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Symbol
Name
ID

Vcp
valosin containing protein
MGI:99919

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Elevated circulating creatine kinase concentration	Elevated alkaline phosphatase of bone origin
Disease(s) Associated with VCP	Elevated circulating creatine kinase concentration	Elevated alkaline phosphatase of bone origin
Charcot-Marie-Tooth disease type 2Y
frontotemporal dementia and/or amyotrophic lateral sclerosis 6
inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1
inclusion body myositis

Mouse Phenotypes		homeostasis/metabolism phenotype	abnormal autophagy	abnormal DNA repair	decreased susceptibility to diet-induced obesity	increased susceptibility to diet-induced obesity	increased circulating triglyceride level	increased insulin sensitivity
Availability	Mouse Genotype	homeostasis/metabolism phenotype	abnormal autophagy	abnormal DNA repair	decreased susceptibility to diet-induced obesity	increased susceptibility to diet-induced obesity	increased circulating triglyceride level	increased insulin sensitivity
	Vcp^tm1Itl/Vcp^tm1Itl
	Vcp^em1Kene/Vcp⁺	*
	Vcp^tm1.1Hiok/Vcp⁺
	Vcp^tm1Itl/Vcp⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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