Symbol
Name
ID

Mecp2
methyl CpG binding protein 2
MGI:99918

Phenotype annotations related to growth/size/body

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Short neck	Short stature	Decreased body weight	Failure to thrive	Cachexia	Obesity	Growth delay
Disease(s) Associated with MECP2	Short neck	Short stature	Decreased body weight	Failure to thrive	Cachexia	Obesity	Growth delay
Rett syndrome
severe congenital encephalopathy due to MECP2 mutation
syndromic X-linked intellectual disability Lubs type
X-linked intellectual disability-psychosis-macroorchidism syndrome

Mouse Phenotypes

increased heart weight

abnormal tooth morphology

malocclusion

growth/size/body region phenotype

decreased body weight

slow postnatal weight gain

weight loss

cachexia

increased body weight

obese

abnormal body weight

increased susceptibility to age related obesity

postnatal growth retardation

increased liver weight

Availability

Mouse Genotype

Mecp2^tm1.1Bird/Mecp2^tm1.1Bird

Mecp2^tm1.1Vnar/Mecp2^tm1.1Vnar

Mecp2^tm1.1Dhy/Mecp2⁺

Mecp2^tm1.1Irsf/Mecp2⁺

Mecp2^tm1.1Jae/Mecp2⁺

Mecp2^tm1.1Joez/Mecp2⁺

Mecp2^tm1.1Jtc/Mecp2⁺

Mecp2^tm1Nlnd/Mecp2⁺

Mecp2^tm2Bird/Mecp2⁺

Mecp2^tm1.1Bird/Y

Mecp2^tm1.1Dhy/Y

Mecp2^tm1.1Irsf/Y

Mecp2^tm1.1Jae/Y

Mecp2^tm1.1Joez/Y

Mecp2^tm1.1Jtc/Y

Mecp2^tm1Bird/Y

Mecp2^tm1Jae/Y

Mecp2^tm1Nlnd/Y

Mecp2^tm1Pplt/Y

Mecp2^tm1Vnar/Y

Mecp2^tm2.1Jae/Y

Mecp2^tm2.1Joez/Y

Mecp2^tm3.1Bird/Y

Mecp2^tm4.1Bird/Y

Mecp2^tm5.1Bird/Y

Mecp2^tm6.1Bird/Y

Mecp2^tm1Pplt/0

Mecp2^tm1Jae/Mecp2⁺
Tg(Nes-cre)1Atp/0 (conditional)

Mecp2^tm2Bird/Mecp2⁺
Tg(CAG-cre/Esr1*)5Amc/? (conditional)

Mecp2^tm1Bird/Y
Tg(Nes-cre)1Kln/0 (conditional)

Mecp2^tm1Bird/Y
Tg(Slc32a1-cre)2.1Hzo/0 (conditional)

Mecp2^tm1Jae/Y
Tg(Nes-cre)1Atp/0 (conditional)

Mecp2^tm1Jae/Y
Tg(Camk2a-cre)93Kln/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23