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Symbol
Name
ID
Mecp2
methyl CpG binding protein 2
MGI:99918
Phenotype annotations related to behavior/neurological
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Drooling
Anorexia
Attention deficit hyperactivity disorder
Abnormal aggressive, impulsive or violent behavior
Aggressive behavior
Irritability
Impaired social interactions
Impaired ability to form peer relationships
Impaired use of nonverbal behaviors
Lack of peer relationships
Poor eye contact
Autistic behavior
Autism
Restrictive behavior
Abnormal fear/anxiety-related behavior
Anxiety
Bipolar affective disorder
Depressivity
Impulsivity
Hostility
Inflexible adherence to routines or rituals
Lack of spontaneous play
Psychomotor retardation
Psychosis
Sleep disturbance
Bruxism
Disease(s) Associated with MECP2
autistic disorder
Rett syndrome
syndromic X-linked intellectual disability Lubs type
X-linked intellectual disability-psychosis-macroorchidism syndrome

Mouse Phenotypes
behavior/neurological phenotype
abnormal behavior
increased susceptibility to pharmacologically induced seizures
abnormal associative learning
abnormal contextual conditioning behavior
impaired contextual conditioning behavior
abnormal cued conditioning behavior
impaired cued conditioning behavior
abnormal motor learning
abnormal long term object recognition memory
abnormal spatial learning
abnormal fear/anxiety-related behavior
decreased anxiety-related response
increased anxiety-related response
increased fear-related response
abnormal response to novelty
abnormal response to novel object
increased grooming behavior
abnormal motor capabilities/coordination/movement
abnormal pilomotor reflex
decreased startle reflex
limb grasping
tremors
abnormal motor coordination/balance
ataxia
impaired coordination
decreased grip strength
abnormal locomotor behavior
abnormal locomotor activation
decreased vertical activity
increased vertical activity
akinesia
hyperactivity
hypoactivity
lethargy
abnormal locomotor coordination
abnormal gait
short stride length
stereotypic behavior
increased stereotypic behavior
abnormal touch/ nociception
increased thermal nociceptive threshold
abnormal nest building behavior
abnormal social investigation
seizures
tonic-clonic seizures
sporadic seizures
Availability Mouse Genotype
Mecp2tm1.1Bird/Mecp2tm1.1Bird
Mecp2tm1.1Jtc/Mecp2tm1.1Jtc
Mecp2tm1.1Vnar/Mecp2tm1.1Vnar *
Mecp2tm1.1Bird/Mecp2+ *
Mecp2tm1.1Dhy/Mecp2+
Mecp2tm1.1Irsf/Mecp2+
Mecp2tm1.1Jae/Mecp2+
Mecp2tm1.1Joez/Mecp2+
Mecp2tm1.1Jtc/Mecp2+
Mecp2tm1Hzo/Mecp2+
Mecp2tm1Pplt/Mecp2+
Mecp2tm1Vnar/Mecp2+ *
Mecp2tm2Bird/Mecp2+
Mecp2tm4.1Bird/Mecp2+
Mecp2tm5.1Bird/Mecp2+
Mecp2tm6.1Bird/Mecp2+
Mecp2tm1.1Bird/Y *
Mecp2tm1.1Dhy/Y
Mecp2tm1.1Irsf/Y
Mecp2tm1.1Jae/Y
Mecp2tm1.1Joez/Y
Mecp2tm1.1Jtc/Y
Mecp2tm1.1Meg/Y *
Mecp2tm1Bird/Y *! !
Mecp2tm1Hzo/Y
Mecp2tm1Jae/Y
Mecp2tm1Jchr/Y
Mecp2tm1Pplt/Y *
Mecp2tm1Vnar/Y *
Mecp2tm2.1Jae/Y
Mecp2tm2.1Meg/Y
Mecp2tm2Bird/Y
Mecp2tm3.1Bird/Y
Mecp2tm3.1Jae/Y
Mecp2tm3Meg/Y
Mecp2tm4.1Bird/Y
Mecp2tm5.1Bird/Y
Mecp2tm6.1Bird/Y
Mecp2tm1Pplt/0
Mecp2tm1Jae/Y
Chattm2(cre)Lowl/Chat+  (conditional)
*
Chattm2(cre)Lowl/Chat+
Mecp2tm2Bird/Y  (conditional)
*
Mecp2tm1Jae/Mecp2+
Tg(Nes-cre)1Atp/0  (conditional)
Mecp2tm2Bird/Mecp2+
Tg(CAG-cre/Esr1*)5Amc/?  (conditional)
Mecp2tm1Bird/Y
Pvalbtm1.1(cre)Aibs/Pvalb+  (conditional)
Mecp2tm1Bird/Y
Ssttm2.1(cre)Zjh/Sst+  (conditional)
Mecp2tm1Bird/Y
Tg(Nes-cre)1Kln/0  (conditional)
Mecp2tm1Bird/Y
Tg(dlx5a-cre)1Mekk/0  (conditional)
*
Mecp2tm1Bird/Y
Tg(Slc32a1-cre)2.1Hzo/0  (conditional)
*
Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0  (conditional)
Mecp2tm1Jae/Y
Tg(Camk2a-cre)93Kln/0  (conditional)
Mecp2tm1Jae/Y
Tg(Myh6-cre)2182Mds/0  (conditional)
*
Mecp2tm2Bird/Y
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory