Symbol
Name
ID

Hnf1b
HNF1 homeobox B
MGI:98505

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Elevated circulating creatinine concentration

Hyperuricemia

Elevated circulating hepatic transaminase concentration

Abnormality of alkaline phosphatase level

Glucose intolerance

Diabetes mellitus

Maturity-onset diabetes of the young

Type II diabetes mellitus

Impaired glucose tolerance

Insulin resistance

Glycosuria

Proteinuria

Disease(s) Associated with HNF1B

maturity-onset diabetes of the young type 5

type 2 diabetes mellitus

Mouse Phenotypes		homeostasis/metabolism phenotype	decreased insulin secretion	increased circulating bilirubin level	increased fasting circulating glucose level	hyperglycemia	decreased circulating insulin level	increased circulating cholesterol level	increased circulating triglyceride level	impaired glucose tolerance	abnormal lipid homeostasis
Availability	Mouse Genotype	homeostasis/metabolism phenotype	decreased insulin secretion	increased circulating bilirubin level	increased fasting circulating glucose level	hyperglycemia	decreased circulating insulin level	increased circulating cholesterol level	increased circulating triglyceride level	impaired glucose tolerance	abnormal lipid homeostasis
	Hnf1b^tm2Ics/Hnf1b⁺	*
	Hnf1b^tm1Mya/Hnf1b^tm3Mya Tg(Alb1-cre)7Gsc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23