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Symbol
Name
ID 		Thra
thyroid hormone receptor alpha
MGI:98742
Phenotype annotations related to skeleton
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Relative macrocephaly
Wormian bones
Congenital hip dislocation
Delayed skeletal maturation
Disease(s) Associated with THRA
congenital nongoitrous hypothyroidism 6

Mouse Phenotypes
skeleton phenotype
decreased osteoclast cell number
abnormal osteoclast physiology
short femur
short tibia
abnormal long bone epiphyseal plate morphology
decreased width of hypertrophic chondrocyte zone
increased long bone epiphyseal plate size
abnormal bone structure
decreased bone mineral content
increased bone mineral content
decreased areal bone mineral density
decreased bone mineral density
increased bone mineral density
abnormal compact bone morphology
decreased compact bone area
decreased compact bone thickness
abnormal trabecular bone morphology
decreased trabecular bone thickness
increased trabecular bone thickness
increased bone mass
osteosclerosis
delayed endochondral bone ossification
delayed bone ossification
abnormal chondrocyte physiology
Availability Mouse Genotype
Thratm1Jas/Thratm1Jas
Thratm2Jas/Thratm2Jas *
Thratm2Ven/Thratm2Ven
Thraem1Ffla/Thra+ *
Thraem2Ffla/Thra+ *
Thraem3Ffla/Thra+ *
Thraem4Ffla/Thra+ *
Thraem5Ffla/Thra+ *
Thratm1b(EUCOMM)Wtsi/Thra+
Thratm2Ven/Thra+
Tg(CAG-cre/Esr1*)5Amc/?
Thratm1Ffla/Thra+  (conditional)
Thratm1Ffla/Thra+
Tg(Sycp1-cre)4Min/?  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory