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Symbol
Name
ID

Irs1
insulin receptor substrate 1
MGI:99454

Phenotype annotations related to skeleton

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Osteoporosis	Gout
Disease(s) Associated with IRS1	Osteoporosis	Gout
coronary artery disease

Mouse Phenotypes

skeleton phenotype

impaired osteoblast differentiation

abnormal osteoclast differentiation

decreased osteoblast proliferation

abnormal osteoblast physiology

increased osteoclast cell number

abnormal osteoclast physiology

abnormal bone healing

abnormal femur morphology

short femur

short tibia

abnormal long bone epiphyseal plate proliferative zone

abnormal long bone hypertrophic chondrocyte zone

decreased long bone epiphyseal plate size

abnormal bone structure

decreased bone mineral content

decreased bone mineral density of femur

decreased bone mineral density

decreased compact bone thickness

decreased osteoblast cell number

increased osteoblast cell number

abnormal trabecular bone morphology

decreased trabecular bone thickness

decreased chondrocyte number

abnormal bone mineralization

Availability

Mouse Genotype

Irs1^mpc178H/Irs1^mpc178H

Irs1^Sml/Irs1^Sml

Irs1^tm1Jos/Irs1^tm1Jos

*

Irs1^tm1Tka/Irs1^tm1Tka

Irs1^Sml/Irs1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23