About   Help   FAQ
Symbol
Name
ID
Ryr2
ryanodine receptor 2, cardiac
MGI:99685
Phenotype annotations related to cardiovascular system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Left ventricular dysfunction
Atrial fibrillation
Atrial standstill
Ventricular tachycardia
Effort-induced polymorphic ventricular tachycardia
Ventricular arrhythmia
Syncope
Dilatation of the ventricular cavity
Right ventricular cardiomyopathy
Disease(s) Associated with RYR2
arrhythmogenic right ventricular dysplasia 2
catecholaminergic polymorphic ventricular tachycardia 1

Mouse Phenotypes
cardiovascular system phenotype
abnormal myocardial fiber morphology
abnormal myocardial trabeculae morphology
disorganized myocardium
heart left ventricle hypertrophy
abnormal fetal cardiomyocyte morphology
abnormal heart morphology
thick interventricular septum
thin interventricular septum
increased heart weight
enlarged heart
cardiac hypertrophy
abnormal heart left ventricle morphology
abnormal heart right ventricle morphology
thick ventricular wall
abnormal epicardium morphology
cardiac fibrosis
abnormal cardiovascular system physiology
decreased cardiac output
abnormal cardiac muscle contractility
decreased cardiac muscle contractility
decreased ventricle muscle contractility
abnormal sinus arrhythmia
decreased heart rate
sinus bradycardia
increased heart rate
ventricular tachycardia
absent heartbeat
irregular heartbeat
atrial fibrillation
ventricular fibrillation
ventricular premature beat
atrioventricular block
abnormal heart electrocardiography waveform feature
abnormal T wave
abnormal myocardial fiber physiology
altered response of heart to induced stress
increased response of heart to induced stress
altered response to myocardial infarction
cardiomyopathy
congestive heart failure
Availability Mouse Genotype
Ryr2M1Btlr/Ryr2M1Btlr
Ryr2m2Btlr/Ryr2m2Btlr
Ryr2m3Btlr/Ryr2m3Btlr
Ryr2tm1.1Clhh/Ryr2tm1.1Clhh
Ryr2tm1.1Hnis/Ryr2tm1.1Hnis *
Ryr2tm1.1Hta/Ryr2tm1.1Hta
Ryr2tm1.1Msnr/Ryr2tm1.1Msnr
Ryr2tm1.1Wex/Ryr2tm1.1Wex *
Ryr2tm1Amks/Ryr2tm1Amks
Ryr2tm1Hhv/Ryr2tm1Hhv *
Ryr2tm2.1Msnr/Ryr2tm2.1Msnr *
Ryr2tm2.1Wex/Ryr2tm2.1Wex *
Ryr2tm1.1Clhh/Ryr2+
Ryr2tm1.1Maya/Ryr2+
Ryr2tm1.1Msnr/Ryr2+
Ryr2tm1.1Swch/Ryr2+
Ryr2tm1.1Swch/Ryr2tm2.1Swch
Ryr2tm1Sgp/Ryr2+ *
Ryr2tm1Slh/Ryr2+
Ryr2tm2.1Maya/Ryr2+ *
Ryr2tm2.1Swch/Ryr2+
Ryr2tm2Amks/Ryr2+
Ryr2tm2Hhv/Ryr2+
Ryr2tm3.1Amks/Ryr2+
Ryr2tm3.1Hhv/Ryr2+
Ryr2tm3.1Swch/Ryr2+
Ryr2tm4.1Amks/Ryr2+
Ryr2tm1Krbr/Ryr2tm1Krbr
A1cfTg(Myh6-cre/Esr1*)1Jmk/0  (conditional)
Ryr2tm1Krbr/Ryr2tm3.1Swch
A1cfTg(Myh6-cre/Esr1*)1Jmk/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/13/2019
MGI 6.14
The Jackson Laboratory