIDINEKIN-RXN)
PREDECESSORS - (CDPKIN-RXN CMPKI-RXN)
PREDECESSORS - (URACIL-PRIBOSYLTRANS-RXN CYTDEAM-RXN)
PREDECESSORS - (URACIL-PRIBOSYLTRANS-RXN URPHOS-RXN)
REACTION-LAYOUT - (CYTIDINEKIN-RXN (:LEFT-PRIMARIES CYTIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CMP))
REACTION-LAYOUT - (URKI-RXN (:LEFT-PRIMARIES URIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UMP))
REACTION-LAYOUT - (CYTDEAM-RXN (:LEFT-PRIMARIES CYTOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES URACIL))
REACTION-LAYOUT - (CYTIDEAM2-RXN (:LEFT-PRIMARIES CYTIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES URIDINE))
REACTION-LAYOUT - (URPHOS-RXN (:LEFT-PRIMARIES URIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES URACIL))
REACTION-LAYOUT - (CMPKI-RXN (:LEFT-PRIMARIES CMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CDP))
REACTION-LAYOUT - (CDPKIN-RXN (:LEFT-PRIMARIES CDP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CTP))
REACTION-LAYOUT - (URACIL-PRIBOSYLTRANS-RXN (:LEFT-PRIMARIES UMP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES URACIL))
REACTION-LIST - CYTIDINEKIN-RXN
REACTION-LIST - URKI-RXN
REACTION-LIST - CYTDEAM-RXN
REACTION-LIST - CYTIDEAM2-RXN
REACTION-LIST - URPHOS-RXN
REACTION-LIST - CMPKI-RXN
REACTION-LIST - CDPKIN-RXN
REACTION-LIST - URACIL-PRIBOSYLTRANS-RXN
SYNONYMS - pyrimidine ribonucleotide/ribonucleoside metabolism
//
UNIQUE-ID - PWY0-166
TYPES - PYR-NUC-SYN
COMMON-NAME - pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |fulcher|
PATHWAY-LINKS - (CTP PWY0-162)
PATHWAY-LINKS - (UTP PWY0-162)
PATHWAY-LINKS - (CDP PWY0-162)
PATHWAY-LINKS - (UDP PWY0-162)
PREDECESSORS - (DUDPKIN-RXN RXN0-722)
PREDECESSORS - (DCTP-DEAM-RXN DCDPKIN-RXN)
PREDECESSORS - (DTDPKIN-RXN DTMPKI-RXN)
PREDECESSORS - (DTMPKI-RXN)
PREDECESSORS - (THYMIDYLATESYN-RXN)
PREDECESSORS - (DTMPKI-RXN THYMIDYLATESYN-RXN)
PREDECESSORS - (DUTP-PYROP-RXN DUDPKIN-RXN)
PREDECESSORS - (THYMIDYLATESYN-RXN DUTP-PYROP-RXN)
PREDECESSORS - (DUTP-PYROP-RXN DCTP-DEAM-RXN)
PREDECESSORS - (DCDPKIN-RXN CDPREDUCT-RXN)
PREDECESSORS - (DUDPKIN-RXN UDPREDUCT-RXN)
PREDECESSORS - (DCDPKIN-RXN RIBONUCLEOSIDE-DIP-REDUCTII-RXN)
PREDECESSORS - (DCTP-DEAM-RXN RXN0-723)
PREDECESSORS - (DUTP-PYROP-RXN RXN0-724)
PRIMARIES - (RIBONUCLEOSIDE-DIP-REDUCTII-RXN (CDP) NIL)
PRIMARIES - (RXN0-722 (UDP) NIL)
PRIMARIES - (UDPREDUCT-RXN (UDP) (DUDP))
PRIMARIES - (CDPREDUCT-RXN (CDP) (DCDP))
REACTION-LAYOUT - (RXN0-723 (:LEFT-PRIMARIES CTP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DCTP))
REACTION-LAYOUT - (RXN0-724 (:LEFT-PRIMARIES UTP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DUTP))
REACTION-LAYOUT - (RIBONUCLEOSIDE-DIP-REDUCTII-RXN (:LEFT-PRIMARIES DCDP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CDP))
REACTION-LAYOUT - (RXN0-722 (:LEFT-PRIMARIES UDP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DUDP))
REACTION-LAYOUT - (CDPREDUCT-RXN (:LEFT-PRIMARIES DCDP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CDP))
REACTION-LAYOUT - (UDPREDUCT-RXN (:LEFT-PRIMARIES DUDP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES UDP))
REACTION-LAYOUT - (DTDPKIN-RXN (:LEFT-PRIMARIES TDP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TTP))
REACTION-LAYOUT - (DTMPKI-RXN (:LEFT-PRIMARIES TMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TDP))
REACTION-LAYOUT - (THYMIDYLATESYN-RXN (:LEFT-PRIMARIES DUMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TMP))
REACTION-LAYOUT - (DUTP-PYROP-RXN (:LEFT-PRIMARIES DUTP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DUMP))
REACTION-LAYOUT - (DUDPKIN-RXN (:LEFT-PRIMARIES DUDP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DUTP))
REACTION-LAYOUT - (DCTP-DEAM-RXN (:LEFT-PRIMARIES DCTP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DUTP))
REACTION-LAYOUT - (DCDPKIN-RXN (:LEFT-PRIMARIES DCDP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DCTP))
REACTION-LIST - RXN0-723
REACTION-LIST - RXN0-724
REACTION-LIST - RIBONUCLEOSIDE-DIP-REDUCTII-RXN
REACTION-LIST - RXN0-722
REACTION-LIST - CDPREDUCT-RXN
REACTION-LIST - UDPREDUCT-RXN
REACTION-LIST - DTDPKIN-RXN
REACTION-LIST - DTMPKI-RXN
REACTION-LIST - THYMIDYLATESYN-RXN
REACTION-LIST - DUTP-PYROP-RXN
REACTION-LIST - DUDPKIN-RXN
REACTION-LIST - DCTP-DEAM-RXN
REACTION-LIST - DCDPKIN-RXN
SYNONYMS - deoxypyrimidine nucleotide/nucleoside metabolism
//
UNIQUE-ID - PWY0-181
TYPES - PYR-NUC-SYN
COMMON-NAME - salvage pathways of pyrimidine deoxyribonucleotides
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - |ingraham|
CREDITS - O0-3
CREDITS - SRI
CREDITS - |arnaud|
PATHWAY-LINKS - (TMP PWY0-166)
PATHWAY-LINKS - (DUMP PWY0-166)
PREDECESSORS - (THYKI-RXN THYM-PHOSPH-RXN)
PREDECESSORS - (THYM-PHOSPH-RXN URA-PHOSPH-RXN)
PREDECESSORS - (URA-PHOSPH-RXN CYTIDEAM-RXN)
PREDECESSORS - (DURIDKI-RXN CYTIDEAM-RXN)
REACTION-LAYOUT - (THYKI-RXN (:LEFT-PRIMARIES THYMIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TMP))
REACTION-LAYOUT - (THYM-PHOSPH-RXN (:LEFT-PRIMARIES THYMIDINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES DEOXY-RIBOSE-1P))
REACTION-LAYOUT - (URA-PHOSPH-RXN (:LEFT-PRIMARIES DEOXYURIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DEOXY-RIBOSE-1P))
REACTION-LAYOUT - (DURIDKI-RXN (:LEFT-PRIMARIES DEOXYURIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DUMP))
REACTION-LAYOUT - (CYTIDEAM-RXN (:LEFT-PRIMARIES DEOXYCYTIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DEOXYURIDINE))
REACTION-LIST - THYKI-RXN
REACTION-LIST - THYM-PHOSPH-RXN
REACTION-LIST - URA-PHOSPH-RXN
REACTION-LIST - DURIDKI-RXN
REACTION-LIST - CYTIDEAM-RXN
SYNONYMS - deoxypyrimidine nucleotide/nucleoside metabolism
//
UNIQUE-ID - PWY-5109
TYPES - Other-biosynthesis
COMMON-NAME - 2-methylbutyrate biosynthesis
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (METHYLACETOACETYLCOATHIOL-RXN PROPIONATE-COA-TRANSFERASE-RXN)
PREDECESSORS - (2-MEBUCOA-FAD-RXN TIGLYLCOA-HYDROXY-RXN)
PREDECESSORS - (TIGLYLCOA-HYDROXY-RXN 1.1.1.178-RXN)
PREDECESSORS - (1.1.1.178-RXN METHYLACETOACETYLCOATHIOL-RXN)
PRIMARIES - (METHYLACETOACETYLCOATHIOL-RXN (PROPIONYL-COA) NIL)
PRIMARIES - (ACECOATRANS-RXN (ACET) NIL)
REACTION-LAYOUT - (PROPIONATE-COA-TRANSFERASE-RXN (:LEFT-PRIMARIES ACETYL-COA PROPIONATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PROPIONYL-COA))
REACTION-LAYOUT - (2-MEBUCOA-FAD-RXN (:LEFT-PRIMARIES 2-METHYL-BUTYRYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CPD-1083))
REACTION-LAYOUT - (TIGLYLCOA-HYDROXY-RXN (:LEFT-PRIMARIES CPD-1083) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 2-METHYL-3-HYDROXY-BUTYRYL-COA))
REACTION-LAYOUT - (1.1.1.178-RXN (:LEFT-PRIMARIES 2-METHYL-3-HYDROXY-BUTYRYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 2-METHYL-ACETO-ACETYL-COA))
REACTION-LAYOUT - (METHYLACETOACETYLCOATHIOL-RXN (:LEFT-PRIMARIES 2-METHYL-ACETO-ACETYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ACETYL-COA PROPIONYL-COA))
REACTION-LIST - PROPIONATE-COA-TRANSFERASE-RXN
REACTION-LIST - 2-MEBUCOA-FAD-RXN
REACTION-LIST - TIGLYLCOA-HYDROXY-RXN
REACTION-LIST - 1.1.1.178-RXN
REACTION-LIST - METHYLACETOACETYLCOATHIOL-RXN
//
UNIQUE-ID - PWY-5389
TYPES - Other-biosynthesis
COMMON-NAME - methylthiopropionate biosynthesis
CITATIONS - :EV-COMP-AINF:3422805051:ave
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |tissier|
PATHWAY-LINKS - (CPD-85 PWY-4361)
PREDECESSORS - (R146-RXN)
PRIMARIES - (R146-RXN (CPD-85) (CPD-7672))
REACTION-LAYOUT - (R146-RXN (:LEFT-PRIMARIES CPD-85) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-7672))
REACTION-LIST - R146-RXN
//
UNIQUE-ID - PWY-5670
TYPES - TRITERPENOID-SYN
TYPES - Other-biosynthesis
COMMON-NAME - epoxysqualene biosynthesis
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - PWY66-4
IN-PATHWAY - PWY66-3
IN-PATHWAY - PWY66-341
PATHWAY-LINKS - (FARNESYL-PP PWY-5123)
PREDECESSORS - (SQUALENE-MONOOXYGENASE-RXN RXN66-281)
PREDECESSORS - (RXN66-281 2.5.1.21-RXN)
PRIMARIES - (RXN-8352 (CPD-8134) (CPD-4161))
PRIMARIES - (RXN-8353 (CPD-4141) (CPD-8134))
PRIMARIES - (2.1.1.143-RXN (CPD-4101) (CPD-4124))
REACTION-LAYOUT - (SQUALENE-MONOOXYGENASE-RXN (:LEFT-PRIMARIES SQUALENE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES EPOXYSQUALENE))
REACTION-LAYOUT - (RXN66-281 (:LEFT-PRIMARIES CPD-465) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SQUALENE))
REACTION-LAYOUT - (2.5.1.21-RXN (:LEFT-PRIMARIES FARNESYL-PP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-465))
REACTION-LIST - SQUALENE-MONOOXYGENASE-RXN
REACTION-LIST - RXN66-281
REACTION-LIST - 2.5.1.21-RXN
SUPER-PATHWAYS - PWY66-4
SUPER-PATHWAYS - PWY66-3
SUPER-PATHWAYS - PWY66-341
//
UNIQUE-ID - PWY0-662
TYPES - PRPP-Biosynthesis
COMMON-NAME - PRPP biosynthesis I
CITATIONS - :EV-COMP-AINF:3380892013:cjb
PREDECESSORS - (PRPPSYN-RXN)
REACTION-LAYOUT - (PRPPSYN-RXN (:LEFT-PRIMARIES RIBOSE-5P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PRPP))
REACTION-LIST - PRPPSYN-RXN
SYNONYMS - 5-phosphoribosyl 1-pyrophosphate biosynthesis
//
UNIQUE-ID - ARGSPECAT-PWY
TYPES - Polyamine-Biosynthesis
COMMON-NAME - spermine biosynthesis
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - |caspi|
CREDITS - SRI
CREDITS - |hying|
PATHWAY-LINKS - (5-METHYLTHIOADENOSINE PWY-4361)
PATHWAY-LINKS - (SPERMINE PWY-3981)
PATHWAY-LINKS - (SPERMIDINE BSUBPOLYAMSYN-PWY)
PREDECESSORS - (SPERMINE-SYNTHASE-RXN SAMDECARB-RXN)
PRIMARIES - (SPERMINE-SYNTHASE-RXN (S-ADENOSYLMETHIONINAMINE SPERMIDINE) (5-METHYLTHIOADENOSINE SPERMINE))
REACTION-LAYOUT - (SAMDECARB-RXN (:LEFT-PRIMARIES S-ADENOSYLMETHIONINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES S-ADENOSYLMETHIONINAMINE))
REACTION-LAYOUT - (SPERMINE-SYNTHASE-RXN (:LEFT-PRIMARIES S-ADENOSYLMETHIONINAMINE SPERMIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-METHYLTHIOADENOSINE SPERMINE))
REACTION-LIST - SAMDECARB-RXN
REACTION-LIST - SPERMINE-SYNTHASE-RXN
//
UNIQUE-ID - BSUBPOLYAMSYN-PWY
TYPES - Polyamine-Biosynthesis
COMMON-NAME - spermidine biosynthesis
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
CREDITS - O-18
CREDITS - |pellegrini-toole|
PATHWAY-LINKS - (5-METHYLTHIOADENOSINE PWY-4361)
PATHWAY-LINKS - (SPERMIDINE ARGSPECAT-PWY)
PATHWAY-LINKS - (PUTRESCINE PWY-46)
PREDECESSORS - (SPERMIDINESYN-RXN SAMDECARB-RXN)
PRIMARIES - (SPERMIDINESYN-RXN (S-ADENOSYLMETHIONINAMINE PUTRESCINE) (5-METHYLTHIOADENOSINE SPERMIDINE))
REACTION-LAYOUT - (SAMDECARB-RXN (:LEFT-PRIMARIES S-ADENOSYLMETHIONINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES S-ADENOSYLMETHIONINAMINE))
REACTION-LAYOUT - (SPERMIDINESYN-RXN (:LEFT-PRIMARIES S-ADENOSYLMETHIONINAMINE PUTRESCINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-METHYLTHIOADENOSINE SPERMIDINE))
REACTION-LIST - SAMDECARB-RXN
REACTION-LIST - SPERMIDINESYN-RXN
SYNONYMS - arginine degradation to spermidine
SYNONYMS - spermidine biosynthesis
//
UNIQUE-ID - GLYCGREAT-PWY
TYPES - GLYCINE-DEG
TYPES - Polyamine-Biosynthesis
COMMON-NAME - glycine degradation (creatine biosynthesis)
CREDITS - SRI
CREDITS - |fulcher|
PREDECESSORS - (GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN GLYCINE-AMIDINOTRANSFERASE-RXN)
PREDECESSORS - (GLYCINE-AMIDINOTRANSFERASE-RXN)
REACTION-LAYOUT - (GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN (:LEFT-PRIMARIES GUANIDOACETIC_ACID) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CREATINE))
REACTION-LAYOUT - (GLYCINE-AMIDINOTRANSFERASE-RXN (:LEFT-PRIMARIES ARG GLY) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GUANIDOACETIC_ACID))
REACTION-LIST - GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN
REACTION-LIST - GLYCINE-AMIDINOTRANSFERASE-RXN
SYNONYMS - glycine degradation II
SYNONYMS - glycine degradation
//
UNIQUE-ID - ORNSPNANA-PWY
TYPES - Polyamine-Biosynthesis
COMMON-NAME - spermine biosynthesis II
PREDECESSORS - (SPERMINE-SYNTHASE-RXN SPERMIDINESYN-RXN)
PREDECESSORS - (ORNDECARBOX-RXN)
PREDECESSORS - (SPERMIDINESYN-RXN ORNDECARBOX-RXN)
PRIMARIES - (ORNDECARBOX-RXN (L-ORNITHINE) (PUTRESCINE))
PRIMARIES - (SPERMIDINESYN-RXN (PUTRESCINE) (SPERMIDINE))
PRIMARIES - (SPERMINE-SYNTHASE-RXN (SPERMIDINE) (SPERMINE))
REACTION-LAYOUT - (SPERMINE-SYNTHASE-RXN (:LEFT-PRIMARIES SPERMIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SPERMINE))
REACTION-LAYOUT - (SPERMIDINESYN-RXN (:LEFT-PRIMARIES PUTRESCINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SPERMIDINE))
REACTION-LAYOUT - (ORNDECARBOX-RXN (:LEFT-PRIMARIES L-ORNITHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PUTRESCINE))
REACTION-LIST - SPERMINE-SYNTHASE-RXN
REACTION-LIST - SPERMIDINESYN-RXN
REACTION-LIST - ORNDECARBOX-RXN
SYNONYMS - ornithine spermine biosynthesis
//
UNIQUE-ID - PWY-5695
TYPES - Polyamine-Biosynthesis
COMMON-NAME - urate biosynthesis
CITATIONS - :EV-COMP-AINF:3422805051:ave
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - URSIN-PWY
PREDECESSORS - (RXN0-901 XANTHOSINEPHOSPHORY-RXN)
PREDECESSORS - (IMP-DEHYDROG-RXN)
PREDECESSORS - (XMPXAN-RXN IMP-DEHYDROG-RXN)
PREDECESSORS - (XANTHOSINEPHOSPHORY-RXN XMPXAN-RXN)
REACTION-LAYOUT - (RXN0-901 (:LEFT-PRIMARIES XANTHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES URATE))
REACTION-LAYOUT - (XANTHOSINEPHOSPHORY-RXN (:LEFT-PRIMARIES XANTHOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHINE))
REACTION-LAYOUT - (XMPXAN-RXN (:LEFT-PRIMARIES XANTHOSINE-5-PHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHOSINE))
REACTION-LAYOUT - (IMP-DEHYDROG-RXN (:LEFT-PRIMARIES IMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHOSINE-5-PHOSPHATE))
REACTION-LIST - RXN0-901
REACTION-LIST - XANTHOSINEPHOSPHORY-RXN
REACTION-LIST - XMPXAN-RXN
REACTION-LIST - IMP-DEHYDROG-RXN
SYNONYMS - ureide biogenesis
//
UNIQUE-ID - PWY-6173
TYPES - Polyamine-Biosynthesis
COMMON-NAME - histamine biosynthesis
CITATIONS - :EV-COMP-AINF:3482054332:ave
PATHWAY-LINKS - (HIS ("transport of L-histidine" . :INCOMING))
PREDECESSORS - (HISTIDINE-DECARBOXYLASE-RXN)
REACTION-LAYOUT - (HISTIDINE-DECARBOXYLASE-RXN (:LEFT-PRIMARIES HIS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES HISTAMINE))
REACTION-LIST - HISTIDINE-DECARBOXYLASE-RXN
//
UNIQUE-ID - PWY0-823
TYPES - ARGININE-DEG
TYPES - Polyamine-Biosynthesis
COMMON-NAME - arginine degradation III (arginine decarboxylase/agmatinase pathway)
CITATIONS - :EV-COMP-AINF:3380892013:cjb
COMMENT - Mammals have two ways for arginine degradation - via arginase (conversion of arginine to ornithine, e.g. in the urea cycle), and via the arginine decarboxylase pathway.  The arginine decarboxylase pathway is important because the intermediate product - agmatine - is believed to be an important neurotransmitter in mammalian brain.  While no gene for the Mus musculus arginine decarboxylase has been identified yet (see EC 4.1.1.19), the functional enzymes for this pathway in rodents have been characterized biochemically.
CREDITS - |caspi|
CREDITS - SRI
CREDITS - |arnaud|
PREDECESSORS - (AGMATIN-RXN ARGDECARBOX-RXN)
PRIMARIES - (AGMATIN-RXN NIL (PUTRESCINE))
REACTION-LAYOUT - (ARGDECARBOX-RXN (:LEFT-PRIMARIES ARG) (:DIRECTION :L2R) (:RIGHT-PRIMARIES AGMATHINE))
REACTION-LAYOUT - (AGMATIN-RXN (:LEFT-PRIMARIES AGMATHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PUTRESCINE))
REACTION-LIST - ARGDECARBOX-RXN
REACTION-LIST - AGMATIN-RXN
//
UNIQUE-ID - PWY3DJ-35588
TYPES - Polyamine-Biosynthesis
COMMON-NAME - creatine biosynthesis
CITATIONS - :EV-COMP-AINF:3380892013:cjb
COMMENT - Creatine is one of the major energy suppliers for muscle and nerve cells.  It functions by conversion to and from phospho-creatine via the action of creatine kinase enzymes.
CREDITS - O3DJ-6
CREDITS - AU3DJ-15
CREDITS - AU3DJ-34097
PREDECESSORS - (RXN3DJ-35618 CREATINE-KINASE-RXN)
PREDECESSORS - (CREATINE-KINASE-RXN GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN)
PREDECESSORS - (GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN GLYCINE-AMIDINOTRANSFERASE-RXN)
PREDECESSORS - (GLYCINE-AMIDINOTRANSFERASE-RXN)
PRIMARIES - (GLYCINE-AMIDINOTRANSFERASE-RXN (ARG) (GUANIDOACETIC_ACID))
REACTION-LAYOUT - (RXN3DJ-35618 (:LEFT-PRIMARIES CREATINE-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CREATININE))
REACTION-LAYOUT - (CREATINE-KINASE-RXN (:LEFT-PRIMARIES CREATINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CREATINE-P))
REACTION-LAYOUT - (GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN (:LEFT-PRIMARIES GUANIDOACETIC_ACID) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CREATINE))
REACTION-LAYOUT - (GLYCINE-AMIDINOTRANSFERASE-RXN (:LEFT-PRIMARIES ARG) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GUANIDOACETIC_ACID))
REACTION-LIST - RXN3DJ-35618
REACTION-LIST - CREATINE-KINASE-RXN
REACTION-LIST - GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN
REACTION-LIST - GLYCINE-AMIDINOTRANSFERASE-RXN
//
UNIQUE-ID - URSIN-PWY
TYPES - Polyamine-Biosynthesis
TYPES - Super-Pathways
COMMON-NAME - ureide biosynthesis
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (URATE-OXIDASE-RXN RXN0-901)
PREDECESSORS - PWY-5691
PREDECESSORS - PWY-5695
REACTION-LAYOUT - (PWY-5691 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (PWY-5695 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - PWY-5691
REACTION-LIST - PWY-5695
SYNONYMS - ureide biogenesis
//
UNIQUE-ID - PWY-40
TYPES - Putrescine-Biosynthesis
COMMON-NAME - putrescine biosynthesis I
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (PUTRESCINE BSUBPOLYAMSYN-PWY)
PREDECESSORS - (AGMATIN-RXN ARGDECARBOX-RXN)
PRIMARIES - (AGMATIN-RXN (AGMATHINE) (PUTRESCINE))
REACTION-LAYOUT - (AGMATIN-RXN (:LEFT-PRIMARIES AGMATHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PUTRESCINE))
REACTION-LAYOUT - (ARGDECARBOX-RXN (:LEFT-PRIMARIES ARG) (:DIRECTION :L2R) (:RIGHT-PRIMARIES AGMATHINE))
REACTION-LIST - AGMATIN-RXN
REACTION-LIST - ARGDECARBOX-RXN
//
UNIQUE-ID - PWY-46
TYPES - Putrescine-Biosynthesis
COMMON-NAME - putrescine biosynthesis III
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (PUTRESCINE BSUBPOLYAMSYN-PWY)
PREDECESSORS - (ORNDECARBOX-RXN)
PRIMARIES - (ORNDECARBOX-RXN (L-ORNITHINE) (PUTRESCINE))
REACTION-LAYOUT - (ORNDECARBOX-RXN (:LEFT-PRIMARIES L-ORNITHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PUTRESCINE))
REACTION-LIST - ORNDECARBOX-RXN
SYNONYMS - ODC pathway
//
UNIQUE-ID - UDPNACETYLGALSYN-PWY
TYPES - UDP-NAc-Glucosamine-Biosynthesis
COMMON-NAME - UDP-<i>N</i>-acetyl-D-glucosamine biosynthesis II
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - |fulcher|
CREDITS - SRI
CREDITS - |hying|
PREDECESSORS - (NAG1P-URIDYLTRANS-RXN PHOSACETYLGLUCOSAMINEMUT-RXN)
PREDECESSORS - (PHOSACETYLGLUCOSAMINEMUT-RXN GLUCOSAMINEPNACETYLTRANS-RXN)
PREDECESSORS - (GLUCOSAMINEPNACETYLTRANS-RXN L-GLN-FRUCT-6-P-AMINOTRANS-RXN)
PREDECESSORS - (L-GLN-FRUCT-6-P-AMINOTRANS-RXN)
REACTION-LAYOUT - (NAG1P-URIDYLTRANS-RXN (:LEFT-PRIMARIES N-ACETYL-D-GLUCOSAMINE-1-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-N-ACETYL-D-GLUCOSAMINE))
REACTION-LAYOUT - (PHOSACETYLGLUCOSAMINEMUT-RXN (:LEFT-PRIMARIES N-ACETYL-D-GLUCOSAMINE-1-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES N-ACETYL-D-GLUCOSAMINE-6-P))
REACTION-LAYOUT - (GLUCOSAMINEPNACETYLTRANS-RXN (:LEFT-PRIMARIES D-GLUCOSAMINE-6-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES N-ACETYL-D-GLUCOSAMINE-6-P))
REACTION-LAYOUT - (L-GLN-FRUCT-6-P-AMINOTRANS-RXN (:LEFT-PRIMARIES FRUCTOSE-6P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D-GLUCOSAMINE-6-P))
REACTION-LIST - NAG1P-URIDYLTRANS-RXN
REACTION-LIST - PHOSACETYLGLUCOSAMINEMUT-RXN
REACTION-LIST - GLUCOSAMINEPNACETYLTRANS-RXN
REACTION-LIST - L-GLN-FRUCT-6-P-AMINOTRANS-RXN
SYNONYMS - UDP-<i>N</i>-acetylgalactosamine biosynthesis
//
UNIQUE-ID - PWY-5409
TYPES - FATTY-ACID-DERIVATIVE-SYN
COMMON-NAME - divinyl ether biosynthesis II (13-LOX)
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |zhang|
PREDECESSORS - (RXN-8504 LIPOXYGENASE-RXN)
REACTION-LAYOUT - (LIPOXYGENASE-RXN (:LEFT-PRIMARIES LINOLEIC_ACID) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 13-HYDROPEROXYOCTADECA-911-DIENOATE))
REACTION-LAYOUT - (RXN-8504 (:LEFT-PRIMARIES 13-HYDROPEROXYOCTADECA-911-DIENOATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8690))
REACTION-LIST - LIPOXYGENASE-RXN
REACTION-LIST - RXN-8504
//
UNIQUE-ID - PWY-5410
TYPES - FATTY-ACID-DERIVATIVE-SYN
COMMON-NAME - 13-LOX and 13-HPL pathway
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |zhang|
PREDECESSORS - (RXN-1349 HYDROHEX-RXN)
PREDECESSORS - (HYDROHEX-RXN LIPOXYGENASE-RXN)
PREDECESSORS - (RXN-1345 RXN-1321)
PREDECESSORS - (RXN-1346 RXN-1345)
PREDECESSORS - (RXN-1348 RXN-1346)
PREDECESSORS - (RXN-1347 RXN-1345)
PREDECESSORS - (RXN-1349 RXN-1345)
PRIMARIES - (RXN-1345 (CPD-725) (CIS-3-HEXENAL 12-OXO-CIS-9-DODECENOATE))
PRIMARIES - (HYDROHEX-RXN (13-HYDROPEROXYOCTADECA-911-DIENOATE) (12-OXO-CIS-9-DODECENOATE HEXANAL))
REACTION-LAYOUT - (RXN-1349 (:LEFT-PRIMARIES 12-OXO-CIS-9-DODECENOATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 12-OXO-TRANS-10-DODECENOATE))
REACTION-LAYOUT - (RXN-1348 (:LEFT-PRIMARIES TRANS-2-HEXENAL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TRANS-2-HEXENOL))
REACTION-LAYOUT - (RXN-1347 (:LEFT-PRIMARIES CIS-3-HEXENAL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CIS-3-HEXENOL))
REACTION-LAYOUT - (RXN-1346 (:LEFT-PRIMARIES CIS-3-HEXENAL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TRANS-2-HEXENAL))
REACTION-LAYOUT - (RXN-1345 (:LEFT-PRIMARIES CPD-725) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CIS-3-HEXENAL 12-OXO-CIS-9-DODECENOATE))
REACTION-LAYOUT - (RXN-1321 (:LEFT-PRIMARIES LINOLENIC_ACID) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-725))
REACTION-LAYOUT - (HYDROHEX-RXN (:LEFT-PRIMARIES 13-HYDROPEROXYOCTADECA-911-DIENOATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES HEXANAL 12-OXO-CIS-9-DODECENOATE))
REACTION-LAYOUT - (LIPOXYGENASE-RXN (:LEFT-PRIMARIES LINOLEIC_ACID) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 13-HYDROPEROXYOCTADECA-911-DIENOATE))
REACTION-LIST - RXN-1349
REACTION-LIST - RXN-1348
REACTION-LIST - RXN-1347
REACTION-LIST - RXN-1346
REACTION-LIST - RXN-1345
REACTION-LIST - RXN-1321
REACTION-LIST - HYDROHEX-RXN
REACTION-LIST - LIPOXYGENASE-RXN
SYNONYMS - 13-lipoxygenase and 13-hydroperoxide lyase pathway
//
UNIQUE-ID - PWY-4681
TYPES - ISOFLAVONOID-PHYTOALEXINS
TYPES - ISOFLAVONOID-SYN
COMMON-NAME - kievitone biosynthesis
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |hartmut|
PATHWAY-LINKS - (CPD-6641 PWY-4502)
PREDECESSORS - (RXN-7225 RXN-7224)
PREDECESSORS - (RXN-7224 RXN-7226)
PREDECESSORS - (RXN-7227 RXN-7226)
PRIMARIES - (RXN-7227 (CPD-6645) NIL)
PRIMARIES - (RXN-7226 (CPD-6641) (CPD-6645))
PRIMARIES - (RXN-7225 (CPD-6646) (KIEVITONE-CPD))
PRIMARIES - (RXN-7224 (CPD-6641) NIL)
REACTION-LAYOUT - (RXN-7227 (:LEFT-PRIMARIES CPD-6645) (:DIRECTION :L2R) (:RIGHT-PRIMARIES KIEVITONE-CPD))
REACTION-LAYOUT - (RXN-7226 (:LEFT-PRIMARIES CPD-6641) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-6645))
REACTION-LAYOUT - (RXN-7225 (:LEFT-PRIMARIES CPD-6646) (:DIRECTION :L2R) (:RIGHT-PRIMARIES KIEVITONE-CPD))
REACTION-LAYOUT - (RXN-7224 (:LEFT-PRIMARIES CPD-6646) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CPD-6641))
REACTION-LIST - RXN-7227
REACTION-LIST - RXN-7226
REACTION-LIST - RXN-7225
REACTION-LIST - RXN-7224
//
UNIQUE-ID - PWY-2301
TYPES - Cyclitols-Biosynthesis
COMMON-NAME - <i>myo</i>-inositol biosynthesis
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN)
PREDECESSORS - (MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN)
REACTION-LAYOUT - (MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN (:LEFT-PRIMARIES 1-L-MYO-INOSITOL-1-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MYO-INOSITOL))
REACTION-LAYOUT - (MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN (:LEFT-PRIMARIES |D-glucose-6-phosphate|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 1-L-MYO-INOSITOL-1-P))
REACTION-LIST - MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN
REACTION-LIST - MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN
//
UNIQUE-ID - PWY-6351
TYPES - Cyclitols-Biosynthesis
COMMON-NAME - D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis
CITATIONS - :EV-COMP-AINF:3482054332:ave
PATHWAY-LINKS - (INOSITOL-1-4-5-TRISPHOSPHATE PWY-6362 PWY-6364 PWY-6363)
PATHWAY-LINKS - (MYO-INOSITOL PWY-2301)
PREDECESSORS - (3.1.4.11-RXN 2.7.1.149-RXN)
PREDECESSORS - (3.1.4.11-RXN 2.7.1.68-RXN)
PREDECESSORS - (2.7.1.68-RXN 1-PHOSPHATIDYLINOSITOL-KINASE-RXN)
PREDECESSORS - (1-PHOSPHATIDYLINOSITOL-KINASE-RXN 2.7.8.11-RXN)
PRIMARIES - (2.7.1.149-RXN (1-PHOSPHATIDYL-1D-MYO-INOSITOL-5-PHOSPHA) (PHOSPHATIDYL-MYO-INOSITOL-45-BISPHOSPHA))
PRIMARIES - (3.1.4.11-RXN NIL (INOSITOL-1-4-5-TRISPHOSPHATE))
PRIMARIES - (2.7.8.11-RXN (MYO-INOSITOL) NIL)
PRIMARIES - (1-PHOSPHATIDYLINOSITOL-KINASE-RXN (|L-1-phosphatidyl-inositols|) (CPD-1108))
REACTION-LAYOUT - (2.7.1.149-RXN (:LEFT-PRIMARIES 1-PHOSPHATIDYL-1D-MYO-INOSITOL-5-PHOSPHA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHATIDYL-MYO-INOSITOL-45-BISPHOSPHA))
REACTION-LAYOUT - (3.1.4.11-RXN (:LEFT-PRIMARIES PHOSPHATIDYL-MYO-INOSITOL-45-BISPHOSPHA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES INOSITOL-1-4-5-TRISPHOSPHATE))
REACTION-LAYOUT - (2.7.8.11-RXN (:LEFT-PRIMARIES MYO-INOSITOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |L-1-phosphatidyl-inositols|))
REACTION-LAYOUT - (1-PHOSPHATIDYLINOSITOL-KINASE-RXN (:LEFT-PRIMARIES |L-1-phosphatidyl-inositols|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-1108))
REACTION-LAYOUT - (2.7.1.68-RXN (:LEFT-PRIMARIES CPD-1108) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHATIDYL-MYO-INOSITOL-45-BISPHOSPHA))
REACTION-LIST - 2.7.1.149-RXN
REACTION-LIST - 3.1.4.11-RXN
REACTION-LIST - 2.7.8.11-RXN
REACTION-LIST - 1-PHOSPHATIDYLINOSITOL-KINASE-RXN
REACTION-LIST - 2.7.1.68-RXN
SYNONYMS - IP3 biosynthesis
//
UNIQUE-ID - PWY-6358
TYPES - Cyclitols-Biosynthesis
TYPES - Super-Pathways
COMMON-NAME - superpathway of D-<i>myo</i>-inositol (1,4,5)-trisphosphate metabolism
PATHWAY-LINKS - (MYO-INOSITOL PWY-6351)
PATHWAY-LINKS - (INOSITOL-1-3-4-TRIPHOSPHATE PWY-6362)
PATHWAY-LINKS - (INOSITOL-1-4-5-TRISPHOSPHATE PWY-6351)
PREDECESSORS - (3.1.3.56-RXN 3.1.3.62-RXN)
PREDECESSORS - PWY-6363
PREDECESSORS - PWY-6364
REACTION-LAYOUT - (PWY-6363 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (PWY-6364 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - PWY-6363
REACTION-LIST - PWY-6364
SUB-PATHWAYS - PWY-6363
SUB-PATHWAYS - PWY-6364
//
UNIQUE-ID - PWY-6363
TYPES - Cyclitols-Biosynthesis
COMMON-NAME - D-<i>myo</i>-inositol (1,4,5)-trisphosphate degradation
CITATIONS - :EV-COMP-AINF:3482054332:ave
IN-PATHWAY - PWY-6358
PATHWAY-LINKS - (MYO-INOSITOL PWY-6352 PWY-6351)
PATHWAY-LINKS - (INOSITOL-1-4-5-TRISPHOSPHATE PWY-6351)
PREDECESSORS - (RXN-10952 3.1.3.57-RXN)
PREDECESSORS - (3.1.3.57-RXN 3.1.3.56-RXN)
PRIMARIES - (3.1.3.56-RXN (INOSITOL-1-4-5-TRISPHOSPHATE) (INOSITOL-1-4-BISPHOSPHATE))
REACTION-LAYOUT - (RXN-10952 (:LEFT-PRIMARIES D-MYO-INOSITOL-4-PHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MYO-INOSITOL))
REACTION-LAYOUT - (3.1.3.56-RXN (:LEFT-PRIMARIES INOSITOL-1-4-5-TRISPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES INOSITOL-1-4-BISPHOSPHATE))
REACTION-LAYOUT - (3.1.3.57-RXN (:LEFT-PRIMARIES INOSITOL-1-4-BISPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D-MYO-INOSITOL-4-PHOSPHATE))
REACTION-LIST - RXN-10952
REACTION-LIST - 3.1.3.56-RXN
REACTION-LIST - 3.1.3.57-RXN
SUPER-PATHWAYS - PWY-6358
//
UNIQUE-ID - PWY-6364
TYPES - Cyclitols-Biosynthesis
COMMON-NAME - D-<i>myo</i>-inositol (1,3,4)-trisphosphate biosynthesis
CITATIONS - :EV-COMP-AINF:3482054332:ave
IN-PATHWAY - PWY-6358
PATHWAY-LINKS - (INOSITOL-1-3-4-TRIPHOSPHATE PWY-6365 PWY-6366 PWY-6362)
PATHWAY-LINKS - (INOSITOL-1-4-5-TRISPHOSPHATE PWY-6351)
PREDECESSORS - (2.7.1.127-RXN 3.1.3.62-RXN)
PREDECESSORS - (3.1.3.62-RXN 2.7.1.127-RXN)
PREDECESSORS - (RXN-8730 2.7.1.127-RXN)
PRIMARIES - (2.7.1.127-RXN (INOSITOL-1-4-5-TRISPHOSPHATE) (CPD-506))
REACTION-LAYOUT - (3.1.3.62-RXN (:LEFT-PRIMARIES CPD-506) (:DIRECTION :L2R) (:RIGHT-PRIMARIES INOSITOL-1-4-5-TRISPHOSPHATE))
REACTION-LAYOUT - (RXN-8730 (:LEFT-PRIMARIES CPD-506) (:DIRECTION :L2R) (:RIGHT-PRIMARIES INOSITOL-1-3-4-TRIPHOSPHATE))
REACTION-LAYOUT - (2.7.1.127-RXN (:LEFT-PRIMARIES INOSITOL-1-4-5-TRISPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-506))
REACTION-LIST - 3.1.3.62-RXN
REACTION-LIST - RXN-8730
REACTION-LIST - 2.7.1.127-RXN
SUPER-PATHWAYS - PWY-6358
//
UNIQUE-ID - PWY-6365
TYPES - Cyclitols-Biosynthesis
COMMON-NAME - D-<i>myo</i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis
CITATIONS - :EV-COMP-AINF:3482054332:ave
PATHWAY-LINKS - (INOSITOL-1-3-4-TRIPHOSPHATE PWY-6364)
PREDECESSORS - (RXN-10955 2.7.1.134-RXN)
PREDECESSORS - (2.7.1.134-RXN RXN-10955)
PREDECESSORS - (RXN-10955 2.7.1.140-RXN)
PREDECESSORS - (2.7.1.140-RXN 2.7.1.133-RXN)
PRIMARIES - (RXN-10955 (CPD-1107) (CPD-178))
REACTION-LAYOUT - (2.7.1.134-RXN (:LEFT-PRIMARIES CPD-178) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-1107))
REACTION-LAYOUT - (2.7.1.133-RXN (:LEFT-PRIMARIES INOSITOL-1-3-4-TRIPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-505))
REACTION-LAYOUT - (2.7.1.140-RXN (:LEFT-PRIMARIES CPD-505) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-1107))
REACTION-LAYOUT - (RXN-10955 (:LEFT-PRIMARIES CPD-1107) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-178))
REACTION-LIST - 2.7.1.134-RXN
REACTION-LIST - 2.7.1.133-RXN
REACTION-LIST - 2.7.1.140-RXN
REACTION-LIST - RXN-10955
//
UNIQUE-ID - PWY-6362
TYPES - Phytate-Biosynthesis
TYPES - CYCLITOLS-DEG
COMMON-NAME - 1D-<i>myo</i>-inositol hexakisphosphate biosynthesis II (mammalian)
CITATIONS - :EV-COMP-AINF:3482054332:ave
PATHWAY-LINKS - (MI-HEXAKISPHOSPHATE PWY-6369)
PATHWAY-LINKS - (INOSITOL-1-4-5-TRISPHOSPHATE PWY-6351)
PREDECESSORS - (RXN-8730 2.7.1.127-RXN)
PREDECESSORS - (2.7.1.133-RXN RXN-8730)
PREDECESSORS - (RXN-7163 2.7.1.140-RXN)
PREDECESSORS - (2.7.1.140-RXN 2.7.1.133-RXN)
PRIMARIES - (RXN-7163 (CPD-1107) (MI-HEXAKISPHOSPHATE))
PRIMARIES - (2.7.1.140-RXN (CPD-505) (CPD-1107))
PRIMARIES - (2.7.1.133-RXN (INOSITOL-1-3-4-TRIPHOSPHATE) (CPD-505))
REACTION-LAYOUT - (RXN-8730 (:LEFT-PRIMARIES CPD-506) (:DIRECTION :L2R) (:RIGHT-PRIMARIES INOSITOL-1-3-4-TRIPHOSPHATE))
REACTION-LAYOUT - (2.7.1.127-RXN (:LEFT-PRIMARIES INOSITOL-1-4-5-TRISPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-506))
REACTION-LAYOUT - (RXN-7163 (:LEFT-PRIMARIES CPD-1107) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MI-HEXAKISPHOSPHATE))
REACTION-LAYOUT - (2.7.1.133-RXN (:LEFT-PRIMARIES INOSITOL-1-3-4-TRIPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-505))
REACTION-LAYOUT - (2.7.1.140-RXN (:LEFT-PRIMARIES CPD-505) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-1107))
REACTION-LIST - RXN-8730
REACTION-LIST - 2.7.1.127-RXN
REACTION-LIST - RXN-7163
REACTION-LIST - 2.7.1.133-RXN
REACTION-LIST - 2.7.1.140-RXN
SYNONYMS - phytate biosynthesis
//
UNIQUE-ID - PWY-6348
TYPES - Degradation
COMMON-NAME - phosphate acquisition I
CITATIONS - :EV-COMP-AINF:3482054332:ave
PREDECESSORS - (ACID-PHOSPHATASE-RXN)
PRIMARIES - (ACID-PHOSPHATASE-RXN (|Orthophosphoric-Monoesters|) (|Pi|))
REACTION-LAYOUT - (ACID-PHOSPHATASE-RXN (:LEFT-PRIMARIES |Orthophosphoric-Monoesters|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Pi|))
REACTION-LIST - ACID-PHOSPHATASE-RXN
//
UNIQUE-ID - PWY-6355
TYPES - Degradation
COMMON-NAME - phosphate acquisition II
CITATIONS - :EV-COMP-AINF:3482054330:ave
PREDECESSORS - (PEROXID-RXN)
PREDECESSORS - (ACID-PHOSPHATASE-RXN)
PRIMARIES - (PEROXID-RXN (|Donor-H2|) (|Acceptor|))
PRIMARIES - (ACID-PHOSPHATASE-RXN (|Orthophosphoric-Monoesters|) (|Pi|))
REACTION-LAYOUT - (PEROXID-RXN (:LEFT-PRIMARIES |Donor-H2|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Acceptor|))
REACTION-LAYOUT - (ACID-PHOSPHATASE-RXN (:LEFT-PRIMARIES |Orthophosphoric-Monoesters|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Pi|))
REACTION-LIST - PEROXID-RXN
REACTION-LIST - ACID-PHOSPHATASE-RXN
//
UNIQUE-ID - PWY66-21
TYPES - Ethanol-Degradation
COMMON-NAME - oxidative ethanol degradation I
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |wagg|
PREDECESSORS - (ACETATE--COA-LIGASE-RXN RXN66-3)
PREDECESSORS - (RXN66-3 ALCOHOL-DEHYDROG-RXN)
PRIMARIES - (ACETATE--COA-LIGASE-ADP-FORMING-RXN (ACET) (ACETYL-COA))
PRIMARIES - (ACETATE--COA-LIGASE-RXN (ACET) (ACETYL-COA))
PRIMARIES - (ACETYL-COA-HYDROLASE-RXN (ACET) (ACETYL-COA))
REACTION-LAYOUT - (ACETATE--COA-LIGASE-RXN (:LEFT-PRIMARIES ACET) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETYL-COA))
REACTION-LAYOUT - (RXN66-3 (:LEFT-PRIMARIES ACETALD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACET))
REACTION-LAYOUT - (ALCOHOL-DEHYDROG-RXN (:LEFT-PRIMARIES ETOH) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETALD))
REACTION-LIST - ACETATE--COA-LIGASE-RXN
REACTION-LIST - RXN66-3
REACTION-LIST - ALCOHOL-DEHYDROG-RXN
//
UNIQUE-ID - PWY-4261
TYPES - Fatty-Acid-and-Lipid-Degradation
TYPES - GLYCEROL-DEG
COMMON-NAME - glycerol degradation IV
CITATIONS - :EV-COMP-AINF:3453644158:ave
PATHWAY-LINKS - (DIHYDROXY-ACETONE-PHOSPHATE GLUCONEO-PWY GLYCOLYSIS-VARIANTS)
PREDECESSORS - (RXN-9927 GLYCEROL-KIN-RXN)
PRIMARIES - (RXN-9927 (GLYCEROL-3P) (DIHYDROXY-ACETONE-PHOSPHATE))
PRIMARIES - (GLYCEROL-KIN-RXN (GLYCEROL) (GLYCEROL-3P))
REACTION-LAYOUT - (RXN-9927 (:LEFT-PRIMARIES GLYCEROL-3P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LAYOUT - (GLYCEROL-KIN-RXN (:LEFT-PRIMARIES GLYCEROL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLYCEROL-3P))
REACTION-LIST - RXN-9927
REACTION-LIST - GLYCEROL-KIN-RXN
//
UNIQUE-ID - PWY-5386
TYPES - Methylglyoxal-Detoxification
TYPES - Aldehyde-Degradation
COMMON-NAME - methylglyoxal degradation I
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (PYRUVATE PYRUVDEHYD-PWY)
PREDECESSORS - (DLACTDEHYDROGFAD-RXN GLYOXII-RXN)
PREDECESSORS - (GLYOXII-RXN GLYOXI-RXN)
PRIMARIES - (|D-LACTATE-DEHYDROGENASE-(CYTOCHROME)-RXN| NIL (PYRUVATE))
PRIMARIES - (DLACTDEHYDROGFAD-RXN NIL (PYRUVATE))
PRIMARIES - (GLYOXII-RXN (S-LACTOYL-GLUTATHIONE) (D-LACTATE))
PRIMARIES - (PYRUVDEH-RXN NIL (ACETYL-COA))
REACTION-LAYOUT - (DLACTDEHYDROGFAD-RXN (:LEFT-PRIMARIES D-LACTATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRUVATE))
REACTION-LAYOUT - (GLYOXII-RXN (:LEFT-PRIMARIES S-LACTOYL-GLUTATHIONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D-LACTATE))
REACTION-LAYOUT - (GLYOXI-RXN (:LEFT-PRIMARIES S-LACTOYL-GLUTATHIONE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES METHYL-GLYOXAL))
REACTION-LIST - DLACTDEHYDROGFAD-RXN
REACTION-LIST - GLYOXII-RXN
REACTION-LIST - GLYOXI-RXN
//
UNIQUE-ID - PWY-901
TYPES - Methylglyoxal-Detoxification
TYPES - Aldehyde-Degradation
COMMON-NAME - methylglyoxal degradation II
CITATIONS - :EV-COMP-AINF:3422608265:ave
CREDITS - SRI
CREDITS - |caspi|
CREDITS - O-18
CREDITS - |pellegrini-toole|
PATHWAY-LINKS - (METHYL-GLYOXAL THRDLCTCAT-PWY)
PATHWAY-LINKS - (PYRUVATE PYRUVDEHYD-PWY)
PREDECESSORS - (DLACTDEHYDROGFAD-RXN GLYOXIII-RXN)
PRIMARIES - (DLACTDEHYDROGFAD-RXN NIL (PYRUVATE))
PRIMARIES - (|D-LACTATE-DEHYDROGENASE-(CYTOCHROME)-RXN| NIL (PYRUVATE))
PRIMARIES - (GLYOXIII-RXN (METHYL-GLYOXAL) (D-LACTATE))
PRIMARIES - (GLYOXI-RXN (METHYL-GLYOXAL) NIL)
REACTION-LAYOUT - (DLACTDEHYDROGFAD-RXN (:LEFT-PRIMARIES D-LACTATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRUVATE))
REACTION-LAYOUT - (GLYOXIII-RXN (:LEFT-PRIMARIES METHYL-GLYOXAL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D-LACTATE))
REACTION-LIST - DLACTDEHYDROGFAD-RXN
REACTION-LIST - GLYOXIII-RXN
SYNONYMS - glyoxalase pathway
SYNONYMS - methylglyoxal catabolism
//
UNIQUE-ID - GLCMANNANAUT-PWY
TYPES - AMINE-DEG
TYPES - Super-Pathways
COMMON-NAME - superpathway of <i>N</i>-acetylglucosamine, <i>N</i>-acetylmannosamine and <i>N</i>-acetylneuraminate degradation
PATHWAY-LINKS - (FRUCTOSE-6P GLYCOLYSIS)
PREDECESSORS - (NAG6PDEACET-RXN NANE-RXN)
PREDECESSORS - PWY0-1324
PREDECESSORS - GLUAMCAT-PWY
PREDECESSORS - (GLUCOSAMINE-6-P-DEAMIN-RXN)
REACTION-LAYOUT - (PWY0-1324 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (GLUAMCAT-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - PWY0-1324
REACTION-LIST - GLUAMCAT-PWY
SUB-PATHWAYS - PWY0-1324
SUB-PATHWAYS - GLUAMCAT-PWY
SYNONYMS - N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminic acid dissimilation
//
UNIQUE-ID - GLUAMCAT-PWY
TYPES - AMINE-DEG
TYPES - Sugar-Derivatives
COMMON-NAME - <i>N</i>-acetylglucosamine degradation
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - O-18
CREDITS - |riley|
CREDITS - SRI
CREDITS - |keseler|
CREDITS - O0-3
CREDITS - |ingraham|
IN-PATHWAY - GLCMANNANAUT-PWY
PREDECESSORS - (GLUCOSAMINE-6-P-DEAMIN-RXN NAG6PDEACET-RXN)
PRIMARIES - (TRANS-RXN-167A (GLUCOSAMINE) (D-GLUCOSAMINE-6-P))
REACTION-LAYOUT - (NAG6PDEACET-RXN (:LEFT-PRIMARIES N-ACETYL-D-GLUCOSAMINE-6-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D-GLUCOSAMINE-6-P))
REACTION-LAYOUT - (GLUCOSAMINE-6-P-DEAMIN-RXN (:LEFT-PRIMARIES D-GLUCOSAMINE-6-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LIST - NAG6PDEACET-RXN
REACTION-LIST - GLUCOSAMINE-6-P-DEAMIN-RXN
SUPER-PATHWAYS - GLCMANNANAUT-PWY
SYNONYMS - glucosamine degradation
SYNONYMS - N-acetyl-glucosamine degradation
//
UNIQUE-ID - PWY-3661
TYPES - AMINE-DEG
COMMON-NAME - glycine betaine degradation
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (4.3.1.17-RXN GLYOHMETRANS-RXN)
PREDECESSORS - (DIMETHYLGLYCINE-DEHYDROGENASE-RXN 2.1.1.5-RXN)
PREDECESSORS - (SARCOX-RXN DIMETHYLGLYCINE-DEHYDROGENASE-RXN)
PREDECESSORS - (GLYOHMETRANS-RXN SARCOX-RXN)
PRIMARIES - (SARCOSINE-DEHYDROGENASE-RXN (SARCOSINE) (GLY))
PRIMARIES - (2.1.1.5-RXN (BETAINE) NIL)
PRIMARIES - (SARCOX-RXN (SARCOSINE) (GLY))
REACTION-LAYOUT - (4.3.1.17-RXN (:LEFT-PRIMARIES SER) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRUVATE))
REACTION-LAYOUT - (GLYOHMETRANS-RXN (:LEFT-PRIMARIES SER) (:DIRECTION :R2L) (:RIGHT-PRIMARIES GLY))
REACTION-LAYOUT - (SARCOX-RXN (:LEFT-PRIMARIES SARCOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLY))
REACTION-LAYOUT - (DIMETHYLGLYCINE-DEHYDROGENASE-RXN (:LEFT-PRIMARIES DIMETHYL-GLYCINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SARCOSINE))
REACTION-LAYOUT - (2.1.1.5-RXN (:LEFT-PRIMARIES BETAINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIMETHYL-GLYCINE))
REACTION-LIST - 4.3.1.17-RXN
REACTION-LIST - GLYOHMETRANS-RXN
REACTION-LIST - SARCOX-RXN
REACTION-LIST - DIMETHYLGLYCINE-DEHYDROGENASE-RXN
REACTION-LIST - 2.1.1.5-RXN
//
UNIQUE-ID - PWY-6181
TYPES - AMINE-DEG
COMMON-NAME - histamine degradation
CITATIONS - :EV-COMP-AINF:3482054330:ave
KEY-REACTIONS - HISTAMINE-N-METHYLTRANSFERASE-RXN
PREDECESSORS - (RXN-10089 RXN-9600)
PREDECESSORS - (GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN RXN-9600)
PREDECESSORS - (HISTAMINE-N-METHYLTRANSFERASE-RXN RXN-9600)
PREDECESSORS - (RXN-9600)
PRIMARIES - (HISTAMINE-N-METHYLTRANSFERASE-RXN (HISTAMINE) (N-METHYL-HISTAMINE))
PRIMARIES - (RXN-9600 (HISTAMINE) (IMIDAZOLE_ACETALDEHYDE))
PRIMARIES - (GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN (HISTAMINE) (NALPHA-GAMMA-L-GLUTAMYLHISTAMINE))
REACTION-LAYOUT - (RXN-10089 (:LEFT-PRIMARIES IMIDAZOLE_ACETALDEHYDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 4-IMIDAZOLEACETATE))
REACTION-LAYOUT - (RXN-9600 (:LEFT-PRIMARIES HISTAMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES IMIDAZOLE_ACETALDEHYDE))
REACTION-LAYOUT - (GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN (:LEFT-PRIMARIES HISTAMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES NALPHA-GAMMA-L-GLUTAMYLHISTAMINE))
REACTION-LAYOUT - (HISTAMINE-N-METHYLTRANSFERASE-RXN (:LEFT-PRIMARIES HISTAMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES N-METHYL-HISTAMINE))
REACTION-LIST - RXN-10089
REACTION-LIST - RXN-9600
REACTION-LIST - GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN
REACTION-LIST - HISTAMINE-N-METHYLTRANSFERASE-RXN
//
UNIQUE-ID - PWY0-1324
TYPES - Sugars-And-Polysaccharides
TYPES - AMINE-DEG
COMMON-NAME - <i>N</i>-acetylneuraminate and <i>N</i>-acetylmannosamine degradation
CITATIONS - :EV-COMP-AINF:3442068425:ave
CREDITS - SRI
CREDITS - |keseler|
IN-PATHWAY - GLCMANNANAUT-PWY
PATHWAY-LINKS - (N-ACETYL-D-GLUCOSAMINE-6-P GLUAMCAT-PWY)
PREDECESSORS - (NANE-RXN NANK-RXN)
PREDECESSORS - (NANK-RXN ACNEULY-RXN)
REACTION-LAYOUT - (NANK-RXN (:LEFT-PRIMARIES N-ACETYL-D-MANNOSAMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES N-ACETYL-D-MANNOSAMINE-6P))
REACTION-LAYOUT - (ACNEULY-RXN (:LEFT-PRIMARIES N-ACETYLNEURAMINATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES N-ACETYL-D-MANNOSAMINE))
REACTION-LAYOUT - (NANE-RXN (:LEFT-PRIMARIES N-ACETYL-D-MANNOSAMINE-6P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES N-ACETYL-D-GLUCOSAMINE-6-P))
REACTION-LIST - NANK-RXN
REACTION-LIST - ACNEULY-RXN
REACTION-LIST - NANE-RXN
SUPER-PATHWAYS - GLCMANNANAUT-PWY
//
UNIQUE-ID - PWY6666-2
TYPES - AMINE-DEG
COMMON-NAME - dopamine degradation
PREDECESSORS - (RXN6666-9)
PREDECESSORS - (RXN6666-7)
PREDECESSORS - (RXN6666-6 RXN6666-5)
PREDECESSORS - (RXN6666-5 RXN6666-4)
PREDECESSORS - (RXN6666-4)
PRIMARIES - (RXN6666-9 (DOPAMINE) (CPD-7649))
PRIMARIES - (RXN6666-7 (DOPAMINE) (CPD-7650))
PRIMARIES - (RXN6666-6 (CPD-782) (CPD-7651))
REACTION-LAYOUT - (RXN6666-9 (:LEFT-PRIMARIES DOPAMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-7649))
REACTION-LAYOUT - (RXN6666-7 (:LEFT-PRIMARIES DOPAMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-7650))
REACTION-LAYOUT - (RXN6666-6 (:LEFT-PRIMARIES CPD-782) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-7651))
REACTION-LAYOUT - (RXN6666-5 (:LEFT-PRIMARIES 34-DIHYDROXYPHENYLACETALDEHYDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-782))
REACTION-LAYOUT - (RXN6666-4 (:LEFT-PRIMARIES DOPAMINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 34-DIHYDROXYPHENYLACETALDEHYDE))
REACTION-LIST - RXN6666-9
REACTION-LIST - RXN6666-7
REACTION-LIST - RXN6666-6
REACTION-LIST - RXN6666-5
REACTION-LIST - RXN6666-4
//
UNIQUE-ID - 4AMINOBUTMETAB-PWY
TYPES - 4-Aminobutyraye-Degradation
COMMON-NAME - 4-aminobutyrate degradation I
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - |caspi|
CREDITS - SRI
CREDITS - |keseler|
CREDITS - O-18
CREDITS - |riley|
PATHWAY-LINKS - (SUC TCA)
PREDECESSORS - (SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN GABATRANSAM-RXN)
PREDECESSORS - (SUCCSEMIALDDEHYDROG-RXN GABATRANSAM-RXN)
PREDECESSORS - (GABATRANSAM-RXN)
REACTION-LAYOUT - (SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN (:LEFT-PRIMARIES SUCC-S-ALD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUC))
REACTION-LAYOUT - (SUCCSEMIALDDEHYDROG-RXN (:LEFT-PRIMARIES SUCC-S-ALD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUC))
REACTION-LAYOUT - (GABATRANSAM-RXN (:LEFT-PRIMARIES 4-AMINO-BUTYRATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUCC-S-ALD))
REACTION-LIST - SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
REACTION-LIST - SUCCSEMIALDDEHYDROG-RXN
REACTION-LIST - GABATRANSAM-RXN
SYNONYMS - &gamma;-amino-butyrate shunt
SYNONYMS - GABA degradation
//
UNIQUE-ID - PWY-5697
TYPES - Allantoin-degradation
COMMON-NAME - allantoin degradation to ureidoglycolate I (urea producing)
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (ALLANTOICASE-RXN ALLANTOINASE-RXN)
PRIMARIES - (ALLANTOICASE-RXN NIL (CPD-1091))
REACTION-LAYOUT - (ALLANTOICASE-RXN (:LEFT-PRIMARIES ALLANTOATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-1091))
REACTION-LAYOUT - (ALLANTOINASE-RXN (:LEFT-PRIMARIES S-ALLANTOIN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALLANTOATE))
REACTION-LIST - ALLANTOICASE-RXN
REACTION-LIST - ALLANTOINASE-RXN
//
UNIQUE-ID - CRNFORCAT-PWY
TYPES - Creatinine-Degradation
COMMON-NAME - creatinine degradation I
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - |caspi|
CREDITS - SRI
CREDITS - |hying|
PREDECESSORS - (SARCOX-RXN CREATINASE-RXN)
PREDECESSORS - (CREATININASE-RXN)
PREDECESSORS - (CREATINASE-RXN CREATININASE-RXN)
PREDECESSORS - (SARCOSINE-DEHYDROGENASE-RXN CREATINASE-RXN)
PRIMARIES - (SARCOX-RXN (SARCOSINE) (GLY))
PRIMARIES - (SARCOSINE-DEHYDROGENASE-RXN (SARCOSINE) (GLY))
REACTION-LAYOUT - (SARCOX-RXN (:LEFT-PRIMARIES SARCOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLY))
REACTION-LAYOUT - (SARCOSINE-DEHYDROGENASE-RXN (:LEFT-PRIMARIES SARCOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLY))
REACTION-LAYOUT - (CREATINASE-RXN (:LEFT-PRIMARIES CREATINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SARCOSINE))
REACTION-LAYOUT - (CREATININASE-RXN (:LEFT-PRIMARIES CREATININE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CREATINE))
REACTION-LIST - SARCOX-RXN
REACTION-LIST - SARCOSINE-DEHYDROGENASE-RXN
REACTION-LIST - CREATINASE-RXN
REACTION-LIST - CREATININASE-RXN
SYNONYMS - creatinine catabolism
//
UNIQUE-ID - PWY-0
TYPES - Putrescine-Degradation
COMMON-NAME - putrescine degradation III
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (4-AMINO-BUTYRATE GLUDEG-I-PWY)
PREDECESSORS - (RXN-1 RXN-0)
PREDECESSORS - (RXN-37 RXN-1)
PREDECESSORS - (RXN-36 RXN-37)
PRIMARIES - (RXN-36 NIL (4-AMINO-BUTYRATE))
REACTION-LAYOUT - (RXN-36 (:LEFT-PRIMARIES CPD-35) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 4-AMINO-BUTYRATE))
REACTION-LAYOUT - (RXN-37 (:LEFT-PRIMARIES CPD-30) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-35))
REACTION-LAYOUT - (RXN-1 (:LEFT-PRIMARIES CPD-569) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-30))
REACTION-LAYOUT - (RXN-0 (:LEFT-PRIMARIES PUTRESCINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-569))
REACTION-LIST - RXN-36
REACTION-LIST - RXN-37
REACTION-LIST - RXN-1
REACTION-LIST - RXN-0
//
UNIQUE-ID - BETA-ALA-DEGRADATION-I-PWY
TYPES - Amino-Acid-Degradation
COMMON-NAME - &beta;-alanine degradation I
CITATIONS - :EV-COMP-AINF:3380892013:cjb
PREDECESSORS - (RXN-2902 RXN-2901)
PREDECESSORS - (RXN-2901)
PRIMARIES - (RXN-2902 (MALONATE-S-ALD) (CARBON-DIOXIDE))
PRIMARIES - (1.2.1.18-RXN (MALONATE-S-ALD) (CARBON-DIOXIDE))
PRIMARIES - (RXN-2901 (B-ALANINE) (MALONATE-S-ALD))
REACTION-LAYOUT - (RXN-2902 (:LEFT-PRIMARIES MALONATE-S-ALD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CARBON-DIOXIDE))
REACTION-LAYOUT - (RXN-2901 (:LEFT-PRIMARIES B-ALANINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MALONATE-S-ALD))
REACTION-LIST - RXN-2902
REACTION-LIST - RXN-2901
//
UNIQUE-ID - PWY-5046
TYPES - Respiration
TYPES - Amino-Acid-Degradation
COMMON-NAME - branched-chain &alpha;-keto acid dehydrogenase complex
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (RXN-7719 2.3.1.168-RXN)
PREDECESSORS - (2.3.1.168-RXN 1.2.4.4-RXN)
PREDECESSORS - (1.2.4.4-RXN RXN-7719)
REACTION-LAYOUT - (RXN-7719 (:LEFT-PRIMARIES |BCAA-dehydrogenase-DH-lipoyl|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |BCAA-dehydrogenase-lipoyl|))
REACTION-LAYOUT - (2.3.1.168-RXN (:LEFT-PRIMARIES |BCAA-dehydrogenase-2MP-DH-lipoyl|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |BCAA-dehydrogenase-DH-lipoyl|))
REACTION-LAYOUT - (1.2.4.4-RXN (:LEFT-PRIMARIES |BCAA-dehydrogenase-lipoyl|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |BCAA-dehydrogenase-2MP-DH-lipoyl|))
REACTION-LIST - RXN-7719
REACTION-LIST - 2.3.1.168-RXN
REACTION-LIST - 1.2.4.4-RXN
SYNONYMS - 2-oxo acid dehydrogenase complex
//
UNIQUE-ID - PWY-5084
TYPES - Respiration
TYPES - Amino-Acid-Degradation
COMMON-NAME - 2-ketoglutarate dehydrogenase complex
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (RXN0-1147 2OXOGLUTDECARB-RXN)
PREDECESSORS - (RXN-7716 RXN0-1147)
PREDECESSORS - (2OXOGLUTDECARB-RXN RXN-7716)
REACTION-LAYOUT - (RXN-7716 (:LEFT-PRIMARIES |Oxo-glutarate-dehydrogenase-DH-lipoyl|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Oxo-glutarate-dehydrogenase-lipoyl|))
REACTION-LAYOUT - (RXN0-1147 (:LEFT-PRIMARIES |Oxo-glutarate-dehydrogenase-DH-lipoyl|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES |Oxo-glutarate-dehydro-suc-DH-lipoyl|))
REACTION-LAYOUT - (2OXOGLUTDECARB-RXN (:LEFT-PRIMARIES |Oxo-glutarate-dehydrogenase-lipoyl|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Oxo-glutarate-dehydro-suc-DH-lipoyl|))
REACTION-LIST - RXN-7716
REACTION-LIST - RXN0-1147
REACTION-LIST - 2OXOGLUTDECARB-RXN
SYNONYMS - 2-oxoglutarate dehydrogenase complex
//
UNIQUE-ID - HYDROXYPRODEG-PWY
TYPES - 4-Hydroxyproline-Degradation
COMMON-NAME - 4-hydroxyproline degradation I
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |fulcher|
PREDECESSORS - (4OH2OXOGLUTARALDOL-RXN 4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN)
PREDECESSORS - (4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN HYDROXYPYRROLINEDEH-RXN)
PREDECESSORS - (HYDROXYPYRROLINEDEH-RXN HYDROXYPRODEHYDROG-RXN)
REACTION-LAYOUT - (4OH2OXOGLUTARALDOL-RXN (:LEFT-PRIMARIES D-4-HYDROXY-2-KETO-GLUTARATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRUVATE GLYOX))
REACTION-LAYOUT - (HYDROXYPRODEHYDROG-RXN (:LEFT-PRIMARIES 4-HYDROXY-L-PROLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRROLINE-HYDROXY-CARBOXYLATE))
REACTION-LAYOUT - (4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN (:LEFT-PRIMARIES L-ERYTHRO-4-HYDROXY-GLUTAMATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D-4-HYDROXY-2-KETO-GLUTARATE))
REACTION-LAYOUT - (HYDROXYPYRROLINEDEH-RXN (:LEFT-PRIMARIES PYRROLINE-HYDROXY-CARBOXYLATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-ERYTHRO-4-HYDROXY-GLUTAMATE))
REACTION-LIST - 4OH2OXOGLUTARALDOL-RXN
REACTION-LIST - HYDROXYPRODEHYDROG-RXN
REACTION-LIST - 4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN
REACTION-LIST - HYDROXYPYRROLINEDEH-RXN
SYNONYMS - 4-hydroxyproline degradation
//
UNIQUE-ID - ALANINE-DEG3-PWY
TYPES - ALANINE-DEG
COMMON-NAME - alanine degradation III
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |fulcher|
PATHWAY-LINKS - (PYRUVATE TCA GLUCONEO-PWY)
PREDECESSORS - (ALANINE-AMINOTRANSFERASE-RXN)
PRIMARIES - (ALANINE-AMINOTRANSFERASE-RXN (L-ALPHA-ALANINE) (PYRUVATE))
PRIMARIES - (D-ALANINE-AMINOTRANSFERASE-RXN (D-ALANINE) (PYRUVATE))
REACTION-LAYOUT - (ALANINE-AMINOTRANSFERASE-RXN (:LEFT-PRIMARIES L-ALPHA-ALANINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRUVATE))
REACTION-LIST - ALANINE-AMINOTRANSFERASE-RXN
//
UNIQUE-ID - ASPARAGINE-DEG1-PWY
TYPES - ASPARAGINE-DEG
COMMON-NAME - asparagine degradation I
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |fulcher|
PATHWAY-LINKS - (L-ASPARTATE ASPARTATE-DEG1-PWY)
PREDECESSORS - (ASPARAGHYD-RXN)
REACTION-LAYOUT - (ASPARAGHYD-RXN (:LEFT-PRIMARIES ASN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-ASPARTATE))
REACTION-LIST - ASPARAGHYD-RXN
SYNONYMS - asparagine degradation 1
//
UNIQUE-ID - ASPARTATE-DEG1-PWY
TYPES - ASPARTATE-DEG
COMMON-NAME - aspartate degradation I
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |fulcher|
PATHWAY-LINKS - (OXALACETIC_ACID GLUCONEO-PWY)
PREDECESSORS - (ASPAMINOTRANS-RXN)
REACTION-LAYOUT - (ASPAMINOTRANS-RXN (:LEFT-PRIMARIES L-ASPARTATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OXALACETIC_ACID))
REACTION-LIST - ASPAMINOTRANS-RXN
//
UNIQUE-ID - MALATE-ASPARTATE-SHUTTLE-PWY
TYPES - ASPARTATE-DEG
COMMON-NAME - malate/aspartate shuttle pathway
IN-PATHWAY - PWY3DJ-1574
PREDECESSORS - (RXN3DJ-10 RXN3DJ-4528)
REACTION-LAYOUT - (RXN3DJ-4528 (:LEFT-PRIMARIES L-ASPARTATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OXALACETIC_ACID))
REACTION-LAYOUT - (RXN3DJ-10 (:LEFT-PRIMARIES MAL) (:DIRECTION :R2L) (:RIGHT-PRIMARIES OXALACETIC_ACID))
REACTION-LIST - RXN3DJ-4528
REACTION-LIST - RXN3DJ-10
SUPER-PATHWAYS - PWY3DJ-1574
SYNONYMS - aspartate degradation II
//
UNIQUE-ID - CYSDEGRV-PWY
TYPES - CYSTEINE-DEG
COMMON-NAME - L-cysteine degradation VI
PREDECESSORS - (SULFINOALANINE-DECARBOXYLASE-RXN CYSTEINE-DIOXYGENASE-RXN)
REACTION-LAYOUT - (SULFINOALANINE-DECARBOXYLASE-RXN (:LEFT-PRIMARIES 3-SULFINOALANINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES HYPOTAURINE))
REACTION-LAYOUT - (CYSTEINE-DIOXYGENASE-RXN (:LEFT-PRIMARIES CYS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-SULFINOALANINE))
REACTION-LIST - SULFINOALANINE-DECARBOXYLASE-RXN
REACTION-LIST - CYSTEINE-DIOXYGENASE-RXN
//
UNIQUE-ID - CYSTEINE-DEG-PWY
TYPES - CYSTEINE-DEG
COMMON-NAME - L-cysteine degradation I
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - |caspi|
CREDITS - SRI
CREDITS - |wagg|
IN-PATHWAY - PWY-5328
PATHWAY-LINKS - (PYRUVATE PYRUVDEHYD-PWY)
PATHWAY-LINKS - (CYS HOMOCYSDEGR-PWY)
PATHWAY-LINKS - (SO3 PWY-5326)
PREDECESSORS - (3-SULFINOALANINE-AMINOTRANSFERASE-RXN CYSTEINE-DIOXYGENASE-RXN)
PREDECESSORS - (3-SULFINYL-PYRUVATE-SPON-RXN 3-SULFINOALANINE-AMINOTRANSFERASE-RXN)
PRIMARIES - (3-SULFINYL-PYRUVATE-SPON-RXN (3-SULFINYL-PYRUVATE) (PYRUVATE SO3))
PRIMARIES - (3-SULFINOALANINE-AMINOTRANSFERASE-RXN (3-SULFINOALANINE) (3-SULFINYL-PYRUVATE))
REACTION-LAYOUT - (3-SULFINYL-PYRUVATE-SPON-RXN (:LEFT-PRIMARIES 3-SULFINYL-PYRUVATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRUVATE SO3))
REACTION-LAYOUT - (3-SULFINOALANINE-AMINOTRANSFERASE-RXN (:LEFT-PRIMARIES 3-SULFINOALANINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-SULFINYL-PYRUVATE))
REACTION-LAYOUT - (CYSTEINE-DIOXYGENASE-RXN (:LEFT-PRIMARIES CYS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-SULFINOALANINE))
REACTION-LIST - 3-SULFINYL-PYRUVATE-SPON-RXN
REACTION-LIST - 3-SULFINOALANINE-AMINOTRANSFERASE-RXN
REACTION-LIST - CYSTEINE-DIOXYGENASE-RXN
SUPER-PATHWAYS - PWY-5328
SYNONYMS - cysteine degradation I
//
UNIQUE-ID - PWY-5329
TYPES - CYSTEINE-DEG
COMMON-NAME - L-cysteine degradation III
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (PYRUVATE PYRUVDEHYD-PWY)
PREDECESSORS - (MERCAPYSTRANS-RXN CYSTEINE-AMINOTRANSFERASE-RXN)
PREDECESSORS - (CYSTEINE-AMINOTRANSFERASE-RXN)
PRIMARIES - (MERCAPYSTRANS-RXN NIL (PYRUVATE))
REACTION-LAYOUT - (MERCAPYSTRANS-RXN (:LEFT-PRIMARIES 3-MERCAPTO-PYRUVATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRUVATE))
REACTION-LAYOUT - (CYSTEINE-AMINOTRANSFERASE-RXN (:LEFT-PRIMARIES CYS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-MERCAPTO-PYRUVATE))
REACTION-LIST - MERCAPYSTRANS-RXN
REACTION-LIST - CYSTEINE-AMINOTRANSFERASE-RXN
//
UNIQUE-ID - GLUDEG-I-PWY
TYPES - GLUTAMATE-DEG
COMMON-NAME - glutamate degradation III (via 4-aminobutyrate)
CREDITS - |caspi|
CREDITS - SRI
CREDITS - |hying|
PATHWAY-LINKS - (SUC TCA)
PREDECESSORS - (GABATRANSAM-RXN GLUTDECARBOX-RXN)
PREDECESSORS - (SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN GABATRANSAM-RXN)
REACTION-LAYOUT - (SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN (:LEFT-PRIMARIES SUCC-S-ALD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUC))
REACTION-LAYOUT - (GLUTDECARBOX-RXN (:LEFT-PRIMARIES GLT) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 4-AMINO-BUTYRATE))
REACTION-LAYOUT - (GABATRANSAM-RXN (:LEFT-PRIMARIES 4-AMINO-BUTYRATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUCC-S-ALD GLT))
REACTION-LIST - SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
REACTION-LIST - GLUTDECARBOX-RXN
REACTION-LIST - GABATRANSAM-RXN
SYNONYMS - GABA shunt
//
UNIQUE-ID - GLUTOXA-PWY
TYPES - GLUTAMATE-DEG
COMMON-NAME - glutamate degradation VII
PREDECESSORS - (SUCC-FUM-OXRED-RXN SUCCCOASYN-RXN)
PREDECESSORS - (FUMHYDR-RXN SUCC-FUM-OXRED-RXN)
PREDECESSORS - (RXN0-1146 ASPAMINOTRANS-RXN)
PREDECESSORS - (DIHYDLIPSUCCTRANS-RXN RXN0-1146)
PREDECESSORS - (SUCCCOASYN-RXN DIHYDLIPSUCCTRANS-RXN)
REACTION-LAYOUT - (RXN0-1146 (:LEFT-PRIMARIES 2-KETOGLUTARATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD0-341))
REACTION-LAYOUT - (DIHYDLIPSUCCTRANS-RXN (:LEFT-PRIMARIES SUC-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CPD0-341))
REACTION-LAYOUT - (FUMHYDR-RXN (:LEFT-PRIMARIES MAL) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FUM))
REACTION-LAYOUT - (SUCC-FUM-OXRED-RXN (:LEFT-PRIMARIES SUC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FUM))
REACTION-LAYOUT - (SUCCCOASYN-RXN (:LEFT-PRIMARIES SUC) (:DIRECTION :R2L) (:RIGHT-PRIMARIES SUC-COA))
REACTION-LAYOUT - (ASPAMINOTRANS-RXN (:LEFT-PRIMARIES 2-KETOGLUTARATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES GLT OXALACETIC_ACID))
REACTION-LIST - RXN0-1146
REACTION-LIST - DIHYDLIPSUCCTRANS-RXN
REACTION-LIST - FUMHYDR-RXN
REACTION-LIST - SUCC-FUM-OXRED-RXN
REACTION-LIST - SUCCCOASYN-RXN
REACTION-LIST - ASPAMINOTRANS-RXN
//
UNIQUE-ID - PWY-4321
TYPES - GLUTAMATE-DEG
COMMON-NAME - glutamate degradation IV
CITATIONS - :EV-COMP-AINF:3380892013:cjb
PREDECESSORS - (RXN-6903 GABATRANSAM-RXN)
PREDECESSORS - (RXN-6902 GLUTDECARBOX-RXN)
PREDECESSORS - (GABATRANSAM-RXN GLUTDECARBOX-RXN)
PREDECESSORS - (SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN GABATRANSAM-RXN)
PREDECESSORS - (SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN RXN-6902)
PRIMARIES - (RXN-6903 (SUCC-S-ALD) (4-HYDROXY-BUTYRATE))
PRIMARIES - (SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN (SUCC-S-ALD) (SUC))
PRIMARIES - (RXN-6902 (4-AMINO-BUTYRATE) (SUCC-S-ALD))
PRIMARIES - (GABATRANSAM-RXN (4-AMINO-BUTYRATE) (SUCC-S-ALD))
PRIMARIES - (GLUTDECARBOX-RXN (GLT) (4-AMINO-BUTYRATE))
REACTION-LAYOUT - (RXN-6903 (:LEFT-PRIMARIES SUCC-S-ALD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 4-HYDROXY-BUTYRATE))
REACTION-LAYOUT - (RXN-6902 (:LEFT-PRIMARIES 4-AMINO-BUTYRATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUCC-S-ALD))
REACTION-LAYOUT - (SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN (:LEFT-PRIMARIES SUCC-S-ALD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUC))
REACTION-LAYOUT - (GABATRANSAM-RXN (:LEFT-PRIMARIES 4-AMINO-BUTYRATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUCC-S-ALD GLT))
REACTION-LAYOUT - (GLUTDECARBOX-RXN (:LEFT-PRIMARIES GLT) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 4-AMINO-BUTYRATE))
REACTION-LIST - RXN-6903
REACTION-LIST - RXN-6902
REACTION-LIST - SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
REACTION-LIST - GABATRANSAM-RXN
REACTION-LIST - GLUTDECARBOX-RXN
SYNONYMS - GABA shunt
SYNONYMS - 4-aminobutyrate shunt
SYNONYMS - &gamma;-aminobutyrate shunt
//
UNIQUE-ID - PWY-5766
TYPES - GLUTAMATE-DEG
COMMON-NAME - glutamate degradation X
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (GLT (GLUTAMINE-DEG . :INCOMING) (ARGININE-DEG . :INCOMING) (HISTIDINE-DEG . :INCOMING) (PROLINE-DEG . :INCOMING))
PATHWAY-LINKS - (2-KETOGLUTARATE (TCA . :OUTGOING))
PREDECESSORS - (GLUTAMATE-DEHYDROGENASE-NADP+-RXN)
PRIMARIES - (GLUTAMATE-DEHYDROGENASE-RXN (GLT) (2-KETOGLUTARATE))
PRIMARIES - (GLUTAMATE-DEHYDROGENASE-NADP+-RXN (GLT) (2-KETOGLUTARATE))
REACTION-LAYOUT - (GLUTAMATE-DEHYDROGENASE-NADP+-RXN (:LEFT-PRIMARIES GLT) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-KETOGLUTARATE))
REACTION-LIST - GLUTAMATE-DEHYDROGENASE-NADP+-RXN
//
UNIQUE-ID - GLUTAMINE-DEG1-PWY
TYPES - GLUTAMINE-DEG
COMMON-NAME - glutamine degradation I
CITATIONS - :EV-COMP-AINF:3380892013:cjb
PREDECESSORS - (GLUTAMATE-DEHYDROGENASE-NADP+-RXN GLUTAMIN-RXN)
PRIMARIES - (GLUTAMATE-DEHYDROGENASE-NADP+-RXN (GLT) (2-KETOGLUTARATE))
PRIMARIES - (GLUTAMIN-RXN (GLN) (GLT))
REACTION-LAYOUT - (GLUTAMIN-RXN (:LEFT-PRIMARIES GLN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLT))
REACTION-LAYOUT - (GLUTAMATE-DEHYDROGENASE-NADP+-RXN (:LEFT-PRIMARIES GLT) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-KETOGLUTARATE))
REACTION-LIST - GLUTAMIN-RXN
REACTION-LIST - GLUTAMATE-DEHYDROGENASE-NADP+-RXN
SYNONYMS - glutamine degradation 1
//
UNIQUE-ID - GLUTFUMARATE-PWY
TYPES - GLUTAMINE-DEG
COMMON-NAME - glutamine degradation II
CITATIONS - :EV-COMP-AINF:3380892013:cjb
PREDECESSORS - (ASPAMINOTRANS-RXN GLUTAMIN-RXN)
PREDECESSORS - (GLUTAMIN-RXN)
PRIMARIES - (ASPAMINOTRANS-RXN (GLT) (L-ASPARTATE))
REACTION-LAYOUT - (ASPAMINOTRANS-RXN (:LEFT-PRIMARIES L-ASPARTATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES GLT))
REACTION-LAYOUT - (GLUTAMIN-RXN (:LEFT-PRIMARIES GLN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLT))
REACTION-LIST - ASPAMINOTRANS-RXN
REACTION-LIST - GLUTAMIN-RXN
//
UNIQUE-ID - GLYCLEAV-PWY
TYPES - GLYCINE-DEG
COMMON-NAME - glycine cleavage complex
CREDITS - |fulcher|
CREDITS - SRI
CREDITS - |caspi|
CREDITS - O-18
CREDITS - |riley|
PREDECESSORS - (GCVT-RXN GCVP-RXN)
PREDECESSORS - (RXN-8629 GCVT-RXN)
PREDECESSORS - (GCVP-RXN RXN-8629)
PRIMARIES - (GCVMULTI-RXN (GLY) NIL)
PRIMARIES - (GLYOHMETRANS-RXN NIL (GLY))
REACTION-LAYOUT - (RXN-8629 (:LEFT-PRIMARIES DIHYDROLIPOYL-GCVH) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PROTEIN-LIPOYLLYSINE))
REACTION-LAYOUT - (GCVT-RXN (:LEFT-PRIMARIES AMINOMETHYLDIHYDROLIPOYL-GCVH) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIHYDROLIPOYL-GCVH))
REACTION-LAYOUT - (GCVP-RXN (:LEFT-PRIMARIES PROTEIN-LIPOYLLYSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES AMINOMETHYLDIHYDROLIPOYL-GCVH))
REACTION-LIST - RXN-8629
REACTION-LIST - GCVT-RXN
REACTION-LIST - GCVP-RXN
SYNONYMS - glycine cleavage system
SYNONYMS - glycine decarboxylase complex
SYNONYMS - gcv system
//
UNIQUE-ID - PWY-5030
TYPES - HISTIDINE-DEG
COMMON-NAME - histidine degradation III
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (10-FORMYL-THF PWY-2201)
PATHWAY-LINKS - (GLT GLUDEG-I-PWY)
PREDECESSORS - (GLUTAMATE-FORMIMINOTRANSFERASE-RXN IMIDAZOLONEPROPIONASE-RXN)
PREDECESSORS - (UROCANATE-HYDRATASE-RXN HISTIDINE-AMMONIA-LYASE-RXN)
PREDECESSORS - (IMIDAZOLONEPROPIONASE-RXN UROCANATE-HYDRATASE-RXN)
PREDECESSORS - (4.3.1.4-RXN GLUTAMATE-FORMIMINOTRANSFERASE-RXN)
PREDECESSORS - (METHENYLTHFCYCLOHYDRO-RXN 4.3.1.4-RXN)
PRIMARIES - (GLUTAMATE-FORMIMINOTRANSFERASE-RXN NIL (GLT))
PRIMARIES - (FORMIMINOGLUTAMASE-RXN NIL (GLT))
REACTION-LAYOUT - (METHENYLTHFCYCLOHYDRO-RXN (:LEFT-PRIMARIES 5-10-METHENYL-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 10-FORMYL-THF))
REACTION-LAYOUT - (4.3.1.4-RXN (:LEFT-PRIMARIES CPD-671) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-10-METHENYL-THF))
REACTION-LAYOUT - (GLUTAMATE-FORMIMINOTRANSFERASE-RXN (:LEFT-PRIMARIES CPD-671 GLT) (:DIRECTION :R2L) (:RIGHT-PRIMARIES N-FORMIMINO-L-GLUTAMATE))
REACTION-LAYOUT - (IMIDAZOLONEPROPIONASE-RXN (:LEFT-PRIMARIES 4-IMIDAZOLONE-5-PROPIONATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES N-FORMIMINO-L-GLUTAMATE))
REACTION-LAYOUT - (UROCANATE-HYDRATASE-RXN (:LEFT-PRIMARIES 4-IMIDAZOLONE-5-PROPIONATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES UROCANATE))
REACTION-LAYOUT - (HISTIDINE-AMMONIA-LYASE-RXN (:LEFT-PRIMARIES HIS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UROCANATE))
REACTION-LIST - METHENYLTHFCYCLOHYDRO-RXN
REACTION-LIST - 4.3.1.4-RXN
REACTION-LIST - GLUTAMATE-FORMIMINOTRANSFERASE-RXN
REACTION-LIST - IMIDAZOLONEPROPIONASE-RXN
REACTION-LIST - UROCANATE-HYDRATASE-RXN
REACTION-LIST - HISTIDINE-AMMONIA-LYASE-RXN
//
UNIQUE-ID - PWY3DJ-0
TYPES - ISOLEUCINE-DEG
COMMON-NAME - isoleucine degradation
CITATIONS - 12696021
CITATIONS - 16950638:EV-EXP-TAS:3388848068:ave
COMMENT - <A href="http://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=ILEUDEG-PWY">Pathway summary from MetaCyc</A>.
/
/In humans, mutations in <A href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&id=36"><I>ACADSB</I></A> gene cause an inborn error of metabolism called <A href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=610006">2-Methylbutyryl-CoA dehydrogenase deficiency</A> |CITS: [12696021]|.
/
CREDITS - AU3DJ-34097
CREDITS - AU3DJ-7
PATHWAY-LINKS - (SUC-COA TCA)
PATHWAY-LINKS - (ACETYL-COA TCA)
PREDECESSORS - (METHYLMALONYL-COA-MUT-RXN METHYLMALONYL-COA-EPIM-RXN)
PREDECESSORS - (METHYLMALONYL-COA-EPIM-RXN PROPIONYL-COA-CARBOXY-RXN)
PREDECESSORS - (PROPIONYL-COA-CARBOXY-RXN METHYLACETOACETYLCOATHIOL-RXN)
PREDECESSORS - (METHYLACETOACETYLCOATHIOL-RXN 1.1.1.178-RXN)
PREDECESSORS - (1.1.1.178-RXN TIGLYLCOA-HYDROXY-RXN)
PREDECESSORS - (TIGLYLCOA-HYDROXY-RXN 2-METHYLACYL-COA-DEHYDROGENASE-RXN)
PREDECESSORS - (2-METHYLACYL-COA-DEHYDROGENASE-RXN MBCOA-DHLIPOAMIDE-RXN)
PREDECESSORS - (METHYLVALERATE-RXN BRANCHED-CHAINAMINOTRANSFERILEU-RXN)
PREDECESSORS - (MBCOA-DHLIPOAMIDE-RXN METHYLVALERATE-RXN)
PREDECESSORS - (MBCOA-DHLIPOAMIDE-RXN BRANCHED-CHAINAMINOTRANSFERILEU-RXN)
PRIMARIES - (METHYLACETOACETYLCOATHIOL-RXN (2-METHYL-ACETO-ACETYL-COA) (PROPIONYL-COA ACETYL-COA))
PRIMARIES - (METHYLVALERATE-RXN (2-KETO-3-METHYL-VALERATE) (2-METHYL-BUTANOYL-DIHYDROLIPOYL-E2))
PRIMARIES - (MBCOA-DHLIPOAMIDE-RXN (2-METHYL-BUTANOYL-DIHYDROLIPOYL-E2) (2-METHYL-BUTYRYL-COA))
PRIMARIES - (BRANCHED-CHAINAMINOTRANSFERILEU-RXN (ILE) (2-KETO-3-METHYL-VALERATE))
REACTION-LAYOUT - (METHYLMALONYL-COA-MUT-RXN (:LEFT-PRIMARIES METHYL-MALONYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUC-COA))
REACTION-LAYOUT - (METHYLMALONYL-COA-EPIM-RXN (:LEFT-PRIMARIES METHYL-MALONYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES D-METHYL-MALONYL-COA))
REACTION-LAYOUT - (PROPIONYL-COA-CARBOXY-RXN (:LEFT-PRIMARIES PROPIONYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D-METHYL-MALONYL-COA))
REACTION-LAYOUT - (METHYLACETOACETYLCOATHIOL-RXN (:LEFT-PRIMARIES 2-METHYL-ACETO-ACETYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETYL-COA PROPIONYL-COA))
REACTION-LAYOUT - (1.1.1.178-RXN (:LEFT-PRIMARIES 2-METHYL-3-HYDROXY-BUTYRYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-METHYL-ACETO-ACETYL-COA))
REACTION-LAYOUT - (TIGLYLCOA-HYDROXY-RXN (:LEFT-PRIMARIES CPD-1083) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-METHYL-3-HYDROXY-BUTYRYL-COA))
REACTION-LAYOUT - (2-METHYLACYL-COA-DEHYDROGENASE-RXN (:LEFT-PRIMARIES 2-METHYL-BUTYRYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-1083))
REACTION-LAYOUT - (MBCOA-DHLIPOAMIDE-RXN (:LEFT-PRIMARIES |BCAA-dehydrogenase-2MB-DH-lipoyl|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-METHYL-BUTYRYL-COA))
REACTION-LAYOUT - (METHYLVALERATE-RXN (:LEFT-PRIMARIES 2-KETO-3-METHYL-VALERATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |BCAA-dehydrogenase-2MB-DH-lipoyl|))
REACTION-LAYOUT - (BRANCHED-CHAINAMINOTRANSFERILEU-RXN (:LEFT-PRIMARIES ILE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-KETO-3-METHYL-VALERATE))
REACTION-LIST - METHYLMALONYL-COA-MUT-RXN
REACTION-LIST - METHYLMALONYL-COA-EPIM-RXN
REACTION-LIST - PROPIONYL-COA-CARBOXY-RXN
REACTION-LIST - METHYLACETOACETYLCOATHIOL-RXN
REACTION-LIST - 1.1.1.178-RXN
REACTION-LIST - TIGLYLCOA-HYDROXY-RXN
REACTION-LIST - 2-METHYLACYL-COA-DEHYDROGENASE-RXN
REACTION-LIST - MBCOA-DHLIPOAMIDE-RXN
REACTION-LIST - METHYLVALERATE-RXN
REACTION-LIST - BRANCHED-CHAINAMINOTRANSFERILEU-RXN
//
UNIQUE-ID - PWY3DJ-34120
TYPES - LEUCINE-DEG
COMMON-NAME - leucine degradation
COMMENT - <A href="http://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=LEU-DEG2-PWY">Pathway summary from MetaCyc</A>.
/
/In humans, mutations in the alpha or beta subunits of 3-methylcrotonyl-CoA carboxylase result in inborn errors of matabolism
/called <A href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=210200">methylcrotonylglycinuria type I</A> and <A href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=210210">methylcrotonylglycinuria type II</A>,
/respectively.  Another inborn error of metabolism associated with this pathway are caused by mutations in the <A href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&id=3155"><I>HMGCL</I></A> gene that lead to <A href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=246450">3-hydroxy-3-methylglutaryl-CoA lyase deficiency</A>.
CREDITS - AU3DJ-7
PATHWAY-LINKS - (3-KETOBUTYRATE ACETOACETATE-DEG-PWY)
PATHWAY-LINKS - (ACETYL-COA TCA)
PREDECESSORS - (HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN METHYLGLUTACONYL-COA-HYDRATASE-RXN)
PREDECESSORS - (METHYLGLUTACONYL-COA-HYDRATASE-RXN METHYLCROTONYL-COA-CARBOXYLASE-RXN)
PREDECESSORS - (METHYLCROTONYL-COA-CARBOXYLASE-RXN ISOVALERYL-COA-FAD-RXN)
PREDECESSORS - (ISOVALERYL-COA-FAD-RXN ISOVALERYLCOA-DHLIPOAMIDE-RXN)
PREDECESSORS - (ISOVALERYLCOA-DHLIPOAMIDE-RXN KETOISOCAPROATE-RXN)
PREDECESSORS - (KETOISOCAPROATE-RXN BRANCHED-CHAINAMINOTRANSFERLEU-RXN)
PRIMARIES - (HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN (3-HYDROXY-3-METHYL-GLUTARYL-COA) (3-KETOBUTYRATE ACETYL-COA))
PRIMARIES - (ACETOACETYL-COA-TRANSFER-RXN (3-KETOBUTYRATE) (ACETOACETYL-COA))
PRIMARIES - (ISOVALERYLCOA-DHLIPOAMIDE-RXN (3-METHYL-BUTANOYL-DIHYDROLIPOYL-E2) (ISOVALERYL-COA))
REACTION-LAYOUT - (HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN (:LEFT-PRIMARIES 3-HYDROXY-3-METHYL-GLUTARYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETYL-COA 3-KETOBUTYRATE))
REACTION-LAYOUT - (METHYLGLUTACONYL-COA-HYDRATASE-RXN (:LEFT-PRIMARIES 3-HYDROXY-3-METHYL-GLUTARYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES TRANS-3-METHYL-GLUTACONYL-COA))
REACTION-LAYOUT - (METHYLCROTONYL-COA-CARBOXYLASE-RXN (:LEFT-PRIMARIES 3-METHYL-CROTONYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TRANS-3-METHYL-GLUTACONYL-COA))
REACTION-LAYOUT - (ISOVALERYL-COA-FAD-RXN (:LEFT-PRIMARIES ISOVALERYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-METHYL-CROTONYL-COA))
REACTION-LAYOUT - (ISOVALERYLCOA-DHLIPOAMIDE-RXN (:LEFT-PRIMARIES |BCAA-dehydrogenase-3MB-DH-lipoyl|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ISOVALERYL-COA))
REACTION-LAYOUT - (KETOISOCAPROATE-RXN (:LEFT-PRIMARIES 2K-4CH3-PENTANOATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |BCAA-dehydrogenase-3MB-DH-lipoyl|))
REACTION-LAYOUT - (BRANCHED-CHAINAMINOTRANSFERLEU-RXN (:LEFT-PRIMARIES LEU) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2K-4CH3-PENTANOATE))
REACTION-LIST - HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN
REACTION-LIST - METHYLGLUTACONYL-COA-HYDRATASE-RXN
REACTION-LIST - METHYLCROTONYL-COA-CARBOXYLASE-RXN
REACTION-LIST - ISOVALERYL-COA-FAD-RXN
REACTION-LIST - ISOVALERYLCOA-DHLIPOAMIDE-RXN
REACTION-LIST - KETOISOCAPROATE-RXN
REACTION-LIST - BRANCHED-CHAINAMINOTRANSFERLEU-RXN
//
UNIQUE-ID - PWY3DJ-6
TYPES - LEUCINE-DEG
COMMON-NAME - Leucine Catabolism
COMMENT - <A href="http://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=LEU-DEG2-PWY">Pathway summary from MetaCyc</A>.
/
/In humans, mutations in the alpha or beta subunits of 3-methylcrotonyl-CoA carboxylase result in inborn errors of matabolism
/called <A href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=210200">methylcrotonylglycinuria type I</A> and <A href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=210210">methylcrotonylglycinuria type II</A>,
/respectively.  Another inborn error of metabolism associated with this pathway are caused by mutations in the <A href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&id=3155"><I>HMGCL</I></A> gene that lead to <A href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=246450">3-hydroxy-3-methylglutaryl-CoA lyase deficiency</A>.
/
CREDITS - AU3DJ-15
PATHWAY-LINKS - (3-KETOBUTYRATE ACETOACETATE-DEG-PWY)
PATHWAY-LINKS - (ACETYL-COA TCA)
PREDECESSORS - (HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN METHYLGLUTACONYL-COA-HYDRATASE-RXN)
PREDECESSORS - (METHYLGLUTACONYL-COA-HYDRATASE-RXN METHYLCROTONYL-COA-CARBOXYLASE-RXN)
PREDECESSORS - (METHYLCROTONYL-COA-CARBOXYLASE-RXN ISOVALERYL-COA-FAD-RXN)
PREDECESSORS - (KETOISOCAPROATE-RXN RXN-7719)
PREDECESSORS - (RXN-7719 ISOVALERYLCOA-DHLIPOAMIDE-RXN)
PREDECESSORS - (ISOVALERYL-COA-FAD-RXN ISOVALERYLCOA-DHLIPOAMIDE-RXN)
PREDECESSORS - (ISOVALERYLCOA-DHLIPOAMIDE-RXN KETOISOCAPROATE-RXN)
PREDECESSORS - (KETOISOCAPROATE-RXN BRANCHED-CHAINAMINOTRANSFERLEU-RXN)
PRIMARIES - (HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN (3-HYDROXY-3-METHYL-GLUTARYL-COA) (3-KETOBUTYRATE ACETYL-COA))
PRIMARIES - (KETOISOCAPROATE-RXN (2K-4CH3-PENTANOATE) (|BCAA-dehydrogenase-3MB-DH-lipoyl|))
PRIMARIES - (ISOVALERYLCOA-DHLIPOAMIDE-RXN (|BCAA-dehydrogenase-3MB-DH-lipoyl|) (|BCAA-dehydrogenase-DH-lipoyl| ISOVALERYL-COA))
REACTION-LAYOUT - (HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN (:LEFT-PRIMARIES 3-HYDROXY-3-METHYL-GLUTARYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETYL-COA 3-KETOBUTYRATE))
REACTION-LAYOUT - (METHYLGLUTACONYL-COA-HYDRATASE-RXN (:LEFT-PRIMARIES 3-HYDROXY-3-METHYL-GLUTARYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES TRANS-3-METHYL-GLUTACONYL-COA))
REACTION-LAYOUT - (METHYLCROTONYL-COA-CARBOXYLASE-RXN (:LEFT-PRIMARIES 3-METHYL-CROTONYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TRANS-3-METHYL-GLUTACONYL-COA))
REACTION-LAYOUT - (ISOVALERYL-COA-FAD-RXN (:LEFT-PRIMARIES ISOVALERYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-METHYL-CROTONYL-COA))
REACTION-LAYOUT - (RXN-7719 (:LEFT-PRIMARIES |BCAA-dehydrogenase-DH-lipoyl|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |BCAA-dehydrogenase-lipoyl|))
REACTION-LAYOUT - (ISOVALERYLCOA-DHLIPOAMIDE-RXN (:LEFT-PRIMARIES |BCAA-dehydrogenase-3MB-DH-lipoyl|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ISOVALERYL-COA |BCAA-dehydrogenase-DH-lipoyl|))
REACTION-LAYOUT - (KETOISOCAPROATE-RXN (:LEFT-PRIMARIES 2K-4CH3-PENTANOATE |BCAA-dehydrogenase-lipoyl|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |BCAA-dehydrogenase-3MB-DH-lipoyl|))
REACTION-LAYOUT - (BRANCHED-CHAINAMINOTRANSFERLEU-RXN (:LEFT-PRIMARIES LEU) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2K-4CH3-PENTANOATE))
REACTION-LIST - HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN
REACTION-LIST - METHYLGLUTACONYL-COA-HYDRATASE-RXN
REACTION-LIST - METHYLCROTONYL-COA-CARBOXYLASE-RXN
REACTION-LIST - ISOVALERYL-COA-FAD-RXN
REACTION-LIST - RXN-7719
REACTION-LIST - ISOVALERYLCOA-DHLIPOAMIDE-RXN
REACTION-LIST - KETOISOCAPROATE-RXN
REACTION-LIST - BRANCHED-CHAINAMINOTRANSFERLEU-RXN
//
UNIQUE-ID - LYSINE-DEG1-PWY
TYPES - LYSINE-DEG
COMMON-NAME - lysine degradation II
CITATIONS - :EV-COMP-AINF:3482054329:ave
PATHWAY-LINKS - (GLUTARYL-COA PWY-5177)
PREDECESSORS - (2-AMINOADIPATE-AMINOTRANSFERASE-RXN RXN-8162)
PREDECESSORS - (RXN-8162 RXN-8173)
PREDECESSORS - (RXN-8173 1.5.1.9-RXN)
PREDECESSORS - (2-KETO-ADIPATE-DEHYDROG-RXN 2-AMINOADIPATE-AMINOTRANSFERASE-RXN)
PREDECESSORS - (1.5.1.9-RXN 1.5.1.8-RXN)
PRIMARIES - (2-AMINOADIPATE-AMINOTRANSFERASE-RXN (CPD-468) (2K-ADIPATE))
PRIMARIES - (1.5.1.9-RXN (SACCHAROPINE) (ALLYSINE))
PRIMARIES - (1.5.1.8-RXN (LYS) (SACCHAROPINE))
REACTION-LAYOUT - (RXN-8162 (:LEFT-PRIMARIES CPD-7682) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-468))
REACTION-LAYOUT - (RXN-8173 (:LEFT-PRIMARIES CPD-7682) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ALLYSINE))
REACTION-LAYOUT - (2-KETO-ADIPATE-DEHYDROG-RXN (:LEFT-PRIMARIES 2K-ADIPATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLUTARYL-COA))
REACTION-LAYOUT - (2-AMINOADIPATE-AMINOTRANSFERASE-RXN (:LEFT-PRIMARIES CPD-468) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2K-ADIPATE))
REACTION-LAYOUT - (1.5.1.9-RXN (:LEFT-PRIMARIES SACCHAROPINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALLYSINE))
REACTION-LAYOUT - (1.5.1.8-RXN (:LEFT-PRIMARIES SACCHAROPINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES LYS))
REACTION-LIST - RXN-8162
REACTION-LIST - RXN-8173
REACTION-LIST - 2-KETO-ADIPATE-DEHYDROG-RXN
REACTION-LIST - 2-AMINOADIPATE-AMINOTRANSFERASE-RXN
REACTION-LIST - 1.5.1.9-RXN
REACTION-LIST - 1.5.1.8-RXN
SYNONYMS - lysine degradation I
//
UNIQUE-ID - METHIONINE-DEG1-PWY
TYPES - METHIONINE-DEG
COMMON-NAME - methionine degradation I (to homocysteine)
CITATIONS - :EV-COMP-AINF:3482054330:ave
IN-PATHWAY - PWY-5328
IN-PATHWAY - PWY-6292
PATHWAY-LINKS - (HOMO-CYS ADENOSYLHOMOCYSCAT-PWY HOMOCYSDEGR-PWY)
PATHWAY-LINKS - (CYS CYSTEINE-DEG-PWY)
PREDECESSORS - (ADENOSYLHOMOCYSTEINASE-RXN 2.1.1.73-RXN)
PREDECESSORS - (2.1.1.73-RXN S-ADENMETSYN-RXN)
PRIMARIES - (ADENOSYLHOMOCYSTEINASE-RXN (ADENOSYL-HOMO-CYS) (HOMO-CYS))
PRIMARIES - (2.1.1.73-RXN (S-ADENOSYLMETHIONINE) (ADENOSYL-HOMO-CYS))
PRIMARIES - (S-ADENMETSYN-RXN (MET) (S-ADENOSYLMETHIONINE))
REACTION-LAYOUT - (2.1.1.73-RXN (:LEFT-PRIMARIES S-ADENOSYLMETHIONINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ADENOSYL-HOMO-CYS))
REACTION-LAYOUT - (ADENOSYLHOMOCYSTEINASE-RXN (:LEFT-PRIMARIES ADENOSYL-HOMO-CYS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES HOMO-CYS))
REACTION-LAYOUT - (S-ADENMETSYN-RXN (:LEFT-PRIMARIES MET) (:DIRECTION :L2R) (:RIGHT-PRIMARIES S-ADENOSYLMETHIONINE))
REACTION-LIST - 2.1.1.73-RXN
REACTION-LIST - ADENOSYLHOMOCYSTEINASE-RXN
REACTION-LIST - S-ADENMETSYN-RXN
SUPER-PATHWAYS - PWY-5328
SUPER-PATHWAYS - PWY-6292
//
UNIQUE-ID - PWY-5328
TYPES - METHIONINE-DEG
TYPES - Super-Pathways
COMMON-NAME - superpathway of methionine degradation
PATHWAY-LINKS - (SUC-COA TCA)
PREDECESSORS - (SULFITE-OXIDASE-RXN 3-SULFINYL-PYRUVATE-SPON-RXN)
PREDECESSORS - PWY-5326
PREDECESSORS - (CYSTEINE-DIOXYGENASE-RXN CYSTAGLY-RXN)
PREDECESSORS - CYSTEINE-DEG-PWY
PREDECESSORS - (RXN-7790 CYSTAGLY-RXN)
PREDECESSORS - PROPIONMET-PWY
PREDECESSORS - (CYSTATHIONINE-BETA-SYNTHASE-RXN ADENOSYLHOMOCYSTEINASE-RXN)
PREDECESSORS - HOMOCYSDEGR-PWY
PREDECESSORS - METHIONINE-DEG1-PWY
PREDECESSORS - ADENOSYLHOMOCYSCAT-PWY
PRIMARIES - (CYSTATHIONINE-BETA-SYNTHASE-RXN (HOMO-CYS) NIL)
REACTION-LAYOUT - (ADENOSYLHOMOCYSCAT-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (PWY-5326 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (CYSTEINE-DEG-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (PROPIONMET-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (HOMOCYSDEGR-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (METHIONINE-DEG1-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - ADENOSYLHOMOCYSCAT-PWY
REACTION-LIST - PWY-5326
REACTION-LIST - CYSTEINE-DEG-PWY
REACTION-LIST - PROPIONMET-PWY
REACTION-LIST - HOMOCYSDEGR-PWY
REACTION-LIST - METHIONINE-DEG1-PWY
SUB-PATHWAYS - ADENOSYLHOMOCYSCAT-PWY
SUB-PATHWAYS - PWY-5326
SUB-PATHWAYS - CYSTEINE-DEG-PWY
SUB-PATHWAYS - HOMOCYSDEGR-PWY
SUB-PATHWAYS - METHIONINE-DEG1-PWY
//
UNIQUE-ID - CITRULLINE-DEG-PWY
TYPES - MISCELLANEOUS-DEG
COMMON-NAME - citrulline degradation
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |hartmut|
CREDITS - |caspi|
CREDITS - SRI
CREDITS - |hying|
PREDECESSORS - (CARBAMATE-KINASE-RXN ORNCARBAMTRANSFER-RXN)
PRIMARIES - (ORNCARBAMTRANSFER-RXN (L-CITRULLINE) (CARBAMOYL-P))
PRIMARIES - (CARBAMATE-KINASE-RXN (CARBAMOYL-P) (CARBON-DIOXIDE))
REACTION-LAYOUT - (CARBAMATE-KINASE-RXN (:LEFT-PRIMARIES CARBON-DIOXIDE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CARBAMOYL-P))
REACTION-LAYOUT - (ORNCARBAMTRANSFER-RXN (:LEFT-PRIMARIES CARBAMOYL-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES L-CITRULLINE))
REACTION-LIST - CARBAMATE-KINASE-RXN
REACTION-LIST - ORNCARBAMTRANSFER-RXN
//
UNIQUE-ID - PHENYLALANINE-DEG1-PWY
TYPES - PHENYLALANINE-DEG
COMMON-NAME - phenylalanine degradation I (aerobic)
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |fulcher|
PATHWAY-LINKS - (TYR TYRFUMCAT-PWY)
PREDECESSORS - (RXN-7909 RXN-7908)
PREDECESSORS - (RXN-7908 PHENYLALANINE-4-MONOOXYGENASE-RXN)
PREDECESSORS - (PHENYLALANINE-4-MONOOXYGENASE-RXN RXN-7909)
PRIMARIES - (PHENYLALANINE-4-MONOOXYGENASE-RXN (PHE) (TYR))
PRIMARIES - (FUMARYLACETOACETASE-RXN (4-FUMARYL-ACETOACETATE) (FUM))
PRIMARIES - (4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN (P-HYDROXY-PHENYLPYRUVATE) (HOMOGENTISATE))
PRIMARIES - (TYROSINE-AMINOTRANSFERASE-RXN (TYR) (P-HYDROXY-PHENYLPYRUVATE))
REACTION-LAYOUT - (RXN-7909 (:LEFT-PRIMARIES BIOPTERIN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TETRA-H-BIOPTERIN))
REACTION-LAYOUT - (RXN-7908 (:LEFT-PRIMARIES CPD-5881) (:DIRECTION :L2R) (:RIGHT-PRIMARIES BIOPTERIN))
REACTION-LAYOUT - (PHENYLALANINE-4-MONOOXYGENASE-RXN (:LEFT-PRIMARIES PHE TETRA-H-BIOPTERIN) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-5881 TYR))
REACTION-LIST - RXN-7909
REACTION-LIST - RXN-7908
REACTION-LIST - PHENYLALANINE-4-MONOOXYGENASE-RXN
//
UNIQUE-ID - PWY-5079
TYPES - PHENYLALANINE-DEG
COMMON-NAME - phenylalanine degradation III
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (PHENYLPYRUVATE-DECARBOXYLASE-RXN 2.6.1.58-RXN)
PREDECESSORS - (PHEAMINOTRANS-RXN)
PREDECESSORS - (PHENYLPYRUVATE-DECARBOXYLASE-RXN PHEAMINOTRANS-RXN)
PREDECESSORS - (RXN-7700 PHENYLPYRUVATE-DECARBOXYLASE-RXN)
PRIMARIES - (2.6.1.58-RXN (PHE) NIL)
REACTION-LAYOUT - (2.6.1.58-RXN (:LEFT-PRIMARIES PHE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHENYL-PYRUVATE))
REACTION-LAYOUT - (RXN-7700 (:LEFT-PRIMARIES PHENYLACETALDEHYDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-7035))
REACTION-LAYOUT - (PHENYLPYRUVATE-DECARBOXYLASE-RXN (:LEFT-PRIMARIES PHENYL-PYRUVATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHENYLACETALDEHYDE))
REACTION-LAYOUT - (PHEAMINOTRANS-RXN (:LEFT-PRIMARIES PHENYL-PYRUVATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES PHE))
REACTION-LIST - 2.6.1.58-RXN
REACTION-LIST - RXN-7700
REACTION-LIST - PHENYLPYRUVATE-DECARBOXYLASE-RXN
REACTION-LIST - PHEAMINOTRANS-RXN
SYNONYMS - Ehrlich pathway
//
UNIQUE-ID - PROLINE-DEG2-PWY
TYPES - PROLINE-DEG
COMMON-NAME - proline degradation III
PREDECESSORS - (GLUTAMATE-DEHYDROGENASE-NADP+-RXN PYRROLINECARBDEHYDROG-RXN)
PREDECESSORS - (PYRROLINECARBDEHYDROG-RXN RXN-821)
REACTION-LAYOUT - (RXN-821 (:LEFT-PRIMARIES PRO) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-DELTA1-PYRROLINE_5-CARBOXYLATE))
REACTION-LAYOUT - (PYRROLINECARBDEHYDROG-RXN (:LEFT-PRIMARIES L-DELTA1-PYRROLINE_5-CARBOXYLATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLT))
REACTION-LIST - RXN-821
REACTION-LIST - PYRROLINECARBDEHYDROG-RXN
SYNONYMS - procat
//
UNIQUE-ID - PWY-4561
TYPES - PROLINE-DEG
COMMON-NAME - proline degradation II
CITATIONS - :EV-COMP-AINF:3380892013:cjb
PREDECESSORS - (RXN-7183 RXN-7181)
PRIMARIES - (RXN-7183 (L-DELTA1-PYRROLINE_5-CARBOXYLATE) (GLT))
PRIMARIES - (RXN-7181 (PRO) (L-DELTA1-PYRROLINE_5-CARBOXYLATE))
PRIMARIES - (PYRROLINECARBDEHYDROG-RXN (L-DELTA1-PYRROLINE_5-CARBOXYLATE) (GLT))
REACTION-LAYOUT - (RXN-7183 (:LEFT-PRIMARIES L-DELTA1-PYRROLINE_5-CARBOXYLATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLT))
REACTION-LAYOUT - (RXN-7181 (:LEFT-PRIMARIES PRO) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-DELTA1-PYRROLINE_5-CARBOXYLATE))
REACTION-LIST - RXN-7183
REACTION-LIST - RXN-7181
SYNONYMS - proline catabolism
//
UNIQUE-ID - PWY3DJ-35778
TYPES - SERINE-DEG
COMMON-NAME - Serine degradation II
CREDITS - AU3DJ-7
PREDECESSORS - (RXN-8629 GCVT-RXN)
PREDECESSORS - (GCVP-RXN RXN-8629)
PREDECESSORS - (GCVT-RXN GCVP-RXN)
PREDECESSORS - (GCVP-RXN GLYOHMETRANS-RXN)
PRIMARIES - (GCVP-RXN (PROTEIN-LIPOYLLYSINE) (AMINOMETHYLDIHYDROLIPOYL-GCVH))
PRIMARIES - (GCVT-RXN (AMINOMETHYLDIHYDROLIPOYL-GCVH) (DIHYDROLIPOYL-GCVH))
PRIMARIES - (GCVMULTI-RXN (GLY) (AMMONIA))
PRIMARIES - (GLYOHMETRANS-RXN (SER) (GLY))
REACTION-LAYOUT - (RXN-8629 (:LEFT-PRIMARIES DIHYDROLIPOYL-GCVH) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PROTEIN-LIPOYLLYSINE))
REACTION-LAYOUT - (GCVT-RXN (:LEFT-PRIMARIES AMINOMETHYLDIHYDROLIPOYL-GCVH) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIHYDROLIPOYL-GCVH))
REACTION-LAYOUT - (GCVP-RXN (:LEFT-PRIMARIES GLY PROTEIN-LIPOYLLYSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES AMINOMETHYLDIHYDROLIPOYL-GCVH))
REACTION-LAYOUT - (GLYOHMETRANS-RXN (:LEFT-PRIMARIES SER) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLY))
REACTION-LIST - RXN-8629
REACTION-LIST - GCVT-RXN
REACTION-LIST - GCVP-RXN
REACTION-LIST - GLYOHMETRANS-RXN
//
UNIQUE-ID - SERDEG-PWY
TYPES - SERINE-DEG
COMMON-NAME - L-serine degradation
CITATIONS - :EV-COMP-AINF:3419591313:ave
CREDITS - SRI
CREDITS - |shearer|
PREDECESSORS - (4.3.1.17-RXN)
REACTION-LAYOUT - (4.3.1.17-RXN (:LEFT-PRIMARIES SER) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRUVATE))
REACTION-LIST - 4.3.1.17-RXN
//
UNIQUE-ID - THRDLCTCAT-PWY
TYPES - THREONINE-DEG
COMMON-NAME - threonine degradation III (to methylglyoxal)
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - |caspi|
CREDITS - SRI
CREDITS - |hying|
PATHWAY-LINKS - (METHYL-GLYOXAL PWY-901)
PREDECESSORS - (AMACETOXID-RXN THREOSPON-RXN)
PREDECESSORS - (THREOSPON-RXN THREODEHYD-RXN)
PREDECESSORS - (THREODEHYD-RXN)
REACTION-LAYOUT - (AMACETOXID-RXN (:LEFT-PRIMARIES AMINO-ACETONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES METHYL-GLYOXAL))
REACTION-LAYOUT - (THREOSPON-RXN (:LEFT-PRIMARIES AMINO-OXOBUT) (:DIRECTION :L2R) (:RIGHT-PRIMARIES AMINO-ACETONE))
REACTION-LAYOUT - (THREODEHYD-RXN (:LEFT-PRIMARIES THR) (:DIRECTION :L2R) (:RIGHT-PRIMARIES AMINO-OXOBUT))
REACTION-LIST - AMACETOXID-RXN
REACTION-LIST - THREOSPON-RXN
REACTION-LIST - THREODEHYD-RXN
SYNONYMS - threonine D-lactate catabolism
SYNONYMS - threonine catabolism
//
UNIQUE-ID - PWY-5651
TYPES - TRYPTOPHAN-DEG
COMMON-NAME - tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - TRYPTOPHAN-DEGRADATION-1
IN-PATHWAY - PWY-6309
IN-PATHWAY - NADSYN-PWY
PATHWAY-LINKS - (2-AMINO-3-3-OXOPROP-2-ENYL-BUT-2-ENEDI PWY-5653 PWY-5652)
PATHWAY-LINKS - (2-AMINO-3-3-OXOPROP-2-ENYL-BUT-2-ENEDI PWY-5653)
PREDECESSORS - (KYNURENINE-3-MONOOXYGENASE-RXN ARYLFORMAMIDASE-RXN)
PREDECESSORS - (ARYLFORMAMIDASE-RXN TRYPTOPHAN-23-DIOXYGENASE-RXN)
PREDECESSORS - (3-HYDROXY-KYNURENINASE-RXN KYNURENINE-3-MONOOXYGENASE-RXN)
PREDECESSORS - (1.13.11.6-RXN 3-HYDROXY-KYNURENINASE-RXN)
REACTION-LAYOUT - (1.13.11.6-RXN (:LEFT-PRIMARIES 3-HYDROXY-ANTHRANILATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-AMINO-3-3-OXOPROP-2-ENYL-BUT-2-ENEDI))
REACTION-LAYOUT - (3-HYDROXY-KYNURENINASE-RXN (:LEFT-PRIMARIES 3-HYDROXY-L-KYNURENINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HYDROXY-ANTHRANILATE))
REACTION-LAYOUT - (KYNURENINE-3-MONOOXYGENASE-RXN (:LEFT-PRIMARIES L-KYNURENINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HYDROXY-L-KYNURENINE))
REACTION-LAYOUT - (ARYLFORMAMIDASE-RXN (:LEFT-PRIMARIES N-FORMYLKYNURENINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-KYNURENINE))
REACTION-LAYOUT - (TRYPTOPHAN-23-DIOXYGENASE-RXN (:LEFT-PRIMARIES TRP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES N-FORMYLKYNURENINE))
REACTION-LIST - 1.13.11.6-RXN
REACTION-LIST - 3-HYDROXY-KYNURENINASE-RXN
REACTION-LIST - KYNURENINE-3-MONOOXYGENASE-RXN
REACTION-LIST - ARYLFORMAMIDASE-RXN
REACTION-LIST - TRYPTOPHAN-23-DIOXYGENASE-RXN
SUPER-PATHWAYS - TRYPTOPHAN-DEGRADATION-1
SUPER-PATHWAYS - PWY-6309
SUPER-PATHWAYS - NADSYN-PWY
//
UNIQUE-ID - PWY-6309
TYPES - TRYPTOPHAN-DEG
TYPES - Super-Pathways
COMMON-NAME - tryptophan degradation XI (mammalian, via kynurenine)
KEY-REACTIONS - RXN-8665
KEY-REACTIONS - 2.6.1.7-RXN
PATHWAY-LINKS - (2-AMINO-3-3-OXOPROP-2-ENYL-BUT-2-ENEDI PWY-5653)
PATHWAY-LINKS - (GLUTARYL-COA PWY-5177)
PREDECESSORS - (1.13.11.6-RXN RXN-10724)
PREDECESSORS - (3-HYDROXY-KYNURENINASE-RXN KYNURENINASE-RXN)
PREDECESSORS - (RXN-10724 KYNURENINASE-RXN)
PREDECESSORS - (KYNURENINASE-RXN ARYLFORMAMIDASE-RXN)
PREDECESSORS - PWY-5651
PREDECESSORS - (RXN-10722 RXN-10721)
PREDECESSORS - (RXN-10721 KYNURENINE-3-MONOOXYGENASE-RXN)
PREDECESSORS - (RXN-10720 2.6.1.7-RXN)
PREDECESSORS - (2.6.1.7-RXN ARYLFORMAMIDASE-RXN)
PREDECESSORS - (AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN 1.13.11.6-RXN)
PREDECESSORS - (1.13.11.6-RXN 3-HYDROXY-KYNURENINASE-RXN)
PREDECESSORS - (3-HYDROXY-KYNURENINASE-RXN KYNURENINE-3-MONOOXYGENASE-RXN)
PREDECESSORS - (KYNURENINE-3-MONOOXYGENASE-RXN ARYLFORMAMIDASE-RXN)
PREDECESSORS - (ARYLFORMAMIDASE-RXN RXN-8665)
PREDECESSORS - (RXN-8665)
PREDECESSORS - (RXN-10723 AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN)
PREDECESSORS - PWY-5652
PRIMARIES - (KYNURENINASE-RXN (L-KYNURENINE) (ANTHRANILATE))
PRIMARIES - (3-HYDROXY-KYNURENINASE-RXN (3-HYDROXY-L-KYNURENINE) (3-HYDROXY-ANTHRANILATE))
PRIMARIES - (ARYLFORMAMIDASE-RXN (N-FORMYLKYNURENINE) (L-KYNURENINE))
PRIMARIES - (2-KETO-ADIPATE-DEHYDROG-RXN (2K-ADIPATE) (GLUTARYL-COA))
REACTION-LAYOUT - (RXN-10724 (:LEFT-PRIMARIES ANTHRANILATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HYDROXY-ANTHRANILATE))
REACTION-LAYOUT - (PWY-5651 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (1.13.11.6-RXN (:LEFT-PRIMARIES 3-HYDROXY-ANTHRANILATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-AMINO-3-3-OXOPROP-2-ENYL-BUT-2-ENEDI))
REACTION-LAYOUT - (3-HYDROXY-KYNURENINASE-RXN (:LEFT-PRIMARIES 3-HYDROXY-L-KYNURENINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HYDROXY-ANTHRANILATE))
REACTION-LAYOUT - (KYNURENINE-3-MONOOXYGENASE-RXN (:LEFT-PRIMARIES L-KYNURENINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HYDROXY-L-KYNURENINE))
REACTION-LAYOUT - (ARYLFORMAMIDASE-RXN (:LEFT-PRIMARIES N-FORMYLKYNURENINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-KYNURENINE))
REACTION-LAYOUT - (RXN-8665 (:LEFT-PRIMARIES TRP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES N-FORMYLKYNURENINE))
REACTION-LAYOUT - (RXN-10723 (:LEFT-PRIMARIES 2-AMINOMUCONATE_SEMIALDEHYDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PICOLINATE))
REACTION-LAYOUT - (RXN-10722 (:LEFT-PRIMARIES CPD-11552) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHURENATE))
REACTION-LAYOUT - (RXN-10721 (:LEFT-PRIMARIES 3-HYDROXY-L-KYNURENINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-11552))
REACTION-LAYOUT - (KYNURENINASE-RXN (:LEFT-PRIMARIES L-KYNURENINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ANTHRANILATE))
REACTION-LAYOUT - (RXN-10720 (:LEFT-PRIMARIES CPD-476) (:DIRECTION :L2R) (:RIGHT-PRIMARIES KYNURENATE))
REACTION-LAYOUT - (2.6.1.7-RXN (:LEFT-PRIMARIES L-KYNURENINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-476))
REACTION-LAYOUT - (PWY-5652 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - RXN-10724
REACTION-LIST - PWY-5651
REACTION-LIST - 1.13.11.6-RXN
REACTION-LIST - 3-HYDROXY-KYNURENINASE-RXN
REACTION-LIST - KYNURENINE-3-MONOOXYGENASE-RXN
REACTION-LIST - ARYLFORMAMIDASE-RXN
REACTION-LIST - RXN-8665
REACTION-LIST - RXN-10723
REACTION-LIST - RXN-10722
REACTION-LIST - RXN-10721
REACTION-LIST - KYNURENINASE-RXN
REACTION-LIST - RXN-10720
REACTION-LIST - 2.6.1.7-RXN
REACTION-LIST - PWY-5652
SUB-PATHWAYS - PWY-5651
SUB-PATHWAYS - PWY-5652
//
UNIQUE-ID - TRPCAT-PWY
TYPES - TRYPTOPHAN-DEG
COMMON-NAME - tryptophan degradation I (via anthranilate)
CITATIONS - :EV-COMP-AINF:3453644158:ave
CREDITS - |caspi|
CREDITS - SRI
CREDITS - |hying|
PATHWAY-LINKS - (ANTHRANILATE PWY-6079)
PREDECESSORS - (ARYLFORMAMIDASE-RXN TRYPTOPHAN-23-DIOXYGENASE-RXN)
PREDECESSORS - (KYNURENINASE-RXN ARYLFORMAMIDASE-RXN)
PRIMARIES - (KYNURENINASE-RXN NIL (ANTHRANILATE))
REACTION-LAYOUT - (ARYLFORMAMIDASE-RXN (:LEFT-PRIMARIES N-FORMYLKYNURENINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-KYNURENINE))
REACTION-LAYOUT - (TRYPTOPHAN-23-DIOXYGENASE-RXN (:LEFT-PRIMARIES TRP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES N-FORMYLKYNURENINE))
REACTION-LAYOUT - (KYNURENINASE-RXN (:LEFT-PRIMARIES L-KYNURENINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ANTHRANILATE))
REACTION-LIST - ARYLFORMAMIDASE-RXN
REACTION-LIST - TRYPTOPHAN-23-DIOXYGENASE-RXN
REACTION-LIST - KYNURENINASE-RXN
SYNONYMS - anthranilate pathway
//
UNIQUE-ID - TRYPTOPHAN-DEGRADATION-1
TYPES - TRYPTOPHAN-DEG
TYPES - Super-Pathways
COMMON-NAME - tryptophan degradation III (eukaryotic)
PATHWAY-LINKS - (ACETYL-COA TCA)
PREDECESSORS - (GLUTARYL-COA-DEHYDROG-RXN 2-KETO-ADIPATE-DEHYDROG-RXN)
PREDECESSORS - PWY-5177
PREDECESSORS - (AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN 1.13.11.6-RXN)
PREDECESSORS - PWY-5651
PREDECESSORS - PWY-5652
REACTION-LAYOUT - (PWY-5177 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (PWY-5651 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (PWY-5652 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - PWY-5177
REACTION-LIST - PWY-5651
REACTION-LIST - PWY-5652
SUB-PATHWAYS - PWY-5177
SUB-PATHWAYS - PWY-5651
SUB-PATHWAYS - PWY-5652
SYNONYMS - the kynurenine pathway
//
UNIQUE-ID - PWY3O-4108
TYPES - TYROSINE-DEG
COMMON-NAME - tyrosine degradation III
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - SRI
CREDITS - |caspi|
CREDITS - O-16
CREDITS - |krieger|
PREDECESSORS - (RXN3O-4113 4.1.1.80-RXN)
PREDECESSORS - (4.1.1.80-RXN TYRAMINOTRANS-RXN)
PREDECESSORS - (4.1.1.80-RXN RXN3O-4157)
PRIMARIES - (RXN3O-4157 (TYR) (P-HYDROXY-PHENYLPYRUVATE))
REACTION-LAYOUT - (RXN3O-4157 (:LEFT-PRIMARIES P-HYDROXY-PHENYLPYRUVATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES TYR))
REACTION-LAYOUT - (RXN3O-4113 (:LEFT-PRIMARIES HYDRPHENYLAC-CPD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD3O-4151))
REACTION-LAYOUT - (4.1.1.80-RXN (:LEFT-PRIMARIES P-HYDROXY-PHENYLPYRUVATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES HYDRPHENYLAC-CPD))
REACTION-LAYOUT - (TYRAMINOTRANS-RXN (:LEFT-PRIMARIES P-HYDROXY-PHENYLPYRUVATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES TYR))
REACTION-LIST - RXN3O-4157
REACTION-LIST - RXN3O-4113
REACTION-LIST - 4.1.1.80-RXN
REACTION-LIST - TYRAMINOTRANS-RXN
//
UNIQUE-ID - TYRFUMCAT-PWY
TYPES - TYROSINE-DEG
COMMON-NAME - tyrosine degradation I
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |fulcher|
PATHWAY-LINKS - (TYR PHENYLALANINE-DEG1-PWY)
PATHWAY-LINKS - (3-KETOBUTYRATE ACETOACETATE-DEG-PWY)
PATHWAY-LINKS - (FUM TCA)
PREDECESSORS - (FUMARYLACETOACETASE-RXN MALEYLACETOACETATE-ISOMERASE-RXN)
PREDECESSORS - (MALEYLACETOACETATE-ISOMERASE-RXN HOMOGENTISATE-12-DIOXYGENASE-RXN)
PREDECESSORS - (HOMOGENTISATE-12-DIOXYGENASE-RXN 4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN)
PREDECESSORS - (4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN TYROSINE-AMINOTRANSFERASE-RXN)
PREDECESSORS - (TYROSINE-AMINOTRANSFERASE-RXN)
REACTION-LAYOUT - (FUMARYLACETOACETASE-RXN (:LEFT-PRIMARIES 4-FUMARYL-ACETOACETATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-KETOBUTYRATE FUM))
REACTION-LAYOUT - (MALEYLACETOACETATE-ISOMERASE-RXN (:LEFT-PRIMARIES 4-MALEYL-ACETOACETATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 4-FUMARYL-ACETOACETATE))
REACTION-LAYOUT - (HOMOGENTISATE-12-DIOXYGENASE-RXN (:LEFT-PRIMARIES HOMOGENTISATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 4-MALEYL-ACETOACETATE))
REACTION-LAYOUT - (4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN (:LEFT-PRIMARIES P-HYDROXY-PHENYLPYRUVATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES HOMOGENTISATE))
REACTION-LAYOUT - (TYROSINE-AMINOTRANSFERASE-RXN (:LEFT-PRIMARIES TYR) (:DIRECTION :L2R) (:RIGHT-PRIMARIES P-HYDROXY-PHENYLPYRUVATE))
REACTION-LIST - FUMARYLACETOACETASE-RXN
REACTION-LIST - MALEYLACETOACETATE-ISOMERASE-RXN
REACTION-LIST - HOMOGENTISATE-12-DIOXYGENASE-RXN
REACTION-LIST - 4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN
REACTION-LIST - TYROSINE-AMINOTRANSFERASE-RXN
SYNONYMS - tyrosine fumarate catabolism
//
UNIQUE-ID - PWY3DJ-86
TYPES - VALINE-DEG
COMMON-NAME - valine degradation
CREDITS - AU3DJ-7
PATHWAY-LINKS - (SUC-COA TCA)
PREDECESSORS - (METHYLMALONYL-COA-MUT-RXN METHYLMALONYL-COA-EPIM-RXN)
PREDECESSORS - (METHYLMALONYL-COA-EPIM-RXN PROPIONYL-COA-CARBOXY-RXN)
PREDECESSORS - (PROPIONYL-COA-CARBOXY-RXN 1.2.1.27-RXN)
PREDECESSORS - (1.2.1.27-RXN 3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN)
PREDECESSORS - (3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN 3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN)
PREDECESSORS - (3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN METHYLACYLYLCOA-HYDROXY-RXN)
PREDECESSORS - (METHYLACYLYLCOA-HYDROXY-RXN MEPROPCOA-FAD-RXN)
PREDECESSORS - (MEPROPCOA-FAD-RXN 2.3.1.168-RXN)
PREDECESSORS - (2.3.1.168-RXN 1.2.4.4-RXN)
PREDECESSORS - (1.2.4.4-RXN BRANCHED-CHAINAMINOTRANSFERVAL-RXN)
PRIMARIES - (2.3.1.168-RXN (N6-METHYLPROPANOYLDIHYDROLIPOATE) (ISOBUTYRYL-COA))
REACTION-LAYOUT - (METHYLMALONYL-COA-MUT-RXN (:LEFT-PRIMARIES METHYL-MALONYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUC-COA))
REACTION-LAYOUT - (METHYLMALONYL-COA-EPIM-RXN (:LEFT-PRIMARIES METHYL-MALONYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES D-METHYL-MALONYL-COA))
REACTION-LAYOUT - (PROPIONYL-COA-CARBOXY-RXN (:LEFT-PRIMARIES PROPIONYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D-METHYL-MALONYL-COA))
REACTION-LAYOUT - (1.2.1.27-RXN (:LEFT-PRIMARIES CH3-MALONATE-S-ALD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PROPIONYL-COA))
REACTION-LAYOUT - (3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN (:LEFT-PRIMARIES 3-HYDROXY-ISOBUTYRATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CH3-MALONATE-S-ALD))
REACTION-LAYOUT - (3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN (:LEFT-PRIMARIES 3-HYDROXY-ISOBUTYRYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HYDROXY-ISOBUTYRATE))
REACTION-LAYOUT - (METHYLACYLYLCOA-HYDROXY-RXN (:LEFT-PRIMARIES METHACRYLYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HYDROXY-ISOBUTYRYL-COA))
REACTION-LAYOUT - (MEPROPCOA-FAD-RXN (:LEFT-PRIMARIES ISOBUTYRYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES METHACRYLYL-COA))
REACTION-LAYOUT - (2.3.1.168-RXN (:LEFT-PRIMARIES |BCAA-dehydrogenase-2MP-DH-lipoyl|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ISOBUTYRYL-COA))
REACTION-LAYOUT - (1.2.4.4-RXN (:LEFT-PRIMARIES 2-KETO-ISOVALERATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |BCAA-dehydrogenase-2MP-DH-lipoyl|))
REACTION-LAYOUT - (BRANCHED-CHAINAMINOTRANSFERVAL-RXN (:LEFT-PRIMARIES VAL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-KETO-ISOVALERATE))
REACTION-LIST - METHYLMALONYL-COA-MUT-RXN
REACTION-LIST - METHYLMALONYL-COA-EPIM-RXN
REACTION-LIST - PROPIONYL-COA-CARBOXY-RXN
REACTION-LIST - 1.2.1.27-RXN
REACTION-LIST - 3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN
REACTION-LIST - 3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN
REACTION-LIST - METHYLACYLYLCOA-HYDROXY-RXN
REACTION-LIST - MEPROPCOA-FAD-RXN
REACTION-LIST - 2.3.1.168-RXN
REACTION-LIST - 1.2.4.4-RXN
REACTION-LIST - BRANCHED-CHAINAMINOTRANSFERVAL-RXN
//
UNIQUE-ID - PARATHION-DEGRADATION-PWY
TYPES - AROMATIC-COMPOUNDS-DEGRADATION
COMMON-NAME - parathion degradation
CREDITS - SRI
CREDITS - |caspi|
HYPOTHETICAL-REACTIONS - PHOSPHO-DETHIO-RXN
PREDECESSORS - (ARYLDIALKYL-PHOSPHATASE-RXN)
PREDECESSORS - (PHOSPHO-DETHIO-RXN ARYLDIALKYL-PHOSPHATASE-RXN)
PRIMARIES - (RXN-8748 NIL (|Pi|))
PRIMARIES - (ARYLDIALKYL-PHOSPHATASE-RXN NIL (P-NITROPHENOL DIETHYLTHIOPHOSPHATE))
REACTION-LAYOUT - (PHOSPHO-DETHIO-RXN (:LEFT-PRIMARIES DIETHYLTHIOPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIETHYLPHOSPHATE))
REACTION-LAYOUT - (ARYLDIALKYL-PHOSPHATASE-RXN (:LEFT-PRIMARIES PARATHION) (:DIRECTION :L2R) (:RIGHT-PRIMARIES P-NITROPHENOL DIETHYLTHIOPHOSPHATE))
REACTION-LIST - PHOSPHO-DETHIO-RXN
REACTION-LIST - ARYLDIALKYL-PHOSPHATASE-RXN
//
UNIQUE-ID - PWY-5489
TYPES - AROMATIC-COMPOUNDS-DEGRADATION
COMMON-NAME - methyl parathion degradation
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (RXN-8743)
PRIMARIES - (RXN-8743 (CPD-8973) (P-NITROPHENOL CPD-8974))
REACTION-LAYOUT - (RXN-8743 (:LEFT-PRIMARIES CPD-8973) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-8974 P-NITROPHENOL))
REACTION-LIST - RXN-8743
//
UNIQUE-ID - PWY-5490
TYPES - AROMATIC-COMPOUNDS-DEGRADATION
COMMON-NAME - paraoxon degradation
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
HYPOTHETICAL-REACTIONS - RXN-8747
HYPOTHETICAL-REACTIONS - RXN-8748
PREDECESSORS - (RXN-8746)
PRIMARIES - (RXN-8746 NIL (DIETHYLPHOSPHATE P-NITROPHENOL))
REACTION-LAYOUT - (RXN-8746 (:LEFT-PRIMARIES PARAOXON) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIETHYLPHOSPHATE P-NITROPHENOL))
REACTION-LIST - RXN-8746
//
UNIQUE-ID - PWY0-321
TYPES - Phenylacetate-Degradation
COMMON-NAME - phenylacetate degradation I (aerobic)
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - SRI
CREDITS - |arnaud|
HYPOTHETICAL-REACTIONS - RXN0-2042
HYPOTHETICAL-REACTIONS - RXN0-2043
HYPOTHETICAL-REACTIONS - RXN0-2044
PATHWAY-LINKS - (SUC-COA TCA)
PREDECESSORS - (RXN-3641 RXN0-2044)
PREDECESSORS - (RXN0-2042 PHENYLACETATE--COA-LIGASE-RXN)
PREDECESSORS - (RXN0-2043 RXN0-2042)
PREDECESSORS - (RXN0-2044 RXN0-2043)
PRIMARIES - (PHENYLACETATE--COA-LIGASE-RXN (PHENYLACETATE) NIL)
REACTION-LAYOUT - (RXN-3641 (:LEFT-PRIMARIES SUC-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 3-KETO-ADIPYL-COA))
REACTION-LAYOUT - (RXN0-2042 (:LEFT-PRIMARIES CPD-207) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CIS-DIHYDRODIOL-DERIV-PHEAC))
REACTION-LAYOUT - (RXN0-2043 (:LEFT-PRIMARIES CIS-DIHYDRODIOL-DERIV-PHEAC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HYDROXYADIPYL-COA))
REACTION-LAYOUT - (RXN0-2044 (:LEFT-PRIMARIES 3-HYDROXYADIPYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-KETO-ADIPYL-COA))
REACTION-LAYOUT - (PHENYLACETATE--COA-LIGASE-RXN (:LEFT-PRIMARIES PHENYLACETATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-207))
REACTION-LIST - RXN-3641
REACTION-LIST - RXN0-2042
REACTION-LIST - RXN0-2043
REACTION-LIST - RXN0-2044
REACTION-LIST - PHENYLACETATE--COA-LIGASE-RXN
//
UNIQUE-ID - PWY-5691
TYPES - Urate-Degradation
COMMON-NAME - urate degradation to allantoin
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - URSIN-PWY
PATHWAY-LINKS - (URATE PWY-5044)
PREDECESSORS - (3.5.2.17-RXN URATE-OXIDASE-RXN)
PREDECESSORS - (RXN-6201 3.5.2.17-RXN)
PRIMARIES - (R14-RXN NIL (GLYOX))
PRIMARIES - (UREIDOGLYCOLATE-LYASE-RXN (CPD-1091) (GLYOX))
REACTION-LAYOUT - (3.5.2.17-RXN (:LEFT-PRIMARIES 5-HYDROXYISOURATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-5821))
REACTION-LAYOUT - (RXN-6201 (:LEFT-PRIMARIES CPD-5821) (:DIRECTION :L2R) (:RIGHT-PRIMARIES S-ALLANTOIN))
REACTION-LAYOUT - (URATE-OXIDASE-RXN (:LEFT-PRIMARIES URATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-HYDROXYISOURATE))
REACTION-LIST - 3.5.2.17-RXN
REACTION-LIST - RXN-6201
REACTION-LIST - URATE-OXIDASE-RXN
//
UNIQUE-ID - CODH-PWY
TYPES - Autotrophic-CO2-Fixation
COMMON-NAME - reductive acetyl coenzyme A pathway
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - SRI
CREDITS - |caspi|
CREDITS - O-18
CREDITS - |pellegrini-toole|
