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Symbol
Name
ID
Tcf4
transcription factor 4
MGI:98506
Phenotype annotations related to nervous system
Darker colors indicate more annotations
Human Phenotypes
Microcephaly
Aganglionic megacolon
Small cerebral cortex
Aplasia/Hypoplasia of the corpus callosum
Hypoplasia of the corpus callosum
Ataxia
Gait ataxia
Incoordination
Absent speech
Aphasia
Dysphasia
Echolalia
Mutism
Aggressive behavior
Self-injurious behavior
Happy demeanor
Autistic behavior
Sleep disturbance
Sleep apnea
Encephalopathy
Intellectual disability
Intellectual disability, moderate
Intellectual disability, progressive
Intellectual disability, severe
Global developmental delay
Motor delay
Specific learning disability
Seizures
Abnormal autonomic nervous system physiology
Disease(s) Associated with TCF4
Pitt-Hopkins syndrome

Mouse Phenotypes
abnormal brain morphology
abnormal brain development
decreased brain weight
abnormal action potential
reduced sensorimotor gating
enhanced NMDA-mediated synaptic currents
enhanced long term potentiation
abnormal prepulse inhibition
decreased prepulse inhibition
increased prepulse inhibition
Availability Mouse Genotype
Tcf4tm1Zhu/Tcf4tm1Zhu
Tg(Thy1-Tcf4)1Mjro/0
Tcf4em1Bdph/?
Tcf4em2Bdph/?
Tcf4tm1Hmb/Tcf4+
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+  (conditional)
Tcf4tm1Hmb/Tcf4+
Tg(Nes-cre)1Kln/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory