About   Help   FAQ
Symbol
Name
ID
Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
MGI:99607
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Decreased HDL cholesterol concentration
Hypercholesterolemia
Disease(s) Associated with ABCA1
familial hypercholesterolemia
Tangier disease

Mouse Phenotypes
homeostasis/metabolism phenotype
decreased cholesterol efflux
increased cholesterol efflux
decreased intestinal cholesterol absorption
increased intestinal cholesterol absorption
abnormal platelet physiology
decreased circulating estradiol level
decreased circulating progesterone level
decreased circulating HDL cholesterol level
decreased circulating LDL cholesterol level
decreased circulating cholesterol level
abnormal circulating phospholipid level
abnormal circulating phytosterol level
increased circulating triglyceride level
abnormal lipid homeostasis
abnormal cholesterol homeostasis
abnormal protein level
abnormal fat-soluble vitamin level
amyloid beta deposits
Availability Mouse Genotype
Abca1m4620Dajl/Abca1m4620Dajl
Abca1mpc227H/Abca1mpc227H
Abca1tm1.1Jp/Abca1tm1.1Jp
Abca1tm1Blt/Abca1tm1Blt
Abca1tm1Jdm/Abca1tm1Jdm *
Abca1tm1Wpfl/Abca1tm1Wpfl
Abca1m4620Dajl/Abca1+
Abca1tm1Jdm/Abca1+
Abca1tm1Wpfl/Abca1+
Tg(Prnp-Abca1)EHol/0 *
Abca1tm1Jp/Abca1tm1Jp
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
Abca1tm1Jp/Abca1tm1Jp
Tg(Vil1-cre)997Gum/0  (conditional)
Abca1tm1Jp/Abca1tm1Jp
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Tg(Vil1-cre)997Gum/0  (conditional)
Abca1tm1Jp/Abca1+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
Abca1tm1Jp/Abca1+
Tg(Vil1-cre)997Gum/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/14/2019
MGI 6.14
The Jackson Laboratory