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Symbol
Name
ID
Irs1
insulin receptor substrate 1
MGI:99454
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Type II diabetes mellitus
Insulin resistance
Disease(s) Associated with IRS1
type 2 diabetes mellitus

Mouse Phenotypes
homeostasis/metabolism phenotype
abnormal vascular wound healing
decreased insulin secretion
decreased circulating glucose level
increased circulating insulin level
decreased circulating HDL cholesterol level
increased circulating free fatty acid level
increased circulating triglyceride level
abnormal glucose homeostasis
impaired glucose tolerance
insulin resistance
abnormal lipid level
impaired lipolysis
abnormal bone healing
Availability Mouse Genotype
Irs1m1Btlr/Irs1m1Btlr
Irs1Sml/Irs1Sml
Irs1tm1Jos/Irs1tm1Jos
Irs1tm1Tka/Irs1tm1Tka *
Irs1tm2.1Mfw/Irs1tm2.1Mfw
Irs1Sml/Irs1+
Irs1tm2.1Mfw/Irs1+
Irs1tm1Mfw/Irs1tm1Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
Irs1tm2Tka/Irs1tm2Tka
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory