About Help FAQ

Symbol
Name
ID

Trp53
transformation related protein 53
MGI:98834

Phenotype annotations related to vision/eye

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Central retinal vessel vascular tortuosity	Optic atrophy	Papilledema	Leber optic atrophy	Optic neuropathy	Retinoblastoma	Proptosis	Myopia	Centrocecal scotoma	Visual loss	Open angle glaucoma
Disease(s) Associated with TP53	Central retinal vessel vascular tortuosity	Optic atrophy	Papilledema	Leber optic atrophy	Optic neuropathy	Retinoblastoma	Proptosis	Myopia	Centrocecal scotoma	Visual loss	Open angle glaucoma
choroid plexus papilloma
Graves' disease
Leber hereditary optic neuropathy
osteosarcoma
primary open angle glaucoma

Mouse Phenotypes

abnormal retina vasculature morphology

abnormal optic nerve morphology

absent optic nerve

optic nerve degeneration

optic nerve hypoplasia

retina coloboma

persistence of hyaloid vascular system

abnormal posterior eye segment morphology

abnormal ocular fundus morphology

abnormal retina morphology

retina fold

increased opacity of vitreous body

Availability

Mouse Genotype

Trp53^tm1.2Awbr/Trp53^tm1.2Awbr

Trp53^{tm1b(EUCOMM)Hmgu}/Trp53^{tm1b(EUCOMM)Hmgu}

Trp53^tm1Tyj/Trp53^tm1Tyj

!

!

!

!

!

!

!

!

Tg(CMV-cre)1Cgn/0
Trp53^tm4Att/Trp53⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23