Symbol Name ID |
Ptpn11
protein tyrosine phosphatase, non-receptor type 11 MGI:99511 |
Darker colors indicate more annotations |
Human Phenotypes | Low posterior hairline |
Parietal bossing |
Micrognathia |
Mandibular prognathia |
Macrocephaly |
Triangular face |
Preauricular pit |
Midface retrusion |
Broad forehead |
High forehead |
Thick lower lip vermilion |
Cleft palate |
High palate |
High, narrow palate |
Dental malocclusion |
Depressed nasal ridge |
Hyposmia |
Downslanted palpebral fissures |
Epicanthus |
Disease(s) Associated with PTPN11 | |||||||||||||||||||
Noonan syndrome | |||||||||||||||||||
Noonan syndrome 1 | |||||||||||||||||||
Noonan syndrome with multiple lentigines 1 | |||||||||||||||||||
tetralogy of Fallot |
Mouse Phenotypes | abnormal craniofacial morphology |
abnormal cranium size |
decreased cranium height |
decreased cranium length |
small cranium |
abnormal mandible morphology |
absent mandible |
micrognathia |
abnormal nasal bone morphology |
absent craniofacial bones |
abnormal craniofacial development |
absent nasal capsule |
abnormal facial morphology |
abnormal tongue morphology |
depressed nasal bridge |
abnormal nasal cartilage morphology |
broad snout |
flattened snout |
small snout |
small ears |
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Availability | Mouse Genotype | ||||||||||||||||||||
Ptpn11tm7Bgn/Ptpn11tm7Bgn | |||||||||||||||||||||
Ptpn11tm1.1Ics/Ptpn11+ | |||||||||||||||||||||
Ptpn11tm1Bgn/Ptpn11+ | |||||||||||||||||||||
Ptpn11tm4.2Bgn/Ptpn11+ | |||||||||||||||||||||
Ptpn11tm7Bgn/Ptpn11+ | |||||||||||||||||||||
Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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Ptpn11tm6Bgn/Ptpn11+ H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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Hprt1tm1(CAG-cre)Mnn/Hprt1+ Ptpn11tm1Ckq/Ptpn11+ (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/19/2024 MGI 6.23 |
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