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Symbol
Name
ID
Ptpn11
protein tyrosine phosphatase, non-receptor type 11
MGI:99511
Phenotype annotations related to craniofacial
Darker colors indicate more annotations
Human Phenotypes
Low posterior hairline
Parietal bossing
Micrognathia
Mandibular prognathia
Macrocephaly
Triangular face
Preauricular pit
Midface retrusion
Broad forehead
High forehead
Thick lower lip vermilion
Cleft palate
High palate
High, narrow palate
Dental malocclusion
Depressed nasal ridge
Hyposmia
Downslanted palpebral fissures
Epicanthus
Disease(s) Associated with PTPN11
Noonan syndrome
Noonan syndrome 1
Noonan syndrome with multiple lentigines 1
tetralogy of Fallot

Mouse Phenotypes
abnormal craniofacial morphology
abnormal cranium size
decreased cranium height
decreased cranium length
small cranium
abnormal mandible morphology
absent mandible
micrognathia
abnormal nasal bone morphology
absent craniofacial bones
abnormal craniofacial development
absent nasal capsule
abnormal facial morphology
abnormal tongue morphology
depressed nasal bridge
abnormal nasal cartilage morphology
broad snout
flattened snout
small snout
small ears
Availability Mouse Genotype
Ptpn11tm7Bgn/Ptpn11tm7Bgn
Ptpn11tm1.1Ics/Ptpn11+
Ptpn11tm1Bgn/Ptpn11+
Ptpn11tm4.2Bgn/Ptpn11+
Ptpn11tm7Bgn/Ptpn11+
Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)
Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)
Ptpn11tm6Bgn/Ptpn11+
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)
Hprt1tm1(CAG-cre)Mnn/Hprt1+
Ptpn11tm1Ckq/Ptpn11+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory