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Symbol
Name
ID
Lama2
laminin, alpha 2
MGI:99912
Phenotype annotations related to muscle
Darker colors indicate more annotations
Human Phenotypes
Facial palsy
Macroglossia
Scapular winging
Shoulder girdle muscle weakness
Limb-girdle muscular dystrophy
Myositis
Flexion contracture
Hypotonia
Neonatal hypotonia
EMG abnormality
Muscle weakness
Intercostal muscle weakness
Respiratory insufficiency due to muscle weakness
Myotonia
Absent muscle fiber merosin
Central core regions in muscle fibers
Increased endomysial connective tissue
Muscle fiber atrophy
Muscular dystrophy
Myopathy
Disease(s) Associated with LAMA2
congenital merosin-deficient muscular dystrophy 1A
muscular dystrophy

Mouse Phenotypes
opisthotonus
skeletal muscle fiber necrosis
myositis
abnormal sarcolemma morphology
abnormal skeletal muscle fiber morphology
increased variability of skeletal muscle fiber size
centrally nucleated skeletal muscle fibers
decreased skeletal muscle fiber number
abnormal skeletal muscle morphology
skeletal muscle endomysial fibrosis
skeletal muscle interstitial fibrosis
dystrophic muscle
muscle degeneration
abnormal muscle physiology
enhanced skeletal muscle regeneration
impaired skeletal muscle regeneration
muscle spasm
muscle weakness
progressive muscle weakness
myopathy
Availability Mouse Genotype
Lama2dy-2J/Lama2dy-2J
Lama2dy-6J/Lama2dy-6J
Lama2dy-7J/Lama2dy-7J
Lama2dy-8J/Lama2dy-8J
Lama2dy-Pas/Lama2dy-Pas
Lama2dy/Lama2dy
Lama2tm1Eeng/Lama2tm1Eeng
Lama2tm1Stk/Lama2tm1Stk

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory