|
Symbol Name ID |
Ptpn11
protein tyrosine phosphatase, non-receptor type 11 MGI:99511 |
| Darker colors indicate more annotations |
| Human Phenotypes | Blue irides |
Hypertelorism |
Proptosis |
Strabismus |
Nystagmus |
Myopia |
Ptosis |
| Disease(s) Associated with PTPN11 | |||||||
| Noonan syndrome | |||||||
| Noonan syndrome 1 | |||||||
| Noonan syndrome with multiple lentigines 1 | |||||||
| tetralogy of Fallot |
| Mouse Phenotypes | abnormal lacrimal gland development |
absent lacrimal glands |
retina ganglion cell degeneration |
optic nerve atrophy |
abnormal eye distance/ position |
ocular hypertelorism |
increased inner canthal distance |
thin retina ganglion layer |
abnormal retina inner nuclear layer morphology |
thin retina inner nuclear layer |
thin retina inner plexiform layer |
thin retina outer nuclear layer |
retina outer nuclear layer degeneration |
retina degeneration |
decreased a-wave amplitude |
decreased b-wave amplitude |
abnormal cone electrophysiology |
abnormal rod electrophysiology |
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| Availability | Mouse Genotype | ||||||||||||||||||
| Ptpn11tm7Bgn/Ptpn11tm7Bgn | |||||||||||||||||||
| Ptpn11tm1.1Ics/Ptpn11+ | |||||||||||||||||||
| Ptpn11tm1Bgn/Ptpn11+ | |||||||||||||||||||
| Ptpn11tm4.2Bgn/Ptpn11+ | |||||||||||||||||||
| Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Pax6-cre,GFP)1Pgr/0 (conditional) |
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| Ptpn11tm1Gsf/Ptpn11tm1Gsf Tg(Six3-cre)69Frty/0 (conditional) |
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| Ptpn11tm6Bgn/Ptpn11+ H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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