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Symbol Name ID |
Ptpn11
protein tyrosine phosphatase, non-receptor type 11 MGI:99511 |
| Darker colors indicate more annotations |
| Human Phenotypes | Thickened nuchal skin fold |
| Disease(s) Associated with PTPN11 | |
| Noonan syndrome |
| Mouse Phenotypes | decreased trophectoderm cell proliferation |
abnormal gastrulation |
failure of initiation of embryo turning |
abnormal endoderm development |
abnormal rostral-caudal axis patterning |
caudal body truncation |
embryonic growth arrest |
embryonic growth retardation |
abnormal axial mesoderm morphology |
abnormal neural tube morphology |
abnormal embryonic neuroepithelium morphology |
decreased enteric neural crest cell number |
open neural tube |
kinked neural tube |
abnormal notochord morphology |
incomplete somite formation |
disorganized embryonic tissue |
abnormal blastocyst morphology |
inner cell mass degeneration |
abnormal trophectoderm morphology |
abnormal allantois morphology |
abnormal visceral yolk sac morphology |
abnormal vitelline vascular remodeling |
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| Availability | Mouse Genotype | |||||||||||||||||||||||
| Ptpn11tm1Paw/Ptpn11tm1Paw | ||||||||||||||||||||||||
| Ptpn11tm2Bgn/Ptpn11tm2Bgn | ||||||||||||||||||||||||
| Ptpn11tm5Bgn/Ptpn11tm5Bgn | ||||||||||||||||||||||||
| Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Hprt1tm1(CAG-cre)Mnn/Hprt1+ Ptpn11tm1Ckq/Ptpn11+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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