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Symbol
Name
ID
Fgf8
fibroblast growth factor 8
MGI:99604
Phenotype annotations related to craniofacial
Darker colors indicate more annotations
Human Phenotypes
High palate
Anosmia
Hyposmia
Disease(s) Associated with FGF8
hypogonadotropic hypogonadism 6 with or without anosmia

Mouse Phenotypes
abnormal pharyngeal arch artery morphology
abnormal fourth pharyngeal arch artery morphology
absent fourth pharyngeal arch artery
fourth pharyngeal arch artery hypoplasia
abnormal sixth pharyngeal arch artery morphology
absent sixth pharyngeal arch artery
abnormal third pharyngeal arch artery morphology
enlarged third pharyngeal arch artery
third pharyngeal arch artery hypoplasia
abnormal craniofacial morphology
abnormal mandible morphology
abnormal maxilla morphology
absent molars
absent incus
abnormal craniofacial development
absent Meckel's cartilage
abnormal pharyngeal arch morphology
small first pharyngeal arch
abnormal pharyngeal arch mesenchyme morphology
small pharyngeal arch
pharyngeal arch hypoplasia
decreased tongue size
Availability Mouse Genotype
Fgf8tm1.1Jyhl/Fgf8tm1.1Jyhl
Fgf8tm1.1Mrt/Fgf8tm1.2Mrt
Fgf8tm1Mrc/Fgf8tm3Mrc
Fgf8tm1Moon/Fgf8tm1Moon
Mesp1tm2(cre)Ysa/Mesp1+  (conditional)
Fgf8tm1.2Mrt/Fgf8tm1.3Mrt
Tg(Nes-cre)1Atp/0  (conditional)
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Nkx2-5tm1(cre)Rjs/Nkx2-5+  (conditional)
Fgf8tm1.3Mrt/Fgf8tm2Mrt
Nkx2-5tm1(cre)Rjs/Nkx2-5+  (conditional)
Fgf8tm1Mrc/Fgf8tm1Moon
Tfap2atm1(cre)Moon/Tfap2a+  (conditional)
Fgf8tm1Mrc/Fgf8tm1Moon
Hoxa3tm1(cre)Moon/Hoxa3+  (conditional)
Fgf8tm1Mrc/Fgf8tm2Mrc
Tfap2atm1(cre)Moon/Tfap2a+  (conditional)
Fgf8tm1Mrc/Fgf8tm2Mrc
Hoxa3tm1(cre)Moon/Hoxa3+  (conditional)
Fgf8tm2Moon/Fgf8tm1Mrc
Isl1tm1(cre)Sev/Isl1+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory