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Symbol
Name
ID
Trp53
transformation related protein 53
MGI:98834
Phenotype annotations related to mortality/aging
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Sudden cardiac death
Disease(s) Associated with TP53
coronary artery disease

Mouse Phenotypes
mortality/aging
decreased mortality induced by ionizing radiation
increased mortality induced by ionizing radiation
increased mortality induced by gamma-irradiation
increased susceptibility to xenobiotic induced morbidity/mortality
decreased susceptibility to induced morbidity/mortality
decreased tumor-free survival time
extended life span
lethality, incomplete penetrance
decreased survivor rate
premature death
lethality throughout fetal growth and development, complete penetrance
lethality throughout fetal growth and development, incomplete penetrance
postnatal lethality, complete penetrance
postnatal lethality, incomplete penetrance
embryonic lethality during organogenesis, complete penetrance
embryonic lethality during organogenesis, incomplete penetrance
prenatal lethality, complete penetrance
prenatal lethality, incomplete penetrance
preweaning lethality, complete penetrance
preweaning lethality, incomplete penetrance
premature aging
Availability Mouse Genotype
Trp53bhy/Trp53bhy
Trp53tm1.1Hwan/Trp53tm1.1Hwan
Trp53tm1.1Manf/Trp53tm1.1Manf
Trp53tm1.1Thst/Trp53tm1.1Thst
Trp53tm1.1Tldo/Trp53tm1.1Tldo
Trp53tm1.1Umol/Trp53tm1.1Umol
Trp53tm1.1Xlu/Trp53tm1.1Xlu *
Trp53tm1.2Awbr/Trp53tm1.2Awbr
Trp53tm1b(EUCOMM)Hmgu/Trp53tm1b(EUCOMM)Hmgu
Trp53tm1Brd/Trp53tm1Brd
Trp53tm1Glo/Trp53tm1Glo
Trp53tm1Sia/Trp53tm1Sia
Trp53tm1Thst/Trp53tm1Thst
Trp53tm1Tyj/Trp53tm1Tyj
Trp53tm1Yjc/Trp53tm1Yjc
Trp53tm2.1Kasa/Trp53tm2.1Kasa *
Trp53tm2.1Snj/Trp53tm2.1Snj
Trp53tm2.1Thst/Trp53tm2.1Thst
Trp53tm2.1Tldo/Trp53tm2.1Tldo *
Trp53tm2.1Umol/Trp53tm2.1Umol
Trp53tm2Glo/Trp53tm2Glo
Trp53tm2Wahl/Trp53tm2Wahl *
Trp53tm3.1Glo/Trp53tm3.1Glo
Trp53tm3Wahl/Trp53tm3Wahl *
Trp53tm3Xu/Trp53tm3Xu *
Trp53tm4.1Glo/Trp53tm4.1Glo *
Trp53tm4Glo/Trp53tm4Glo
Trp53tm4Tyj/Trp53tm4Tyj
Trp53tm4Xu/Trp53tm4Xu
Trp53tm5Wahl/Trp53tm5Wahl *
Trp53tm6Wahl/Trp53tm6Wahl *
Trp53tm7.1Xu/Trp53tm7.1Xu
Trp53tm8Xu/Trp53tm8Xu
Trp53tm1.1Att/Trp53+
Trp53tm1.1Thst/Trp53+
Trp53tm1.1Tldo/Trp53+ *
Trp53tm1.2Awbr/Trp53+
Trp53tm1Brd/Trp53+
Trp53tm1Brd/Trp53tm1Ldo
Trp53tm1Brd/Trp53tm8Xu
Trp53tm1Glo/Trp53+
Trp53tm1Glo/Trp53tm4Glo
Trp53tm1Ldo/Trp53+
Trp53tm1Thst/Trp53+
Trp53tm1Thst/Trp53tm1.1Thst
Trp53tm1Tyj/Trp53+
Trp53tm1Tyj/Trp53tm1.1Umol
Trp53tm1Tyj/Trp53tm2.1Tyj
Trp53tm1Tyj/Trp53tm2.1Umol
Trp53tm1Tyj/Trp53tm3.1Glo
Trp53tm1Tyj/Trp53tm3.1Tyj
Trp53tm2.1Thst/Trp53+
Trp53tm2.1Tyj/Trp53+
Trp53tm2Thst/Trp53+
Trp53tm2Thst/Trp53tm2.1Thst
Trp53tm3.1Glo/Trp53+
Trp53tm3.1Glo/Trp53tm4Glo
Trp53tm3.1Tyj/Trp53+
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Tg(tetO-RNAi:Trp53)ASlowe/0
Trp53tm1Brd/Trp53tm1Brd
Tg(Nes-cre)1Kln/0  (conditional)
Trp53tm1Brd/Trp53tm1Brd
Tg(Lck-cre)1Cwi/0  (conditional)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Trp53tm1Brn/Trp53tm1Brn  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT5-cre/PGR)1Der/0  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+  (conditional)
Trp53tm1Elee/Trp53tm1Elee
Tg(GFAP-cre)25Mes/0  (conditional)
Trp53tm6Xu/Trp53tm6Xu
Tg(Lck-cre)1Cwi/0  (conditional)
Trp53tm1Brn/Trp53+
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+  (conditional)
Trp53tm1Elee/Trp53tm1Tyj
Tg(GFAP-cre)25Mes/0  (conditional)
Trp53tm1Glo/Trp53tm4Glo
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)
Tg(CMV-cre)1Cgn/0
Trp53tm2Att/Trp53+  (conditional)
Trp53tm3.1Glo/Trp53tm4Glo
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)
Trp53tm3Tyj/Trp53+
Tg(Wap-cre)11738Mam/0  (conditional)
Tg(CMV-cre)1Cgn/0
Trp53tm4Att/Trp53+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory