|
Symbol Name ID |
Abca1
ATP-binding cassette, sub-family A member 1 MGI:99607 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased HDL cholesterol concentration |
Increased LDL cholesterol concentration |
Hypercholesterolemia |
Hypertriglyceridemia |
Decreased circulating apolipoprotein A-I concentration |
Elevated circulating apolipoprotein A-II concentration |
Decreased resting energy expenditure |
Glucose intolerance |
Diabetes mellitus |
Type II diabetes mellitus |
Impaired glucose tolerance |
Insulin resistance |
| Disease(s) Associated with ABCA1 | ||||||||||||
| coronary artery disease | ||||||||||||
| obesity | ||||||||||||
| primary hypoalphalipoproteinemia 1 | ||||||||||||
| Tangier disease | ||||||||||||
| type 2 diabetes mellitus |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
decreased cholesterol efflux |
increased cholesterol efflux |
decreased intestinal cholesterol absorption |
increased intestinal cholesterol absorption |
abnormal platelet physiology |
decreased circulating estradiol level |
decreased circulating progesterone level |
decreased circulating HDL cholesterol level |
decreased circulating LDL cholesterol level |
decreased circulating cholesterol level |
abnormal circulating phospholipid level |
decreased circulating phytosterol level |
increased circulating triglyceride level |
abnormal testosterone level |
abnormal lipid homeostasis |
abnormal cholesterol homeostasis |
abnormal fat-soluble vitamin level |
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| Availability | Mouse Genotype | ||||||||||||||||||
| Abca1m4620Dajl/Abca1m4620Dajl | |||||||||||||||||||
| Abca1mpc227H/Abca1mpc227H | |||||||||||||||||||
| Abca1tm1.1Jp/Abca1tm1.1Jp | |||||||||||||||||||
| Abca1tm1Blt/Abca1tm1Blt | |||||||||||||||||||
| Abca1tm1Jdm/Abca1tm1Jdm | * | ||||||||||||||||||
| Abca1tm1Wpfl/Abca1tm1Wpfl | |||||||||||||||||||
| Abca1m4620Dajl/Abca1+ | |||||||||||||||||||
| Abca1tm1Jdm/Abca1+ | |||||||||||||||||||
| Abca1tm1Wpfl/Abca1+ | |||||||||||||||||||
| Abca1tm1Jp/Abca1tm1Jp Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Abca1tm1Jp/Abca1tm1Jp Tg(Vil1-cre)997Gum/0 (conditional) |
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| Abca1tm1Jp/Abca1tm1Jp Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Tg(Vil1-cre)997Gum/0 (conditional) |
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| Abca1tm1Jp/Abca1+ Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Abca1tm1Jp/Abca1+ Tg(Vil1-cre)997Gum/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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