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Symbol
Name
ID
Thrb
thyroid hormone receptor beta
MGI:98743
Phenotype annotations related to skeleton
Darker colors indicate more annotations
Human Phenotypes
Epiphyseal stippling
Disease(s) Associated with THRB
thyroid hormone resistance syndrome

Mouse Phenotypes
abnormal cranium morphology
small fontanelles
spiral ligament degeneration
increased osteoclast cell number
abnormal osteoclast physiology
short femur
short tibia
abnormal long bone epiphyseal plate morphology
abnormal long bone epiphyseal plate proliferative zone
abnormal long bone hypertrophic chondrocyte zone
decreased long bone epiphyseal plate size
abnormal bone structure
decreased compact bone thickness
increased compact bone thickness
abnormal trabecular bone morphology
decreased trabecular bone thickness
osteoporosis
abnormal skeleton development
abnormal epiphyseal plate morphology
abnormal bone mineralization
premature endochondral bone ossification
premature intramembranous bone ossification
premature cranial suture closure
abnormal chondrocyte physiology
Availability Mouse Genotype
Thrbtm1.1Syc/Thrbtm1.1Syc
Thrbtm1Olc/Thrbtm1Olc
Thrbtm4Few/Thrbtm4Few
Thrbtm1.1Syc/Thrb+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory