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Symbol
Name
ID
Gcgr
glucagon receptor
MGI:99572
Phenotype annotations related to endocrine/exocrine glands
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Type II diabetes mellitus
Disease(s) Associated with GCGR
type 2 diabetes mellitus

Mouse Phenotypes
abnormal pancreatic alpha cell differentiation
increased pancreatic beta cell proliferation
increased pancreatic alpha cell proliferation
abnormal pancreatic acinar cell morphology
endocrine/exocrine gland phenotype
abnormal pancreatic islet morphology
abnormal pancreatic alpha cell morphology
increased pancreatic alpha cell mass
increased pancreatic alpha cell number
increased pancreatic beta cell mass
enlarged pancreatic islets
pancreatic islet hyperplasia
abnormal exocrine gland morphology
increased pancreas weight
enlarged pancreas
increased pancreas tumor incidence
increased glucagonoma incidence
increased glucagon secretion
Availability Mouse Genotype
Gcgrtm1Jcp/Gcgrtm1Jcp
Gcgrtm1Mjch/Gcgrtm1Mjch *
Gcgrtm2.1Mjch/Gcgrtm2.1Mjch
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/03/2018
MGI 6.12
The Jackson Laboratory