IN-PATHWAY - PWY-6142
PATHWAY-LINKS - (ACETYL-COA PWY-5535)
PREDECESSORS - (ACETYLSYNCLTH-RXN 1.2.7.4-RXN)
PREDECESSORS - (FORMATE-DEHYDROGENASE-NADP+-RXN)
PREDECESSORS - (FORMATETHFLIG-RXN FORMATE-DEHYDROGENASE-NADP+-RXN)
PREDECESSORS - (METHENYLTHFCYCLOHYDRO-RXN FORMATETHFLIG-RXN)
PREDECESSORS - (METHYLENETHFDEHYDROG-NADP-RXN METHENYLTHFCYCLOHYDRO-RXN)
PREDECESSORS - (METLENETHFRED-FERRE-RXN METHYLENETHFDEHYDROG-NADP-RXN)
PREDECESSORS - (METHCOCLTH-RXN METLENETHFRED-FERRE-RXN)
PREDECESSORS - (ACETYLSYNCLTH-RXN METHCOCLTH-RXN)
PRIMARIES - (METHENYLTHFCYCLOHYDRO-RXN (10-FORMYL-THF) (5-10-METHENYL-THF))
PRIMARIES - (FORMATETHFLIG-RXN (FORMATE) (10-FORMYL-THF))
PRIMARIES - (1.2.7.4-RXN (CARBON-DIOXIDE) NIL)
PRIMARIES - (ACETYLSYNCLTH-RXN (CARBON-MONOXIDE |Methylated-corrinoid-Fe-S-Proteins|) (ACETYL-COA))
REACTION-LAYOUT - (1.2.7.4-RXN (:LEFT-PRIMARIES CARBON-MONOXIDE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CARBON-DIOXIDE))
REACTION-LAYOUT - (ACETYLSYNCLTH-RXN (:LEFT-PRIMARIES |Methylated-corrinoid-Fe-S-Proteins| CARBON-MONOXIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETYL-COA))
REACTION-LAYOUT - (METHCOCLTH-RXN (:LEFT-PRIMARIES 5-METHYL-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Methylated-corrinoid-Fe-S-Proteins|))
REACTION-LAYOUT - (METLENETHFRED-FERRE-RXN (:LEFT-PRIMARIES METHYLENE-THF) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 5-METHYL-THF))
REACTION-LAYOUT - (METHYLENETHFDEHYDROG-NADP-RXN (:LEFT-PRIMARIES METHYLENE-THF) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 5-10-METHENYL-THF))
REACTION-LAYOUT - (METHENYLTHFCYCLOHYDRO-RXN (:LEFT-PRIMARIES 5-10-METHENYL-THF) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 10-FORMYL-THF))
REACTION-LAYOUT - (FORMATETHFLIG-RXN (:LEFT-PRIMARIES FORMATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 10-FORMYL-THF))
REACTION-LAYOUT - (FORMATE-DEHYDROGENASE-NADP+-RXN (:LEFT-PRIMARIES FORMATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CARBON-DIOXIDE))
REACTION-LIST - 1.2.7.4-RXN
REACTION-LIST - ACETYLSYNCLTH-RXN
REACTION-LIST - METHCOCLTH-RXN
REACTION-LIST - METLENETHFRED-FERRE-RXN
REACTION-LIST - METHYLENETHFDEHYDROG-NADP-RXN
REACTION-LIST - METHENYLTHFCYCLOHYDRO-RXN
REACTION-LIST - FORMATETHFLIG-RXN
REACTION-LIST - FORMATE-DEHYDROGENASE-NADP+-RXN
SUPER-PATHWAYS - PWY-6142
SYNONYMS - Wood pathway
SYNONYMS - acetate synthesis
SYNONYMS - acetyl-CoA pathway
SYNONYMS - carbon monoxide dehydrogenase pathway
SYNONYMS - carbon fixation
SYNONYMS - CO<SUB>2</SUB> fixation
SYNONYMS - Ljungdahl-Wood pathway
//
UNIQUE-ID - PWY-5743
TYPES - Autotrophic-CO2-Fixation
COMMON-NAME - 3-hydroxypropionate cycle
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (PROPIONYL-COA-CARBOXY-RXN RXN-9087)
PREDECESSORS - (RXN-9087 RXN-6383)
PREDECESSORS - (RXN-6383 RXN-9086)
PREDECESSORS - (RXN-9086 RXN-8974)
PREDECESSORS - (ACETYL-COA-CARBOXYLTRANSFER-RXN MALYL-COA-LYASE-RXN)
PREDECESSORS - (MALYL-COA-LYASE-RXN RXN-8964)
PREDECESSORS - (RXN-8964 METHYLMALONYL-COA-MUT-RXN)
PREDECESSORS - (METHYLMALONYL-COA-MUT-RXN METHYLMALONYL-COA-EPIM-RXN)
PREDECESSORS - (METHYLMALONYL-COA-EPIM-RXN PROPIONYL-COA-CARBOXY-RXN)
PREDECESSORS - (RXN-8974 RXN-8963)
PREDECESSORS - (RXN-8963 ACETYL-COA-CARBOXYLTRANSFER-RXN)
PRIMARIES - (ACETYL-COA-CARBOXYLTRANSFER-RXN NIL NIL)
REACTION-LAYOUT - (RXN-9086 (:LEFT-PRIMARIES 3-HYDROXY-PROPIONATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HYDROXY-PROPIONYL-COA))
REACTION-LAYOUT - (RXN-9087 (:LEFT-PRIMARIES PROPIONYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ACRYLYL-COA))
REACTION-LAYOUT - (RXN-6383 (:LEFT-PRIMARIES 3-HYDROXY-PROPIONYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACRYLYL-COA))
REACTION-LAYOUT - (ACETYL-COA-CARBOXYLTRANSFER-RXN (:LEFT-PRIMARIES ACETYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MALONYL-COA))
REACTION-LAYOUT - (MALYL-COA-LYASE-RXN (:LEFT-PRIMARIES CPD-208) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETYL-COA))
REACTION-LAYOUT - (RXN-8964 (:LEFT-PRIMARIES SUC-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-208))
REACTION-LAYOUT - (METHYLMALONYL-COA-MUT-RXN (:LEFT-PRIMARIES METHYL-MALONYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUC-COA))
REACTION-LAYOUT - (METHYLMALONYL-COA-EPIM-RXN (:LEFT-PRIMARIES METHYL-MALONYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES D-METHYL-MALONYL-COA))
REACTION-LAYOUT - (PROPIONYL-COA-CARBOXY-RXN (:LEFT-PRIMARIES PROPIONYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D-METHYL-MALONYL-COA))
REACTION-LAYOUT - (RXN-8974 (:LEFT-PRIMARIES 3-HYDROXY-PROPIONATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES MALONATE-S-ALD))
REACTION-LAYOUT - (RXN-8963 (:LEFT-PRIMARIES MALONATE-S-ALD) (:DIRECTION :R2L) (:RIGHT-PRIMARIES MALONYL-COA))
REACTION-LIST - RXN-9086
REACTION-LIST - RXN-9087
REACTION-LIST - RXN-6383
REACTION-LIST - ACETYL-COA-CARBOXYLTRANSFER-RXN
REACTION-LIST - MALYL-COA-LYASE-RXN
REACTION-LIST - RXN-8964
REACTION-LIST - METHYLMALONYL-COA-MUT-RXN
REACTION-LIST - METHYLMALONYL-COA-EPIM-RXN
REACTION-LIST - PROPIONYL-COA-CARBOXY-RXN
REACTION-LIST - RXN-8974
REACTION-LIST - RXN-8963
//
UNIQUE-ID - PWY-5789
TYPES - Autotrophic-CO2-Fixation
COMMON-NAME - 3-hydroxypropionate/4-hydroxybutyrate cycle
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (RXN-9092 RXN-11002)
PREDECESSORS - (RXN-11002 RXN-8891)
PREDECESSORS - (ACETYL-COA-CARBOXYLTRANSFER-RXN ACETYL-COA-ACETYLTRANSFER-RXN)
PREDECESSORS - (ACETYL-COA-ACETYLTRANSFER-RXN BHBDCLOS-RXN)
PREDECESSORS - (BHBDCLOS-RXN 3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN)
PREDECESSORS - (3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN VINYLACETYL-COA-DELTA-ISOMERASE-RXN)
PREDECESSORS - (VINYLACETYL-COA-DELTA-ISOMERASE-RXN RXN-8890)
PREDECESSORS - (RXN-8890 RXN-9092)
PREDECESSORS - (RXN-8891 METHYLMALONYL-COA-MUT-RXN)
PREDECESSORS - (PROPIONYL-COA-CARBOXY-RXN RXN-9087)
PREDECESSORS - (RXN-9087 RXN-6383)
PREDECESSORS - (RXN-6383 RXN-9086)
PREDECESSORS - (RXN-9086 RXN-8974)
PREDECESSORS - (METHYLMALONYL-COA-MUT-RXN METHYLMALONYL-COA-EPIM-RXN)
PREDECESSORS - (METHYLMALONYL-COA-EPIM-RXN PROPIONYL-COA-CARBOXY-RXN)
PREDECESSORS - (RXN-8974 RXN-8963)
PREDECESSORS - (RXN-8963 ACETYL-COA-CARBOXYLTRANSFER-RXN)
PRIMARIES - (ACETYL-COA-CARBOXYLTRANSFER-RXN NIL NIL)
REACTION-LAYOUT - (RXN-11002 (:LEFT-PRIMARIES 4-HYDROXY-BUTYRATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES SUCC-S-ALD))
REACTION-LAYOUT - (VINYLACETYL-COA-DELTA-ISOMERASE-RXN (:LEFT-PRIMARIES CPD-226) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CROTONYL-COA))
REACTION-LAYOUT - (RXN-8890 (:LEFT-PRIMARIES 4-HYDROXY-BUTYRYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-226))
REACTION-LAYOUT - (RXN-9092 (:LEFT-PRIMARIES 4-HYDROXY-BUTYRATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 4-HYDROXY-BUTYRYL-COA))
REACTION-LAYOUT - (RXN-8891 (:LEFT-PRIMARIES SUCC-S-ALD) (:DIRECTION :R2L) (:RIGHT-PRIMARIES SUC-COA))
REACTION-LAYOUT - (ACETYL-COA-ACETYLTRANSFER-RXN (:LEFT-PRIMARIES ACETYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ACETOACETYL-COA))
REACTION-LAYOUT - (BHBDCLOS-RXN (:LEFT-PRIMARIES ACETOACETYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CPD-650))
REACTION-LAYOUT - (3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN (:LEFT-PRIMARIES CPD-650) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CROTONYL-COA))
REACTION-LAYOUT - (RXN-9086 (:LEFT-PRIMARIES 3-HYDROXY-PROPIONATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-HYDROXY-PROPIONYL-COA))
REACTION-LAYOUT - (RXN-9087 (:LEFT-PRIMARIES PROPIONYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ACRYLYL-COA))
REACTION-LAYOUT - (RXN-6383 (:LEFT-PRIMARIES 3-HYDROXY-PROPIONYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACRYLYL-COA))
REACTION-LAYOUT - (ACETYL-COA-CARBOXYLTRANSFER-RXN (:LEFT-PRIMARIES ACETYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MALONYL-COA))
REACTION-LAYOUT - (METHYLMALONYL-COA-MUT-RXN (:LEFT-PRIMARIES METHYL-MALONYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUC-COA))
REACTION-LAYOUT - (METHYLMALONYL-COA-EPIM-RXN (:LEFT-PRIMARIES METHYL-MALONYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES D-METHYL-MALONYL-COA))
REACTION-LAYOUT - (PROPIONYL-COA-CARBOXY-RXN (:LEFT-PRIMARIES PROPIONYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D-METHYL-MALONYL-COA))
REACTION-LAYOUT - (RXN-8974 (:LEFT-PRIMARIES 3-HYDROXY-PROPIONATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES MALONATE-S-ALD))
REACTION-LAYOUT - (RXN-8963 (:LEFT-PRIMARIES MALONATE-S-ALD) (:DIRECTION :R2L) (:RIGHT-PRIMARIES MALONYL-COA))
REACTION-LIST - RXN-11002
REACTION-LIST - VINYLACETYL-COA-DELTA-ISOMERASE-RXN
REACTION-LIST - RXN-8890
REACTION-LIST - RXN-9092
REACTION-LIST - RXN-8891
REACTION-LIST - ACETYL-COA-ACETYLTRANSFER-RXN
REACTION-LIST - BHBDCLOS-RXN
REACTION-LIST - 3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN
REACTION-LIST - RXN-9086
REACTION-LIST - RXN-9087
REACTION-LIST - RXN-6383
REACTION-LIST - ACETYL-COA-CARBOXYLTRANSFER-RXN
REACTION-LIST - METHYLMALONYL-COA-MUT-RXN
REACTION-LIST - METHYLMALONYL-COA-EPIM-RXN
REACTION-LIST - PROPIONYL-COA-CARBOXY-RXN
REACTION-LIST - RXN-8974
REACTION-LIST - RXN-8963
//
UNIQUE-ID - P42-PWY
TYPES - Reductive-TCA-Cycles
COMMON-NAME - incomplete reductive TCA cycle
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - SRI
CREDITS - |caspi|
CREDITS - O-18
CREDITS - |pellegrini-toole|
PATHWAY-LINKS - (2-KETOGLUTARATE GLUTAMATE-SYN2-PWY)
PATHWAY-LINKS - (ACETYL-COA PWY0-1313 CODH-PWY)
PREDECESSORS - (SUCCCOASYN-RXN SUCC-FUM-OXRED-RXN)
PREDECESSORS - (SUCC-FUM-OXRED-RXN FUMHYDR-RXN)
PREDECESSORS - (2-OXOGLUTARATE-SYNTHASE-RXN SUCCCOASYN-RXN)
PREDECESSORS - (FUMHYDR-RXN MALATE-DEH-RXN)
PREDECESSORS - (MALATE-DEH-RXN PYRUVATE-CARBOXYLASE-RXN)
PREDECESSORS - (PYRUVATE-CARBOXYLASE-RXN PYRUFLAVREDUCT-RXN)
PRIMARIES - (SUCCCOASYN-RXN (SUC) (SUC-COA))
PRIMARIES - (SUCC-FUM-OXRED-RXN (FUM) (SUC))
PRIMARIES - (2-OXOGLUTARATE-SYNTHASE-RXN (SUC-COA) (2-KETOGLUTARATE))
PRIMARIES - (PYRUFLAVREDUCT-RXN (ACETYL-COA) (PYRUVATE))
REACTION-LAYOUT - (SUCC-FUM-OXRED-RXN (:LEFT-PRIMARIES SUC) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FUM))
REACTION-LAYOUT - (2-OXOGLUTARATE-SYNTHASE-RXN (:LEFT-PRIMARIES 2-KETOGLUTARATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES SUC-COA))
REACTION-LAYOUT - (SUCCCOASYN-RXN (:LEFT-PRIMARIES SUC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUC-COA))
REACTION-LAYOUT - (FUMHYDR-RXN (:LEFT-PRIMARIES MAL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FUM))
REACTION-LAYOUT - (MALATE-DEH-RXN (:LEFT-PRIMARIES MAL) (:DIRECTION :R2L) (:RIGHT-PRIMARIES OXALACETIC_ACID))
REACTION-LAYOUT - (PYRUVATE-CARBOXYLASE-RXN (:LEFT-PRIMARIES PYRUVATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OXALACETIC_ACID))
REACTION-LAYOUT - (PYRUFLAVREDUCT-RXN (:LEFT-PRIMARIES PYRUVATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ACETYL-COA))
REACTION-LIST - SUCC-FUM-OXRED-RXN
REACTION-LIST - 2-OXOGLUTARATE-SYNTHASE-RXN
REACTION-LIST - SUCCCOASYN-RXN
REACTION-LIST - FUMHYDR-RXN
REACTION-LIST - MALATE-DEH-RXN
REACTION-LIST - PYRUVATE-CARBOXYLASE-RXN
REACTION-LIST - PYRUFLAVREDUCT-RXN
SYNONYMS - citric acid cycle variant
SYNONYMS - tricarboxylic acid cycle variant
SYNONYMS - TCA cycle variation I
SYNONYMS - incomplete reductive tricarboxylic acid cycle
//
UNIQUE-ID - PWY-1801
TYPES - Formaldehyde-Oxidation
COMMON-NAME - formaldehyde oxidation II (glutathione-dependent)
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (FORMATE PWY-2201)
PREDECESSORS - (RXN-2961)
PREDECESSORS - (RXN-2962 RXN-2961)
PREDECESSORS - (S-FORMYLGLUTATHIONE-HYDROLASE-RXN RXN-2962)
PRIMARIES - (RXN-2961 (FORMALDEHYDE) (S-HYDROXYMETHYLGLUTATHIONE))
PRIMARIES - (S-FORMYLGLUTATHIONE-HYDROLASE-RXN (CPD-548) (FORMATE))
REACTION-LAYOUT - (RXN-2962 (:LEFT-PRIMARIES S-HYDROXYMETHYLGLUTATHIONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-548))
REACTION-LAYOUT - (RXN-2961 (:LEFT-PRIMARIES S-HYDROXYMETHYLGLUTATHIONE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FORMALDEHYDE))
REACTION-LAYOUT - (S-FORMYLGLUTATHIONE-HYDROLASE-RXN (:LEFT-PRIMARIES CPD-548) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FORMATE))
REACTION-LIST - RXN-2962
REACTION-LIST - RXN-2961
REACTION-LIST - S-FORMYLGLUTATHIONE-HYDROLASE-RXN
SYNONYMS - formaldehyde oxidation II (GSH-dependent)
//
UNIQUE-ID - RUMP-PWY
TYPES - Formaldehyde-Oxidation
COMMON-NAME - formaldehyde oxidation I
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - SRI
CREDITS - |caspi|
CREDITS - O-18
CREDITS - |pellegrini-toole|
PREDECESSORS - (R10-RXN RXN-3341)
PREDECESSORS - (RXN-3341 6PGLUCONOLACT-RXN)
PREDECESSORS - (GLU6PDEHYDROG-RXN)
PREDECESSORS - (GLU6PDEHYDROG-RXN PGLUCISOM-RXN)
PREDECESSORS - (PGLUCISOM-RXN R12-RXN)
PREDECESSORS - (R12-RXN R10-RXN)
PREDECESSORS - (6PGLUCONOLACT-RXN GLU6PDEHYDROG-RXN)
REACTION-LAYOUT - (RXN-3341 (:LEFT-PRIMARIES CPD-2961) (:DIRECTION :L2R) (:RIGHT-PRIMARIES RIBULOSE-5P))
REACTION-LAYOUT - (6PGLUCONOLACT-RXN (:LEFT-PRIMARIES D-6-P-GLUCONO-DELTA-LACTONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-2961))
REACTION-LAYOUT - (GLU6PDEHYDROG-RXN (:LEFT-PRIMARIES GLC-6-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D-6-P-GLUCONO-DELTA-LACTONE))
REACTION-LAYOUT - (PGLUCISOM-RXN (:LEFT-PRIMARIES GLC-6-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LAYOUT - (R12-RXN (:LEFT-PRIMARIES CPD-26) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LAYOUT - (R10-RXN (:LEFT-PRIMARIES CPD-26) (:DIRECTION :R2L) (:RIGHT-PRIMARIES RIBULOSE-5P))
REACTION-LIST - RXN-3341
REACTION-LIST - 6PGLUCONOLACT-RXN
REACTION-LIST - GLU6PDEHYDROG-RXN
REACTION-LIST - PGLUCISOM-RXN
REACTION-LIST - R12-RXN
REACTION-LIST - R10-RXN
//
UNIQUE-ID - PWY-5767
TYPES - Glycogen-Degradation
TYPES - Super-Pathways
COMMON-NAME - glycogen degradation III
CITATIONS - :EV-COMP-AINF:3442068425:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (RXN-9024 3.2.1.33-RXN)
PREDECESSORS - PWY-5941
PRIMARIES - (RXN-9024 (CPD0-1027) (GLC))
PRIMARIES - (3.2.1.33-RXN NIL (CPD0-1027))
PRIMARIES - (RXN0-5146 NIL (CPD0-1027))
REACTION-LAYOUT - (PWY-5941 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (RXN-9024 (:LEFT-PRIMARIES CPD0-1027) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC))
REACTION-LIST - PWY-5941
REACTION-LIST - RXN-9024
SUB-PATHWAYS - PWY-5941
//
UNIQUE-ID - PWY-5941
TYPES - Glycogen-Degradation
COMMON-NAME - glycogen degradation II
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - PWY-5767
PATHWAY-LINKS - (ALPHA-GLC-6-P GLYCOLYSIS)
PREDECESSORS - (PHOSPHOGLUCMUT-RXN RXN-9025)
PREDECESSORS - (RXN-9025 3.2.1.33-RXN)
PREDECESSORS - (3.2.1.33-RXN RXN-9023)
PREDECESSORS - (RXN-9023 GLYCOPHOSPHORYL-RXN)
PRIMARIES - (RXN-9024 (CPD0-1027) (GLC))
PRIMARIES - (3.2.1.33-RXN NIL (CPD0-1027))
PRIMARIES - (RXN0-5146 NIL (CPD0-1027))
REACTION-LAYOUT - (PHOSPHOGLUCMUT-RXN (:LEFT-PRIMARIES GLC-1-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALPHA-GLC-6-P))
REACTION-LAYOUT - (RXN-9025 (:LEFT-PRIMARIES CPD0-1027) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC-1-P))
REACTION-LAYOUT - (RXN-9023 (:LEFT-PRIMARIES CPD0-971) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Truncated-Limit-Dextrins|))
REACTION-LAYOUT - (GLYCOPHOSPHORYL-RXN (:LEFT-PRIMARIES |Glycogens|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC-1-P CPD0-971))
REACTION-LAYOUT - (3.2.1.33-RXN (:LEFT-PRIMARIES |Truncated-Limit-Dextrins|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD0-1027))
REACTION-LIST - PHOSPHOGLUCMUT-RXN
REACTION-LIST - RXN-9025
REACTION-LIST - RXN-9023
REACTION-LIST - GLYCOPHOSPHORYL-RXN
REACTION-LIST - 3.2.1.33-RXN
SUPER-PATHWAYS - PWY-5767
SYNONYMS - glycogenolysis II
//
UNIQUE-ID - GLUCOSE1PMETAB-PWY
TYPES - Sugars-And-Polysaccharides
COMMON-NAME - glucose and glucose-1-phosphate degradation
CITATIONS - :EV-COMP-AINF:3419591312:ave
PREDECESSORS - (GLUC1PURIDYLTRANS-RXN)
PRIMARIES - (GLUCDEHYDROG-RXN (GLC) (GLC-D-LACTONE))
REACTION-LAYOUT - (GLUCOKIN-RXN (:LEFT-PRIMARIES GLC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC-6-P))
REACTION-LAYOUT - (PHOSPHOGLUCMUT-RXN (:LEFT-PRIMARIES GLC-1-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALPHA-GLC-6-P))
REACTION-LAYOUT - (GLUCOSE-1-PHOSPHAT-RXN (:LEFT-PRIMARIES GLC-1-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |D-Glucose|))
REACTION-LAYOUT - (GLUCDEHYDROG-RXN (:LEFT-PRIMARIES GLC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC-D-LACTONE))
REACTION-LIST - GLUCOKIN-RXN
REACTION-LIST - PHOSPHOGLUCMUT-RXN
REACTION-LIST - GLUCOSE-1-PHOSPHAT-RXN
REACTION-LIST - GLUCDEHYDROG-RXN
//
UNIQUE-ID - MANNCAT-PWY
TYPES - Sugars-And-Polysaccharides
COMMON-NAME - D-mannose degradation
CITATIONS - :EV-COMP-AINF:3442068425:ave
CREDITS - SRI
CREDITS - |keseler|
CREDITS - O-18
CREDITS - |riley|
PATHWAY-LINKS - (MANNOSE-6P (MANNKIN-RXN . :INCOMING))
PATHWAY-LINKS - (FRUCTOSE-6P GLYCOLYSIS)
REACTION-LAYOUT - (MANNPISOM-RXN (:LEFT-PRIMARIES MANNOSE-6P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LIST - MANNPISOM-RXN
SYNONYMS - mannose degradation
//
UNIQUE-ID - PWY-3861
TYPES - Sugars-And-Polysaccharides
COMMON-NAME - mannitol degradation II
CITATIONS - :EV-COMP-AINF:3442068425:ave
PATHWAY-LINKS - (FRUCTOSE-6P GLYCOLYSIS)
PREDECESSORS - (1.1.1.255-RXN)
PREDECESSORS - (MANNKIN-RXN 1.1.1.255-RXN)
PREDECESSORS - (MANNPISOM-RXN MANNKIN-RXN)
PRIMARIES - (MANNPISOM-RXN (MANNOSE-6P) (FRUCTOSE-6P))
PRIMARIES - (MANNKIN-RXN (MANNOSE) (MANNOSE-6P))
PRIMARIES - (1.1.1.255-RXN (MANNITOL) (MANNOSE))
REACTION-LAYOUT - (1.1.1.255-RXN (:LEFT-PRIMARIES MANNITOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MANNOSE))
REACTION-LAYOUT - (MANNKIN-RXN (:LEFT-PRIMARIES MANNOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES MANNOSE-6P))
REACTION-LAYOUT - (MANNPISOM-RXN (:LEFT-PRIMARIES MANNOSE-6P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LIST - 1.1.1.255-RXN
REACTION-LIST - MANNKIN-RXN
REACTION-LIST - MANNPISOM-RXN
//
UNIQUE-ID - PWY-5525
TYPES - Sugars-And-Polysaccharides
COMMON-NAME - glucuronate degradation
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |fulcher|
PATHWAY-LINKS - (XYLITOL LARABITOLUTIL-PWY)
PREDECESSORS - (L-XYLULOSE-REDUCTASE-RXN DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN)
PREDECESSORS - (DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN L-GULONATE-3-DEHYDROGENASE-RXN)
PREDECESSORS - (L-GULONATE-3-DEHYDROGENASE-RXN GLUCURONATE-REDUCTASE-RXN)
PREDECESSORS - (GLUCURONATE-REDUCTASE-RXN)
PRIMARIES - (L-XYLULOSE-REDUCTASE-RXN (L-XYLULOSE) (XYLITOL))
PRIMARIES - (GLUCURONATE-REDUCTASE-RXN (GLUCURONATE) (L-GULONATE))
REACTION-LAYOUT - (L-XYLULOSE-REDUCTASE-RXN (:LEFT-PRIMARIES XYLITOL) (:DIRECTION :R2L) (:RIGHT-PRIMARIES L-XYLULOSE))
REACTION-LAYOUT - (DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN (:LEFT-PRIMARIES 3-KETO-L-GULONATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-XYLULOSE))
REACTION-LAYOUT - (L-GULONATE-3-DEHYDROGENASE-RXN (:LEFT-PRIMARIES L-GULONATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-KETO-L-GULONATE))
REACTION-LAYOUT - (GLUCURONATE-REDUCTASE-RXN (:LEFT-PRIMARIES L-GULONATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES GLUCURONATE))
REACTION-LIST - L-XYLULOSE-REDUCTASE-RXN
REACTION-LIST - DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN
REACTION-LIST - L-GULONATE-3-DEHYDROGENASE-RXN
REACTION-LIST - GLUCURONATE-REDUCTASE-RXN
SYNONYMS - pentose pathway
SYNONYMS - glucuronic acid oxidation pathway
SYNONYMS - glucuronate/xylulose pathway
//
UNIQUE-ID - PWY0-1301
TYPES - Sugars-And-Polysaccharides
COMMON-NAME - melibiose degradation
CREDITS - TIGR
CREDITS - |djohnson|
PATHWAY-LINKS - (GALACTOSE GALACTMETAB-PWY)
PATHWAY-LINKS - (GLC GLUCOSE1PMETAB-PWY)
PREDECESSORS - (ALPHAGALACTOSID-RXN)
REACTION-LAYOUT - (ALPHAGALACTOSID-RXN (:LEFT-PRIMARIES MELIBIOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GALACTOSE GLC))
REACTION-LIST - ALPHAGALACTOSID-RXN
//
UNIQUE-ID - RIBOKIN-PWY
TYPES - Sugars-And-Polysaccharides
COMMON-NAME - ribose degradation
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - O-18
CREDITS - |riley|
CREDITS - SRI
CREDITS - |keseler|
CREDITS - O0-3
CREDITS - |ingraham|
PATHWAY-LINKS - (RIBOSE-5P PWY0-662 PENTOSE-P-PWY)
PREDECESSORS - (RIBOKIN-RXN RXN0-5305)
PREDECESSORS - (RXN0-5305 RXN0-5304)
PREDECESSORS - (RXN0-5304)
REACTION-LAYOUT - (RXN0-5305 (:LEFT-PRIMARIES CPD0-1108) (:DIRECTION :L2R) (:RIGHT-PRIMARIES RIBOSE))
REACTION-LAYOUT - (RXN0-5304 (:LEFT-PRIMARIES CPD0-1108) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CPD0-1110))
REACTION-LAYOUT - (RIBOKIN-RXN (:LEFT-PRIMARIES RIBOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES RIBOSE-5P))
REACTION-LIST - RXN0-5305
REACTION-LIST - RXN0-5304
REACTION-LIST - RIBOKIN-RXN
SYNONYMS - ribose catabolism
//
UNIQUE-ID - PWY3DJ-193
TYPES - GALACTOSE-DEGRADATION
COMMON-NAME - Leloir pathway
CITATIONS - 6351722
CITATIONS - 16914342
CITATIONS - 10915771
CITATIONS - 8902187
CITATIONS - 6351722:EV-EXP-TAS:3433853032:ave
COMMENT - Galactose is a hexose sugar found in the disaccharide lactose, which is present in high concentrations in milk and in
/mammals is catabolized via the |FRAME: BGALACT-PWY| pathway. Galactose, which differs from glucose only in the
/stereochemistry of one carbon atom, is toxic in high concentrations.  Indeed, the enzymes of carbohydrate
/metabolism require galactose to be converted to glucose before it can enter glycolysis or other pathways.
/
/Dr. Luis Leloir won the 1970 Nobel Prize in part for his contribution to the understanding of galactose metabolism |CITS: [6351722]|.
/To convert galactose to glucose, it is first phosphorylated by galactokinase to produce galactose-1-phosphate.
/Galactose is then exchanged with the glucose group in UDP-glucose to create UDP-galactose and release glucose-1
/-phosphate. An epimerase enzyme changes the stereochemistry of C4 in UDP-galactose, creating UDP-glucose.
/In the next round of the transfer reaction, this glucose is released as glucose-1-phosphate. Once released, glucose-1
/-phosphate is converted to glucose-6-phosphate and can enter glycolysis to generate energy.
/In humans, mutation of either enzymes result in inborn errors of metabolism known as galactosemias. Galactosemias
/are known as <A href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=230400">type I</A>, <A href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=230200">type II</A> and <A href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=230350">type III</A>, range in severity, and are usually treated through restriction of lactose or 
/galactose in the diet (i.e.,  avoidance of dairy products).
/
/Interestingly, mice lacking either galactokinase |CITS: [10915771]| or galactose-1-phosphate uridyl transferase |CITS: [8902187]| do not exhibit severe phenotypes characteristic
/to human galactosemias, possibly due to the activity of other pathways for galactose metabolism such as |FRAME: PWY-3821| |CITS: [16914342]|.
CREDITS - AU3DJ-15
PATHWAY-LINKS - (GLC-1-P GLYCOLYSIS)
PREDECESSORS - (GALACTURIDYLYLTRANS-RXN UDPGLUCEPIM-RXN)
PREDECESSORS - (UDPGLUCEPIM-RXN GALACTURIDYLYLTRANS-RXN)
PREDECESSORS - (GALACTURIDYLYLTRANS-RXN GALACTOKIN-RXN)
PRIMARIES - (GALACTURIDYLYLTRANS-RXN (UDP-GLUCOSE GALACTOSE-1P) (GLC-1-P))
REACTION-LAYOUT - (UDPGLUCEPIM-RXN (:LEFT-PRIMARIES UDP-GLUCOSE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES UDP-GALACTOSE))
REACTION-LAYOUT - (GALACTURIDYLYLTRANS-RXN (:LEFT-PRIMARIES GALACTOSE-1P UDP-GLUCOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES UDP-GALACTOSE GLC-1-P))
REACTION-LAYOUT - (GALACTOKIN-RXN (:LEFT-PRIMARIES ALPHA-D-GALACTOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GALACTOSE-1P))
REACTION-LIST - UDPGLUCEPIM-RXN
REACTION-LIST - GALACTURIDYLYLTRANS-RXN
REACTION-LIST - GALACTOKIN-RXN
SYNONYMS - galactose degradation III
//
UNIQUE-ID - PWY-5515
TYPES - L-Arabinose-Degradation
COMMON-NAME - L-arabinose degradation II
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |fulcher|
PATHWAY-LINKS - (XYLITOL LARABITOLUTIL-PWY)
PREDECESSORS - (L-XYLULOSE-REDUCTASE-RXN L-ARABINITOL-4-DEHYDROGENASE-RXN)
PREDECESSORS - (L-ARABINITOL-4-DEHYDROGENASE-RXN RXN-8772)
PREDECESSORS - (RXN-8772)
PRIMARIES - (L-XYLULOSE-REDUCTASE-RXN (L-XYLULOSE) (XYLITOL))
REACTION-LAYOUT - (L-XYLULOSE-REDUCTASE-RXN (:LEFT-PRIMARIES XYLITOL) (:DIRECTION :R2L) (:RIGHT-PRIMARIES L-XYLULOSE))
REACTION-LAYOUT - (L-ARABINITOL-4-DEHYDROGENASE-RXN (:LEFT-PRIMARIES L-ARABITOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-XYLULOSE))
REACTION-LAYOUT - (RXN-8772 (:LEFT-PRIMARIES L-ARABINOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-ARABITOL))
REACTION-LIST - L-XYLULOSE-REDUCTASE-RXN
REACTION-LIST - L-ARABINITOL-4-DEHYDROGENASE-RXN
REACTION-LIST - RXN-8772
//
UNIQUE-ID - BGALACT-PWY
TYPES - LACTOSE-DEG
COMMON-NAME - lactose degradation III
CITATIONS - 5010299:EV-EXP-IDA:3435319114:ave
CITATIONS - 6786877:EV-EXP-IDA:3435319114:ave
CITATIONS - 11217851:EV-COMP-HINF:3435319114:ave
COMMENT - <A href="http://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=BGALACT-PWY">Pathway Summary from MetaCyc</A>
/
/Lactose is the main dissacharide present in mammalian milk.  In humans, deficiency of lactase enzyme leads to
/<A href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=223000">congenital lactase deficiency</A>.
