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Symbol
Name
ID
Wnt4
wingless-type MMTV integration site family, member 4
MGI:98957
Phenotype annotations related to skeleton
Darker colors indicate more annotations
Human Phenotypes
Short neck
Brachydactyly
Cubitus valgus
Shield chest
Disease(s) Associated with WNT4
Mullerian aplasia and hyperandrogenism

Mouse Phenotypes
decreased chondrocyte proliferation
abnormal craniofacial bone morphology
small frontal bone
small occipital bone
long incisors
short nasal bone
domed cranium
decreased femoral compact bone area
increased width of hypertrophic chondrocyte zone
disorganized long bone epiphyseal plate
abnormal pubis morphology
kyphosis
short lumbar vertebrae
axial skeleton hypoplasia
abnormal bone marrow morphology
decreased areal bone mineral density
decreased bone mineral density of femur
decreased bone trabecula number
decreased trabecular bone mass
abnormal cartilage morphology
abnormal chondrocyte morphology
delayed endochondral bone ossification
Availability Mouse Genotype
Wnt4tm1.1Bhr/Wnt4tm1.1Bhr
Tg(Prrx1-cre)1Cjt/0  (conditional)
Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+
Tg(Col2a1-cre)1Bhr/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory