Symbol
Name
ID

Chuk
conserved helix-loop-helix ubiquitous kinase
MGI:99484

Phenotype annotations related to integument

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Thin skin
Disease(s) Associated with CHUK	Thin skin
fetal encasement syndrome

Mouse Phenotypes

integument phenotype

abnormal keratinocyte differentiation

increased keratinocyte proliferation

abnormal mammary gland growth during pregnancy

abnormal mammary gland epithelium morphology

abnormal mammary gland alveolus morphology

abnormal lactation

impaired skin barrier function

skin inflammation

sparse hair

abnormal hair follicle morphology

abnormal hair follicle development

abnormal vibrissa follicle morphology

absent vibrissae

abnormal skin morphology

abnormal epidermal layer morphology

abnormal epidermis stratum basale morphology

abnormal epidermis stratum corneum morphology

absent epidermis stratum corneum

parakeratosis

abnormal epidermis stratum granulosum morphology

absent epidermis stratum granulosum

abnormal epidermis stratum spinosum morphology

abnormal epidermis suprabasal layer morphology

epidermal desquamation

epidermal hyperplasia

thick epidermis

abnormal skin appearance

shiny skin

skin lesions

tight skin

translucent skin

wrinkled skin

abnormal skin condition

thick skin

increased skin tumor incidence

increased skin papilloma incidence

increased skin squamous cell carcinoma incidence

abnormal skin physiology

Availability

Mouse Genotype

Chuk^tm1.1Mpa/Chuk^tm1.1Mpa

Chuk^tm1Aki/Chuk^tm1Aki

Chuk^tm1Mka/Chuk^tm1Mka

Chuk^tm1Ver/Chuk^tm1Ver

Chuk^tm2Mka/Chuk^tm2Mka

Chuk^tm2Yhu/Chuk^tm2Yhu

Chuk^tm1Mpa/Chuk^tm1Mpa
Tg(KRT14-cre)1Cgn/? (conditional)

Chuk^tm1Yhu/Chuk^tm1Yhu
Tg(KRT5-cre)5132Jlj/0 (conditional)

Chuk^tm1Yhu/Chuk^tm1Yhu
Tg(KRT14-cre)1Cgn/0 (conditional)

Chuk^tm1Yhu/Chuk^tm1Yhu
Tg(MMTV-cre)4Mam/0 (conditional)

Chuk^tm1Yhu/Chuk^tm1Yhu
Tg(Krt1-15-cre/PGR*)22Cot/0 (conditional)

Chuk^tm1Yhu/Chuk^tm1Yhu
Tg(Krt1-5-cre/ERT)1Ipc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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