CREDITS - O-18
CREDITS - |riley|
PREDECESSORS - (BETAGALACTOSID-RXN)
PRIMARIES - (BETAGALACTOSID-RXN NIL (GALACTOSE GLC))
REACTION-LAYOUT - (BETAGALACTOSID-RXN (:LEFT-PRIMARIES LACTOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC GALACTOSE))
REACTION-LIST - BETAGALACTOSID-RXN
SYNONYMS - lactose degradation 3
//
UNIQUE-ID - PWY3DJ-5523
TYPES - SUCROSE-DEG
COMMON-NAME - sucrose degradation
CREDITS - AU3DJ-7
PATHWAY-LINKS - (GLC-1-P GLUCONEO-PWY)
PREDECESSORS - (PHOSPHOGLUCMUT-RXN RXN-1685)
PREDECESSORS - (PHOSPHOGLUCMUT-RXN RXN-6182)
PREDECESSORS - (RXN-1685 RXN-1461)
PREDECESSORS - (RXN-6182 FRUCTOKINASE-RXN)
PREDECESSORS - (FRUCTOKINASE-RXN RXN-1461)
PRIMARIES - (PHOSPHOGLUCMUT-RXN (ALPHA-GLC-6-P) (GLC-1-P))
PRIMARIES - (RXN-1461 (SUCROSE) (ALPHA-GLUCOSE FRU))
REACTION-LAYOUT - (RXN-6182 (:LEFT-PRIMARIES ALPHA-GLC-6-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LAYOUT - (FRUCTOKINASE-RXN (:LEFT-PRIMARIES FRU) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LAYOUT - (RXN-1685 (:LEFT-PRIMARIES ALPHA-GLUCOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALPHA-GLC-6-P))
REACTION-LAYOUT - (RXN-1461 (:LEFT-PRIMARIES SUCROSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALPHA-GLUCOSE FRU))
REACTION-LIST - RXN-6182
REACTION-LIST - FRUCTOKINASE-RXN
REACTION-LIST - RXN-1685
REACTION-LIST - RXN-1461
//
UNIQUE-ID - PWY0-1182
TYPES - Trehalose-Degradation
COMMON-NAME - trehalose degradation II (trehalase)
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (GLC-6-P GLYCOLYSIS)
PREDECESSORS - (GLUCOKIN-RXN TREHALA-RXN)
PREDECESSORS - (TREHALA-RXN)
REACTION-LAYOUT - (GLUCOKIN-RXN (:LEFT-PRIMARIES GLC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC-6-P))
REACTION-LAYOUT - (TREHALA-RXN (:LEFT-PRIMARIES TREHALOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC))
REACTION-LIST - GLUCOKIN-RXN
REACTION-LIST - TREHALA-RXN
//
UNIQUE-ID - PWY-2361
TYPES - CARBOXYLATES-DEG
COMMON-NAME - 3-oxoadipate degradation
CITATIONS - :EV-IC:3445186842:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (ACETYL-COA TCA)
PREDECESSORS - (3-OXOADIPATE-COA-TRANSFERASE-RXN)
PREDECESSORS - (RXN-3641 3-OXOADIPATE-COA-TRANSFERASE-RXN)
PRIMARIES - (RXN-3641 (3-KETO-ADIPYL-COA) (ACETYL-COA))
PRIMARIES - (KETOACYLCOATHIOL-RXN (3-KETOACYL-COA) (ACETYL-COA))
PRIMARIES - (3-OXOADIPATE-COA-TRANSFERASE-RXN (3-KETO-ADIPATE) (3-KETO-ADIPYL-COA))
REACTION-LAYOUT - (RXN-3641 (:LEFT-PRIMARIES ACETYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 3-KETO-ADIPYL-COA))
REACTION-LAYOUT - (3-OXOADIPATE-COA-TRANSFERASE-RXN (:LEFT-PRIMARIES 3-KETO-ADIPATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-KETO-ADIPYL-COA))
REACTION-LIST - RXN-3641
REACTION-LIST - 3-OXOADIPATE-COA-TRANSFERASE-RXN
SYNONYMS - &beta;-ketoadipate degradation
//
UNIQUE-ID - PWY-5177
TYPES - CARBOXYLATES-DEG
COMMON-NAME - glutaryl-CoA degradation
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - TRYPTOPHAN-DEGRADATION-1
PATHWAY-LINKS - (GLUTARYL-COA TRYPTOPHAN-DEGRADATION-1 LYSINE-DEG1-PWY)
PREDECESSORS - (GLUTACONYL-COA-DECARBOXYLASE-RXN GLUTARYL-COA-DEHYDROG-RXN)
PREDECESSORS - (3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN GLUTACONYL-COA-DECARBOXYLASE-RXN)
PREDECESSORS - (BHBDCLOS-RXN 3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN)
PREDECESSORS - (ACETYL-COA-ACETYLTRANSFER-RXN BHBDCLOS-RXN)
PRIMARIES - (BENZOATE--COA-LIGASE-RXN (BENZOATE) (BENZOYLCOA))
PRIMARIES - (R281-RXN (CPD-575) (CPD-577))
REACTION-LAYOUT - (ACETYL-COA-ACETYLTRANSFER-RXN (:LEFT-PRIMARIES ACETYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ACETOACETYL-COA))
REACTION-LAYOUT - (BHBDCLOS-RXN (:LEFT-PRIMARIES ACETOACETYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CPD-650))
REACTION-LAYOUT - (3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN (:LEFT-PRIMARIES CPD-650) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CROTONYL-COA))
REACTION-LAYOUT - (GLUTACONYL-COA-DECARBOXYLASE-RXN (:LEFT-PRIMARIES GLUTACONYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CROTONYL-COA))
REACTION-LAYOUT - (GLUTARYL-COA-DEHYDROG-RXN (:LEFT-PRIMARIES GLUTARYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLUTACONYL-COA))
REACTION-LIST - ACETYL-COA-ACETYLTRANSFER-RXN
REACTION-LIST - BHBDCLOS-RXN
REACTION-LIST - 3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN
REACTION-LIST - GLUTACONYL-COA-DECARBOXYLASE-RXN
REACTION-LIST - GLUTARYL-COA-DEHYDROG-RXN
SUPER-PATHWAYS - TRYPTOPHAN-DEGRADATION-1
//
UNIQUE-ID - PWY-5652
TYPES - CARBOXYLATES-DEG
COMMON-NAME - 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |wagg|
IN-PATHWAY - TRYPTOPHAN-DEGRADATION-1
IN-PATHWAY - PWY-6309
PATHWAY-LINKS - (2-AMINO-3-3-OXOPROP-2-ENYL-BUT-2-ENEDI PWY-5651)
PATHWAY-LINKS - (GLUTARYL-COA PWY-5177)
PREDECESSORS - (1.2.1.32-RXN AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN)
PREDECESSORS - (2-AMINOMUCONATE-REDUCTASE-RXN 1.2.1.32-RXN)
PREDECESSORS - (2-KETO-ADIPATE-DEHYDROG-RXN 2-AMINOMUCONATE-REDUCTASE-RXN)
REACTION-LAYOUT - (2-KETO-ADIPATE-DEHYDROG-RXN (:LEFT-PRIMARIES 2K-ADIPATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLUTARYL-COA))
REACTION-LAYOUT - (2-AMINOMUCONATE-REDUCTASE-RXN (:LEFT-PRIMARIES 2-AMINO-MUCONATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2K-ADIPATE))
REACTION-LAYOUT - (1.2.1.32-RXN (:LEFT-PRIMARIES 2-AMINOMUCONATE_SEMIALDEHYDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-AMINO-MUCONATE))
REACTION-LAYOUT - (AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN (:LEFT-PRIMARIES 2-AMINO-3-3-OXOPROP-2-ENYL-BUT-2-ENEDI) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-AMINOMUCONATE_SEMIALDEHYDE))
REACTION-LIST - 2-KETO-ADIPATE-DEHYDROG-RXN
REACTION-LIST - 2-AMINOMUCONATE-REDUCTASE-RXN
REACTION-LIST - 1.2.1.32-RXN
REACTION-LIST - AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN
SUPER-PATHWAYS - TRYPTOPHAN-DEGRADATION-1
SUPER-PATHWAYS - PWY-6309
//
UNIQUE-ID - PWY0-1313
TYPES - CARBOXYLATES-DEG
COMMON-NAME - acetate conversion to acetyl-CoA
CITATIONS - :EV-COMP-AINF:3419591313:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (ACETATE--COA-LIGASE-RXN)
PRIMARIES - (ACETATE--COA-LIGASE-RXN (ACET) (ACETYL-COA))
REACTION-LAYOUT - (ACETATE--COA-LIGASE-RXN (:LEFT-PRIMARIES ACET) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETYL-COA))
REACTION-LIST - ACETATE--COA-LIGASE-RXN
//
UNIQUE-ID - PYRUVDEHYD-PWY
TYPES - CARBOXYLATES-DEG
TYPES - Energy-Metabolism
COMMON-NAME - acetyl-CoA biosynthesis (from pyruvate)
CITATIONS - :EV-COMP-AINF:3482054330:ave
KEY-REACTIONS - RXN0-1134
PREDECESSORS - (RXN0-1134 RXN0-1132)
PREDECESSORS - (RXN0-1132 RXN0-1133)
PREDECESSORS - (RXN0-1133 RXN0-1134)
REACTION-LAYOUT - (RXN0-1132 (:LEFT-PRIMARIES |Pyruvate-dehydrogenase-dihydrolipoate|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Pyruvate-dehydrogenase-lipoate|))
REACTION-LAYOUT - (RXN0-1133 (:LEFT-PRIMARIES |Pyruvate-dehydrogenase-dihydrolipoate|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES |Pyruvate-dehydrogenase-acetylDHlipoyl|))
REACTION-LAYOUT - (RXN0-1134 (:LEFT-PRIMARIES |Pyruvate-dehydrogenase-lipoate|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Pyruvate-dehydrogenase-acetylDHlipoyl|))
REACTION-LIST - RXN0-1132
REACTION-LIST - RXN0-1133
REACTION-LIST - RXN0-1134
SYNONYMS - pyruvate dehydrogenase complex
//
UNIQUE-ID - PWY-5535
TYPES - Acetate-Formation
COMMON-NAME - acetate formation from acetyl-CoA II
CITATIONS - :EV-COMP-AINF:3419591313:ave
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - PWY-5483
PREDECESSORS - (ACETATE--COA-LIGASE-ADP-FORMING-RXN)
PRIMARIES - (ACETATE--COA-LIGASE-ADP-FORMING-RXN (ACETYL-COA) (ACET))
REACTION-LAYOUT - (ACETATE--COA-LIGASE-ADP-FORMING-RXN (:LEFT-PRIMARIES ACET) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ACETYL-COA))
REACTION-LIST - ACETATE--COA-LIGASE-ADP-FORMING-RXN
//
UNIQUE-ID - PROPIONMET-PWY
TYPES - Propionate-Degradation
COMMON-NAME - methylmalonyl pathway
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - O-18
CREDITS - |riley|
IN-PATHWAY - PWY-5328
PATHWAY-LINKS - (SUC-COA TCA)
PREDECESSORS - (METHYLMALONYL-COA-MUT-RXN METHYLMALONYL-COA-EPIM-RXN)
PREDECESSORS - (METHYLMALONYL-COA-EPIM-RXN PROPIONYL-COA-CARBOXY-RXN)
PREDECESSORS - (PROPIONYL-COA-CARBOXY-RXN)
REACTION-LAYOUT - (PROPIONYL-COA-CARBOXY-RXN (:LEFT-PRIMARIES PROPIONYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D-METHYL-MALONYL-COA))
REACTION-LAYOUT - (METHYLMALONYL-COA-MUT-RXN (:LEFT-PRIMARIES METHYL-MALONYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUC-COA))
REACTION-LAYOUT - (METHYLMALONYL-COA-EPIM-RXN (:LEFT-PRIMARIES METHYL-MALONYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES D-METHYL-MALONYL-COA))
REACTION-LIST - PROPIONYL-COA-CARBOXY-RXN
REACTION-LIST - METHYLMALONYL-COA-MUT-RXN
REACTION-LIST - METHYLMALONYL-COA-EPIM-RXN
//
UNIQUE-ID - PWY-5874
TYPES - HEME
COMMON-NAME - heme degradation
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (BILIRUBIN "excretion in the bile")
PREDECESSORS - (BILIVERDIN-REDUCTASE-RXN HEME-OXYGENASE-DECYCLIZING-RXN)
REACTION-LAYOUT - (BILIVERDIN-REDUCTASE-RXN (:LEFT-PRIMARIES BILIRUBIN) (:DIRECTION :R2L) (:RIGHT-PRIMARIES BILIVERDINE))
REACTION-LAYOUT - (HEME-OXYGENASE-DECYCLIZING-RXN (:LEFT-PRIMARIES PROTOHEME) (:DIRECTION :L2R) (:RIGHT-PRIMARIES BILIVERDINE))
REACTION-LIST - BILIVERDIN-REDUCTASE-RXN
REACTION-LIST - HEME-OXYGENASE-DECYCLIZING-RXN
//
UNIQUE-ID - ACETOACETATE-DEG-PWY
TYPES - Fatty-Acid-and-Lipid-Degradation
COMMON-NAME - acetoacetate degradation (to acetyl CoA)
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - O-18
CREDITS - |riley|
CREDITS - O0-3
CREDITS - |ingraham|
PATHWAY-LINKS - (ACETYL-COA TCA)
PREDECESSORS - (ACETOACETYL-COA-TRANSFER-RXN)
PREDECESSORS - (ACETYL-COA-ACETYLTRANSFER-RXN ACETOACETYL-COA-TRANSFER-RXN)
PRIMARIES - (ACETOACETYL-COA-TRANSFER-RXN NIL (ACETOACETYL-COA))
REACTION-LAYOUT - (ACETOACETYL-COA-TRANSFER-RXN (:LEFT-PRIMARIES ACETYL-COA 3-KETOBUTYRATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETOACETYL-COA))
REACTION-LAYOUT - (ACETYL-COA-ACETYLTRANSFER-RXN (:LEFT-PRIMARIES ACETYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ACETOACETYL-COA))
REACTION-LIST - ACETOACETYL-COA-TRANSFER-RXN
REACTION-LIST - ACETYL-COA-ACETYLTRANSFER-RXN
//
UNIQUE-ID - LIPAS-PWY
TYPES - Fatty-Acid-and-Lipid-Degradation
COMMON-NAME - triacylglycerol degradation
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |Iourovitski|
PREDECESSORS - (RXN-1602 TRIACYLGLYCEROL-LIPASE-RXN)
PREDECESSORS - (RXN-1603 RXN-1602)
PREDECESSORS - (3.1.1.23-RXN RXN-1603)
PRIMARIES - (3.1.1.23-RXN (CPD-504) (GLYCEROL))
PRIMARIES - (RXN-1602 (|Diacylglycerides|) (CPD-409))
REACTION-LAYOUT - (RXN-1603 (:LEFT-PRIMARIES CPD-409) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-504))
REACTION-LAYOUT - (RXN-1602 (:LEFT-PRIMARIES |Diacylglycerides|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-409))
REACTION-LAYOUT - (3.1.1.23-RXN (:LEFT-PRIMARIES CPD-504) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLYCEROL))
REACTION-LAYOUT - (TRIACYLGLYCEROL-LIPASE-RXN (:LEFT-PRIMARIES |Triacylglycerols|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Diacylglycerides|))
REACTION-LIST - RXN-1603
REACTION-LIST - RXN-1602
REACTION-LIST - 3.1.1.23-RXN
REACTION-LIST - TRIACYLGLYCEROL-LIPASE-RXN
SYNONYMS - triacylglyceride degradation
SYNONYMS - triacylglycerol hydrolysis
SYNONYMS - lipolysis
//
UNIQUE-ID - LIPASYN-PWY
TYPES - Fatty-Acid-and-Lipid-Degradation
COMMON-NAME - phospholipases
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - |zhang|
PREDECESSORS - (3.1.4.11-RXN)
PRIMARIES - (3.1.4.11-RXN (PHOSPHATIDYL-MYO-INOSITOL-45-BISPHOSPHA) (DIACYLGLYCEROL))
PRIMARIES - (PHOSPHOLIPASE-C-RXN (PHOSPHATIDYLCHOLINE) (DIACYLGLYCEROL))
PRIMARIES - (PHOSPHOLIPASE-A2-RXN (PHOSPHATIDYLCHOLINE) (|1-Acylglycero-Phosphocholines| |Fatty-Acids|))
PRIMARIES - (PHOSPHOLIPASE-A1-RXN (PHOSPHATIDYLCHOLINE) (|2-Acylglycero-Phosphocholines|))
PRIMARIES - (PHOSCHOL-RXN (PHOSPHATIDYLCHOLINE) (L-PHOSPHATIDATE))
REACTION-LAYOUT - (PHOSPHOLIPASE-C-RXN (:LEFT-PRIMARIES PHOSPHATIDYLCHOLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIACYLGLYCEROL))
REACTION-LAYOUT - (PHOSPHOLIPASE-A1-RXN (:LEFT-PRIMARIES PHOSPHATIDYLCHOLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |2-Acylglycero-Phosphocholines|))
REACTION-LAYOUT - (PHOSPHOLIPASE-A2-RXN (:LEFT-PRIMARIES PHOSPHATIDYLCHOLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |1-Acylglycero-Phosphocholines|))
REACTION-LAYOUT - (PHOSCHOL-RXN (:LEFT-PRIMARIES PHOSPHATIDYLCHOLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-PHOSPHATIDATE))
REACTION-LAYOUT - (3.1.4.11-RXN (:LEFT-PRIMARIES PHOSPHATIDYL-MYO-INOSITOL-45-BISPHOSPHA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIACYLGLYCEROL))
REACTION-LIST - PHOSPHOLIPASE-C-RXN
REACTION-LIST - PHOSPHOLIPASE-A1-RXN
REACTION-LIST - PHOSPHOLIPASE-A2-RXN
REACTION-LIST - PHOSCHOL-RXN
REACTION-LIST - 3.1.4.11-RXN
SYNONYMS - phospholipase pathway
//
UNIQUE-ID - PWY6666-1
TYPES - Fatty-Acid-and-Lipid-Degradation
COMMON-NAME - anandamide degradation
PATHWAY-LINKS - (ETHANOL-AMINE PHOSLIPSYN2-PWY)
PATHWAY-LINKS - (ARACHIDONIC_ACID FAO-PWY)
PREDECESSORS - (RXN6666-2)
REACTION-LAYOUT - (RXN6666-2 (:LEFT-PRIMARIES CPD-7598) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ETHANOL-AMINE ARACHIDONIC_ACID))
REACTION-LIST - RXN6666-2
//
UNIQUE-ID - FAO-PWY
TYPES - Fatty-Acid-Degradation
COMMON-NAME - fatty acid &beta;-oxidation I
CITATIONS - :EV-COMP-AINF:3380892013:cjb
COMMENT - <A href="http://biocyc.org/META/NEW-IMAGE?type=NIL&object=FAO-PWY">Pathway Summary from MetaCyc</A>.
/
/In humans, this and related |FRAME: PWY-5136| pathways are perurbed in patients with an inborn error of
/metabolism called <A href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=231530">3-hydroxyacyl-coenzyme A dehydrogenase deficiency</A>.
CREDITS - O-18
CREDITS - |riley|
POLYMERIZATION-LINKS - (|Saturated-Fatty-Acyl-CoA| KETOACYLCOATHIOL-RXN ACYLCOADEHYDROG-RXN)
PREDECESSORS - (KETOACYLCOATHIOL-RXN OHACYL-COA-DEHYDROG-RXN)
PREDECESSORS - (OHACYL-COA-DEHYDROG-RXN OHBUTYRYL-COA-EPIM-RXN)
PREDECESSORS - (OHBUTYRYL-COA-EPIM-RXN)
PREDECESSORS - (ACYLCOADEHYDROG-RXN ACYLCOASYN-RXN)
PREDECESSORS - (ACYLCOASYN-RXN)
PREDECESSORS - (ENOYL-COA-HYDRAT-RXN ENOYL-COA-DELTA-ISOM-RXN)
PREDECESSORS - (ENOYL-COA-DELTA-ISOM-RXN)
PREDECESSORS - (OHACYL-COA-DEHYDROG-RXN ENOYL-COA-HYDRAT-RXN)
PREDECESSORS - (ENOYL-COA-HYDRAT-RXN ACYLCOADEHYDROG-RXN)
PRIMARIES - (KETOACYLCOATHIOL-RXN NIL (|Saturated-Fatty-Acyl-CoA| ACETYL-COA))
REACTION-LAYOUT - (ENOYL-COA-HYDRAT-RXN (:LEFT-PRIMARIES L-3-HYDROXYACYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES TRANS-D2-ENOYL-COA))
REACTION-LAYOUT - (ENOYL-COA-DELTA-ISOM-RXN (:LEFT-PRIMARIES CIS-DELTA3-ENOYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TRANS-D2-ENOYL-COA))
REACTION-LAYOUT - (ACYLCOADEHYDROG-RXN (:LEFT-PRIMARIES |Saturated-Fatty-Acyl-CoA|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D2-ENOYL-COA))
REACTION-LAYOUT - (ACYLCOASYN-RXN (:LEFT-PRIMARIES |Fatty-Acids| CO-A) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Saturated-Fatty-Acyl-CoA|))
REACTION-LAYOUT - (OHBUTYRYL-COA-EPIM-RXN (:LEFT-PRIMARIES D-3-HYDROXYACYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-3-HYDROXYACYL-COA))
REACTION-LAYOUT - (KETOACYLCOATHIOL-RXN (:LEFT-PRIMARIES ACETYL-COA |Saturated-Fatty-Acyl-CoA|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CO-A 3-KETOACYL-COA))
REACTION-LAYOUT - (OHACYL-COA-DEHYDROG-RXN (:LEFT-PRIMARIES L-3-HYDROXYACYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-KETOACYL-COA))
REACTION-LIST - ENOYL-COA-HYDRAT-RXN
REACTION-LIST - ENOYL-COA-DELTA-ISOM-RXN
REACTION-LIST - ACYLCOADEHYDROG-RXN
REACTION-LIST - ACYLCOASYN-RXN
REACTION-LIST - OHBUTYRYL-COA-EPIM-RXN
REACTION-LIST - KETOACYLCOATHIOL-RXN
REACTION-LIST - OHACYL-COA-DEHYDROG-RXN
//
UNIQUE-ID - PWY-2501
TYPES - Fatty-Acid-Degradation
COMMON-NAME - fatty acid &alpha;-oxidation
CITATIONS - :EV-COMP-AINF:3380892013:cjb
POLYMERIZATION-LINKS - (|Fatty-Acids| RXN-4142 RXN-4121)
PREDECESSORS - (RXN-4142 RXN-4122)
PREDECESSORS - (RXN-4141 RXN-4121)
PREDECESSORS - (RXN-4122 RXN-4121)
REACTION-LAYOUT - (RXN-4142 (:LEFT-PRIMARIES |Fatty-Aldehydes|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Fatty-Acids|))
REACTION-LAYOUT - (RXN-4141 (:LEFT-PRIMARIES 2R-HYDROPEROXY-FATTY-ACIDS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2R-HYDROXY-FATTY-ACIDS))
REACTION-LAYOUT - (RXN-4122 (:LEFT-PRIMARIES 2R-HYDROPEROXY-FATTY-ACIDS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Fatty-Aldehydes|))
REACTION-LAYOUT - (RXN-4121 (:LEFT-PRIMARIES |Fatty-Acids|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2R-HYDROPEROXY-FATTY-ACIDS))
REACTION-LIST - RXN-4142
REACTION-LIST - RXN-4141
REACTION-LIST - RXN-4122
REACTION-LIST - RXN-4121
//
UNIQUE-ID - PWY-5136
TYPES - Fatty-Acid-Degradation
COMMON-NAME - fatty acid &beta;-oxidation II (core pathway)
COMMENT - <A href="http:///biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-5136">Pathway summary from MetaCyc</A>.
/
/In humans, this and related |FRAME: FAO-PWY| pathways are perturbed in patients with an inborn error of metabolism
/called <A href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=231530">3-hydroxyacyl-coenzyme A dehydrogenase deficiency</A>.
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |zhang|
PATHWAY-LINKS - (TRANS-D2-ENOYL-COA PWY-5137)
PATHWAY-LINKS - (L-3-HYDROXYACYL-COA PWY-5138)
PREDECESSORS - (RXN-11026 ACYLCOASYN-RXN)
PREDECESSORS - (ENOYL-COA-HYDRAT-RXN RXN-11026)
PREDECESSORS - (OHACYL-COA-DEHYDROG-RXN ENOYL-COA-HYDRAT-RXN)
PREDECESSORS - (KETOACYLCOATHIOL-RXN OHACYL-COA-DEHYDROG-RXN)
PRIMARIES - (OHACYL-COA-DEHYDROG-RXN (L-3-HYDROXYACYL-COA) (3-KETOACYL-COA))
PRIMARIES - (KETOACYLCOATHIOL-RXN (3-KETOACYL-COA) (ACYL-COA))
PRIMARIES - (ENOYL-COA-HYDRAT-RXN (TRANS-D2-ENOYL-COA) (L-3-HYDROXYACYL-COA))
PRIMARIES - (ACYLCOASYN-RXN (|Fatty-Acids|) (ACYL-COA))
PRIMARIES - (ACYL-COA-OXIDASE-RXN (ACYL-COA) (TRANS-D2-ENOYL-COA))
REACTION-LAYOUT - (RXN-11026 (:LEFT-PRIMARIES |Saturated-Fatty-Acyl-CoA|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TRANS-D2-ENOYL-COA))
REACTION-LAYOUT - (KETOACYLCOATHIOL-RXN (:LEFT-PRIMARIES |Saturated-Fatty-Acyl-CoA|) (:DIRECTION :R2L) (:RIGHT-PRIMARIES 3-KETOACYL-COA))
REACTION-LAYOUT - (OHACYL-COA-DEHYDROG-RXN (:LEFT-PRIMARIES L-3-HYDROXYACYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-KETOACYL-COA))
REACTION-LAYOUT - (ENOYL-COA-HYDRAT-RXN (:LEFT-PRIMARIES L-3-HYDROXYACYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES TRANS-D2-ENOYL-COA))
REACTION-LAYOUT - (ACYLCOASYN-RXN (:LEFT-PRIMARIES |Fatty-Acids|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Saturated-Fatty-Acyl-CoA|))
REACTION-LIST - RXN-11026
REACTION-LIST - KETOACYLCOATHIOL-RXN
REACTION-LIST - OHACYL-COA-DEHYDROG-RXN
REACTION-LIST - ENOYL-COA-HYDRAT-RXN
REACTION-LIST - ACYLCOASYN-RXN
SYNONYMS - fatty acid degradation
//
UNIQUE-ID - PWY-5137
TYPES - Fatty-Acid-Degradation
COMMON-NAME - fatty acid &beta;-oxidation III (unsaturated, odd number)
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |zhang|
PATHWAY-LINKS - (TRANS-D2-ENOYL-COA PWY-5136)
PREDECESSORS - (ENOYL-COA-DELTA-ISOM-RXN)
PRIMARIES - (ENOYL-COA-DELTA-ISOM-RXN (CIS-DELTA3-ENOYL-COA) (TRANS-D2-ENOYL-COA))
REACTION-LAYOUT - (ENOYL-COA-DELTA-ISOM-RXN (:LEFT-PRIMARIES CIS-DELTA3-ENOYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TRANS-D2-ENOYL-COA))
REACTION-LIST - ENOYL-COA-DELTA-ISOM-RXN
//
UNIQUE-ID - PWY-5138
TYPES - Fatty-Acid-Degradation
COMMON-NAME - fatty acid &beta;-oxidation IV (unsaturated, even number)
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - SRI
CREDITS - |caspi|
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |zhang|
PATHWAY-LINKS - (L-3-HYDROXYACYL-COA PWY-5136)
PATHWAY-LINKS - (ACYL-COA PWY-5136)
PREDECESSORS - (ENOYL-COA-HYDRAT-RXN RXN-7699)
PREDECESSORS - (RXN-7699 RXN-7838)
PREDECESSORS - (OHBUTYRYL-COA-EPIM-RXN RXN-7838)
PREDECESSORS - (ENOYL-COA-HYDRAT-RXN RXN-7836)
PREDECESSORS - (RXN-7836 RXN-7835)
PRIMARIES - (RXN-7838 (|Cis-2-enoyl-CoAs|) (D-3-HYDROXYACYL-COA))
PRIMARIES - (RXN-7699 (D-3-HYDROXYACYL-COA) (TRANS-D2-ENOYL-COA))
PRIMARIES - (RXN-7835 (|2-trans-4-cis-dienoyl-CoAs|) (|Trans-3-enoyl-CoAs|))
REACTION-LAYOUT - (RXN-7699 (:LEFT-PRIMARIES D-3-HYDROXYACYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TRANS-D2-ENOYL-COA))
REACTION-LAYOUT - (RXN-7835 (:LEFT-PRIMARIES |2-trans-4-cis-dienoyl-CoAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Trans-3-enoyl-CoAs|))
REACTION-LAYOUT - (ENOYL-COA-HYDRAT-RXN (:LEFT-PRIMARIES L-3-HYDROXYACYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES TRANS-D2-ENOYL-COA))
REACTION-LAYOUT - (OHBUTYRYL-COA-EPIM-RXN (:LEFT-PRIMARIES D-3-HYDROXYACYL-COA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-3-HYDROXYACYL-COA))
REACTION-LAYOUT - (RXN-7838 (:LEFT-PRIMARIES |Cis-2-enoyl-CoAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D-3-HYDROXYACYL-COA))
REACTION-LAYOUT - (RXN-7836 (:LEFT-PRIMARIES |Trans-3-enoyl-CoAs|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES TRANS-D2-ENOYL-COA))
REACTION-LIST - RXN-7699
REACTION-LIST - RXN-7835
REACTION-LIST - ENOYL-COA-HYDRAT-RXN
REACTION-LIST - OHBUTYRYL-COA-EPIM-RXN
REACTION-LIST - RXN-7838
REACTION-LIST - RXN-7836
//
UNIQUE-ID - PWY3FA-1022
TYPES - Fatty-Acid-Degradation
COMMON-NAME - ketone oxidation
CITATIONS - :EV-EXP:3453804024:ave
CREDITS - O3FA-6
CREDITS - AU3FA-5
PREDECESSORS - (ACETYL-COA-ACETYLTRANSFER-RXN RXNI-2)
PREDECESSORS - (RXNI-2 3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN)
PREDECESSORS - (3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN)
PRIMARIES - (ACETYL-COA-ACETYLTRANSFER-RXN (ACETOACETYL-COA) (ACETYL-COA))
PRIMARIES - (RXNI-2 (3-KETOBUTYRATE) (ACETOACETYL-COA))
PRIMARIES - (3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN (CPD-335) (3-KETOBUTYRATE))
REACTION-LAYOUT - (ACETYL-COA-ACETYLTRANSFER-RXN (:LEFT-PRIMARIES ACETYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ACETOACETYL-COA))
REACTION-LAYOUT - (RXNI-2 (:LEFT-PRIMARIES 3-KETOBUTYRATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETOACETYL-COA))
REACTION-LAYOUT - (3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN (:LEFT-PRIMARIES CPD-335) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-KETOBUTYRATE))
REACTION-LIST - ACETYL-COA-ACETYLTRANSFER-RXN
REACTION-LIST - RXNI-2
REACTION-LIST - 3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN
//
UNIQUE-ID - PWY-6260
TYPES - Thyroid-Hormone-Metabolism
COMMON-NAME - thyroid hormone metabolism I (via deiodination)
CITATIONS - :EV-COMP-AINF:3482054330:ave
KEY-REACTIONS - 1.97.1.11-RXN
KEY-REACTIONS - THYROXINE-DEIODINASE-RXN
PREDECESSORS - (RXN-10604 1.97.1.11-RXN)
PREDECESSORS - (RXN-10605 THYROXINE-DEIODINASE-RXN)
PREDECESSORS - (1.97.1.11-RXN)
PREDECESSORS - (THYROXINE-DEIODINASE-RXN)
PRIMARIES - (RXN-10605 (LIOTHYRONINE) (CPD-11395))
PRIMARIES - (RXN-10604 (CPD-10813) (CPD-11395))
PRIMARIES - (1.97.1.11-RXN (L-THYROXINE) (CPD-10813))
PRIMARIES - (THYROXINE-DEIODINASE-RXN (L-THYROXINE) (LIOTHYRONINE))
REACTION-LAYOUT - (RXN-10605 (:LEFT-PRIMARIES LIOTHYRONINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-11395))
REACTION-LAYOUT - (RXN-10604 (:LEFT-PRIMARIES CPD-10813) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-11395))
REACTION-LAYOUT - (1.97.1.11-RXN (:LEFT-PRIMARIES CPD-10813) (:DIRECTION :R2L) (:RIGHT-PRIMARIES L-THYROXINE))
REACTION-LAYOUT - (THYROXINE-DEIODINASE-RXN (:LEFT-PRIMARIES LIOTHYRONINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES L-THYROXINE))
REACTION-LIST - RXN-10605
REACTION-LIST - RXN-10604
REACTION-LIST - 1.97.1.11-RXN
REACTION-LIST - THYROXINE-DEIODINASE-RXN
//
UNIQUE-ID - PWY-4984
TYPES - NITROGEN-DEG
COMMON-NAME - urea cycle
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - PWY-5004
PREDECESSORS - (ORNCARBAMTRANSFER-RXN 6.3.4.16-RXN)
PREDECESSORS - (ARGSUCCINSYN-RXN ORNCARBAMTRANSFER-RXN)
PREDECESSORS - (ARGSUCCINLYA-RXN ARGSUCCINSYN-RXN)
PREDECESSORS - (ARGINASE-RXN ARGSUCCINLYA-RXN)
PREDECESSORS - (ORNCARBAMTRANSFER-RXN ARGINASE-RXN)
PRIMARIES - (6.3.4.16-RXN (AMMONIA) (CARBAMOYL-P))
REACTION-LAYOUT - (6.3.4.16-RXN (:LEFT-PRIMARIES AMMONIA) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CARBAMOYL-P))
REACTION-LAYOUT - (ARGINASE-RXN (:LEFT-PRIMARIES ARG) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-ORNITHINE))
REACTION-LAYOUT - (ARGSUCCINLYA-RXN (:LEFT-PRIMARIES L-ARGININO-SUCCINATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ARG))
REACTION-LAYOUT - (ARGSUCCINSYN-RXN (:LEFT-PRIMARIES L-CITRULLINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-ARGININO-SUCCINATE))
REACTION-LAYOUT - (ORNCARBAMTRANSFER-RXN (:LEFT-PRIMARIES CARBAMOYL-P L-ORNITHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-CITRULLINE))
REACTION-LIST - 6.3.4.16-RXN
REACTION-LIST - ARGINASE-RXN
REACTION-LIST - ARGSUCCINLYA-RXN
REACTION-LIST - ARGSUCCINSYN-RXN
REACTION-LIST - ORNCARBAMTRANSFER-RXN
SUPER-PATHWAYS - PWY-5004
SYNONYMS - Krebs ornithine cycle
SYNONYMS - Krebs-Henseleit cycle
//
UNIQUE-ID - PWY-5340
TYPES - Sulfur-Assimilation
COMMON-NAME - sulfate activation for sulfonation
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (ADENYLYLSULFKIN-RXN SULFATE-ADENYLYLTRANS-RXN)
PREDECESSORS - (SULFATE-ADENYLYLTRANS-RXN)
PRIMARIES - (ACSERLY-RXN NIL (CYS))
PRIMARIES - (ADENYLYLSULFKIN-RXN (APS) (PAPS))
PRIMARIES - (SULFITE-REDUCTASE-FERREDOXIN-RXN (SO3) (HS))
PRIMARIES - (1.8.4.9-RXN (APS) (SO3))
PRIMARIES - (HOMOCYSMET-RXN (HOMO-CYS) (MET))
PRIMARIES - (SERINE-O-ACETTRAN-RXN (SER) (ACETYLSERINE))
