Symbol
Name
ID

Ucp1
uncoupling protein 1 (mitochondrial, proton carrier)
MGI:98894

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Type II diabetes mellitus	Insulin resistance
Disease(s) Associated with UCP1	Type II diabetes mellitus	Insulin resistance
type 2 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

decreased susceptibility to diet-induced obesity

impaired adaptive thermogenesis

decreased circulating thyroxine level

increased circulating triiodothyronine level

decreased circulating free fatty acids level

decreased circulating triglyceride level

increased body temperature

abnormal body temperature homeostasis

impaired febrile response

abnormal oxygen consumption

decreased oxygen consumption

decreased respiratory quotient

abnormal lipid homeostasis

abnormal physiological response to xenobiotic

decreased physiological sensitivity to xenobiotic

Availability

Mouse Genotype

Ucp1^em1Yqiu/Ucp1^em1Yqiu

Ucp1^m1H/Ucp1^m1H

Ucp1^{tm1b(EUCOMM)Hmgu}/Ucp1^{tm1b(EUCOMM)Hmgu}

Ucp1^tm1Kz/Ucp1^tm1Kz

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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