PRIMARIES - (SULFATE-ADENYLYLTRANS-RXN (SULFATE) (APS))
REACTION-LAYOUT - (ADENYLYLSULFKIN-RXN (:LEFT-PRIMARIES APS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PAPS))
REACTION-LAYOUT - (SULFATE-ADENYLYLTRANS-RXN (:LEFT-PRIMARIES SULFATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES APS))
REACTION-LIST - ADENYLYLSULFKIN-RXN
REACTION-LIST - SULFATE-ADENYLYLTRANS-RXN
SYNONYMS - sulfation pathway
//
UNIQUE-ID - PWY3DJ-35888
TYPES - Sulfur-Assimilation
COMMON-NAME - sulfur metabolism
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - AU3DJ-7
PREDECESSORS - (SULFATE-ADENYLYLTRANS-RXN SO3OXTFER-RXN)
PREDECESSORS - (ADENYLYLSULFKIN-RXN SULFATE-ADENYLYLTRANS-RXN)
PRIMARIES - (SO3OXTFER-RXN (SO3) (SULFATE))
PRIMARIES - (SULFATE-ADENYLYLTRANS-RXN (SULFATE) (APS))
PRIMARIES - (ACETYLHOMOSER-CYS-RXN (HS) (HOMO-CYS))
REACTION-LAYOUT - (SO3OXTFER-RXN (:LEFT-PRIMARIES SO3) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SULFATE))
REACTION-LAYOUT - (ADENYLYLSULFKIN-RXN (:LEFT-PRIMARIES APS) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PAPS))
REACTION-LAYOUT - (SULFATE-ADENYLYLTRANS-RXN (:LEFT-PRIMARIES SULFATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES APS))
REACTION-LIST - SO3OXTFER-RXN
REACTION-LIST - ADENYLYLSULFKIN-RXN
REACTION-LIST - SULFATE-ADENYLYLTRANS-RXN
//
UNIQUE-ID - PWY-5326
TYPES - Sulfite-Oxidation
COMMON-NAME - sulfite oxidation IV
CREDITS - SRI
CREDITS - |caspi|
IN-PATHWAY - PWY-5328
PREDECESSORS - (SULFITE-OXIDASE-RXN)
PRIMARIES - (SULFITE-OXIDASE-RXN (SO3) (SULFATE))
REACTION-LAYOUT - (SULFITE-OXIDASE-RXN (:LEFT-PRIMARIES SO3) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SULFATE))
REACTION-LIST - SULFITE-OXIDASE-RXN
SUPER-PATHWAYS - PWY-5328
//
UNIQUE-ID - PWY-5350
TYPES - Thiosulfate-Disproportionation
COMMON-NAME - thiosulfate disproportionation III (rhodanese)
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (THIOSULFATE-SULFURTRANSFERASE-RXN)
PRIMARIES - (THIOSULFATE-SULFURTRANSFERASE-RXN (S2O3) (SO3 HSCN))
REACTION-LAYOUT - (THIOSULFATE-SULFURTRANSFERASE-RXN (:LEFT-PRIMARIES S2O3) (:DIRECTION :L2R) (:RIGHT-PRIMARIES HSCN SO3))
REACTION-LIST - THIOSULFATE-SULFURTRANSFERASE-RXN
//
UNIQUE-ID - DRIBOPMET-PWY
TYPES - NUCLEO-DEG
COMMON-NAME - (deoxy)ribose phosphate degradation
CITATIONS - :EV-COMP-AINF:3380892013:cjb
PREDECESSORS - (CYTIDEAM2-RXN)
PREDECESSORS - (D-PPENTOMUT-RXN URA-PHOSPH-RXN)
PREDECESSORS - (D-PPENTOMUT-RXN THYM-PHOSPH-RXN)
PREDECESSORS - (THYM-PHOSPH-RXN)
PREDECESSORS - (DEOXYRIBOSE-P-ALD-RXN D-PPENTOMUT-RXN)
PREDECESSORS - (URA-PHOSPH-RXN CYTIDEAM-RXN)
PREDECESSORS - (PPENTOMUT-RXN URPHOS-RXN)
PREDECESSORS - (1TRANSKETO-RXN PPENTOMUT-RXN)
PREDECESSORS - (URPHOS-RXN CYTIDEAM2-RXN)
PRIMARIES - (URPHOS-RXN NIL (URACIL))
REACTION-LAYOUT - (CYTIDEAM2-RXN (:LEFT-PRIMARIES CYTIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES URIDINE))
REACTION-LAYOUT - (D-PPENTOMUT-RXN (:LEFT-PRIMARIES DEOXY-RIBOSE-1P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DEOXY-RIBOSE-5P))
REACTION-LAYOUT - (THYM-PHOSPH-RXN (:LEFT-PRIMARIES THYMIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DEOXY-RIBOSE-1P))
REACTION-LAYOUT - (DEOXYRIBOSE-P-ALD-RXN (:LEFT-PRIMARIES DEOXY-RIBOSE-5P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GAP ACETALD))
REACTION-LAYOUT - (URA-PHOSPH-RXN (:LEFT-PRIMARIES DEOXYURIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES URACIL DEOXY-RIBOSE-1P))
REACTION-LAYOUT - (CYTIDEAM-RXN (:LEFT-PRIMARIES DEOXYCYTIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DEOXYURIDINE))
REACTION-LAYOUT - (1TRANSKETO-RXN (:LEFT-PRIMARIES GAP D-SEDOHEPTULOSE-7-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES RIBOSE-5P))
REACTION-LAYOUT - (PPENTOMUT-RXN (:LEFT-PRIMARIES RIBOSE-1P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES RIBOSE-5P))
REACTION-LAYOUT - (URPHOS-RXN (:LEFT-PRIMARIES URIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES URACIL RIBOSE-1P))
REACTION-LIST - CYTIDEAM2-RXN
REACTION-LIST - D-PPENTOMUT-RXN
REACTION-LIST - THYM-PHOSPH-RXN
REACTION-LIST - DEOXYRIBOSE-P-ALD-RXN
REACTION-LIST - URA-PHOSPH-RXN
REACTION-LIST - CYTIDEAM-RXN
REACTION-LIST - 1TRANSKETO-RXN
REACTION-LIST - PPENTOMUT-RXN
REACTION-LIST - URPHOS-RXN
//
UNIQUE-ID - PWY0-1295
TYPES - NUCLEO-DEG
COMMON-NAME - degradation of pyrimidine ribonucleosides
CREDITS - O0-3
CREDITS - |ingraham|
PATHWAY-LINKS - (RIBOSE-5P NONOXIPENT-PWY)
PREDECESSORS - (PPENTOMUT-RXN URPHOS-RXN)
PREDECESSORS - (URPHOS-RXN CYTIDEAM2-RXN)
PRIMARIES - (URPHOS-RXN (URIDINE) (RIBOSE-1P URACIL))
REACTION-LAYOUT - (PPENTOMUT-RXN (:LEFT-PRIMARIES RIBOSE-1P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES RIBOSE-5P))
REACTION-LAYOUT - (URPHOS-RXN (:LEFT-PRIMARIES URIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES URACIL RIBOSE-1P))
REACTION-LAYOUT - (CYTIDEAM2-RXN (:LEFT-PRIMARIES CYTIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES URIDINE))
REACTION-LIST - PPENTOMUT-RXN
REACTION-LIST - URPHOS-RXN
REACTION-LIST - CYTIDEAM2-RXN
//
UNIQUE-ID - PWY0-1296
TYPES - NUCLEO-DEG
COMMON-NAME - degradation of purine ribonucleosides
CREDITS - O0-3
CREDITS - |ingraham|
PATHWAY-LINKS - (RIBOSE-5P NONOXIPENT-PWY)
PREDECESSORS - (INOPHOSPHOR-RXN ADENODEAMIN-RXN)
PREDECESSORS - (PPENTOMUT-RXN RXN0-5199)
PREDECESSORS - (PPENTOMUT-RXN INOPHOSPHOR-RXN)
PREDECESSORS - (PPENTOMUT-RXN ADENPHOSPHOR-RXN)
PREDECESSORS - (PPENTOMUT-RXN XANTHOSINEPHOSPHORY-RXN)
REACTION-LAYOUT - (RXN0-5199 (:LEFT-PRIMARIES GUANOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES RIBOSE-1P))
REACTION-LAYOUT - (PPENTOMUT-RXN (:LEFT-PRIMARIES RIBOSE-1P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES RIBOSE-5P))
REACTION-LAYOUT - (INOPHOSPHOR-RXN (:LEFT-PRIMARIES INOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES RIBOSE-1P))
REACTION-LAYOUT - (ADENODEAMIN-RXN (:LEFT-PRIMARIES ADENOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES INOSINE))
REACTION-LAYOUT - (ADENPHOSPHOR-RXN (:LEFT-PRIMARIES ADENOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES RIBOSE-1P))
REACTION-LAYOUT - (XANTHOSINEPHOSPHORY-RXN (:LEFT-PRIMARIES XANTHOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES RIBOSE-1P))
REACTION-LIST - RXN0-5199
REACTION-LIST - PPENTOMUT-RXN
REACTION-LIST - INOPHOSPHOR-RXN
REACTION-LIST - ADENODEAMIN-RXN
REACTION-LIST - ADENPHOSPHOR-RXN
REACTION-LIST - XANTHOSINEPHOSPHORY-RXN
//
UNIQUE-ID - PWY0-1298
TYPES - NUCLEO-DEG
COMMON-NAME - pyrimidine deoxyribonucleosides degradation
CREDITS - O0-3
CREDITS - |ingraham|
PATHWAY-LINKS - (ACETYL-COA TCA)
PATHWAY-LINKS - (GAP GLYCOLYSIS)
PREDECESSORS - (D-PPENTOMUT-RXN THYM-PHOSPH-RXN)
PREDECESSORS - (ACETALD-DEHYDROG-RXN DEOXYRIBOSE-P-ALD-RXN)
PREDECESSORS - (DEOXYRIBOSE-P-ALD-RXN D-PPENTOMUT-RXN)
PREDECESSORS - (D-PPENTOMUT-RXN URA-PHOSPH-RXN)
PREDECESSORS - (URA-PHOSPH-RXN CYTIDEAM-RXN)
PRIMARIES - (ACETALD-DEHYDROG-RXN (ACETALD) (ACETYL-COA))
PRIMARIES - (THYM-PHOSPH-RXN (THYMIDINE) (DEOXY-RIBOSE-1P))
PRIMARIES - (DEOXYRIBOSE-P-ALD-RXN (DEOXY-RIBOSE-5P) (ACETALD GAP))
PRIMARIES - (URA-PHOSPH-RXN (DEOXYURIDINE) (DEOXY-RIBOSE-1P))
REACTION-LAYOUT - (ACETALD-DEHYDROG-RXN (:LEFT-PRIMARIES ACETALD) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETYL-COA))
REACTION-LAYOUT - (DEOXYRIBOSE-P-ALD-RXN (:LEFT-PRIMARIES DEOXY-RIBOSE-5P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GAP ACETALD))
REACTION-LAYOUT - (D-PPENTOMUT-RXN (:LEFT-PRIMARIES DEOXY-RIBOSE-1P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DEOXY-RIBOSE-5P))
REACTION-LAYOUT - (THYM-PHOSPH-RXN (:LEFT-PRIMARIES THYMIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DEOXY-RIBOSE-1P))
REACTION-LAYOUT - (URA-PHOSPH-RXN (:LEFT-PRIMARIES DEOXYURIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DEOXY-RIBOSE-1P))
REACTION-LAYOUT - (CYTIDEAM-RXN (:LEFT-PRIMARIES DEOXYCYTIDINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DEOXYURIDINE))
REACTION-LIST - ACETALD-DEHYDROG-RXN
REACTION-LIST - DEOXYRIBOSE-P-ALD-RXN
REACTION-LIST - D-PPENTOMUT-RXN
REACTION-LIST - THYM-PHOSPH-RXN
REACTION-LIST - URA-PHOSPH-RXN
REACTION-LIST - CYTIDEAM-RXN
//
UNIQUE-ID - PWY-5044
TYPES - Purine-Degradation
COMMON-NAME - purine degradation I (aerobic)
CITATIONS - :EV-COMP-AINF:3419591312:ave
PATHWAY-LINKS - (URATE PWY-5691)
PREDECESSORS - (RXN0-363 GUANOSINE-DEAMINASE-RXN)
PREDECESSORS - (GUANINE-DEAMINASE-RXN RXN0-366)
PREDECESSORS - (RXN0-366 RXN-7609)
PREDECESSORS - (GUANOSINE-DEAMINASE-RXN RXN-7609)
PREDECESSORS - (RXN-7609)
PREDECESSORS - (RXN0-363 XMPXAN-RXN)
PREDECESSORS - (IMP-DEHYDROG-RXN AMP-DEAMINASE-RXN)
PREDECESSORS - (XMPXAN-RXN IMP-DEHYDROG-RXN)
PREDECESSORS - (INOSINE-NUCLEOSIDASE-RXN RXN-7607)
PREDECESSORS - (RXN-7682 INOSINE-NUCLEOSIDASE-RXN)
PREDECESSORS - (RXN-7607 AMP-DEAMINASE-RXN)
PREDECESSORS - (RXN0-901 RXN0-363)
PREDECESSORS - (RXN0-901 GUANINE-DEAMINASE-RXN)
PREDECESSORS - (RXN0-901 RXN-7682)
PRIMARIES - (RXN0-901 (XANTHINE) (URATE))
PRIMARIES - (RXN0-366 (GUANOSINE) (GUANINE))
PRIMARIES - (RXN0-363 (XANTHOSINE) (XANTHINE))
PRIMARIES - (GUANOSINE-DEAMINASE-RXN (GUANOSINE) (XANTHOSINE))
PRIMARIES - (RXN-7609 (GMP) (GUANOSINE))
PRIMARIES - (RXN-7682 (HYPOXANTHINE) (XANTHINE))
PRIMARIES - (INOSINE-NUCLEOSIDASE-RXN (INOSINE) (HYPOXANTHINE))
PRIMARIES - (RXN-7607 (IMP) (INOSINE))
PRIMARIES - (GUANINE-DEAMINASE-RXN (GUANINE) (XANTHINE))
PRIMARIES - (XMPXAN-RXN (XANTHOSINE-5-PHOSPHATE) (XANTHOSINE))
PRIMARIES - (IMP-DEHYDROG-RXN (IMP) (XANTHOSINE-5-PHOSPHATE))
PRIMARIES - (AMP-DEAMINASE-RXN (AMP) (IMP))
REACTION-LAYOUT - (RXN0-901 (:LEFT-PRIMARIES XANTHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES URATE))
REACTION-LAYOUT - (RXN0-366 (:LEFT-PRIMARIES GUANOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GUANINE))
REACTION-LAYOUT - (GUANOSINE-DEAMINASE-RXN (:LEFT-PRIMARIES GUANOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHOSINE))
REACTION-LAYOUT - (RXN-7609 (:LEFT-PRIMARIES GMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GUANOSINE))
REACTION-LAYOUT - (RXN0-363 (:LEFT-PRIMARIES XANTHOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHINE))
REACTION-LAYOUT - (RXN-7682 (:LEFT-PRIMARIES HYPOXANTHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHINE))
REACTION-LAYOUT - (INOSINE-NUCLEOSIDASE-RXN (:LEFT-PRIMARIES INOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES HYPOXANTHINE))
REACTION-LAYOUT - (RXN-7607 (:LEFT-PRIMARIES IMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES INOSINE))
REACTION-LAYOUT - (GUANINE-DEAMINASE-RXN (:LEFT-PRIMARIES GUANINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHINE))
REACTION-LAYOUT - (XMPXAN-RXN (:LEFT-PRIMARIES XANTHOSINE-5-PHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHOSINE))
REACTION-LAYOUT - (IMP-DEHYDROG-RXN (:LEFT-PRIMARIES IMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHOSINE-5-PHOSPHATE))
REACTION-LAYOUT - (AMP-DEAMINASE-RXN (:LEFT-PRIMARIES AMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES IMP))
REACTION-LIST - RXN0-901
REACTION-LIST - RXN0-366
REACTION-LIST - GUANOSINE-DEAMINASE-RXN
REACTION-LIST - RXN-7609
REACTION-LIST - RXN0-363
REACTION-LIST - RXN-7682
REACTION-LIST - INOSINE-NUCLEOSIDASE-RXN
REACTION-LIST - RXN-7607
REACTION-LIST - GUANINE-DEAMINASE-RXN
REACTION-LIST - XMPXAN-RXN
REACTION-LIST - IMP-DEHYDROG-RXN
REACTION-LIST - AMP-DEAMINASE-RXN
SYNONYMS - purine catabolism
SYNONYMS - purine nucleotide degradation
SYNONYMS - purine nucleotide catabolism
//
UNIQUE-ID - PWY-6353
TYPES - Purine-Degradation
COMMON-NAME - purine degradation IV (aerobic)
CITATIONS - :EV-COMP-AINF:3482054330:ave
KEY-REACTIONS - RXN0-5199
KEY-REACTIONS - XANTHOSINEPHOSPHORY-RXN
KEY-REACTIONS - RXN0-901
KEY-REACTIONS - RXN-7682
KEY-REACTIONS - INOPHOSPHOR-RXN
PATHWAY-LINKS - (URATE PWY-5691)
PREDECESSORS - (RXN0-901 GUANINE-DEAMINASE-RXN)
PREDECESSORS - (GUANINE-DEAMINASE-RXN RXN0-5199)
PREDECESSORS - (RXN0-5199 RXN-7609)
PREDECESSORS - (RXN0-901 XANTHOSINEPHOSPHORY-RXN)
PREDECESSORS - (XANTHOSINEPHOSPHORY-RXN XMPXAN-RXN)
PREDECESSORS - (RXN0-901 RXN-7682)
PREDECESSORS - (RXN-7682 INOPHOSPHOR-RXN)
PREDECESSORS - (INOPHOSPHOR-RXN ADENODEAMIN-RXN)
PREDECESSORS - (INOPHOSPHOR-RXN RXN-7607)
PREDECESSORS - (ADENODEAMIN-RXN)
PREDECESSORS - (RXN-7607 AMP-DEAMINASE-RXN)
PREDECESSORS - (AMP-DEAMINASE-RXN AMP-DEPHOSPHORYLATION-RXN)
PREDECESSORS - (AMP-DEPHOSPHORYLATION-RXN)
PRIMARIES - (RXN0-5199 (GUANOSINE) (GUANINE))
PRIMARIES - (XANTHOSINEPHOSPHORY-RXN (XANTHOSINE) (XANTHINE))
PRIMARIES - (INOPHOSPHOR-RXN (INOSINE) (HYPOXANTHINE))
REACTION-LAYOUT - (RXN0-5199 (:LEFT-PRIMARIES GUANOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GUANINE))
REACTION-LAYOUT - (GUANINE-DEAMINASE-RXN (:LEFT-PRIMARIES GUANINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHINE))
REACTION-LAYOUT - (XANTHOSINEPHOSPHORY-RXN (:LEFT-PRIMARIES XANTHOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHINE))
REACTION-LAYOUT - (RXN-7609 (:LEFT-PRIMARIES GMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GUANOSINE))
REACTION-LAYOUT - (XMPXAN-RXN (:LEFT-PRIMARIES XANTHOSINE-5-PHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHOSINE))
REACTION-LAYOUT - (RXN0-901 (:LEFT-PRIMARIES XANTHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES URATE))
REACTION-LAYOUT - (RXN-7682 (:LEFT-PRIMARIES HYPOXANTHINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XANTHINE))
REACTION-LAYOUT - (INOPHOSPHOR-RXN (:LEFT-PRIMARIES INOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES HYPOXANTHINE))
REACTION-LAYOUT - (ADENODEAMIN-RXN (:LEFT-PRIMARIES ADENOSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES INOSINE))
REACTION-LAYOUT - (RXN-7607 (:LEFT-PRIMARIES IMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES INOSINE))
REACTION-LAYOUT - (AMP-DEPHOSPHORYLATION-RXN (:LEFT-PRIMARIES AMP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ADENOSINE))
REACTION-LAYOUT - (AMP-DEAMINASE-RXN (:LEFT-PRIMARIES AMP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES IMP))
REACTION-LIST - RXN0-5199
REACTION-LIST - GUANINE-DEAMINASE-RXN
REACTION-LIST - XANTHOSINEPHOSPHORY-RXN
REACTION-LIST - RXN-7609
REACTION-LIST - XMPXAN-RXN
REACTION-LIST - RXN0-901
REACTION-LIST - RXN-7682
REACTION-LIST - INOPHOSPHOR-RXN
REACTION-LIST - ADENODEAMIN-RXN
REACTION-LIST - RXN-7607
REACTION-LIST - AMP-DEPHOSPHORYLATION-RXN
REACTION-LIST - AMP-DEAMINASE-RXN
SYNONYMS - purine nucleotide degradation
SYNONYMS - purine catabolism
SYNONYMS - purine nucleotide catabolism
//
UNIQUE-ID - PWY-4061
TYPES - Other-Degradation
COMMON-NAME - glutathione-mediated detoxification
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - |caspi|
CREDITS - SRI
PREDECESSORS - (2.3.1.80-RXN RXN-6642)
PREDECESSORS - (RXN-6641 GSHTRAN-RXN)
PREDECESSORS - (RXN-6642 RXN-6641)
PREDECESSORS - (RXN-6763 RXN-6642)
PRIMARIES - (RXN-6763 (|S-Substituted-L-Cysteines|) (|Thiols|))
PRIMARIES - (GSHTRAN-RXN (RX) NIL)
REACTION-LAYOUT - (RXN-6763 (:LEFT-PRIMARIES |S-Substituted-L-Cysteines|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Thiols|))
REACTION-LAYOUT - (RXN-6641 (:LEFT-PRIMARIES |S-Substituted-Glutathione|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-6262))
REACTION-LAYOUT - (2.3.1.80-RXN (:LEFT-PRIMARIES |S-Substituted-L-Cysteines|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |S-Substituted-N-Acetyl-L-Cysteines|))
REACTION-LAYOUT - (RXN-6642 (:LEFT-PRIMARIES CPD-6262) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |S-Substituted-L-Cysteines|))
REACTION-LAYOUT - (GSHTRAN-RXN (:LEFT-PRIMARIES RX) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |S-Substituted-Glutathione|))
REACTION-LIST - RXN-6763
REACTION-LIST - RXN-6641
REACTION-LIST - 2.3.1.80-RXN
REACTION-LIST - RXN-6642
REACTION-LIST - GSHTRAN-RXN
//
UNIQUE-ID - PWY66-241
TYPES - Other-Degradation
COMMON-NAME - bupropion degradation
CITATIONS - :EV-COMP-AINF:3380892013:cjb
PREDECESSORS - (RXN66-185 RXN66-184)
PREDECESSORS - (RXN66-184)
PREDECESSORS - (RXN66-183)
PREDECESSORS - (RXN66-182)
PREDECESSORS - (RXN66-181)
PRIMARIES - (RXN66-185 (CPD-3486) (CPD-3487))
REACTION-LAYOUT - (RXN66-185 (:LEFT-PRIMARIES CPD-3486) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3487))
REACTION-LAYOUT - (RXN66-184 (:LEFT-PRIMARIES CPD-3481) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3486))
REACTION-LAYOUT - (RXN66-183 (:LEFT-PRIMARIES CPD-3481) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3482))
REACTION-LAYOUT - (RXN66-181 (:LEFT-PRIMARIES CPD-3481) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3483))
REACTION-LAYOUT - (RXN66-182 (:LEFT-PRIMARIES CPD-3481) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3484))
REACTION-LIST - RXN66-185
REACTION-LIST - RXN66-184
REACTION-LIST - RXN66-183
REACTION-LIST - RXN66-181
REACTION-LIST - RXN66-182
//
UNIQUE-ID - PWY66-201
TYPES - Nicotine-Degradation
COMMON-NAME - nicotine degradation II
CITATIONS - :EV-COMP-AINF:3380892013:cjb
HYPOTHETICAL-REACTIONS - RXN66-145
HYPOTHETICAL-REACTIONS - RXN66-144
HYPOTHETICAL-REACTIONS - RXN66-142
HYPOTHETICAL-REACTIONS - RXN66-141
HYPOTHETICAL-REACTIONS - RXN66-105
PATHWAY-LINKS - (CPD-2742 PWY66-221)
PREDECESSORS - (RXN66-145 RXN66-144)
PREDECESSORS - (RXN66-144 RXN66-142)
PREDECESSORS - (RXN66-142 RXN66-141)
PREDECESSORS - (RXN66-141 RXN66-105)
PREDECESSORS - (RXN66-61)
PREDECESSORS - (RXN66-62 RXN66-61)
PREDECESSORS - (RXN66-101)
PREDECESSORS - (RXN66-103 RXN66-101)
PREDECESSORS - (RXN66-104 RXN66-103)
PREDECESSORS - (RXN66-105 RXN66-104)
PREDECESSORS - (RXN66-146)
PREDECESSORS - (RXN66-147 RXN66-146)
PREDECESSORS - (RXN66-148 RXN66-147)
PREDECESSORS - (RXN66-141 RXN66-148)
PRIMARIES - (RXN66-61 (NICOTINE) (CPD-3186))
PRIMARIES - (RXN66-62 (CPD-3186) NIL)
PRIMARIES - (RXN66-103 (CPD-2748) (CPD-2749))
PRIMARIES - (RXN66-101 (NICOTINE) (CPD-2748))
PRIMARIES - (RXN66-82 (NICOTINE) (CPD-3183))
PRIMARIES - (RXN66-83 (NICOTINE) (CPD-2744))
PRIMARIES - (RXN66-81 (NICOTINE) (CPD-2743))
REACTION-LAYOUT - (RXN66-148 (:LEFT-PRIMARIES CPD-3189) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3192))
REACTION-LAYOUT - (RXN66-147 (:LEFT-PRIMARIES CPD-3187) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3189))
REACTION-LAYOUT - (RXN66-146 (:LEFT-PRIMARIES NICOTINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3187))
REACTION-LAYOUT - (RXN66-145 (:LEFT-PRIMARIES 4-3-PYRIDYL-BUTANOATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-PYRIDYLACETIC-ACID))
REACTION-LAYOUT - (RXN66-144 (:LEFT-PRIMARIES CPD-3194) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 4-3-PYRIDYL-BUTANOATE))
REACTION-LAYOUT - (RXN66-142 (:LEFT-PRIMARIES CPD-3193) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3194))
REACTION-LAYOUT - (RXN66-141 (:LEFT-PRIMARIES CPD-3192) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3193))
REACTION-LAYOUT - (RXN66-105 (:LEFT-PRIMARIES CPD-3190) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3192))
REACTION-LAYOUT - (RXN66-104 (:LEFT-PRIMARIES CPD-2749) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3190))
REACTION-LAYOUT - (RXN66-103 (:LEFT-PRIMARIES CPD-2748) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-2749))
REACTION-LAYOUT - (RXN66-101 (:LEFT-PRIMARIES NICOTINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-2748))
REACTION-LAYOUT - (RXN66-83 (:LEFT-PRIMARIES NICOTINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-2744))
REACTION-LAYOUT - (RXN66-81 (:LEFT-PRIMARIES NICOTINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-2743))
REACTION-LAYOUT - (RXN66-82 (:LEFT-PRIMARIES NICOTINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3183))
REACTION-LAYOUT - (RXN66-62 (:LEFT-PRIMARIES CPD-3186) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-2742))
REACTION-LAYOUT - (RXN66-61 (:LEFT-PRIMARIES NICOTINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3186))
REACTION-LIST - RXN66-148
REACTION-LIST - RXN66-147
REACTION-LIST - RXN66-146
REACTION-LIST - RXN66-145
REACTION-LIST - RXN66-144
REACTION-LIST - RXN66-142
REACTION-LIST - RXN66-141
REACTION-LIST - RXN66-105
REACTION-LIST - RXN66-104
REACTION-LIST - RXN66-103
REACTION-LIST - RXN66-101
REACTION-LIST - RXN66-83
REACTION-LIST - RXN66-81
REACTION-LIST - RXN66-82
REACTION-LIST - RXN66-62
REACTION-LIST - RXN66-61
//
UNIQUE-ID - PWY66-221
TYPES - Nicotine-Degradation
COMMON-NAME - nicotine degradation III
CITATIONS - :EV-COMP-AINF:3380892013:cjb
HYPOTHETICAL-REACTIONS - RXN66-104
HYPOTHETICAL-REACTIONS - RXN66-145
HYPOTHETICAL-REACTIONS - RXN66-144
HYPOTHETICAL-REACTIONS - RXN66-142
HYPOTHETICAL-REACTIONS - RXN66-141
HYPOTHETICAL-REACTIONS - RXN66-165
PATHWAY-LINKS - (NICOTINE PWY66-201)
PREDECESSORS - (RXN66-169 RXN66-62)
PREDECESSORS - (RXN66-163 RXN66-62)
PREDECESSORS - (RXN66-141 RXN66-105)
PREDECESSORS - (RXN66-105 RXN66-104)
PREDECESSORS - (RXN66-104 RXN66-170)
PREDECESSORS - (RXN66-170 RXN66-169)
PREDECESSORS - (RXN66-162 RXN66-161)
PREDECESSORS - (RXN66-161 RXN66-62)
PREDECESSORS - (RXN66-168 RXN66-62)
PREDECESSORS - (RXN66-167 RXN66-62)
PREDECESSORS - (RXN66-166 RXN66-62)
PREDECESSORS - (RXN66-145 RXN66-144)
PREDECESSORS - (RXN66-144 RXN66-142)
PREDECESSORS - (RXN66-142 RXN66-141)
PREDECESSORS - (RXN66-141 RXN66-165)
PREDECESSORS - (RXN66-165 RXN66-164)
PREDECESSORS - (RXN66-164 RXN66-163)
PREDECESSORS - (RXN66-62 RXN66-61)
PREDECESSORS - (RXN66-61)
PRIMARIES - (RXN66-162 NIL (CPD-2752))
PRIMARIES - (RXN66-168 NIL (CPD-2747))
REACTION-LAYOUT - (RXN66-105 (:LEFT-PRIMARIES CPD-3190) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3192))
REACTION-LAYOUT - (RXN66-104 (:LEFT-PRIMARIES CPD-2749) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3190))
REACTION-LAYOUT - (RXN66-170 (:LEFT-PRIMARIES CPD-3188) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-2749))
REACTION-LAYOUT - (RXN66-169 (:LEFT-PRIMARIES CPD-2742) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3188))
REACTION-LAYOUT - (RXN66-168 (:LEFT-PRIMARIES CPD-2742) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-2747))
REACTION-LAYOUT - (RXN66-167 (:LEFT-PRIMARIES CPD-2742) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3184))
REACTION-LAYOUT - (RXN66-166 (:LEFT-PRIMARIES CPD-2742) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3185))
REACTION-LAYOUT - (RXN66-145 (:LEFT-PRIMARIES 4-3-PYRIDYL-BUTANOATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 3-PYRIDYLACETIC-ACID))
REACTION-LAYOUT - (RXN66-144 (:LEFT-PRIMARIES CPD-3194) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 4-3-PYRIDYL-BUTANOATE))
REACTION-LAYOUT - (RXN66-142 (:LEFT-PRIMARIES CPD-3193) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3194))
REACTION-LAYOUT - (RXN66-141 (:LEFT-PRIMARIES CPD-3192) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3193))
REACTION-LAYOUT - (RXN66-165 (:LEFT-PRIMARIES CPD-3191) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3192))
REACTION-LAYOUT - (RXN66-164 (:LEFT-PRIMARIES CPD-2751) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3191))
REACTION-LAYOUT - (RXN66-163 (:LEFT-PRIMARIES CPD-2742) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-2751))
REACTION-LAYOUT - (RXN66-162 (:LEFT-PRIMARIES CPD-2750) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-2752))
REACTION-LAYOUT - (RXN66-161 (:LEFT-PRIMARIES CPD-2742) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-2750))
REACTION-LAYOUT - (RXN66-62 (:LEFT-PRIMARIES CPD-3186) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-2742))
REACTION-LAYOUT - (RXN66-61 (:LEFT-PRIMARIES NICOTINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-3186))
REACTION-LIST - RXN66-105
REACTION-LIST - RXN66-104
REACTION-LIST - RXN66-170
REACTION-LIST - RXN66-169
REACTION-LIST - RXN66-168
REACTION-LIST - RXN66-167
REACTION-LIST - RXN66-166
REACTION-LIST - RXN66-145
REACTION-LIST - RXN66-144
REACTION-LIST - RXN66-142
REACTION-LIST - RXN66-141
REACTION-LIST - RXN66-165
REACTION-LIST - RXN66-164
REACTION-LIST - RXN66-163
REACTION-LIST - RXN66-162
REACTION-LIST - RXN66-161
REACTION-LIST - RXN66-62
REACTION-LIST - RXN66-61
//
UNIQUE-ID - PWY3DJ-213
TYPES - Polymer-Degadation
COMMON-NAME - Targeted protein degradation
CREDITS - AU3DJ-15
PREDECESSORS - (3.4.25.1-RXN UBIQUITIN--PROTEIN-LIGASE-RXN)
PRIMARIES - (3.4.25.1-RXN (PROTEIN-N-UBIQUITYL-LYSINE) (|Peptides|))
REACTION-LAYOUT - (3.4.25.1-RXN (:LEFT-PRIMARIES PROTEIN-N-UBIQUITYL-LYSINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Peptides|))
REACTION-LAYOUT - (UBIQUITIN--PROTEIN-LIGASE-RXN (:LEFT-PRIMARIES |Protein-L-lysine|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PROTEIN-N-UBIQUITYL-LYSINE))
REACTION-LIST - 3.4.25.1-RXN
REACTION-LIST - UBIQUITIN--PROTEIN-LIGASE-RXN
//
UNIQUE-ID - LARABITOLUTIL-PWY
TYPES - SUGAR-ALCOHOLS-DEG
COMMON-NAME - xylitol degradation
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - |hying|
CREDITS - SRI
CREDITS - |fulcher|
PATHWAY-LINKS - (XYLITOL PWY-5525 PWY-5515)
PATHWAY-LINKS - (XYLULOSE-5-PHOSPHATE NONOXIPENT-PWY)
PREDECESSORS - (XYLULOKIN-RXN D-XYLULOSE-REDUCTASE-RXN)
PREDECESSORS - (D-XYLULOSE-REDUCTASE-RXN)
REACTION-LAYOUT - (XYLULOKIN-RXN (:LEFT-PRIMARIES D-XYLULOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XYLULOSE-5-PHOSPHATE))
REACTION-LAYOUT - (D-XYLULOSE-REDUCTASE-RXN (:LEFT-PRIMARIES XYLITOL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D-XYLULOSE))
REACTION-LIST - XYLULOKIN-RXN
REACTION-LIST - D-XYLULOSE-REDUCTASE-RXN
SYNONYMS - L-arabitol and xylitol utilization
SYNONYMS - L-arabitol and xylitol degradation
//
UNIQUE-ID - DETOX1-PWY
TYPES - Detoxification
COMMON-NAME - superoxide radicals degradation
CITATIONS - :EV-COMP-AINF:3380892013:cjb
COMMENT - <A href="http://biocyc.org/META/NEW-IMAGE?type=NIL&object=DETOX1-PWY">Pathway summary from MetaCyc</A>.
/
/In humans, mutations in the gene encoding catalase are associated with an inborn error of metabolism called <A href="http://http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=115500">acatalasia</A>
CREDITS - SRI
CREDITS - |caspi|
CREDITS - O-18
CREDITS - |riley|
CREDITS - THE-ARABIDOPSIS-INFORMATION-RESOURCE
CREDITS - |hartmut|
PREDECESSORS - (SUPEROX-DISMUT-RXN)
PREDECESSORS - (CATAL-RXN SUPEROX-DISMUT-RXN)
PRIMARIES - (SUPEROX-DISMUT-RXN (SUPER-OXIDE) (HYDROGEN-PEROXIDE))
PRIMARIES - (CATAL-RXN (HYDROGEN-PEROXIDE) (OXYGEN-MOLECULE))
REACTION-LAYOUT - (CATAL-RXN (:LEFT-PRIMARIES HYDROGEN-PEROXIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OXYGEN-MOLECULE))
REACTION-LAYOUT - (SUPEROX-DISMUT-RXN (:LEFT-PRIMARIES SUPER-OXIDE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OXYGEN-MOLECULE HYDROGEN-PEROXIDE))
REACTION-LIST - CATAL-RXN
REACTION-LIST - SUPEROX-DISMUT-RXN
SYNONYMS - removal of superoxide radicals
//
UNIQUE-ID - PWY-4202
TYPES - Arsenate-Detoxification
COMMON-NAME - arsenate detoxification I (glutaredoxin)
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (2.1.1.137-RXN RXN-7002)
PREDECESSORS - (RXN-7002 RXN-7001)
PREDECESSORS - (2.1.1.137-RXN RXN-982)
PREDECESSORS - (1.20.4.2-RXN 2.1.1.137-RXN)
PREDECESSORS - (2.1.1.138-RXN 1.20.4.2-RXN)
PREDECESSORS - (RXN-6981 2.1.1.138-RXN)
PRIMARIES - (RXN-7002 (RIBOSE-1-ARSENATE) (CPD-763))
PRIMARIES - (RXN-7001 (ARSENATE) (RIBOSE-1-ARSENATE))
PRIMARIES - (RXN-982 (ARSENATE) (CPD-763))
PRIMARIES - (1.20.4.2-RXN (METHYLARSONATE) (METHYLARSONITE))
REACTION-LAYOUT - (RXN-7001 (:LEFT-PRIMARIES ARSENATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES RIBOSE-1-ARSENATE))
REACTION-LAYOUT - (RXN-7002 (:LEFT-PRIMARIES RIBOSE-1-ARSENATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-763))
REACTION-LAYOUT - (RXN-6981 (:LEFT-PRIMARIES DIMETHYLARSINATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIMETHYLARSINOUS-ACID))
REACTION-LAYOUT - (2.1.1.138-RXN (:LEFT-PRIMARIES METHYLARSONITE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIMETHYLARSINATE))
REACTION-LAYOUT - (1.20.4.2-RXN (:LEFT-PRIMARIES METHYLARSONATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES METHYLARSONITE))
REACTION-LAYOUT - (2.1.1.137-RXN (:LEFT-PRIMARIES CPD-763) (:DIRECTION :L2R) (:RIGHT-PRIMARIES METHYLARSONATE))
REACTION-LAYOUT - (RXN-982 (:LEFT-PRIMARIES ARSENATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-763))
REACTION-LIST - RXN-7001
REACTION-LIST - RXN-7002
REACTION-LIST - RXN-6981
REACTION-LIST - 2.1.1.138-RXN
REACTION-LIST - 1.20.4.2-RXN
REACTION-LIST - 2.1.1.137-RXN
REACTION-LIST - RXN-982
//
UNIQUE-ID - PWY-5172
TYPES - Energy-Metabolism
COMMON-NAME - acetyl-CoA biosynthesis (from citrate)
PATHWAY-LINKS - (CIT TCA)
PATHWAY-LINKS - (ACETYL-COA PWY-922)
PREDECESSORS - (ATP-CITRATE-PRO-S--LYASE-RXN)
PRIMARIES - (ATP-CITRATE-PRO-S--LYASE-RXN (CIT) (ACETYL-COA))
REACTION-LAYOUT - (ATP-CITRATE-PRO-S--LYASE-RXN (:LEFT-PRIMARIES ACETYL-COA) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CIT))
REACTION-LIST - ATP-CITRATE-PRO-S--LYASE-RXN
//
UNIQUE-ID - PWY3DJ-471
TYPES - Energy-Metabolism
COMMON-NAME - creatine-phosphate energy transfer
CREDITS - AU3DJ-15
PREDECESSORS - (RXN3DJ-8 TRANS-RXN3DJ-12)
PREDECESSORS - (TRANS-RXN3DJ-12 CREATINE-KINASE-RXN)
PREDECESSORS - (CREATINE-KINASE-RXN TRANS-RXN3DJ-9)
PREDECESSORS - (TRANS-RXN3DJ-9 RXN3DJ-8)
PRIMARIES - (CREATINE-KINASE-RXN (CREATINE-P) (CREATINE))
PRIMARIES - (RXN3DJ-8 (CREATINE) (CREATINE-P))
REACTION-LAYOUT - (TRANS-RXN3DJ-12 (:LEFT-PRIMARIES CREATINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CREATINE))
REACTION-LAYOUT - (TRANS-RXN3DJ-9 (:LEFT-PRIMARIES CREATINE-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CREATINE-P))
REACTION-LAYOUT - (CREATINE-KINASE-RXN (:LEFT-PRIMARIES CREATINE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES CREATINE-P))
REACTION-LAYOUT - (RXN3DJ-8 (:LEFT-PRIMARIES CREATINE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CREATINE-P))
REACTION-LIST - TRANS-RXN3DJ-12
REACTION-LIST - TRANS-RXN3DJ-9
REACTION-LIST - CREATINE-KINASE-RXN
REACTION-LIST - RXN3DJ-8
//
UNIQUE-ID - PWY0-1334
TYPES - Electron-Transfer
TYPES - AEROBIC-RESPIRATION
COMMON-NAME - NADH to cytochrome <i>bd</i> oxidase electron transfer
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - O0-13
CREDITS - |lnolan|
CREDITS - SRI
CREDITS - |kr|
PREDECESSORS - (RXN0-5266 NADH-DEHYDROG-A-RXN)
PRIMARIES - (NADH-DEHYDROG-A-RXN (NADH) (|Ubiquinols|))
REACTION-LAYOUT - (RXN0-5266 (:LEFT-PRIMARIES |Ubiquinols|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Ubiquinones|))
REACTION-LAYOUT - (NADH-DEHYDROG-A-RXN (:LEFT-PRIMARIES |Ubiquinones| NADH) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Ubiquinols|))
REACTION-LIST - RXN0-5266
REACTION-LIST - NADH-DEHYDROG-A-RXN
//
UNIQUE-ID - PWY0-1335
TYPES - Electron-Transfer
TYPES - AEROBIC-RESPIRATION
COMMON-NAME - NADH to cytochrome <i>bo</i> oxidase electron transfer
CITATIONS - :EV-COMP-AINF:3442068424:ave
CREDITS - O0-13
CREDITS - |lnolan|
CREDITS - SRI
CREDITS - |kr|
PREDECESSORS - (RXN0-5268 NADH-DEHYDROG-A-RXN)
PRIMARIES - (NADH-DEHYDROG-A-RXN (NADH) (|Ubiquinols|))
REACTION-LAYOUT - (RXN0-5268 (:LEFT-PRIMARIES |Ubiquinols|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Ubiquinones|))
REACTION-LAYOUT - (NADH-DEHYDROG-A-RXN (:LEFT-PRIMARIES |Ubiquinones| NADH) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Ubiquinols|))
REACTION-LIST - RXN0-5268
REACTION-LIST - NADH-DEHYDROG-A-RXN
//
UNIQUE-ID - PWY-5481
TYPES - Pyruvate-Degradation
COMMON-NAME - pyruvate fermentation to lactate
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (PYRUVATE ANAGLYCOLYSIS-PWY)
PREDECESSORS - (L-LACTATE-DEHYDROGENASE-RXN)
PRIMARIES - (L-LACTATE-DEHYDROGENASE-RXN (PYRUVATE) (L-LACTATE))
REACTION-LAYOUT - (L-LACTATE-DEHYDROGENASE-RXN (:LEFT-PRIMARIES L-LACTATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES PYRUVATE))
REACTION-LIST - L-LACTATE-DEHYDROGENASE-RXN
//
UNIQUE-ID - PWY-5483
TYPES - Pyruvate-Degradation
TYPES - Super-Pathways
COMMON-NAME - pyruvate fermentation to acetate III
CITATIONS - :EV-COMP-AINF:3419591313:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (PYRUVATE P341-PWY)
PREDECESSORS - PWY-5535
PREDECESSORS - (ACETATE--COA-LIGASE-ADP-FORMING-RXN PYRUFLAVREDUCT-RXN)
PRIMARIES - (ALANINE-AMINOTRANSFERASE-RXN (PYRUVATE) (L-ALPHA-ALANINE))
PRIMARIES - (PYRUFLAVREDUCT-RXN (PYRUVATE) (ACETYL-COA))
PRIMARIES - (F16ALDOLASE-RXN NIL (DIHYDROXY-ACETONE-PHOSPHATE GAP))
PRIMARIES - (TRIOSEPISOMERIZATION-RXN (GAP) (DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LAYOUT - (PWY-5535 (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (ACETATE--COA-LIGASE-ADP-FORMING-RXN (:LEFT-PRIMARIES ACET) (:DIRECTION :R2L) (:RIGHT-PRIMARIES ACETYL-COA))
REACTION-LAYOUT - (PYRUFLAVREDUCT-RXN (:LEFT-PRIMARIES PYRUVATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ACETYL-COA))
REACTION-LIST - PWY-5535
REACTION-LIST - ACETATE--COA-LIGASE-ADP-FORMING-RXN
REACTION-LIST - PYRUFLAVREDUCT-RXN
//
UNIQUE-ID - ANAGLYCOLYSIS-PWY
TYPES - GLYCOLYSIS-VARIANTS
TYPES - Super-Pathways
COMMON-NAME - anaerobic glycolysis
CITATIONS - :EV-COMP-AINF:3482054330:ave
KEY-REACTIONS - GLUCOKIN-RXN
PREDECESSORS - (GAPOXNPHOSPHN-RXN TRIOSEPISOMERIZATION-RXN)
PREDECESSORS - (TRIOSEPISOMERIZATION-RXN F16ALDOLASE-RXN)
PREDECESSORS - (PEPDEPHOS-RXN 2PGADEHYDRAT-RXN)
PREDECESSORS - (2PGADEHYDRAT-RXN 3PGAREARR-RXN)
PREDECESSORS - (3PGAREARR-RXN PHOSGLYPHOS-RXN)
PREDECESSORS - (PHOSGLYPHOS-RXN GAPOXNPHOSPHN-RXN)
PREDECESSORS - (GAPOXNPHOSPHN-RXN F16ALDOLASE-RXN)
PREDECESSORS - (F16ALDOLASE-RXN 6PFRUCTPHOS-RXN)
PREDECESSORS - (6PFRUCTPHOS-RXN PGLUCISOM-RXN)
PREDECESSORS - (PGLUCISOM-RXN GLUCOKIN-RXN)
PREDECESSORS - (GLUCOKIN-RXN)
PRIMARIES - (TRIOSEPISOMERIZATION-RXN (DIHYDROXY-ACETONE-PHOSPHATE) (GAP))
REACTION-LAYOUT - (PEPDEPHOS-RXN (:LEFT-PRIMARIES PYRUVATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES PHOSPHO-ENOL-PYRUVATE))
REACTION-LAYOUT - (2PGADEHYDRAT-RXN (:LEFT-PRIMARIES 2-PG) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHO-ENOL-PYRUVATE))
REACTION-LAYOUT - (3PGAREARR-RXN (:LEFT-PRIMARIES G3P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-PG))
REACTION-LAYOUT - (PHOSGLYPHOS-RXN (:LEFT-PRIMARIES G3P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES DPG))
REACTION-LAYOUT - (GAPOXNPHOSPHN-RXN (:LEFT-PRIMARIES GAP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DPG))
REACTION-LAYOUT - (TRIOSEPISOMERIZATION-RXN (:LEFT-PRIMARIES GAP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LAYOUT - (F16ALDOLASE-RXN (:LEFT-PRIMARIES FRUCTOSE-16-DIPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GAP DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LAYOUT - (6PFRUCTPHOS-RXN (:LEFT-PRIMARIES FRUCTOSE-6P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FRUCTOSE-16-DIPHOSPHATE))
REACTION-LAYOUT - (PGLUCISOM-RXN (:LEFT-PRIMARIES GLC-6-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LAYOUT - (GLUCOKIN-RXN (:LEFT-PRIMARIES GLC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC-6-P))
REACTION-LIST - PEPDEPHOS-RXN
REACTION-LIST - 2PGADEHYDRAT-RXN
REACTION-LIST - 3PGAREARR-RXN
REACTION-LIST - PHOSGLYPHOS-RXN
REACTION-LIST - GAPOXNPHOSPHN-RXN
REACTION-LIST - TRIOSEPISOMERIZATION-RXN
REACTION-LIST - F16ALDOLASE-RXN
REACTION-LIST - 6PFRUCTPHOS-RXN
REACTION-LIST - PGLUCISOM-RXN
REACTION-LIST - GLUCOKIN-RXN
SYNONYMS - glycolysis III (Thermotoga)
SYNONYMS - Embden-Meyerhof-Parnas pathway
SYNONYMS - EMP pathway
//
UNIQUE-ID - GLYCOLYSIS
TYPES - GLYCOLYSIS-VARIANTS
TYPES - Super-Pathways
COMMON-NAME - glycolysis I
CITATIONS - :EV-COMP-AINF:3482054330:ave
PATHWAY-LINKS - (FRUCTOSE-6P PWY-3861 MANNCAT-PWY)
PATHWAY-LINKS - (G3P SERSYN-PWY)
PATHWAY-LINKS - (PYRUVATE PYRUVDEHYD-PWY |Amino-Acid-Biosynthesis|)
PATHWAY-LINKS - (GLC-6-P (PWY-842 . :INCOMING) PENTOSE-P-PWY)
PREDECESSORS - (GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN RXN-1685)
PREDECESSORS - (PGLUCISOM-RXN GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN)
PREDECESSORS - (PGLUCISOM-RXN R81-RXN)
PREDECESSORS - (F16BDEPHOS-RXN 6PFRUCTPHOS-RXN)
PREDECESSORS - (6PFRUCTPHOS-RXN F16BDEPHOS-RXN)
PREDECESSORS - (PEPDEPHOS-RXN PEPSYNTH-RXN)
PREDECESSORS - (PEPSYNTH-RXN PEPDEPHOS-RXN)
PREDECESSORS - (PEPDEPHOS-RXN 2PGADEHYDRAT-RXN)
PREDECESSORS - (2PGADEHYDRAT-RXN 3PGAREARR-RXN)
PREDECESSORS - (3PGAREARR-RXN PHOSGLYPHOS-RXN)
PREDECESSORS - (PHOSGLYPHOS-RXN GAPOXNPHOSPHN-RXN)
PREDECESSORS - (GAPOXNPHOSPHN-RXN TRIOSEPISOMERIZATION-RXN F16ALDOLASE-RXN)
PREDECESSORS - (TRIOSEPISOMERIZATION-RXN F16ALDOLASE-RXN)
PREDECESSORS - (F16ALDOLASE-RXN 6PFRUCTPHOS-RXN)
PREDECESSORS - (6PFRUCTPHOS-RXN PGLUCISOM-RXN)
REACTION-LAYOUT - (GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN (:LEFT-PRIMARIES ALPHA-GLC-6-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC-6-P))
REACTION-LAYOUT - (RXN-1685 (:LEFT-PRIMARIES ALPHA-GLUCOSE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ALPHA-GLC-6-P))
REACTION-LAYOUT - (R81-RXN (:LEFT-PRIMARIES GLC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC-6-P))
REACTION-LAYOUT - (F16BDEPHOS-RXN (:LEFT-PRIMARIES FRUCTOSE-16-DIPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LAYOUT - (PEPSYNTH-RXN (:LEFT-PRIMARIES PYRUVATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHO-ENOL-PYRUVATE))
REACTION-LAYOUT - (PGLUCISOM-RXN (:LEFT-PRIMARIES GLC-6-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LAYOUT - (6PFRUCTPHOS-RXN (:LEFT-PRIMARIES FRUCTOSE-6P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FRUCTOSE-16-DIPHOSPHATE))
REACTION-LAYOUT - (F16ALDOLASE-RXN (:LEFT-PRIMARIES FRUCTOSE-16-DIPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GAP DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LAYOUT - (TRIOSEPISOMERIZATION-RXN (:LEFT-PRIMARIES GAP) (:DIRECTION :R2L) (:RIGHT-PRIMARIES DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LAYOUT - (GAPOXNPHOSPHN-RXN (:LEFT-PRIMARIES GAP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DPG))
REACTION-LAYOUT - (PHOSGLYPHOS-RXN (:LEFT-PRIMARIES G3P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES DPG))
REACTION-LAYOUT - (3PGAREARR-RXN (:LEFT-PRIMARIES G3P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-PG))
REACTION-LAYOUT - (2PGADEHYDRAT-RXN (:LEFT-PRIMARIES 2-PG) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHO-ENOL-PYRUVATE))
REACTION-LAYOUT - (PEPDEPHOS-RXN (:LEFT-PRIMARIES PYRUVATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES PHOSPHO-ENOL-PYRUVATE))
REACTION-LIST - GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN
REACTION-LIST - RXN-1685
REACTION-LIST - R81-RXN
REACTION-LIST - F16BDEPHOS-RXN
REACTION-LIST - PEPSYNTH-RXN
REACTION-LIST - PGLUCISOM-RXN
REACTION-LIST - 6PFRUCTPHOS-RXN
REACTION-LIST - F16ALDOLASE-RXN
REACTION-LIST - TRIOSEPISOMERIZATION-RXN
REACTION-LIST - GAPOXNPHOSPHN-RXN
REACTION-LIST - PHOSGLYPHOS-RXN
REACTION-LIST - 3PGAREARR-RXN
REACTION-LIST - 2PGADEHYDRAT-RXN
REACTION-LIST - PEPDEPHOS-RXN
SYNONYMS - Embden-Meyerhof pathway
SYNONYMS - glucose degradation
SYNONYMS - Embden-Meyerhof-Parnas pathway
SYNONYMS - EMP pathway
SYNONYMS - glycolysis (plastidic)
//
UNIQUE-ID - P341-PWY
TYPES - GLYCOLYSIS-VARIANTS
COMMON-NAME - glycolysis V
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - O-18
CREDITS - |pellegrini-toole|
PATHWAY-LINKS - (PYRUVATE PWY-5483)
PREDECESSORS - (PGLUCISOM-RXN R301-RXN)
PREDECESSORS - (R302-RXN PGLUCISOM-RXN)
PREDECESSORS - (2PGADEHYDRAT-RXN 3PGAREARR-RXN)
PREDECESSORS - (PEPDEPHOS-RXN 2PGADEHYDRAT-RXN)
PREDECESSORS - (F16ALDOLASE-RXN R302-RXN)
PREDECESSORS - (TRIOSEPISOMERIZATION-RXN F16ALDOLASE-RXN)
PREDECESSORS - (1.2.7.6-RXN F16ALDOLASE-RXN)
PREDECESSORS - (3PGAREARR-RXN 1.2.7.6-RXN)
PRIMARIES - (F16ALDOLASE-RXN NIL (DIHYDROXY-ACETONE-PHOSPHATE GAP))
PRIMARIES - (TRIOSEPISOMERIZATION-RXN (GAP) (DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LAYOUT - (1.2.7.6-RXN (:LEFT-PRIMARIES GAP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES G3P))
REACTION-LAYOUT - (PEPDEPHOS-RXN (:LEFT-PRIMARIES PYRUVATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES PHOSPHO-ENOL-PYRUVATE))
REACTION-LAYOUT - (2PGADEHYDRAT-RXN (:LEFT-PRIMARIES 2-PG) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PHOSPHO-ENOL-PYRUVATE))
REACTION-LAYOUT - (3PGAREARR-RXN (:LEFT-PRIMARIES G3P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-PG))
REACTION-LAYOUT - (TRIOSEPISOMERIZATION-RXN (:LEFT-PRIMARIES GAP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LAYOUT - (F16ALDOLASE-RXN (:LEFT-PRIMARIES FRUCTOSE-16-DIPHOSPHATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GAP DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LAYOUT - (R302-RXN (:LEFT-PRIMARIES FRUCTOSE-6P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FRUCTOSE-16-DIPHOSPHATE))
REACTION-LAYOUT - (PGLUCISOM-RXN (:LEFT-PRIMARIES GLC-6-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FRUCTOSE-6P))
REACTION-LAYOUT - (R301-RXN (:LEFT-PRIMARIES GLC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GLC-6-P))
REACTION-LIST - 1.2.7.6-RXN
REACTION-LIST - PEPDEPHOS-RXN
REACTION-LIST - 2PGADEHYDRAT-RXN
REACTION-LIST - 3PGAREARR-RXN
REACTION-LIST - TRIOSEPISOMERIZATION-RXN
REACTION-LIST - F16ALDOLASE-RXN
REACTION-LIST - R302-RXN
REACTION-LIST - PGLUCISOM-RXN
REACTION-LIST - R301-RXN
SYNONYMS - archaeal Embden-Meyerhof pathway
SYNONYMS - archaeal Embden-Meyerhof-Parnas pathway
SYNONYMS - archaeal EMP pathway
//
UNIQUE-ID - PWY-6118
TYPES - OTHER-ENERGY
COMMON-NAME - glycerol-3-phosphate shuttle
CITATIONS - :EV-COMP-AINF:3453644158:ave
CREDITS - SRI
CREDITS - |caspi|
PATHWAY-LINKS - (DIHYDROXY-ACETONE-PHOSPHATE GLYCOLYSIS)
PREDECESSORS - (1.1.1.8-RXN RXN-9927)
PREDECESSORS - (RXN-9927 1.1.1.8-RXN)
PRIMARIES - (1.1.1.8-RXN (DIHYDROXY-ACETONE-PHOSPHATE) (GLYCEROL-3P))
REACTION-LAYOUT - (RXN-9927 (:LEFT-PRIMARIES GLYCEROL-3P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LAYOUT - (1.1.1.8-RXN (:LEFT-PRIMARIES GLYCEROL-3P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES DIHYDROXY-ACETONE-PHOSPHATE))
REACTION-LIST - RXN-9927
REACTION-LIST - 1.1.1.8-RXN
SYNONYMS - G3P shuttle
SYNONYMS - glycerol-3-P shuttle
//
UNIQUE-ID - NONOXIPENT-PWY
TYPES - Pentose-Phosphate-Cycle
COMMON-NAME - pentose phosphate pathway (non-oxidative branch)
CITATIONS - :EV-COMP-AINF:3380892013:cjb
CREDITS - |riley|
CREDITS - O-18
CREDITS - O0-3
CREDITS - |ingraham|
IN-PATHWAY - PENTOSE-P-PWY
PREDECESSORS - (2TRANSKETO-RXN TRANSALDOL-RXN)
PREDECESSORS - (TRANSALDOL-RXN 1TRANSKETO-RXN)
PREDECESSORS - (1TRANSKETO-RXN RIBULP3EPIM-RXN)
PREDECESSORS - (1TRANSKETO-RXN RIB5PISOM-RXN)
PRIMARIES - (2TRANSKETO-RXN (ERYTHROSE-4P) (GAP))
PRIMARIES - (TRANSALDOL-RXN NIL (FRUCTOSE-6P ERYTHROSE-4P))
REACTION-LAYOUT - (RIB5PISOM-RXN (:LEFT-PRIMARIES RIBOSE-5P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES RIBULOSE-5P))
REACTION-LAYOUT - (RIBULP3EPIM-RXN (:LEFT-PRIMARIES RIBULOSE-5P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES XYLULOSE-5-PHOSPHATE))
REACTION-LAYOUT - (1TRANSKETO-RXN (:LEFT-PRIMARIES GAP D-SEDOHEPTULOSE-7-P) (:DIRECTION :R2L) (:RIGHT-PRIMARIES XYLULOSE-5-PHOSPHATE RIBOSE-5P))
REACTION-LAYOUT - (2TRANSKETO-RXN (:LEFT-PRIMARIES XYLULOSE-5-PHOSPHATE ERYTHROSE-4P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES GAP FRUCTOSE-6P))
REACTION-LAYOUT - (TRANSALDOL-RXN (:LEFT-PRIMARIES D-SEDOHEPTULOSE-7-P GAP) (:DIRECTION :L2R) (:RIGHT-PRIMARIES ERYTHROSE-4P FRUCTOSE-6P))
REACTION-LIST - RIB5PISOM-RXN
REACTION-LIST - RIBULP3EPIM-RXN
REACTION-LIST - 1TRANSKETO-RXN
REACTION-LIST - 2TRANSKETO-RXN
REACTION-LIST - TRANSALDOL-RXN
SUPER-PATHWAYS - PENTOSE-P-PWY
//
UNIQUE-ID - OXIDATIVEPENT-PWY
TYPES - Pentose-Phosphate-Cycle
COMMON-NAME - pentose phosphate pathway (oxidative branch)
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - |riley|
CREDITS - O-18
CREDITS - O0-3
CREDITS - |ingraham|
IN-PATHWAY - PENTOSE-P-PWY
PATHWAY-LINKS - (RIBULOSE-5P NONOXIPENT-PWY)
PREDECESSORS - (6PGLUCONDEHYDROG-RXN 6PGLUCONOLACT-RXN)
PREDECESSORS - (6PGLUCONOLACT-RXN GLU6PDEHYDROG-RXN)
PREDECESSORS - (GLU6PDEHYDROG-RXN)
REACTION-LAYOUT - (GLU6PDEHYDROG-RXN (:LEFT-PRIMARIES GLC-6-P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES D-6-P-GLUCONO-DELTA-LACTONE))
REACTION-LAYOUT - (6PGLUCONDEHYDROG-RXN (:LEFT-PRIMARIES CPD-2961) (:DIRECTION :L2R) (:RIGHT-PRIMARIES RIBULOSE-5P))
REACTION-LAYOUT - (6PGLUCONOLACT-RXN (:LEFT-PRIMARIES D-6-P-GLUCONO-DELTA-LACTONE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CPD-2961))
REACTION-LIST - GLU6PDEHYDROG-RXN
REACTION-LIST - 6PGLUCONDEHYDROG-RXN
REACTION-LIST - 6PGLUCONOLACT-RXN
SUPER-PATHWAYS - PENTOSE-P-PWY
//
UNIQUE-ID - PENTOSE-P-PWY
TYPES - Pentose-Phosphate-Cycle
TYPES - Super-Pathways
COMMON-NAME - pentose phosphate pathway
PATHWAY-LINKS - (GLC-6-P PWY-842)
PREDECESSORS - OXIDATIVEPENT-PWY
PREDECESSORS - NONOXIPENT-PWY
PREDECESSORS - (RIBULP3EPIM-RXN 6PGLUCONDEHYDROG-RXN)
PREDECESSORS - (RIB5PISOM-RXN 6PGLUCONDEHYDROG-RXN)
REACTION-LAYOUT - (OXIDATIVEPENT-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (NONOXIPENT-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LIST - OXIDATIVEPENT-PWY
REACTION-LIST - NONOXIPENT-PWY
SUB-PATHWAYS - NONOXIPENT-PWY
SUB-PATHWAYS - OXIDATIVEPENT-PWY
SYNONYMS - pentose shunt
SYNONYMS - hexose monophosphate shunt
SYNONYMS - phosphogluconate pathway
SYNONYMS - superpathway of oxidative and non-oxidative branches of pentose phosphate pathway
//
UNIQUE-ID - PWY-4302
TYPES - Respiration
COMMON-NAME - aerobic respiration -- electron donor III
CITATIONS - :EV-COMP-AINF:3442068424:ave
PREDECESSORS - (RXN-6883 RXN-6884)
PREDECESSORS - (RXN-6884 RXN-6883)
PREDECESSORS - (RXN-6883 SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN)
PREDECESSORS - (SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN RXN-6883)
PREDECESSORS - (RXN-6883 NADH-DEHYDROG-A-RXN)
PREDECESSORS - (NADH-DEHYDROG-A-RXN RXN-6883)
PRIMARIES - (RXN-6884 (|Reduced-Ferroproteins| OXYGEN-MOLECULE) (|Oxidized-Ferroproteins| WATER))
PRIMARIES - (SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN (|Ubiquinones| SUC) (|Ubiquinols| FUM))
PRIMARIES - (NADH-DEHYDROG-A-RXN (|Ubiquinones| NADH) (|Ubiquinols| NAD))
PRIMARIES - (RXN-6883 (|Oxidized-Ferroproteins| |Ubiquinols|) (|Reduced-Ferroproteins| |Ubiquinones|))
REACTION-LAYOUT - (NADH-DEHYDROG-A-RXN (:LEFT-PRIMARIES |Ubiquinones| NADH) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Ubiquinols| NAD))
REACTION-LAYOUT - (SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN (:LEFT-PRIMARIES SUC |Ubiquinones|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FUM |Ubiquinols|))
REACTION-LAYOUT - (RXN-6884 (:LEFT-PRIMARIES OXYGEN-MOLECULE |Reduced-Ferroproteins|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES WATER |Oxidized-Ferroproteins|))
REACTION-LAYOUT - (RXN-6883 (:LEFT-PRIMARIES |Ubiquinols| |Oxidized-Ferroproteins|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Ubiquinones| |Reduced-Ferroproteins|))
REACTION-LIST - NADH-DEHYDROG-A-RXN
REACTION-LIST - SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN
REACTION-LIST - RXN-6884
REACTION-LIST - RXN-6883
SYNONYMS - aerobic respiration -- alternative oxidase pathway
SYNONYMS - alternative oxidase pathway
//
UNIQUE-ID - AERESPDON-PWY
TYPES - AEROBIC-RESPIRATION
COMMON-NAME - aerobic respiration -- electron donors reaction list
CITATIONS - :EV-COMP-AINF:3419591312:ave
PRIMARIES - (SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN (SUC) (FUM))
PRIMARIES - (HYDROG-RXN (PROTON) (HYDROGEN-MOLECULE))
REACTION-LAYOUT - (L-LACTDEHYDROGFMN-RXN (:LEFT-PRIMARIES L-LACTATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES PYRUVATE))
REACTION-LAYOUT - (DLACTDEHYDROGFAD-RXN (:LEFT-PRIMARIES |Unknown-Quinones| D-LACTATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Unknown-Quinols| PYRUVATE))
REACTION-LAYOUT - (SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN (:LEFT-PRIMARIES SUC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FUM))
REACTION-LAYOUT - (GLYC3PDEHYDROG-RXN (:LEFT-PRIMARIES UBIQUINONE-8 GLYCEROL-3P) (:DIRECTION :L2R) (:RIGHT-PRIMARIES DIHYDROXY-ACETONE-PHOSPHATE CPD-9956))
REACTION-LIST - L-LACTDEHYDROGFMN-RXN
REACTION-LIST - DLACTDEHYDROGFAD-RXN
REACTION-LIST - SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN
REACTION-LIST - GLYC3PDEHYDROG-RXN
//
UNIQUE-ID - PWY-3781
TYPES - AEROBIC-RESPIRATION
COMMON-NAME - aerobic respiration -- electron donor II
CITATIONS - :EV-COMP-AINF:3442068424:ave
PREDECESSORS - (SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN 1.10.2.2-RXN)
PREDECESSORS - (NADH-DEHYDROG-A-RXN 1.10.2.2-RXN)
PREDECESSORS - (1.10.2.2-RXN SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN)
PREDECESSORS - (1.10.2.2-RXN NADH-DEHYDROG-A-RXN)
PREDECESSORS - (CYTOCHROME-C-OXIDASE-RXN 1.10.2.2-RXN)
PREDECESSORS - (1.10.2.2-RXN CYTOCHROME-C-OXIDASE-RXN)
PRIMARIES - (NADH-DEHYDROG-A-RXN (|Ubiquinones| NADH) (|Ubiquinols| NAD))
PRIMARIES - (SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN (|Ubiquinones| SUC) (|Ubiquinols| FUM))
PRIMARIES - (CYTOCHROME-C-OXIDASE-RXN (OXYGEN-MOLECULE) (WATER))
PRIMARIES - (1.10.2.2-RXN (|Cytochromes-C| |Ubiquinols|) (|Cytochromes-C-Reduced| |Ubiquinones|))
REACTION-LAYOUT - (CYTOCHROME-C-OXIDASE-RXN (:LEFT-PRIMARIES |Cytochromes-C-Reduced| OXYGEN-MOLECULE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Cytochromes-C-Oxidized| WATER))
REACTION-LAYOUT - (NADH-DEHYDROG-A-RXN (:LEFT-PRIMARIES |Ubiquinones| NADH) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Ubiquinols| NAD))
REACTION-LAYOUT - (SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN (:LEFT-PRIMARIES SUC |Ubiquinones|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FUM |Ubiquinols|))
REACTION-LAYOUT - (1.10.2.2-RXN (:LEFT-PRIMARIES |Ubiquinols| |Cytochromes-C-Oxidized|) (:DIRECTION :L2R) (:RIGHT-PRIMARIES |Ubiquinones| |Cytochromes-C-Reduced|))
REACTION-LIST - CYTOCHROME-C-OXIDASE-RXN
REACTION-LIST - NADH-DEHYDROG-A-RXN
REACTION-LIST - SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN
REACTION-LIST - 1.10.2.2-RXN
//
UNIQUE-ID - PWY-5690-1
TYPES - TCA-VARIANTS
COMMON-NAME - TCA cycle variation III (eukaryotic)
CREDITS - SRI
CREDITS - |caspi|
PREDECESSORS - (SUCCINATE--COA-LIGASE-GDP-FORMING-RXN 2OXOGLUTARATEDEH-RXN)
PREDECESSORS - (SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN SUCCINATE--COA-LIGASE-GDP-FORMING-RXN)
PREDECESSORS - (2OXOGLUTARATEDEH-RXN ISOCITRATE-DEHYDROGENASE-NAD+-RXN)
PREDECESSORS - (ISOCITRATE-DEHYDROGENASE-NAD+-RXN ACONITATEHYDR-RXN)
PREDECESSORS - (CITSYN-RXN MALATE-DEH-RXN)
PREDECESSORS - (MALATE-DEH-RXN FUMHYDR-RXN)
PREDECESSORS - (FUMHYDR-RXN)
PREDECESSORS - (ACONITATEHYDR-RXN ACONITATEDEHYDR-RXN)
PREDECESSORS - (ACONITATEDEHYDR-RXN CITSYN-RXN)
PREDECESSORS - (FUMHYDR-RXN SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN)
PRIMARIES - (CITSYN-RXN NIL NIL)
PRIMARIES - (MALATE-DEH-RXN (MAL) (OXALACETIC_ACID))
REACTION-LAYOUT - (SUCCINATE--COA-LIGASE-GDP-FORMING-RXN (:LEFT-PRIMARIES SUC) (:DIRECTION :R2L) (:RIGHT-PRIMARIES SUC-COA))
REACTION-LAYOUT - (ISOCITRATE-DEHYDROGENASE-NAD+-RXN (:LEFT-PRIMARIES THREO-DS-ISO-CITRATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-KETOGLUTARATE))
REACTION-LAYOUT - (SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN (:LEFT-PRIMARIES SUC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FUM))
REACTION-LAYOUT - (ACONITATEDEHYDR-RXN (:LEFT-PRIMARIES CIT) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CIS-ACONITATE))
REACTION-LAYOUT - (CITSYN-RXN (:LEFT-PRIMARIES OXALACETIC_ACID) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CIT))
REACTION-LAYOUT - (ACONITATEHYDR-RXN (:LEFT-PRIMARIES CIS-ACONITATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES THREO-DS-ISO-CITRATE))
REACTION-LAYOUT - (2OXOGLUTARATEDEH-RXN (:LEFT-PRIMARIES 2-KETOGLUTARATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUC-COA))
REACTION-LAYOUT - (FUMHYDR-RXN (:LEFT-PRIMARIES MAL) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FUM))
REACTION-LAYOUT - (MALATE-DEH-RXN (:LEFT-PRIMARIES MAL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OXALACETIC_ACID))
REACTION-LIST - SUCCINATE--COA-LIGASE-GDP-FORMING-RXN
REACTION-LIST - ISOCITRATE-DEHYDROGENASE-NAD+-RXN
REACTION-LIST - SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN
REACTION-LIST - ACONITATEDEHYDR-RXN
REACTION-LIST - CITSYN-RXN
REACTION-LIST - ACONITATEHYDR-RXN
REACTION-LIST - 2OXOGLUTARATEDEH-RXN
REACTION-LIST - FUMHYDR-RXN
REACTION-LIST - MALATE-DEH-RXN
SYNONYMS - TCA
SYNONYMS - TCA cycle -- aerobic respiration
SYNONYMS - tricarboxylic acid cycle
SYNONYMS - citric acid cycle
//
UNIQUE-ID - TCA-1
TYPES - TCA-VARIANTS
COMMON-NAME - TCA cycle
CITATIONS - :EV-COMP-AINF:3419591312:ave
PATHWAY-LINKS - (ACETYL-COA PYRUVDEHYD-PWY)
PREDECESSORS - (SUCCINATE--COA-LIGASE-GDP-FORMING-RXN 2OXOGLUTARATEDEH-RXN)
PREDECESSORS - (SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN SUCCINATE--COA-LIGASE-GDP-FORMING-RXN)
PREDECESSORS - (CITSYN-RXN MALATE-DEH-RXN)
PREDECESSORS - (MALATE-DEH-RXN FUMHYDR-RXN)
PREDECESSORS - (FUMHYDR-RXN)
PREDECESSORS - (2OXOGLUTARATEDEH-RXN ISOCITDEH-RXN)
PREDECESSORS - (ISOCITDEH-RXN ACONITATEHYDR-RXN)
PREDECESSORS - (ACONITATEHYDR-RXN ACONITATEDEHYDR-RXN)
PREDECESSORS - (ACONITATEDEHYDR-RXN CITSYN-RXN)
PREDECESSORS - (FUMHYDR-RXN SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN)
REACTION-LAYOUT - (SUCCINATE--COA-LIGASE-GDP-FORMING-RXN (:LEFT-PRIMARIES SUC) (:DIRECTION :R2L) (:RIGHT-PRIMARIES SUC-COA))
REACTION-LAYOUT - (SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN (:LEFT-PRIMARIES SUC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FUM))
REACTION-LAYOUT - (ACONITATEDEHYDR-RXN (:LEFT-PRIMARIES CIT) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CIS-ACONITATE))
REACTION-LAYOUT - (CITSYN-RXN (:LEFT-PRIMARIES ACETYL-COA OXALACETIC_ACID) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CIT))
REACTION-LAYOUT - (ACONITATEHYDR-RXN (:LEFT-PRIMARIES CIS-ACONITATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES THREO-DS-ISO-CITRATE))
REACTION-LAYOUT - (ISOCITDEH-RXN (:LEFT-PRIMARIES THREO-DS-ISO-CITRATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-KETOGLUTARATE))
REACTION-LAYOUT - (2OXOGLUTARATEDEH-RXN (:LEFT-PRIMARIES 2-KETOGLUTARATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUC-COA))
REACTION-LAYOUT - (FUMHYDR-RXN (:LEFT-PRIMARIES MAL) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FUM))
REACTION-LAYOUT - (MALATE-DEH-RXN (:LEFT-PRIMARIES MAL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OXALACETIC_ACID))
REACTION-LIST - SUCCINATE--COA-LIGASE-GDP-FORMING-RXN
REACTION-LIST - SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN
REACTION-LIST - ACONITATEDEHYDR-RXN
REACTION-LIST - CITSYN-RXN
REACTION-LIST - ACONITATEHYDR-RXN
REACTION-LIST - ISOCITDEH-RXN
REACTION-LIST - 2OXOGLUTARATEDEH-RXN
REACTION-LIST - FUMHYDR-RXN
REACTION-LIST - MALATE-DEH-RXN
SYNONYMS - TCA
SYNONYMS - TCA cycle -- aerobic respiration
SYNONYMS - tricarboxylic acid cycle
SYNONYMS - citric acid cycle
//
UNIQUE-ID - PWY3DJ-1574
TYPES - Super-Pathways
COMMON-NAME - TCA cycle and malate/aspartate shuttle superpathway
CITATIONS - :EV-COMP-AINF:3419591312:ave
CREDITS - AU3DJ-15
PREDECESSORS - (2OXOGLUTARATEDEH-RXN ISOCITRATE-DEHYDROGENASE-NAD+-RXN)
PREDECESSORS - (ISOCITRATE-DEHYDROGENASE-NAD+-RXN ACONITATEHYDR-RXN)
PREDECESSORS - (ASPAMINOTRANS-RXN MALATE-DEH-RXN)
PREDECESSORS - (RXN3DJ-4422 ASPAMINOTRANS-RXN)
PREDECESSORS - (RXN3DJ-4528 RXN3DJ-4422)
PREDECESSORS - (TRANS-RXN3DJ-1550 RXN3DJ-10)
PREDECESSORS - MALATE-ASPARTATE-SHUTTLE-PWY
PREDECESSORS - (MALATE-DEH-RXN TRANS-RXN3DJ-1550)
PREDECESSORS - (MALATE-DEH-RXN FUMHYDR-RXN)
PREDECESSORS - (SUCCINATE--COA-LIGASE-GDP-FORMING-RXN 2OXOGLUTARATEDEH-RXN)
PREDECESSORS - (SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN SUCCINATE--COA-LIGASE-GDP-FORMING-RXN)
PREDECESSORS - (CITSYN-RXN MALATE-DEH-RXN)
PREDECESSORS - (FUMHYDR-RXN)
PREDECESSORS - (2OXOGLUTARATEDEH-RXN ISOCITDEH-RXN)
PREDECESSORS - (ISOCITDEH-RXN ACONITATEHYDR-RXN)
PREDECESSORS - (ACONITATEHYDR-RXN ACONITATEDEHYDR-RXN)
PREDECESSORS - (ACONITATEDEHYDR-RXN CITSYN-RXN)
PREDECESSORS - (FUMHYDR-RXN SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN)
PRIMARIES - (CITSYN-RXN (OXALACETIC_ACID) (CIT))
REACTION-LAYOUT - (ISOCITRATE-DEHYDROGENASE-NAD+-RXN (:LEFT-PRIMARIES THREO-DS-ISO-CITRATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-KETOGLUTARATE))
REACTION-LAYOUT - (ASPAMINOTRANS-RXN (:LEFT-PRIMARIES 2-KETOGLUTARATE L-ASPARTATE) (:DIRECTION :R2L) (:RIGHT-PRIMARIES OXALACETIC_ACID))
REACTION-LAYOUT - (RXN3DJ-4422 (:LEFT-PRIMARIES L-ASPARTATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES L-ASPARTATE))
REACTION-LAYOUT - (MALATE-ASPARTATE-SHUTTLE-PWY (:LEFT-PRIMARIES) (:DIRECTION NIL) (:RIGHT-PRIMARIES))
REACTION-LAYOUT - (TRANS-RXN3DJ-1550 (:LEFT-PRIMARIES 2-KETOGLUTARATE MAL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-KETOGLUTARATE MAL))
REACTION-LAYOUT - (SUCCINATE--COA-LIGASE-GDP-FORMING-RXN (:LEFT-PRIMARIES SUC) (:DIRECTION :R2L) (:RIGHT-PRIMARIES SUC-COA))
REACTION-LAYOUT - (SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN (:LEFT-PRIMARIES SUC) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FUM))
REACTION-LAYOUT - (ACONITATEDEHYDR-RXN (:LEFT-PRIMARIES CIT) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CIS-ACONITATE))
REACTION-LAYOUT - (CITSYN-RXN (:LEFT-PRIMARIES OXALACETIC_ACID) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CIT))
REACTION-LAYOUT - (ACONITATEHYDR-RXN (:LEFT-PRIMARIES CIS-ACONITATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES THREO-DS-ISO-CITRATE))
REACTION-LAYOUT - (ISOCITDEH-RXN (:LEFT-PRIMARIES THREO-DS-ISO-CITRATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES 2-KETOGLUTARATE))
REACTION-LAYOUT - (2OXOGLUTARATEDEH-RXN (:LEFT-PRIMARIES 2-KETOGLUTARATE) (:DIRECTION :L2R) (:RIGHT-PRIMARIES SUC-COA))
REACTION-LAYOUT - (FUMHYDR-RXN (:LEFT-PRIMARIES MAL) (:DIRECTION :R2L) (:RIGHT-PRIMARIES FUM))
REACTION-LAYOUT - (MALATE-DEH-RXN (:LEFT-PRIMARIES MAL) (:DIRECTION :L2R) (:RIGHT-PRIMARIES OXALACETIC_ACID))
REACTION-LIST - ISOCITRATE-DEHYDROGENASE-NAD+-RXN
REACTION-LIST - ASPAMINOTRANS-RXN
REACTION-LIST - RXN3DJ-4422
REACTION-LIST - MALATE-ASPARTATE-SHUTTLE-PWY
REACTION-LIST - TRANS-RXN3DJ-1550
REACTION-LIST - SUCCINATE--COA-LIGASE-GDP-FORMING-RXN
REACTION-LIST - SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN
REACTION-LIST - ACONITATEDEHYDR-RXN
REACTION-LIST - CITSYN-RXN
REACTION-LIST - ACONITATEHYDR-RXN
REACTION-LIST - ISOCITDEH-RXN
REACTION-LIST - 2OXOGLUTARATEDEH-RXN
REACTION-LIST - FUMHYDR-RXN
REACTION-LIST - MALATE-DEH-RXN
SUB-PATHWAYS - MALATE-ASPARTATE-SHUTTLE-PWY
//
UNIQUE-ID - PWY-5934
TYPES - Transport-Pathways
COMMON-NAME - Fe(III)-reduction and Fe(II) transport
CITATIONS - :EV-COMP-AINF:3443363899:ave
CREDITS - O-27
CREDITS - |pujar|
PREDECESSORS - (TRANS-RXN-171 FERRIC-CHELATE-REDUCTASE-RXN)
PREDECESSORS - (FERRIC-CHELATE-REDUCTASE-RXN)
PRIMARIES - (FERRIC-CHELATE-REDUCTASE-RXN (FE+3) (FE+2))
REACTION-LAYOUT - (TRANS-RXN-171 (:LEFT-PRIMARIES FE+2) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FE+2))
REACTION-LAYOUT - (FERRIC-CHELATE-REDUCTASE-RXN (:LEFT-PRIMARIES FE+3) (:DIRECTION :L2R) (:RIGHT-PRIMARIES FE+2))
REACTION-LIST - TRANS-RXN-171
REACTION-LIST - FERRIC-CHELATE-REDUCTASE-RXN
SYNONYMS - Fe(III)-reduction
SYNONYMS - Fe(II) transport
SYNONYMS - Fe(III)-chelation and Fe(II) transport
SYNONYMS - strategy I iron uptake
//
UNIQUE-ID - PWY-6137
TYPES - Transport-Pathways
COMMON-NAME - copper transport II
CITATIONS - :EV-COMP-AINF:3482054332:ave
REACTION-LAYOUT - (3.6.3.4-RXN (:LEFT-PRIMARIES CU+2) (:DIRECTION :L2R) (:RIGHT-PRIMARIES CU+2))
REACTION-LIST - 3.6.3.4-RXN
SYNONYMS - copper transport in roots
//